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Journal: 50 Sublingual HPBCD DMT Ayahuasca journeys over a years time Options
 
ava69
#1 Posted : 5/2/2021 1:08:34 AM

DMT-Nexus member


Posts: 330
Joined: 24-Apr-2021
Last visit: 02-May-2022
2 minute easily formed HPBCD DMT liquid on a spoon: very bioavailable sublingually under tongue. HPBCD or hydroxypropyl beta cyclodextrin makes the DMT not only very water soluble but studies show it increases penetration into the sublingual mucosa under the tongue by up to 400% as it is a potent polysaccharide derived from the enzymatic degradation of natural corn starch. HPBCD traps the DMT inside it's molecular cone like a tornado. The HPBCD complexed DMT all adheres to bottom of tongue once you place your tongue onto spoon as it forms sticky complexes like sugar. It also outperforms DMT salts orally by many factors in personal trials, combo with tetrahydroharmine, Ayahuasca.

Skip to page 21 for Sublingual Ayahuasca with journeys & pics:
https://www.dmt-nexus.me...147962&#post1147962

Skip to page 20 for one-shot HPBCD DMT Ayahuasca, masks taste & increases absorption many factors, with pics:
https://www.dmt-nexus.me...144098&#post1144098

Update 4pm 3/21/2022: I am writing this 1.5 hour later: took the 1-shot HPBCD DMT Ayahuasca (150mg HPBCD DMT, 250mg THH, 170mg harmine all dissolved into 30ml hot water) and it worked incredibly well! Phenomenal strength, for the 1st 10 minutes I held on tight as it felt like I was handling a high speed sports car, ego disintegrating & boundaries shattered.

For the first 10 minutes, open or closed eyes, didn't matter, saw same thing: colored neon geometrics on the surface of everything. Felt whole body high tryptamine frequency combined with the THH frequency vibration = amazing amplified whole body frequency, like being tuned into another spirit manifested alien world. It felt like a colored shining tractor beam was going to surround me and take me away, very 3-dimensional.

It was so powerful for 10 minutes, I had to close my eyes to find a happy place. Felt like the most powerful of my past Hawaiian psychotria experiences (40 grams leaf) with Caapi which I only ventured at this dose around 5 times (and all by accident, never meant to, as it is so strong) out of my 70 total Hawaiian psychotria journeys (most 30-35 grams), this was no different, exactly the same as the potent leaf, at the very high end for advanced Ayahuasca use.

Dennis Mckenna once said about one of his Ayahuasca journeys, that for the first 10 minutes it felt like he was riding an elevator to the top floor at high speed, this is how it felt for me, or like handling a high speed sports car.

...then it became at 10 minutes extremely enjoyable, infinite open eyed beauty, incredible closed eye morphing & dancing geometrics in wild neon purple, pink & green that lasted for another 35 minutes with closed eyes. With open eyes, saturated neon colors and neon colored rainbow reflections surrounded everything which glowed intensely with an inner divine light, music playing was just heavenly, incredible music enhancement, +5 Shulgin level experience, most powerful experience I've had in years....very strong for 1.5 hour, when it decreased in strength several notches.

I could not believe the open eyed beauty--phenomenal...this is my preferred method. WOW, unbelievable experience, high euphoria, deep headspace, profound spiritual insights, extremely visual, had the power of 40g Hawaiian psychotria to the highest degree. I experienced zero nausea, zero dizziness (so long as I keep my harmine dose below 200mg).

Part 0: 12 reasons pure THH or tetrahydroharmine rocks (this post #1 in middle)
Part 1: HPBCD complexed DMT experimental dosage, effects & duration, over 44 sublingual DMT experiences over a year's time (this post #1 at bottom with pics). Updated 1-1-2022.

--> See the 5 hour brightly colored CEV trip report using 300mg oral THH once + 60mg sublingual HPBCD DMT + 35mg sublingual harmine fb x 2 re-doses every 1.5 hour at the very bottom of this post #1. HPBCD DMT kicks ass period. Most meaningful & intense CEV visionary experience of my life, and I've taken Ayahuasca x 70 times and high dose cactus tea over 200 times. Incredible music enhancement the whole time as well. <--

Part 2: 200mg oral harmine + 300mg oral THH + 90mg sublingual HPBCD DMT 1 hour later + L-dreamer's 2/4/2022 experience: "Sublingual DMT + oral THH - surprising and underrated" + Closing tips + Receptorome chart & explanation (post #2). L-dreamer's cotton ball sublingual method, page 18, post #42: https://www.dmt-nexus.me...ts&t=96861&p=18

Part 3: 300mg pure Tetrahydroharmine (THH) teaching visions all by her self (post #3)
Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note (post #4)
Part 5: Chemist Patrick Arnold's HPBCD complexed prohormones for sublingual use (millions of dollars in sales) & bloodwork studies (post #5)
part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal, absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection (post #6)
part 7: a little bit on my 70 Ayahuasca experiences, doses & visions (post #7)
part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water [post #8]
part 9: 20 minute visionary visit from a dead Aztec Shaman (post #9)
part 10: One way to make pure tetrahydroharmine (post #12)
part 11: From the archives of dmt world: How to easily extract 2.3g dmt from 170g bark using a 2 liter Erlenmeyer flask (post #19)
part 12: Tetrahydroharmine + 1-acetaldehyde LSD (similar to ALD-52) combo, like high dose mescaline
(page 15, post #284).
part 13: Out of print writings on the Divine Plant of the Incas, coca leaf visions...and writings on strong euphoria from coca leaf tea bags soaked in wine, forming orally active cocaethylene in the liver, discovered in 1994. Explains the popularity of Vin Mariani (coca leaf soaked wine) with both popes, Thomas Edison and countless celebrities.
[page 15, post #286]
part 14: THH + mushrooms report from JKW
(bottom of this page 1, post #20)
part 15: 2-20-2022 experience: 300mg oral THH + 30mg sublingual HPBCD harmine freebase + 90mg sublingual HPBCD DMT fb like 600mg of mescaline for 2 hours, with photos.
(bottom of this page 1, post #20)
Multiple encounters with death and depression & 80mg DMT complexed to 560mg HPBCD oral Ayahuasca report
(bottom of this page 1, post #20)
-----------------------------------------------------
Note: THH is NOT an MAOI, she (feminine spirit) is a psychedelic SRI or serotonin reuptake inhibitor just like the following psychedelic serotonin reuptake inhibitors: mescaline, LSD, shrooms, ibogaine.

Make sure your THH is pure and not contaminated with unconverted harmaline (which is a RIMA/maoi). Dab some THH on a wet vinegar soaked cue tip, rub on paper plate, hold under blacklight, if it glows blue you have THH, if any green glow, you have unconverted harmaline in it, keep in mind harmine also glows blue too though.


(0) Part 0: 12 reasons pure THH or tetrahydroharmine rocks


1. Post #12 of this paper: shows how to convert harmaline to pure THH in 1.5 hour for the first time (very fast) with 75% yield. TIHKAL THH entry also achieved 75% yield. Post also shows how to check the blue glow under blacklight to make sure it is pure. Any green in the glow means you still have un-converted harmaline, but follow instructions and you won't have any unconverted.

1. Dennis Mckenna Ph.D: page 115:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.

In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.

2. She is in the same beta-carboline family as ibogaine. She is the 2nd highest alkaloid in Caapi. She has a 10.5 hour half-life with peak at 5.25 hours.

3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.

4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin.

5. THH has numerous similarities to mescaline, she is like the beta-carboline version of mescaline, few people have used her over 100mg. I have seen the receptorome chart for THH vs. mescaline. She not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors A1-A3 associated with beauty and aesthetic enhancement, just like mescaline. Beauty enhancement is "over the top" when THH is included, she is diamondlike shimmering in her beauty.

Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.

6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, when 2 cups are drank by some of the more advanced members for evening at the vegetals (UDV, Santo Daime, Shuar Indian) people are consuming around 300mg of THH.

7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. The combo of THH + DMT is like listening to music on high-dose cactus tea, heavenly.

8. This pure THH at 300mg all by herself is extremely visual, she's an isomer of a hormone like substance made in the brain naturally.

9. The entry in TIHKAL for 300mg THH is completely wrong, where the unexperienced person compares it to the effects of 100mg harmaline. She is nothing at all like harmaline, and like 69ron once said about the person's comment in TIHKAL, he or she would not be able to tell their ass from their elbow. I agree, what complete nonsense.

10. professor8 (found here from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
Quote:
Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.

11. Trips (from here on 12/2/2011):
Quote:
As to how the THH altered the experience -> I find rue extract+DMT to be very similar to mushrooms. I found the THH added to the rue+DMT to shift the experience to a state much closer to that provided by LSD. It was more clear, more energetic, more focused, and when confusion struck it was definitely more "acid-like".

Espiridion:
Quote:
Tetrahydroharmine is much more like mescaline.

The world is moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development: empathy, spirituality, connectedness. Compounds like tetrahydroharmine in Caapi could be said to improve emotional intelligence, a smart-nutrient for the right side of the brain.

At 300mg of THH all by itself, there are heavy open-eyed tracers like lightening flashes, and hours of teaching closed eye visions that start with colored sparkles and fireworks (red, green, yellow, blue) that dart around and progress into full-fledged way-beyond 4k visions with eyes closed that are not only static but often animated like slow and high speed movies, but all one monochrome color like green or blue for me, when you add DMT, the visions then become colored and patterning on animals for example will display their associated colors, DMT also adds on to or builds on top the THH visions, expanding them, but the teachings and insights & visions are credited to the Vine:

12. Gayle Highpine (Ayahuasca researcher):
Quote:
The vine carries the content of the message, the teaching, and the insight. The purpose of drinking Ayahuasca is to receive the message the vine imparts.

Tetrahydroharmine or THH ranks very high on the "periodic psychedelic table" among all the known entheogens for inducing realistic way beyond 4k monochrome teaching visions for hours...adding even small amounts of DMT brightens and colorizes the visions, example: reptiles, birds & animals such as serpents/snakes/toucans/parrots/jaguars with patterning show their respective associated colors. Many times I have viewed multi-colored serpents, birds & jaguars several times over hour long CEV periods, serpents are the manifest spirit of Ayahuasca.

Daniel Pinchbeck "Breaking Open the Head" (Daniel also states in his book, that Ayahuasca is his favorite entheogen):
Quote:
For many people, Ayahuasca-a slowed-down low-res interface of the DMT flash-seems to convey strong messages from the natural world, of nature as sentient energy and spirit matter, of the need to protect the planet we have been given.

Yage whispers that human beings are meant to be gardeners of this reality, journeyers, storytellers and singers, weavers of the sacred. DMT, on the other hand, conveys no overt human or humane message.

Graham Hancock, "Supernatural", pg 428:
Quote:
My experience with smoked DMT was qualitatively different from the realms and beings Ayahuasca introduced me to. For whereas the Ayahuasca worlds seemed rich, luxurious, and abundant in the transformations of organic and supernatural life, DMT brought me to a world--or to some aspect of a world--that appeared from the outset to be highly artificial, constructed, inorganic, and in essence technological.

Gayle Highpine (Ayahuasca researcher):
Quote:
In the western world, Ayahuasca acquired a new definition: It was now, by definition, the combination of Banisteriopsis caapi and a DMT-containing plant. Ayahuasca became, by definition “orally active DMT.” The first anthropologist to adopt the new definition seems to have been Luis Eduardo Luna in 1984. Luna spent time with Terence McKenna, absorbing his perspective, before beginning his fieldwork. Since then, anthropologists have increasingly adopted this definition and filtered their observations through it. The preeminence of the Ayahuasca vine in the indigenous Amazonian world became the elephant in the living room of Ayahuasca studies, with a tacit agreement to pretend it doesn’t exist.

The leaves were Ayahuasca’s “helpers,” I was told, and their purpose was to “brighten and clarify” the visions. The vine is like a cave, and the leaf is like a torch you use to see what is inside the cave. The vine is like a book, and the leaf is like the candle you use to read the book.

The vine is like a snowy television set, and the leaf helps to tune in the picture. There was a subtle attitude that the need for strong leaf was the sign of a beginner: An experienced ayahuasquero could see the visions even in low light.

Ayahuasca vine is not visionary in the same way as DMT. Visions from vine-only brews are shadowy, monochromatic, like silhouettes, or curling smoke, or clouds moving across the night sky. It is because their visions are usually monochromatic that vines are classified by the color of vision they produce: white, black, blue, red (in my experience, dark maroon).

Snakes, the most common vision on Ayahuasca, are considered the manifest spirit of the vine. Vine visions can be hard to see; in fact, the “visions” may not be visual at all, but auditory or somatic or intuitive. But the vine carries the content of the message, the teaching, and the insight.

The leaf helps illuminate the content, but the teachings are credited to the vine. Vine visions are “frequently associated with writing, to a code that is present in visions…or in the ‘books’ where the spirits keep the secrets of the forest.” (Calavia Saez 2011:135).

The vine is The Teacher, The Healer, The Guide. The purpose of drinking Ayahuasca is to receive the message the vine imparts. This is why it is the vine, not the leaf, that is classified by the type of vision it gives. “For them the vine is, in truth, a living guide, a friend, a paternal authority” (Weiskopf 2005:104).

Psychedelia, page 61:
Quote:
A traditional saying among Ayahuasqueros is that the jungle vine brings powerful realistic visions, but that the chacruna brings light to these visions. According to the view of Western research, this is not the case; essentially the entire psycho-activity resides with the chacruna leaves DMT content.

Ayahuasca researcher Luis Eduardo Luna recently observed that when surveying tribal lore praising the jungle vine, he could find no traces of similar mythology around the two most common plant admixtures; psychotria viridis or diplpterys cabrerana, even though these DMT plants to a Westerner would appear much more important than the harmala alkaloids of the B. caapi liana.


Part 1: HPBCD complexed DMT experimental dosage, effects & duration


How this works: the Hydroxy propyl beta cyclodextrin molecule (HPBCD) has an inner hydrophobic cavity (repels water) which attracts & traps freebase molecules like DMT freebase inside it's tornado shaped cone. The outer cavity is hydrophilic (likes water) and thus makes the DMT molecule water-soluble.

HPBCD, being a potent polysaccharide derived from the enzymatic degradation of starch, improves the penetration of the DMT freebase many factors over (studies show x 4 factors or 400%) into the sublingual mucosa under the tongue. HPBCD then releases the DMT as the potent freebase into the bloodstream once it crosses the sublingual mucosa, these reasons explain it's potency.

Keep in mind using DMT salts sublingually does not work, and there is no penetration enhancement unless HPBCD is used to complex DMT in the freebase form only. The cyclodextrins have toroidal shapes, with the larger and the smaller openings of the toroid exposing to the solvent secondary and primary hydroxyl groups respectively.

You can order HPBCD from China no matter where you live as it is legal, and if you google "Europe + HPBCD" there are a couple places that sell it as well. It is very common in the USA from *mazon or auction sites.

My very first April 2021 sublingual trip report that started all this:

Note: Be sure to always take from 150 to 300mg very pure THH orally around 45 minutes before. You can put it in an empty capsule. Normal Caapi based Ayahuasca always contains an average of 150mg THH per cup. When 2 cups are drank for the evening by more advanced members of the UDV, Santo Daime, Shuar Indian, or advanced members like myself, people are consuming 300mg of THH.

No need to ever re-dose more of the oral tetrahydroharmine or THH as she (feminine teaching spirit) has a half life of 10.5 hours with peak at 5.25 hours.

Always complex the 30mg harmine freebase to HPBCD as well, this makes it very water soluble and increases penetration into the sublingual mucosa under the tongue by many factors, and also completely masks the harmine freebase taste. I've tested how fast it can absorb under the tongue by itself, only 5 minutes it works so well. But always take it at the exact same time as the HPBCD DMT under tongue, mix it into the HPBCD DMT spoon and take it all at once under tongue for the most powerful experience, just as the Shaman's do: all at once.

Depending on total HPBCD harmine + HPBCD dmt dosage, it can all absorb in as little as 10 minutes, for higher doses I give it 15 minutes under tongue, it all completely absorbs. Spit out all the built up saliva at the end of 15 minutes into a cup, all of the sublingual Ayahuasca ingredients should have easily absorbed by then....but if at any point during the 15 minutes you build up too much saliva, and you feel it become too uncomfortable, simply tilt head forward and gently relieve any built up saliva but always keep tongue pressed down to hold any remaining ingredients in the sublingual mucosa under tongue at all times.

There is a mild to moderate sting felt while you do this, and it doesn't bother me at all, as it is so worth enduring for 10 to 15 minutes for the phenomenal spiritually divine experience that begins 22 minutes after you begin all this (the sublingual experience begins in 1/2 the time or 22 minutes instead of 45 minutes like the oral) but still lasts 1.5 hour with super long afterglow. You can re-dose up to two more times, and it continues to work just as strong as the first dose, so long as you continue to use 30mg harmine along with each re-dose of dmt.

--> On my very first 300mg oral THH taken 45 minutes earlier + sublingual 60mg HPBCD DMT fb (60mg DMT complexed to x7 or 420mg HPBCD in 6 drops boiling hot water) combined with sublingual 30mg HPBCD harmine fb (30mg harmine complexed to x6 or 180mg HPBCD in 4 drops boiling hot water) held under tongue at exact same time journey with 2 sublingual re-doses at each 1.5 hour mark (had not used dmt in several months):

...all the way till 5am in the morning I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.

I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea.

I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.

All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."

...all of these visions were brightly colored due to the sublingual DMT/harmine and oral THH combo all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 70 times, cactus 200 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw that first night.

The visions inspired me to buy a book on the Aztec myth of "Quetzalcoatl, the serpent of precious feathers", as I feel somehow this entity is a "teacher to mankind". I saw the brightly colored serpents many times in the 5 hours of visions, and now I understand why they are so commonly reported in Ayahuasca journeys.

They seem to possess divine knowledge that humans were not supposed to have been privileged to, but the serpents gifted this knowledge to humankind.

Recently found a 1.5 hour video on Amazon prime entitled "Ancient Alien Origins" which is all about this ancient alien flying serpent or dragon entity which is found in all religions of the world & "BAM, Builders of the Ancient Mysteries".

Also, see "Alien gods" 2019 on amazon prime, another great video all about this winged serpent, giver of knowledge, culture, music, art, civilization to mankind, first appearing around some 5000 years before Christ. The snake was equated to wisdom & healing, even in the Bible.

Return of the Serpent & of Eden:

https://earthmedicine201...of-the-serpent-of-eden/
hxxps://earthmedicine2015.wordpress.com/2016/01/29/return-of-the-serpent-of-eden/

Reference: Full instructions for sublingual or the one-shot HPBCD DMT Ayahuasca (your choice):
1) place 60mg of DMT onto a spoon (60mg for beginners)
2) add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 8 drops of very hot near boiling water to the mix from a nearby microwaved coffee mug for DMT doses of 90mg, use 10 drops of boiling hot water to mix DMT doses of 120mg. Use 12 drops of hot water for 150mg DMT. You will want to use less drops of hot water (1 drop per 12mg DMT) for higher doses of DMT so it will fit comfortably below the tongue. 60mg DMT = +3 Shulgin level strength, 90mg DMT = +4 Shulgin level life strength. 120 to 150mg DMT = +5 Shulgin level life changing experience.
5) Knead or crush the HPBCD powder into the dmt using the end of another spoon for 2 minutes, scrape & mix everything back and forth hard using your muscles. This is how scientist pre-pare these complexes by kneading.
6) Hold a lighter one inch away from under the spoon to heat up spoon for 20 seconds, then pull flame away, this aids the final complete dissolution or dissolving of the 2 ingredients after heating up a slight bit, mix the contents 10 seconds more before using, just as bodybuilder chemist Patrick Arnold recommended and taught for sublingual pro-hormone mixing.

7) --> For one-shot Ayahuasca: Refer to post #381 on page 20 with 6 pics, simply dunk spoon of HPBCD DMT into 30ml (one-shot) of 125 degree F water from microwave when ready to drink for the evening, stir a few seconds...it dissolves instantly, and leaves a transparent color it dissolves so well, then stir in around 160mg harmine fb and 150 to 300mg tetrahydroharmine freebase, add around 100mg of 100% pure vitamin C powder so the freebase harmalas can dissolve, stir a bit, then drink all at once as the Shaman's do for the most powerful journey.

8] --> For sublingual Ayahuasca: Place 30mg harmine freebase on a spoon, cover it with x6 or 180mg HPBCD to keep at a 1:1 molar ratio of harmine to HPBCD. Use x7 or 210mg HPBCD if using the more common 2-hydroxypropyl beta-cyclodextrin. Add 3 drops of boiling hot water from a nearby microwaved coffee mug, mix and mash it all together hard using muscles for 2 minutes on the spoon using the end of another spoon.

--> General rule for sublingual use: use 1 drop of boiling hot water from a nearby microwaved coffee mug for each 10mg of dmt freebase, or each 10mg of harmine freebase you are mixing and mashing on a spoon using the end of another spoon. Example: Use 6 drops of very hot water from a medicine pipette to mix 60mg of dmt with x7 or 420mg HPBCD on a spoon using the end of another spoon. Use 9 drops of very hot water to mix 90mg of dmt with x7 or 630mg HPBCD. Use 3 drops of very hot water to mix 30mg harmine with x6 or 180mg HPBCD. When preparing for oral one-shot Ayahuasca use, I tend to use slightly more drops as stated in step #4 above.

Then mix this HPBCD complexed harmine into your HPBCD complexed DMT...then place bottom of tongue onto the spoon of harmine and DMT complex, it will all adhere, as HPBCD forms sticky complexes....be sure you took 150mg to 300mg of pure THH orally 45 minutes before....hold this harmine/dmt HPBCD sublingual complex under tongue for 10 to 15 minutes depending on dosage, it will all absorb, experience begins in 22 minutes once you start all this, or 1/2 the time of an oral dosage...but the experience still lasts 1.5 hour or the same time as an oral dosage with super long afterglow. You can re-dose up to two more times and each dose will be as strong as the first for a 4.5 hour total long experience. Remember: sublingual 30mg HPBCD harmine has the power of x6 or 180mg oral harmine, it works very well to activate the DMT.

Note: DRY THE BOTTOM of tongue/sublingual mucosa with a tissue before applying.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017: page 5 of 16 under "Oral products, Kinetics":
Quote:
The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27].

This pharmacology has been used to potentiate these freebase drugs ORALLY as well -- in my experience, this results in an Ayahuasca experience that is strong in potency. Example: HPBCD improves oral absorption profile for Ofloxacin, a second generation fluroquinolones by 54 to 89 percent.

"Sublingual mucosa as a route for systemic drug delivery" by Narang & Sharma 2010:
https://innovareacademic...pps/Vol3Suppl2/1092.pdf

As you can see from this sublingual viagra study, even 50 to 100mg doses can be administered under the tongue, the authors noting that less of the drug was required, and that it began working in only one half the normal time of an oral dose:

"The start of pharmacological activity after sublingual administration of sildenafil citrate in 30 patients affected by erectile dysfunction." by Siati & Franzolin 2003:
https://pubmed.ncbi.nlm.nih.gov/12741340/

References:

Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
I have years of experience with pure tetrahydroharmine, and it does indeed do this very well.

Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.
I use 30mg HPBCD complexed harmine fb sublingually along with the sublingual HPBCD complexed DMT, 30mg sublingual has the power of x6 or 180mg oral harmine.

Dr. Narang:
Quote:
The absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa under tongue is only 100 to 200 microns thick.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017:, under "Kinetics":
Quote:
Cyclodextrins at high doses can increase drug permeability by direct action on mucosal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7].Cyclodextrins are absorbed poorly via mucosal membranes.
HPBCD enhances the drug permeability of guest complexed drug, but the cyclodextrins themselves are poorly absorbed via the sublingual mucosa.

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https://mycotopia.net/to...neys-over-a-years-time/
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ava69
#2 Posted : 5/2/2021 1:18:02 AM

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Joined: 24-Apr-2021
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Igorcarajo said:
Quote:
Instead of the harmine sublingual, have you tried orally ingested harmine, maybe at the same time as THH, 45 minutes before the sublingual HPBCD-complexed DMT?

Great question igorcarajo, in fact, out of the 44 times I've used the sublingual HPBCD DMT over a year's time, the time I took 300mg pure tetrahydroharmine (THH) + 200mg harmine fb at the same time orally in capsules, then around an hour later took 90mg of sublingual HPBCD DMT (held under tongue for 15 minutes) was one of the most powerful experiences visually with open eyes, and very deep head space.

One of my favorites is the sublingual HPBCD dmt, like L-dreamer states: no delirium, very clear and crisp, zero dizziness, zero nausea, when combined with 30mg sublingual HPBCD complexed harmine at exact same time under tongue and 300mg oral very pure tetrahydroharmine taken 45 minutes earlier: perfect experience, intensely beautiful and clear just like mescaline. No words to describe. For music lovers like myself, it is a joy to listen to music for hours on end, sounds heavenly just like high dose cactus tea. Profound music enhancement, open eyed beauty infinite, abundant neon colors, the most beautiful teaching Ayahuasca visions, the divine spiritual insights gained are worth the admission alone.

Dirt cheap experience compared to the rare and expensive cactus which I also love dearly. 90mg HPBCD dmt sublingual + 30mg sublingual HPBCD harmine both taken at exact same time under tongue + 300mg pure THH taken 45 minutes before is like 600mg of mescaline. Intensely beautiful experience.

--> Taking 200mg of oral harmine + 300mg of oral THH + the sublingual HPBCD DMT taken 1 hour later is an experience so incredible and strong, still no nausea and dizziness for me:

In my trip diary that June night, I documented this oral harmine + oral THH + 90mg sublingual HPBCD dmt around 1 hour later as one of the most powerful sublingual experience of my life. Not only was there no dizziness or nausea but no anxiety as well, it was so powerful that I saw curtains of neon-colored visuals in the open doorway when I looked to my right. Everything in all directions was surrounded by brilliant neon-colored rainbow reflections, the euphoria and music enhancement was very powerful.

Open-eyed beauty was beyond belief, divine and infinite. The tracers were so powerful, that they went on forever like a hall of mirrors into the distance, and instead of there just being multiples of my hands when I waved them, there were beautiful colored fractals inside the tracer smears. One hour after the sublingual HPBCD DMT started to work, it was still as strong visually & transcendence wise as when it started. Only at the 1.5 hour point did the DMT ween down in strength several levels.

The 200mg of harmine was so powerful, that I continued by taking a 2nd dose of sublingual 90mg HPBCD DMT again 2 hours later after the 1st dose, and it again worked just as strong as the first dose. With closed eyes were seen brightly colored Ayahuasca visions, in my diary I note that I saw close to a hundred rapidly changing visions from incredibly beautiful women, birds, gardens, palaces, temples, inner decorations of these palaces, artwork of an entire culture, ancient pristine & perfect architecture to elaborate art carvings in stone, way beyond 4k in detail. The visions never repeat, of a beauty that defies comprehension. This resulted in a +5 strength Shulgin level journey with life changing consequences.

The harmine having a half-life of from 1 to 3 hours, did not die off until around 5 hours later, so each time I took a re-dose of sublingual HPBCD DMT for the evening, it continued to work very strongly. I highly recommend this approach, and plan to use the oral harmine again with the oral THH many times again in the future, using the HPBCD DMT sublingually as noted above. Take care, all the best...peace, love and music.

https://www.dmt-nexus.me...p;m=1137474#post1137474
hxxps://www.dmt-nexus.me/forum/default.aspx?g=posts&m=1137474#post1137474
"Sublingual DMT + oral THH - surprising and underrated -- First steps in Hyperspace"

L-dreamer said:
Quote:
Making this thread so that I can post my thoughts on the dosing method described in this thread
https://www.dmt-nexus.me...spx?g=posts&t=96861
hxxps://www.dmt-nexus.me/forum/default.aspx?g=posts&t=96861
My few experiences have consisted of about 60 mg of freebase DMT dissolved in 500 mg of HPBCD, with 250-300 mg of THH, and about 35 mg of sublingual harmala/harmaline

From the start I want to say that sublingual DMT with oral THH is everything I wanted ayahuasca/pharmahuasca to be. And I think it is also the best way for someone to be introduced to DMT
Where do I start with the pros
- no nausea at all, even if you take sublingual harmine/harmaline with it. It is such an odd and pleasant feeling to not have to fight constant nausea and vomit inducing dizziness. I literally don't have to worry about having a handy throwup bucket like I did with typical oral DMT.
- just the right kind of duration, it never overstays it's welcome, in about an hour you will get whatever you had to receive. No need for a bedridden 2+ h long comedown
- crisp, clear headspace. Previous oral DMT experiences have always given me this pinch of delirium and sleepiness to my mental state. But with this combo and I am fully present in it
- no come-up anxiety, the transition is gradual and smooth
- the DMT visuals are there, and in one experience they seemed even more glowing, or with actual real-life landscapes or persons assembling before my vision instead of the usual DMT geometry
- your body will love to move to the music you are listening
- let's say you accidental swallow the DMT solution or the saliva build-up becomes unbearable - you will still have a pharmahuasca experience with less if not any nausea. And also this form of oral DMT seems to absorb way better than a typical pharmahuasca
- you need less DMT than the typical pharmahuasca
- if you aborted the experience (saliva build-up that you spit out) you will now in about 25-30 minutes for sure, and then you can try again with the same DMT dosage, it won't stack like in pharmahuasca where it can sometimes take even 2 hours to enter fully

Now the cons:
- the saliva build-up can abort your start or break it's knees. Now if you swallow the solution you will still get a top-tier pharmahuasca trip, I repeat again, with barely any nausea. I tried with some cotton rolls in my mouth to stop the saliva pooling around the DMT solution but it was useless. Next thing I want to try are some saliva pads dentists use: either I trap the solution between the pad and the mouth floor, or I infuse the pads with the DMT solution, put the pad to the cheek mucosa or sublingual mucosa, and enjoy the slow release of DMT (even your lips can absorb this stuff pretty well, one of these days I will use the solution as ointment only for the lips to test it)
- and that is pretty much it, I can't think of any other cons of this way of taking DMT

I still can't believe people aren't all over this method, especially beginners. It is so versatile and maybe even "comfortable". It is worth experimenting only on it for me, goodbye throw bucket and tissues next to my bed, goodbye retching and holding in the taste of earthy vomit, goodbye 5 hour long sedation and diziness that takes up your entire day.

I predict in a short time sublingual DMT will have it's separate section on the Nexus.

L-dreamer said:
Quote:
- how to get consistently the neon-glowing visions, they feel like such an eye-candy that your eyes feel compelled to see in all their beauty; is it a certain THH treshhold? less harmine/harmaline or more sublingual harmine/harmaline?

Once again, thanks for your amazing post L-dreamer, and keep up the great work. In answer to this important question, I always use 300mg of very pure home-made tetrahydroharmine (made easily from harmaline in 1.5 hour). You can sometimes find harmaline on-line if you don't want to start from rue seed scratch. 35mg sublingual harmine has power of around x6 or 210mg oral harmine. 60mg HPBCD dmt = + 3 Shulgin level strength, and 90mg HPBCD dmt = + 5 Shulgin level strength.

The fact that one of your experiences involved seeing actual real-life landscapes and persons assembling before your vision instead of the usual DMT geometry only indicates you are in the realm of actual Ayahuasca visions. You will find that many of the Ayahuasca visions begin with dancing & morphing geometry but these then progress to actual colored beautiful teaching visions, each time you see a new phase of geometrics many times indicates a transition to more phenomenal Ayahuasca visions, just as Benny Shanon remarks in "Antipodes of the Mind". I have found this to be true.

Always test any THH you may acquire elsewhere. For example, there is a THH many are using that is made in China, with several reports of it not glowing blue when a bit is rubbed on a wet vinegar soaked q-tip and smeared on a paper palate, and the plate held under blacklight. Pure tetrahydroharmine glows light blue like LSD under UV light, any green in the glow indicates unconverted harmaline. Five reports so far from nexus people saying it glows green instead of blue like pure THH even though the paperwork indicates over 98% pure. THH never converts back to harmaline once made and remains stable indefinitely, so this tells me the initial synthesis on those particular batches was incomplete.

As a long time chemist, I take purity seriously, and so should you. What would happen if THH with contaminated un-converted harmaline in it was mixed with LSD at same time like I often do for an incredible journey (feels like a combo of LSD + mescaline as THH is like the beta-carboline version of mescaline in many ways). It would not be a fun journey like it normally is when using pure THH. Always be careful. Test your THH, even home-made to make sure it is pure.

Pure THH at 300mg results in neon-glowing visions with open or closed eyes in every one of my 44 total oral 300mg THH taken 45 minutes earlier + 30mg sublingual HPBCD complexed harmine + 90mg HPBCD complexed DMT held at exact same time under tongue journeys. These 44 times count the 2 subsequent re-doses every 1.5 hour for a strong 4.5 hour experience with super long afterglow beyond that.

Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the pure THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral pure THH with your sublingual or oral DMT. The combo of THH + DMT is like listening to music on high-dose cactus tea, heavenly.

Again with the sublingual: pupil dilation maxed out, strong tryptamine body buzz high frequency, heavy CEV imagery, open eyed beauty profound, music sounds incredible.

L-dreamer said:
Quote:
The THH I have does not glow blue (it did not come with a purity certificate), but it definitely is not harmine or harmaline since it does not give nausea at all. Taking more than 300 mg of it makes me a bit dizzy and that's it. And post experience I do feel the typical calmness or composure I got from previous aya drinks.

Thanks for the update. In answer to your question, using pure 300mg THH (which glows light blue) will most assuredly give you the glowing Ayahuasca visions consistently. Bottom of this post shows THH glow under blacklight. I would recommend making your own, take care, all the best.

Closing tips:

In the 44 times I've used 60 to 90mg HPBCD DMT sublingually under tongue, my tongue felt 100% fine the next day, no burn, completely normal, as if nothing was used the night before. 60mg HPBCD dmt = + 3 Shulgin level strength, and 90mg HPBCD dmt = + 4 Shulgin level strength. 120mg HPBCD dmt and above results in a +5 Shulgin level life changing strength.

Make sure there is no sodium hydroxide contamination in your dmt before you complex it, as any remnants of it will surely burn and make sure the dmt is complexed to the HPBCD as well as you can, as freebase dmt without being complexed might possibly burn as well.

My only other suggestion, is to just stir the HPBCD complexed DMT from off the spoon into 1oz or 1 shot of microwaved hot water (120 degree F) for oral Ayahuasca use, it dissolves instantly, and you will notice the water remains transparent due to the remarkable dissolution. Then just add in 160 harmine freebase + 150 to 300mg THH freebase into the same HPBCD DMT shot glass. Stir in 100mg of pure vitamin C powder so the freebase harmalas can dissolve. Take all at exact same time as the Shaman's do for strongest effects.

The HPBCD masks the taste of the nasty DMT freebase very well when used orally in a tea, and even helps to reduce gastrointestinal irritation by the freebase DMT. I was shocked in my oral use as there was virtually no taste, and zero nausea.

Using it orally works very well, used it this way x 3 times so far. It's many factors stronger than normal dmt freebase or salts used orally, as the HPBCD increases drug penetration x 4 factors or 400% into not only sublingual mucosa but intestinal tissues as well. 80mg HPBCD DMT Oral trip report on bottom of post #20.

Harmine and THH together are both important, just as Dr. Mckenna mentions for preventing the inactivation of DMT by MAO localized in mitrochondria within the cells of the brain, these both prevent zapping of the DMT, and greatly extend the half-life of the DMT several times over, just like with real oral Ayahuasca, as Benny Shanon mentions in "Antipodes of the Mind"..."there is always 90 minutes of very strong activity", this has been my experience as well when your tolerance is low.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017: Page 4 of 16:
Quote:
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes.
HPBCD helps mask the taste of the DMT when used orally in a hot tea.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017: Page 11 of 16:
Quote:
According to the data in section 2 one can conclude that below 20 mg/kg/day no serious adverse effects are to be expected for all routes of administration and no statement is deemed necessary.

Above 20 mg/kg/day, cyclodextrins may show some activity, and because there are insufficient safety data in children below two years old, it is advisable to inform about the quantity of cyclodextrin in the product and that for use in children below two years old, a doctor’s recommendation is needed.

Above 200 mg/kg/day cyclodextrins may theoretically cause problems in the digestive system when given orally, and cause mild renal toxicity when given parenteral, which information can be given. Depending on the amount, cyclodextrins may influence the Cyclodextrins used as excipients permeability of tissues and therefore the bioavailability of active substances given topically (nasal, rectal, dermal, sublingual, ocular).
This is exactly the way I use the HPBCD sublingually, when I complex 90mg DMT to (x7) or 630mg of HPBCD, and I re-dose two more times every 1.5 hour, I am using 1890mg of HPBCD for the evening. I weigh 95kg, so I am using less than 20mg/kg/day or less than 1900mg per day. This always gives me a 4.5 hour long +5 Shulgin level strength experience with super-long afterglow. Very similar to 500mg plus of mescaline when used with 300mg of pure tetrahydroharmine (THH) orally.

Pic 1: use a 1:1 molar ratio HPBCD to DMT

pic 2: 300mg of pure THH for oral use taken 45 minutes before, not shown: 30mg of freebase harmine for sublingual use taken at exact same time under tongue as the 0.5ml (10 drop) 90mg DMT complexed to 630mg HPBCD stored in a 3ml syringe if desired. Locking syringe caps prevent spillage.

Two re-dose syringes at the 1.5 hour point can be "back-filled" by removing plunger & pouring spoon's HPBCD complexed DMT solution down the syringe. Schematic showing sublingual mucosa only 100 to 200 microns thick.

Pic 3: Pure tetrahydroharmine when taken up with a cue tip dipped in vinegar and smeared on a paper plate glows pale blue under blacklight like LSD or psilocin, harmaline reduces to tetrahydroharmine by gaining a hydrogen atom. THH never converts back to harmaline but remains stable indefinitely. Tetrahydroharmine is in the same beta-carboline family as ibogaine, remarkable way beyond 4k monochrome (blue or green for me) closed eye teaching visions at 300mg for hours. No sedation, pleasant stimulation like mescaline. Adding even small amounts of sublingual or oral HPBCD DMT adds color to the visions.

Pic 4: Serpents are the manifest spirit of Ayahuasca

A few additional pics & from article "Return of the Serpent & of Eden" link given near bottom of post #1:

Top left: Egyptian Goddesses Isis (Cobra) & Serapis: depicted as Sacred Serpents

Top middle: Shipibo Ayahuasca Tapestry: The Vase representing the Amazonian Medicine, The Serpents that of the Grandmother Spirit of Ayahuasca

Top middle: Cosmic Serpent: Book by Jeremy Narby

Top right: Mayan ruins

Bottom left: Priestess of Quetzalcoatl

Bottom middle: Aztec Serpent Moon Goddess (Coyolxauhqui). Other Aztec Serpent Symbols include: Quetzalcoatl (Feathered Serpent), Xiuhcoatl (Fire Serpent), Mixcoatl (Cloud Serpent), and Coatlicue (She with Serpent Skirt)

Bottom right: Kundalini Serpent Pathway

Bottom right: Shiva & Shakti: Siddhi Level of Divine Masculine & Feminine Balance


Part 2: receptorome chart & explanation


Receptorome study: how traditional Ayahuasca & snuffs differ from dmt:

https://www.dmt-nexus.me...spx?g=posts&t=83164
hxxps://www.dmt-nexus.me/forum/default.aspx?g=posts&t=83164

This is why I suggest taking the DMT with tetrahydroharmine (as found in true Ayahuasca):

Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
https://journals.plos.or...71/journal.pone.0009019
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max or "off the charts", 0.00=min
Quote:
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty & new ideas)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)

2011 Thomas S. Ray study: Breadth of Receptor Binding, 4.00=max, 0.00=min
Quote:
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (these serotonin filters/gates/barriers/doors make up >80% of brain 5-ht & are broken down when 5-ht1a is agonized)

This study from Mol Pharmacol. 1988 Feb;33(2):178-86. backs up the above study from Thomas S. Ray:

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. https://www.ncbi.nlm.nih.gov/pubmed/2828913
Quote:
5-HT1A agonist: All the tryptamine derivatives substituted in position 5 of the indol were potent agonists [5-HT, 5-CT, 5-MeO-N,N-DMT, 5-methoxytryptamine, and bufotenine (5-ho-DMT)],

whereas tryptamine, N-methyltryptamine, and N,N-dimethyltryptamine (DMT) were poor agonists.

Dr. Nichols (Heffter.org LSD paper):
Quote:
LSD has very strong potency in blocking the action of serotonin. LSD is strongly "anti-serotonin". The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist. 5-ht1a makes up >80% of brain 5-ht receptors

An example of the importance of adding the serotonin reuptake inhibition properties of 5-meo-dmt for example to dmt (which has poor 5-ht1 reuptake properites on it's own) is shown below. This is the same way the snuff's are used in the amazon, as they naturally combine dmt with additives which cause the reuptake of 5-ht like bufotenin for example.

Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":

DMT + tiny amounts of 5-meo-dmt [perhaps similar theoretically to Amazonian snuffs which have a makeup of 7.4% bufotenin (potent 5-ht1a agonist), 0.04% 5-MeO-DMT (potent 5-ht1a agonist) & 0.16% DMT (poor potency as 5-ht1a agonist):
Quote:
As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.

--> With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.

Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.

As we go thru day to day life, the 5-ht1a brain serotonin filters (gates, or day to day survival filters as I like to call them) which make up over 80% of brain 5-ht are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world": https://en.wikipedia.org/wiki/Mind_at_Large

5-ht1a inhibition by entheogens (in green above) theoretically cause this filter system to be lifted, and the infinite mind to manifest in combination with oral dmt with the tetrahydroharmine providing the 5-ht1a inhibition & additional adrenal system agonization (A2A thru A2C), just as bufotenine in snuff's provide the 5-ht1a inhibition combined with the dmt in the snuff's, resulting in a 3 hour experience ie both examples of Teamwork on how these entheogens are used traditionally in the Amazon.

Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor.

Tetrahydroharmine is a serotonin reuptake inhibitor, it is an SRI found in caapi. In other words, both are strong serotonin reuptake inhibitors which inhibit over 80% of brain 5-ht at 5-ht1a.

In contrast, as an example, Cocaethylene (coca leaf tea bags soaked in wine, the orally active & potent ingredient formed in the liver from cocaine + ethanol in the 1860's "Vin Mariani" wine popular with both Popes, Thomas Edison and scores of other famous people) increases the levels of serotonergic, noradrenergic, and dopaminergic neurotransmission in the brain by inhibiting the action of the serotonin transporter, norepinephrine transporter, and dopamine transporter. These pharmacological properties make cocaethylene a serotonin-norepinephrine-dopamine reuptake inhibitor [SNDRI; also known as a "triple reuptake inhibitor"].

Cocaethylene has a higher affinity for the dopamine transporter than does cocaine, but has a lower affinity for the serotonin and norepinephrine transporters. In McCance-Katz et alia's 1993 study cocaethylene "produced greater subjective ratings of 'High' in comparison with administration of cocaine or alcohol alone."

69ron on harmalas:
Quote:
Ayahuasca is Banisteriopsis caapi. It contains mostly harmine and tetrahydroharmine (THH). B. caapi itself contains no DMT and can be used as is to produce visionary states that are like mental day dreams which lack true visual content. Often admixtures are used to increase the visual content of the ayahuasca dreams. Most admixture plants contain DMT.

Harmine & THH used alone, can produce a mild dreamy psychedelic experience in which daydreams or lucid dreams can be experienced if the user chooses to do so. These dreams from the harmalas alone are vague and lack visual content, but usually have story lines and can be quite complex just like a real dream. The harmalas allow one to go in and out of dream consciousness at will. It takes some practice to learn how to enter a lucid dream with the harmalas alone. The harmalas won’t make you enter a lucid dream. You have to do it yourself by allowing your mind to drift off into a lucid dream.

DMT used alone, produces an intense visual experience, often very chaotic and fast moving, and quite amazing to watch. The visions of DMT alone usually lack meaningful content. The DMT visions are often just constantly morphing colors and shapes. Most of it makes absolutely no sense. Rarely will the visuals present to you a full blown dream with people, places, a story line, etc. But this does sometimes happen. But usually you just get a bunch of bazaar visions that are difficult to understand.

When combined, as in Ayahuasca, the harmalas brings a dreamy quality to the DMT experience that makes it more like one is experiencing an actual dream, not just a bunch of fancy colors. With the two together, you have the visuals of DMT, plus the dream content of the harmalas. The harmalas are the boss here in this combination if used in Ayahuasca proportions where the harmalas are not just used as an MAOI but is used specifically to allow dream consciousness to be entered by the user. DMT is just an additive used to increase the visual portion of the harmala induced dreams.

Using harmalas in very low doses, just as an MAOI, is not the same as using properly made Ayahuasca. If the harmalas are used in low doses just for it’s MAOI effects, the trip lacks dream content and is just a bunch of bazaar DMT visual effects. This is not Ayahuasca-like, it’s just orally activated DMT. That’s not the same. Its true that some Ayahuasca is prepared this way, but such Ayahuasca is considered inferior by most natives. With Ayahuasca, the DMT is just an additive, not the main course. This is why Ayahausca made with only caapi is still called Ayahuasca and considered nearly as powerful as Ayahuasca made with additive plants containing DMT.

This is something a lot of people don’t get. Ayahuasca is not simple orally activated DMT. It is the dream consciousness effects of the harmalas that are at play in Ayahuasca. In order to experience lucid dreams from harmine + THH without DMT, you need to practice a lot. But once you know how to do it, you don’t need DMT added to it anymore, unless you want the extra visual depth that DMT adds to the dreams.

So, “Dmt Or Ayahuasca?”, well that question is a personal question. Some people prefer DMT-less ayahuasca. Some people prefer just orally activated DMT. Some people prefer Ayahuasca with a side order of DMT. Some people prefer the truly bazaar effects of smoked DMT alone.

My personal opinion is that DMT alone is FUN and can be quite frightening. It’s like a roller coaster ride and I like roller coasters. But don’t expect a deep meaningful life changing experience from it. Its pure visual FUN and nothing more. If I want a more meaningful experience I’d use an oral Ayahuasca extract, or a smoked Yopo extract (not as effective as ayahuasca because Yopo is low on harmala-like alkaloids)

Authentic Ayahuasca, high in harmine & THH, and low on DMT, is like entering a full blown 3D dream with dream characters, storylines, etc. This can be a life changing experience. It’s more like sitting in a theater for several hours absorbing a story that’s meaningful because its about you. You leave with memories of places, things, people, etc., and possibly a new view on life.
ava69 attached the following image(s):
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ava69
#3 Posted : 5/2/2021 1:22:02 AM

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Part 3: 300mg Tetrahydroharmine (THH) teaching visions all by herself


Tetrahydroharmine or THH is the 2nd largest ingredient in traditional Caapi based Ayahuasca, she is in the same beta-carboline family as Ibogaine. I've made it at home and taken 300mg of it orally many times over a 10 year period, she is as important as mescaline, can't do without her, diamondlike shimmering in her beauty. 300mg THH gives the same healing and teaching visions as 100mg of harmaline, but without all the dizziness and nausea. She causes powerful music enhancement when combined with sublingual or oral DMT, and infinite open-eyed beauty, she is like the beta-carboline version of mescaline, few people have used her over 100mg.

The Ayahuasca closed eye visions using 150 to 300mg tetrahydroharmine or THH and HPBCD complexed DMT (30mg on up) together surpass in magnificence anything I have ever seen in reality or in works of art.

With open eyes, all spiritual things such as nature, art, female form, beauty, joy, take on significant meaning with infinite beauty, just like with cactus or LSD. Extraordinary beauty is manifested with open eyes and with the visions one sees with closed eyes. Impossible neon-like colors are seen that don't exist on this Earth.

The existence of a higher spiritual plane is recognized to which insight can and must be gained, yet it does not reject the mundane reality as inferior or empty. This joyous embracement of the world of form leads to words like infinite pleasure, beauty and joy. This loving reappraisal of the worldly forms leads the way to higher divine planes.

At 9pm one night, took another 100mg of THH, for a total of 350mg of THH for afternoon & night, before I fell asleep, I watched dream-like monochrome imagery (usually always in green or blue for me) as the THH was still working...I viewed mind-blowing vistas--grand architecture and cities, a bookshelf full of ancient books, a view of the gardens in front of what looked like Versailles, France.

I traveled down a street in Midieval period where I saw beautiful women walking along the street, I could make out the houses & markets along the street. Many of these visions are like slow speed movies being played, way beyond 4k, highly detailed...true Ayahuasca visions...this always happens when I take at least 300mg or more of tetrahydroharmine during the late afternoon/early night. This is one of the best parts of the journey imho.

I've taken 300mg of THH on it's own many times and for hours with eyes closed I view endless dream-like visions, like slow and high speed movies being played for several hours...totally unlike normal dreams, she seems to tap into the "Akashic record" of the universe, the ether where all events, past, present, and future are stored...she shows you artwork, architecture, nature, culture, fantasy, history, the future, spiritual, supernatural. The visions are also characterized by the extraordinary beauty that they manifest.

Tetrahydroharmine was called by one researcher "the tryptamine of the beta-carboline world" to give an example of her remarkable visionary properties. She is an isomer of a hormonal-like compound found in the brain naturally, she is what gives Ayahuasca her telapathine or telethapy properties and CEV dream-like visionary power.

300mg THH in Caapi is just as visual as 100mg harmaline but without the nausea and dizziness. At 300mg she gives one several hours of incredible closed eye realistic visions, this places her very high on the "psychedelic periodic table" for visions compared to just about any other entheogen.

It's like entering a university, she teaches you for hours with not only sequential visions one after another, but visions seen in continuous slow and high speed movies. She tells you a story for a long period. There is a theme to it all each time, the beautiful visions never repeat session to session. I only rarely go beyond 300mg THH, as a little dizziness sets in above 300mg for sure. No dizziness at 250mg, only a tiny bit at 300mg.

Several weeks ago, after drinking 300mg tetrahydroharmine, I saw the interior decorations of palaces, the checkered floors, the beautiful windows and furniture, the winding stair cases, I was blown away.

I've seen sacred temples for religious worship, beautiful animals and super fine women, birds of all kinds, even the lost city of Atlantis, I was taken in for a bird's eye view, zooming in from way above to all the way down into the city center.

Caapi tells a story when you drink it with eyes closed, she teaches you things, the most beautiful "realistic visions" that no other entheogen comes close to showing you, these realistic visions go on forever with Caapi, I can recline and watch for 2 hours or more the visions, the visions are quite powerful. You can take additional THH hours later to bring back the visions again for another 45 minutes, the doses are additive.

Tetrahydroharmine or THH (feminine spirit) is the 2nd largest harmala alkaloid in Caapi (next to none found in rue), as this is new research that you will not find anywhere else, no books or web pages or past studies by researchers ever done on tetrahydroharmine at 300mg doses. 300mg pure tetrahydroharmine has the teaching & healing visionary power of 100mg harmaline, but without all the nausea and dizziness of harmaline. Adding even small amounts of sublingual or oral DMT adds color and brightness to the normally monochrome (one color) blue or green teaching visions.

Compilation of caapi & harmala only visions from the literature:

https://www.dmt-nexus.me...spx?g=posts&t=69515
hxxps://www.dmt-nexus.me/forum/default.aspx?g=posts&t=69515

attached papers:
1) Harmaline healing visions by Dr. Claudio Naranjo, experiments with 30 subjects
1) Dr. Naranjo on harmaline and ibogaine
2) Psychotropic properites of the harmala alkaloids by Dr. Claudio Naranjo

Link to "Harmaline and the Collective Unconscious":
https://www.claudionaran...ourney_ch_4_english.pdf
hxxps://www.claudionaranjo.net/pdf_files/not_catagorized/healing_journey_english/healing_journey_ch_4_english.pdf

Pic: 300mg of THH showed me closed eye vision of gardens at Versailles, France
 
ava69
#4 Posted : 5/2/2021 1:22:56 AM

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Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note


A little off topic, but I think tetrahydroharmine is a pretty special compound. I've used 250mg of it to potentiate cactus to very strong levels, it makes a 12" medium san pedro cactus tea which may contain around 250mg mescaline feel like an X-large 12" thick san pedro cactus containing around 400mg mescaline. It makes a 12" thick bridgesii cactus feel closer to a tea made with a 12" bridgesii cactus along with an extra 6" piece.

In the data I've seen for THH, it strongly blocks serotonin just like cactus, but also agonizes the adrenal A2A thru A2C receptors (the receptors associated with aesthetics & beauty), just like mescaline has been shown to do receptorome wise, explaining perhaps why they "overlap" so well. THH being able to make mescaline in cactus feel much stronger than it really is. Anyone who has ever taken cactus or high dose THH knows the appreciation for beauty experienced is "over the top".

But you have to stagger the THH from the cactus by taking the tetrahydroharmine around an hour after the cactus is taken, that way any minor maoi's or rima's in the cactus won't interact with the SRI which is THH, which can result in a faster heartbeat for a few hours which has happened to me before...so long as you take it later, it potentiates the cactus quite incredibly...it feels like I've taken 400mg of mescaline containing cactus tea when it's really only 250mg mescaline containing cactus, and they both lasts around 6 hours with super strong activity, so they wind down at around the same time. I have around 7 months experience combining the two, giving myself around 2 weeks apart from journeys.

It works so well, I won't take cactus any other way from now on. I get much more mileage from cactus this way. Visuals and visions are insane, music is so good sounding, you would think you were an alien experiencing sound and music for the very first time, every instrument stands out on it's own, like hearing a track for the very first time.

Always take the san pedro, bridgesii or torch cactus first (they all contain trace maoi like actives)...then take the THH one hour later, in that order, then the journey is pure bliss and no negative interactions. Beautiful combo beyond belief, just like the combo of THH + LSD or THH + mushrooms.
 
ava69
#5 Posted : 5/2/2021 1:23:53 AM

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Part 5: Chemist Patrick Arnold's HPBCD complexed prohormones for sublingual use (millions of dollars in sales) & bloodwork studies


Several years ago, before "prohormones" were banned (they were legal for 10 years), there was a company called "Ergopharm" ran by chemist Patrick Arnold. Ergopharm had sales in the millions due to their hot selling HPBCD complexed 4-androstenediol (Cyclodiol, see attached pic).

Patent granted to Patrick Arnold:
https://en.wikipedia.org/wiki/Patrick_Arnold

In 2001 Arnold's company introduced the prohormone 4-Androstenediol, under the marketing name 4-AD. 4-AD is a prohormone that is easily converted by the body into testosterone at a rate of 95%, and it sold well. He is the chemist who created hydroxypropyl-beta-cyclodextrin complexed diols such as Cyclo-Diol(TM) and Cyclo-Nordiol(TM).

https://thinksteroids.co.../ask-patrick-arnold-11/
hxxps://thinksteroids.com/articles/ask-patrick-arnold-11/

I bought and used the sublingual HPBCD cyclodiol when it became available and it was very effective, had my testosterone level checked with a blood test at the local labcore one hour after administering the sublingual powder under my tongue (dissolved in less than 10 minutes) and it was 3,500 ng/dl ! when my normal level was 600ng/dl. Highest measured normal levels in men are around 1200 ng/dl. The blood test cost me $70.00. The sublingual HPBCD complexed pro-hormone would cause the 4-ad to enter the bloodstream via sublingual mucosa under tongue, and convert to testosterone via enzyme activity once in the bloodstream. Patrick invented the pro-hormone 4-ad or 4-androstenediol, which converts to testosterone at a rate of 95%.

Patrick Arnold's sublingual powder of HPBCD complexed 4-AD could be grabbed from the bottle with a pre-measured scooper, and the powder need only be held under tongue for less than 10 minutes. The HPBCD complexed DMT on the other hand dissolves in 15 minutes or less under tongue, as it is a slightly higher dosage.

Before Patrick started his company, he used to post on "deja-news" bodybuilding news group (defunct now but bought out and owned currently by Google) and would explain to bodybuilders how to complex HPBCD powder to 4-androstenediol at home using a spoon, drops of hot water, end of another spoon to mix and crush all ingredients together, lighter to heat up, etc. I learned his technique back then, and created my own HPBCD complexed 4-ad for sublingual use just like hundreds of other bodybuilders who read his postings and asked questions daily, there are logs of this that would fill up a book.

Later, the pharmaceutical industry picked up on his idea and started marketing sublingual HPBCD testosterone base (read the 3 studies in the link above from Patrick's column at MesoRx midway thru), which worked remarkably well to raise the testosterone of hypogonadal men to the high-normal level when absorbed under the tongue.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017:
Quote:
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes. Cyclodextrins at high doses can increase drug permeability by direct action on mucosal and intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7]. Cyclodextrins are absorbed poorly via mucosal membranes but can improve complexed drug absorption by up to 400% sublingually.

The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27]. The α- and β-cyclodextrins do not cross the intestinal barrier in significant amounts and are fermented by gut bacteria or excreted whole; γ-cyclodextrins are metabolized by mammalian α-amylases into linear oligosaccharides. Consequently, cyclodextrins in food or otherwise consumed orally or applied sublingually do not usually enter the circulation in significant amounts (Frijlink et al., 1990), and thus are very safe.

Chemist Patrick Arnold taught me how to complex HPBCD to pro-hormones for sublingual use in my 20's, same method I use for sublingual HPBCD DMT. I've also been a bodybuilder & chemist all my life. Bodybuilder chemist Patrick Arnold had millions of dollars in sales with his company Ergopharm which sold sublingual HPBCD complexed pro-hormones for 10 years until the Gov't made pro-hormones illegal as the sublingual HPBCD pro-hormones worked as well as steroids: https://thinksteroids.co.../ask-patrick-arnold-11/

MESO-Rx, "Ask Patrick Arnold #10", April 15, 1999 By Patrick Arnold:
Quote:
Sublingual hydroxypropylbetacyclodextrin (HPBCD) complexed testosterone has a very high bioavailabilty however as the peak blood levels are seen rather quickly (20 to 40 minutes). These peaks are quite high however and the drop off is substantially gradual as in the EMU study testosterone levels of greater than 60% over baseline were still measured after 2 hours.

Straight testosterone or prohormones do not have very good absorption under the tongue. When complexed with cyclodextrin the properties change to enable it to absorb extremely well. It would be a long and detailed explanation but that is the jist of it.

Pic: Ergopharm's hot selling cyclodiol powder, HPBCD complexed 4-androstenediol, when used sublingually, converted into testosterone at a rate of 95% via enzyme activity once it quickly entered the bloodstream from the sublingual mucosa.
ava69 attached the following image(s):
zzz10.JPG (47kb) downloaded 3,484 time(s).
Ergopharm's hot selling cyclodiol powder (HPBCD complexed pro-hormones).JPG (13kb) downloaded 1,533 time(s).
 
ava69
#6 Posted : 5/2/2021 1:24:47 AM

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Part 6: Dr. Narang: "with sublingual" or "under the tongue" better than buccal, gingival & palatal


With Insufflation, sublingual or rectal, DMT is not broken down by monoamine oxidase.

However, tetrahydroharmine and harmine both work to block the inactivation of DMT by MAO localized within the mitochondria of the cells of the brain, this also greatly extends the half-life of the DMT.

See above paper from Narang et al, Intl J Pharm Sci, Vol 3, Suupl 2, 2011, 18-22:
"With sublingual or "under the tongue", the mucosea thickness is only 100-200, high permeability with rich blood supply, much better than buccal or gingival & palatal, 200, 250, 500 micrometer respectively, shuttling the drug directly to bloodstream." The DMT is not broken down via monamine oxidase whatsoever this way. It avoids the liver and first pass metabolism. The drug is rapidly absorbed via the rich blood supply vessels under the tongue rather than being broken down in the digestive track via the enzyme monamine oxidase. According to paper: "Sublingually administered drugs reach directly in to the blood stream through the ventral surface of the tongue and floor of the mouth. The drug solutes are rapidly absorbed into the reticulated vein which lies underneath the oral mucosa, and transported through the facial veins, internal jugular vein, and braciocephalic vein and then drained in to systemic circulation."

According to paper, "the absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Peak blood levels of most products administered sublingually are achieved within 10 to 15 minutes, which is generally much faster than when those same drugs are ingested orally." This has been my experience as well, so long as 150 to 300mg of THH is taken orally 45 minutes before, and 150 to 200mg of harmine is taken orally 45 minutes before, or 35mg of harmine fb is taken sublingually at the exact same time as the sublingual HPBCD DMT, after 15 minutes of sublingual under tongue application, 7 minutes after the 15 minute sublingual absorption, the DMT rush is felt with dilated pupils, followed by 90 minutes of entheogenic activity. According to paper, "sublingual absorption of drugs is efficient. The percent of each dose absorbed is generally higher than that achieved by means of oral ingestion."

Smoked: If DMT is smoked, the maximal effects last for a short period of time (5 to 30 minutes, dose-dependent). The onset after inhalation is very fast (less than 45 seconds) and maximal effects are reached within about a minute.

Insufflation & Sublingual absorption via Oral Mucosa (under tongue): When DMT is insufflated (snorted through the nostrils) or absorbed sublingually the duration is markedly increased.

Injection: Injected DMT produces an experience similar to inhalation in duration, intensity, and characteristics.

Oral ingestion: DMT, which is broken down by the digestive enzyme monoamine oxidase, is practically inactive if taken orally, unless combined with a monoamine oxidase inhibitor (MAOI).
 
ava69
#7 Posted : 5/2/2021 1:28:40 AM

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Part 7: a little bit on my 70 Ayahuasca experiences, doses & visions


FYI: The THH is an SRI (serotonin reuptake inhibitor with significant adrenal activity at A2A thru A2C receptors, similar to mescaline in that regard), it has super weak MAOI activity (see Wikipedia on tetrahydroharmine).

I looked up the data comparing RIMA activity of THH to harmine from a lab supplier who gave the data, and they referenced THH as only having around 1/100th the RIMA strength of harmine, practically non-existent strength as a RIMA. That would mean it would take 20,000mg of THH to equal 200mg of harmine in RIMA strength. Harmine & harmaline however have significant RIMA/MAOI activity.

How to best describe THH or tetrahydroharmine:

THH alone (200 to 300mg) with open eyes = everything is brighter and extremely colorful, beauty enhancement is over the top...neon-diamondlike is my best description, like looking down thru several meters of clear blue ocean water on a bright sunny day, just like professor8 describes it. A study done once on the UDV found that brews with high levels of tetrahydroharmine were preferred over all other brews, they found the "dmt was not the main attraction" but actually brews high in THH, fascinating study.

With 300mg THH, closed eye dream-like Ayahuasca visions actually form with closed eyes that begin with colored sparkles and geometric dots and ziggly lines in orange, green, and blue that dart around and then progress to the monochrome visions for 1.5 to 2 hours, These visions are WAY beyond 4k, and highly detailed. The DMT adds color and brightness to the visions. The DMT also of course adds strong psychedelic alterations & activity to the journey and enhances the quality of music in combo with THH, music sounds incredible as mentioned before for several hours, especially if you keep taking the sublingual DMT around once every 1.5 hour for the next 4.5 hours.

Years ago, I took DMT freebase (70 to 90mg) with harmine and THH pharmahuasca at least a dozen times, and found it mild at best (on a Shulgin scale of 1 to 5, they were all +3 experiences). I even tried to dissolve it into coca cola and citric acid in hot water to make it absorb better as the salt, but it only slightly increased the strength.

After that I switched to taking 30 to 35 grams of Hawaiian psychotria boiled down to a couple oz, then added the harmine + thh to the 2oz of hot pychotria tea....well that blew my mind CONSISTENTLY for many years, as I continued to use it over 65 times! All of the experiences were +5, very strong indeed, much stronger than the freebase used dmt.

This agrees with what I read from clearlight:
Quote:
Clearlight experiments that involved several people found the leaf brew form superior to extracted actives, they found the leaf brews very strong and powerful & clairavoyant (+5 Shulgin scale), while they mentioned that the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood.

Even Jonathan Ott found that in his 20 experiments posted in his book "Ayahuasca Analogues", that none of his later experiments with extracted actives quite matched the power of his 1st actual Ayahuasca brewed with caapi and good real leaf (experiment #1), he had no explanation for this. He did however find 70mg to be close to it, but still not the same.

From "Articulations, On the Utilisation and Meanings of Psychedelics" (2015) by Julian Palmer:
Quote:
Modern day researchers, spearheaded by people such as myself, have realized that Jonathan Ott's calculations fall short of what most explorers need for a truly visionary experience. Even with a strong harmine/Banisteriopsis caapi dosage, 30-60mg of dmt is not sufficient to produce significant visionary effects in most people. So if fact, a dosage of 30-40mg of dmt is where tryptamine-like effects just begin to occur for most people, and 10-25mg dmt is not really noticeable above the gentle psychoactive effects of the harmine.

Each person is different and for some rare individuals, 30-40mg may be about as much dmt as they wish to take--but most people need at least 60-80mg for sufficient psychoactive effects and even at this dosage, you generally cannot expect a full-blown visionary experience, even when using a strong dose of 4 grams of syrian rue or 100 grams of strong caapi vine. Also, it should be pointed out that going beyond 4 grams of syrian rue (around 200-280mg of harmaline) or 100 grams of strong caapi vine (150--250mg of harmine) can increase the negative effects of these beta-carbolines--which include a feeling of heaviness, pressure in the head, inability to walk properly, more purging and perhaps more of an emphasis on bodily processes.

An oral dosage of 100mg of dmt is where the visionary qualities really begin to occur, for most people say when they are taking 3 grams of syrian rue or 80 grams of strong vine, and in context, 40-60 grams of strong vine is enough to fully mao inhibit most people.

I would say to neophyte explorers to tread carefully, and to slowly increase your dmt dosage in increments: perhaps starting at 60mg, going to 100mg, then 150mg. Some people are going to find 100mg of dmt to be exceedingly strong, and it will perhaps give them an experience they did not feel ready for.

--> It came to my attention after an embarrassing number of years, that taking freebase crystal DMT orally was not as potent, colourful, or clear as taking the equivalent amount of DMT in a tea that was brewed from the plant. For many years, I couldn't see how there could be a difference, but after doing some comparisons, it was obvious that the tea was much better, and the experiences resulting from the crystalline extract were inferior.

You could take twice or even three times as much DMT crystal as the equivalent in brew, and the experience from the crystal would never be as bright or full as that from the tea. Why could this be?

With extracted dmt, with chemicals used it would appear that some dimensions and qualities of the tryptamine molecules are compromised. Also, there is the factor of isolating the alkaloids from the rest of the plant. For example, there are very few people who say that extracted pure mescaline from the cactus is as potent of full bodied compared to when they take the tea made from the cactus flesh.

When making a tea from the whole plant, you are extracting the essence of the plant intelligence from its very flesh, not just isolating the alkaloids. In the alchemic method "Spagyrics" developed by Paracelsus, often considered the father of modern medicine, the ashes of the plant are commonly burnt and then blended back into an alcohol-extracted tincture. Friends who have experimented with this procedure report that a Spagyric tincture of Ayahuasca is much more potent than a normal tea prepared from the same amount of Ayahuasca vine.

However, at this point, I have noticed that ALL the dried Hawaiian psychotria is extinct, and is no longer available. But no worries, HPBCD complexed DMT feels the void very well, and is much more potent than plain DMT which is absorbed poorly via the oral or sublingual route. Studies show HPBCD when complexed to poorly absorbed drugs like DMT improve drug penetration many factors when used sublingually or orally.

In one past journey with 30g Hawaiian psychotria, saw three beautiful naked woman dancers twirling in front of stone pillars that rotated slowly. Jungle scenes lit up by the moonlight, full of snakes and palm trees by the beach and lots of people I had known in my life in floating bubbles that were to the left and right of the scene, drifting up into the sky. Elephants from India embellished with vibrantly colored jhools (saddle cloth) and heavy jewellery and sparkling anklets. Detached female faces of breath-taking beauty with freckles. Waterfalls in the middle of the jungle. A merry go round made of horses that spun and melted down from top to bottom, then was rebuilt again from bottom to top, masks and fangs, a ship on the ocean, a trellis full of beautiful flowers.

With another session, saw barely dressed women wearing futuristic clothing and bikinis of some sort, dazzling in it's design. A spinning vortex made of blue color with closed eyes that opened up in front of me that looked like a wormhole of some sort, I travelled inside of it, and was dropped off on an island in the pacific with wooden Tikis all around the perimeter of a small culture. I saw a chalkboard full of mathematical equations and scientific discoveries drawn out. I flew like a bird for nearly a minute over what looked like Los Angeles, as I could see the homes with swimming pools and parks below me.

I've seen pyramids adorned with gold sheen, architecture of the past and future, Egyptian scenery, vast landscapes, medieval scenery, it goes on and on. Everything is brand new as if newly created. Very similar to the Ayahuasca visions encountered by Benny Shanon in "Antipodes of the Mind".

From page 416 "Antipodes of the Mind". These are some of the most commonly seen various content items (the core corpus) that Benny Shannon found that he himself and hundreds of interviewers saw with closed eyes on the Caapi/harmala brews: The use of these plants span many thousands of years of history, back to a time where it was once consumed and revered for its ability to bring someone into contact with spiritual realities, the obtaining of secret inner knowledge, and visionary experiences of a divine world.

I have also seen the scenery listed below (just like Benny Shanon and many others interviewed) hundreds of times. The visions are like slow and high speed movies as well as static visions in my 70 Caapi + Hawaiian psychotria Ayahuasca experiences & the over 44 x 300mg oral pure tetrahydroharmine (THH) dosed once (10.5 hour half life with peak at 5.25 hours) + 35mg sublingual harmine combined with 60 to 90mg sublingual HPBCD DMT at the exact same time under tongue held for 15 minutes. Journey begins in 22 minutes, or 1/2 the time of an oral dose.

These journeys are 1.5 hour long and almost always sublingual re-dosed for the evening at each 1.5 hour point (2 more times) giving me a strong 4.5 hour long journey with super-long afterglow well beyond that.

Page 416 "Antipodes of the Mind" by Benny Shanon:
Quote:

Super-categories:

Human beings
Natural animals
Phatasmagoria/supernatural
Architecture
Objects
Plants
Personal biography

Categories:

Mammals
Objects of art and magic
Birds
Royal and religious figures
Landscapes
Palaces and temples
Non-natural animals
Heavenly scenes
Reptiles
Divine beings
Cities
Vehicles

Details:

Felines
Waterscapes
Flowers
Objects of gold
Serpents
Processions
Dancing women
Forests
Temples
Semi-divine beings
Royal figures
Enchanted cities
Open landscapes
Palaces
Angels and transparent beings
Gardens
Royal objects

Details:

Serpents
Nymphs
ETs and spaceships
Royal figures
Flowers
Royal objects
Chimera and winged beings
Enchanted cities
Religious figures
Angels and transparent beings
Waterscapes
Objects of gold
Forests
Armoury
Guides and guardians
Felines
Egyptian scenes
Personal acquaintances
ancient civilizations
celestial scenes
creatures and beings
Encounters with the Divine
Sea creatures
Insects
Celestial voyages
Cities
Mythology
Symbols
Heavenly scenes
 
ava69
#8 Posted : 5/2/2021 1:29:23 AM

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Part 8: New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water.


Additional reading:

New research: Morning glory contains 5 stimulating LSD-like drugs, soluble only in wine/alcohol, only sparingly soluble in water: page 1: post #10 - #12, page 2: post #29 with pics:
https://mycotopia.net/to...ive-under-tongue/page-1
hxxps://mycotopia.net/topic/111610-hpbcd-dmt-sublingually-active-under-tongue/page-1

Positronic Ayahuasca brewing
https://www.dmt-nexus.me...spx?g=posts&t=82030

Receptorome study: how traditional Ayahuasca & snuffs differ from dmt
https://www.dmt-nexus.me...spx?g=posts&t=83164

Has the Mystery of the Eleusinian Mysteries been solved? by Ivan Valencic
http://www.psychedelic-library.org/valencic.htm

For a visual high dose claviceps paspali (same fresh alkaloid profile as the fresh Mesoamerican Aztec/Mayan morning glory) ergot wine trip report prepared by LSD chemist Todd Skinner, reported in the literature: read Krystle Cole's 3 page report on page 2 post #32 of morning glory link below:

https://mycotopia.net/to...ingly-soluble-in-water/
hxxps://mycotopia.net/topic/110273-new-research-morning-glory-contains-5-stimulating-lsd-like-drugs-soluble-only-in-winealcohol-only-sparingly-soluble-in-water/

She saw "constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head."

It just so happens that the ancient Aztec and Mayan also added the fresh or dried pulverized morning glory seeds to a drink containing alcohol, they learned this would extract all the stimulating actives from the seeds:

Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch:
Quote:
The fresh or dried morning glory seeds normally were added by the Aztec and Mayan to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37).

The merck index shows that (1) elymoclavine, (2) agroclavine, (3) chanoclavine & (4) penniclavine in the seeds are best soluble in alcohol (sparingly soluble in water).

(5) Lysergic acid hydroxyethylamide (LSH) in the seeds only survives outside the seeds in an acidic environment (example: such as cold sherry wine which is already at ph=4). LSH decomposes in ionic conditions, neutral water (plain water), when heated, or in alkaline environments. See very bottom attached illustration of how LSH decomposes to LSA unless extracted into acidic water, wine, etc.

Important new 2020 receptorome binding data just came out this year that is available for LSH or Lysergic acid hydroxyethylamide found in morning glory seeds. See below:

http://www.t3db.ca/toxins/T3D3687
hxxp://www.t3db.ca/toxins/T3D3687

5-ht2a, 5-ht2b, 5-ht2c, adrenal A1A, adrenal A1B, adrenal A1D, adrenal A2A, adrenal A2B & adrenal A2C

This is important as it shows LSH binds to just about all the adrenal receptors, while LSD only binds to one of the adrenal receptors: A2A in comparison (as far as adrenal receptors are concerned). See chart below: DMT, mescaline & psilocin all bind to many of the adrenal receptors. The adrenal receptors are implicated in the perception of aesthetics, beauty.

This may explain why the semi-synthetic man-made LSD has been perceived by many to have less aesthetic appreciation than the natural entheogens: LSH, mescaline, Ayahuasca (harmine + tetrahydroharmine + harmaline) with Caapi, dmt, psilocin. It's man-made quality may be more perceptable due to it's lack of significant adrenal agonism, which is prominent with the natural entheogens.

Example: Mescaline has a rating of 4.00 at adrenal A2C (see below), 4.00 = max = off the charts, and anyone who has ever consumed cactus knows the appreciation for beauty is "thru the roof" or "over the top".

Important teamwork is going on between LSH and penniclavine in the seeds, the 2 highest alkaloids. Agroclavine and penniclavine in the seeds (metabolite of agroclavine) bind to 5-ht1a, 5-ht2a, 5-ht6, 5-ht7, adrenal A2A, A2C, A2D, and most of the dopamine receptors in comparison. See "Agroclavine & Penniclavine radioligand (receptorome) data, Planta Med. 1996 Oct; 62(5): 387-92."

Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
https://journals.plos.or...71/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max (off the charts), 0.00=min, X.XX=receptor is hit but we don't have strength data.
Quote:
LSD: 5ht1a = 3.73, LSH: = 0.00, penniclavine = X.XX, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00
LSD: 5ht1b = 4.00, LSH: = 0.00, penniclavine = 0.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, LSH: = 0.00, penniclavine = 0.00, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, LSH: = 0.00, penniclavine = 0.00, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, LSH: = X.XX, penniclavine = X.XX, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, LSH: = X.XX, penniclavine = 0.00, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69
LSD: 5ht2c = 3.11, LSH: = X.XX, penniclavine = 0.00, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, LSH: = X.XX, penniclavine = 0.00, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, LSH: = X.XX, penniclavine = X.XX, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, LSH: = 0.00, penniclavine = X.XX, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69
LSD: ---D1 = 2.34, LSH: = 0.00, penniclavine = X.XX, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, LSH: = X.XX, penniclavine = X.XX, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00
LSD: -A-2B = 0.00, LSH: = X.XX, penniclavine = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86
LSD: -A-2C = 0.00, LSH: = X.XX, penniclavine = X.XX, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57
LSD: -A-2D = 0.00, LSH: = 0.00, penniclavine = X.XX, DMT: = 0.00, psilocin = 0.00, mescaline = 0.00, 5-meo-DMT: = 0.00
LSD: -A-1A = 0.00, LSH: = X.XX, penniclavine = 0.00, DMT: = 0.00, psilocin = 0.00, mescaline = 0.00, 5-meo-DMT: = 0.00
LSD: -A-1B = 0.00, LSH: = X.XX, penniclavine = 0.00, DMT: = 0.00, psilocin = 0.00, mescaline = 0.00, 5-meo-DMT: = 0.00
LSD: -A-1D = 0.00, LSH: = X.XX, penniclavine = 0.00, DMT: = 0.00, psilocin = 0.00, mescaline = 0.00, 5-meo-DMT: = 0.00
I don't know if you remember morninglory seed from long ago? He was on another forum. Here is one of his old classic posts that makes alot of sense:

morningloryseed:
Quote:
Unlike most alkaloids, LSA is water soluble when it is in its natural, freebase state...the way it is found in the seeds. it is a rare, exception to a rule because by simple definition, alkaloids are very alkaline or basic when in their freebase form as they normally occur in plants. Thus, they do not dissolve well into water. Most likely, many of the other ergoline akaloids probably are not water-soluble in their freebase form and thus are not extracted from the ground seed matter when a "tea" is made. or they get dissolved into the non-polar solvent used when an A/B extract is performed and they are thrown away.

Thus, extracts have a different mix of alkaloids and that is why the trip from A/B extracts or a "tea" of m. g. seeds feels so different than that of the whole seeds. In my vast experience with eating the seeds, and taking extracts, the trip that results is not as good. And I've taken the seeds more than any other psychedelic, except LSD and marijuana. I find them much more narcotic/sedative-like in nature and the effects are really nothing like that which I get from EATING the seeds.

The fact that teas or other extracts feel very different from the trip of the whole seed has also been noted by everyone I've shared m.g. seed tea with, and is a comoon thing reported in trip reports. So this is definitely not a phenomena that I am alone in feeling. Many, many, many people IM or email me with morning glory seed questions and most of them who have tried both have also noted that extracts are not as psychedelic and nowhere near as potent as eating the whole seeds.

The seeds do cause nausea and vomiting (as many other psychedelics like ayahuasca, mescaline, ibogaine, etc.) but a purge, I feel great. Like I said, I think the seeds are one of the best psychedelics, and I have tried quite a number of different ones.

Extractions such as a simple morning glory "tea", or the more complicated A/B extraction, will give you a mixture of different LSA's than those found in the whole seeds. It is the combination of all the ergoline alkaloids in the seeds that make you trip.

The main alkaloid is the mostly sedating LA-111, but many others (up to a dozen or so) including d-lysergic acid hydroxyethylamide (closest molecule to LSD found in nature), are known to occur in the seeds. Together, they have a synergestic efffect and produce a very different kind of experience from pure LA-111. It is (in my opinion) a great trip. One of my favorites. Of course the trip from seeds is very different from LSD. But because it is different than LSD does not mean it is not as good. I think they are both very useful. Some of my most meaningful trips have been with natural lysergic acid amides.

Example page from Merck on agroclavine (found in morning glory seeds):
Quote:
agroclavine is soluble in ethanol, chloroform, pyridine, soluble in benzene and ether, very little water soluble.

From "The Alkaloids: Chemistry and Physiology", page 32:
Quote:
Agroclavine is readily soluble in organic acids, agroclavine is stable to acids", wine stands as one of the sources of organic acids. Page 33 "Elymoclavine is only somewhat soluble in water". Peter Webster states in "Sacred Mushrooms of the Goddess, the Secrets of Eleusis" in the morning glory chapter that Chanoclavine is soluble in alcohol.

The hard data is lacking on whether the alkaloids in the seeds are in the freebase (like morninglory seed above describes) or in the salt form. Alkaloids such as mescaline and dmt are found in the salt form in the plant, and are readily water soluble. However, these half dozen alkaloids from morning glory are found within the tiny rubbery like embryo found within the seed.

To be on the safe side, extract into wine, as this will extract the alkaloids should they be in freebase form. This will give you an extract that is no different from "eating the seeds". Morninglory above is right in that the plain water extract is no where near similar to "eating the seeds" or an acidic wine extract (editor preferred).

(1) Hermes (the Lycaeum) "Saw strong 4D lattice-like open eye visuals and warping and melting of furniture with only 400 seeds. There are around 32 to 36 seeds to a gram. So 12 to 14 grams is 400 seeds to 500 seeds. I extract into water pre-acidified with a squirt of lemon juice. I see amazing three and seemingly four-dimensional shapes morphing and bifurcating. Often I get religious and esoteric themed visuals, like fractal cherub wings and winged eyes like those in some of Alex Grey's work. Eyes are all over everything. I see pyramids and sphinxes and Gigeresque biomechanical forms. I see amazing geometric lattice structures. I watch mathematical space-filling algorithms doing their thing, all of this with nothing more than 500 seeds."

(2) Nogal (the Nook) "Yes I know of someone who tried the CWE method with the Heavenly Blue variety, except with the substitution of a coffee grinder in place of a stone metate (I think that's what is called but I could be wrong), and a squirt of lemon in the water, with around 400-500 seeds. Closed and open eyed visuals were extremely breath taking. Some of the most prominent visions were of Aztec/Mayan glyphic patterns, a menacing and demonic technicolor nymph made of light who tried to seduce the viewer, and this bizare trail of energy spheres which each contained a different stylized animal form (again definately of Aztec/Mayan origin)."

(4) Piper methysticum: "Morning Glory seeds are definitely the most euphoric psychedelic I've ever taken during the onset and the first part of the peak. Not even a strong dose of MDA could compete with the euphoria I felt from 12g of Morning Glory seeds. However, the comparison of LSA alkaloids to MDA is ridiculous. The visuals from Morning Glory seeds are quite inconsistent for me. The first time I tried them, at 9g, the visuals were very dull, but the mental and physical aspects were awesome. My second time at 12g, the visuals were beyond amazing. I got the feeling of being completely in a warp through time and visuals were flying past me and unimaginable speeds. A couple of my unexperienced friends were talking about the tracers they were seeing at the same time this was happening to me. I had to laugh. With just 6g my third time, I also had some pretty amazing visuals, though they weren't nearly as mind blowing."

(5) Myself, 400 black hard fresh seeds right off vine, grown in 75% miracle grow & 25% cow manure compost: extracted with 2 shots (60ml) of fresh just opened cold sherry wine with added 10mg of DL tartaric acid powder added (auction sites or *ma*on), and stirred together in the wine really well.

DO NOT ADD MORE THAN 10mg DL tartaric acid to the 2 shots (60ml) of sherry wine...too much DL tartaric acid can upset ph balance of the body and you will feel really bad...10mg will keep ph no lower than 3.5. The wine will go from natural ph=4 down to ph=3.5, but no lower. You will need a 1mg (0.001g) electronic scale to do this, like the AWS GPR-20 20g x 0.001g scale for example. It needs to be DL tartaric acid and not just plain L tartaric acid, The d-form salt is the form LSD is active as for example, not the L-form.

Turn main light off in room or garage and replace a nearby lamp with a red light bulb (can find in grocery store), this way the fragile light-sensitive alkaloids in the seeds will not be destroyed. I always do this.

You crush the seeds inbetween a paper plate with ends folded in, you hammer the plate on a concrete surface, then you add the crushed seed powder to a coffee grinder, and grind it till it is nearly a dust...then you add the dust like seed powder to the 60ml of cold sherry wine in a tall 1/2 pint jar, then you let it sit in fridge for 3 hours, with shaking & stirring once per hour.

Then at the end of 3 hour period, you decant off the top liquid from the seed debris at the bottom....filter the sherry wine liquid thru a cotton ball in a funnel which sits in a jar, change out the cotton ball when or if it clogs, I usually have to change the cotton ball out once or twice, the top of the cotton will turn black or dark brown. The cotton ball will remove ALL the nauseating debris from the sherry wine/seed mixture. You will be left with a golden clear to light brown golden liquid, this is what you drink--no nausea as all the debris has been removed!

Before you consume, always remember to keep the 2 shot sherry wine extract of the morning glory seeds cold at all times (in the fridge) as acetaldehyde boils off at room temp or 69 degree F. You don't want your LSH decomposing to LSA do you? You can freeze it too if you plan to use it at a later time.

I saw geometric patterns on the surface of everything, with closed eyes, colored vectors spun 360 degrees while traveling from left to right across visual plane. Sounds were not only amplified & music heavenly but audio hallucinations were produced, heavy euphoria component & very strong appreciation for beauty. Remember watching Scarlett Johansson interview on a small television and melting into the seat from her beauty amidst all the breath taking geometrics. Tripped hard as hell.

Note: Cold sherry cooking wine is recommended as an extraction solution since it is already at ph=4 and is 18% alcohol, and is also very cheap ($5 per bottle). It can be found in the wine isle of any grocery store, and is often on sale. It also contains 10mg acetaldehyde per each shot (30ml). A $9 wine preserver canister can be bought at Amazon which contains a gas mixture of argon, carbon dioxide & other inert gases which can be sprayed into an open bottle of sherry wine before sealing cork to preserve the wine indefinitely, otherwise the acetaldehyde in the wine converts to acetic acid over time, giving the wine a vinegar taste. The wine preserver contains enough gas to last for years of sealing many bottles.


2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail:
Quote:
seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio
Immediately vacuum pack and freeze freshly picked dark hard black seeds off vine to preserve potency indefinitely.

Erowid report:
Quote:
400 older dried seeds is similar to a little less than one hit LSD. 400 fresh off vine is like about 2 or three hits.

dmthead420:
Quote:
Seems this does do alot more, its alot more refined, clean, less body high all mind high.. i extracted 700 riveas into 100 ml of lemon juice , 50ml water .. that sat 9hrs in the fridge(water stayed the color of lemon juice but smelled like alkaloids) i filtered and added 100ml of sherry wine and that sat 6hours..

A buddy and i sampled 12ml of this and the effect is way different from just eating the seeds or just a simple water extract..

No body feelings AT ALL, not even the normal body buzz.. just a extreme lsd like head and abstract thoughts, better sense of understanding.... Real soon i am def going to try a large dose ..I Feel GreaT...I will no longer do it any other way.....my friend says the same.

Norman said on 16 September 2019:
Quote:
Years ago I stumbled across a simple method for dosing HBWR.
Grind the seeds and cover them with white wine, let sit in the fridge for a day or so, shaking occasionally, decant, filter and drink.
No nausea no aches no vasoconstriction.
I am now off alcohol completely so I’m thinking of an alternative method short of a full on extraction.
I’m convinced that something in the wine besides water and alcohol is what makes the trip so clean. I’ve tried twelve percent water alcohol mixes in the past and still had the nasty side effects and at the same time the trip is not as strong.
I’m thinking acetaldehyde and or tartaric acid may be involved or at least a good place to start.
Any thought on what chemically may be going on?

Vecktor (advanced chemist like myself):
Quote:
Ava69, you have probably rediscovered something that has long been a curiosity, for example on the now defunct blacklight site there was TLC posted of morning glory seed extract treated with methanol, acetaldehyde-methanol or with acetaldehyde-methanol-water, the extract treated with acetaldehyde-methanol showed a clear difference in the alkaloid profile, with a shift to several new non polar spots which couldn't be identified. IIRC Erhlichs was used to develop the plates so these were indole compounds.

69ron:
Quote:
I know some of you out there are apt to believe the statements above because you've failed at making LSH and those statements above help you feel better about you're failure. Don't fall victim to that kind of crap. Try it again. Find out what you did wrong. When it works, the difference is HUGE, not a tiny difference, the experience is TOTALLY DIFFERENT. SWIM knows the effects of LSA and LSD very well. He’s used them many times. He guarantees that when the reaction works, there is NO NOTICEABLE LSA left at all in the experience. It becomes almost identical to an LSD experience at low doses. Totally different from LSA.

According to Albert Hofmann (the inventor of LSD), LSH is an adduct of LSA and acetaldehyde. Adducts are very simple to make. You just mix them in solution, that's all.

The effect of adding acetaldehyde is HUGE. SWIM cannot feel any leftover LSA when the process is done right. So, like I said, I think those guys don't know what they're talking about and I believe Hoffman does, and that LSH is an adduct of LSA and acetaldehyde and nothing more. No complex reaction is needed to make it. You just mix the two together and LSH forms. And I believe all of the LSA forms LSH, not just a small amount of it because you cannot feel any of the effects of LSA after this is done right.

When the conversion from LSA to LSH is complete it feels COMPLETELY DIFFERENT. The reason some people can't tell the difference is because their conversion failed. It doesn't always works, but when it does, the difference in effects are night and day. No one would ever think the effects of LSH are anything at all like LSA. It's that different.

fastandbulbous (chem wizard from bluelight):
Quote:
Apparently N-(1-hydroxyethyl)lysergamide (LSH) is an adduct compound formed from lysergamide (lysergic acid amide, LSA/LAA, LA-111) and acetaldehyde. This hints towards the idea that isn't the most stable of compounds, but would be pretty easily formed by the combination of lysergamide (LSA) & acetaldehyde under physiological conditions (ie a way to get much more & better psychedelic activity from any lysergamide extracted from seed sources).

Chemist Peter Webster who spoke at the LSD symposium:
Quote:
LSH is a labile adduct of ergine (LSA) and acetaldehyde.

Mid April: I am growing a small fence line of heavenly blue morning glory, so I will let you all know how my new dream experiences go this October or November when I pick them out of the pods once hard and black, then immediately freeze them. The seeds all sprouted only 1 week after planting the seeds in the 75% miracle grow mixed with 25% cow manure compost, both from big box home store. I dug a small 2 to 3" trench into ground, and filled it with the soil mix, planted one seed every few inches, 95% of them sprouted one week later after watering them daily. I feed them 1 tablespoon of miracle grow powder mixed into 1 gallon of water in watering can x once a month only. This will yield seeds of very high potency.

The application of NPK fertilizer (miracle grow) + composted cattle manure increased crop yield by 48.9% compared to NPK fertilizer alone ---> from 2017 Frontiers in Microbiology, 05 Sept 2017 "Composted Cattle Manure Increases Microbial Activity and Soil Fertility." Some users report that their plants grew three times in size once they added miracle grow soil to their existing potting soil.

As you can see, I used zinc #212 "screw eyes" from hardware section of big box store screwed into fence after drilling a tiny hole for each one, and strung fishing line inbetween the eyelits, this supports the vine, this is how I have grown for years. Train the vine horizontally on the fishing line if you want and once the vine reaches top of 5' fence, it can cross over top of fence and continue to grow or droop downwards on opposite side, for many extra feet of growth.

Steps in the morning glory extraction (see very bottom attached photo):

I would suggest doing this under low light conditions, I personally replace a lamp in room with an LED Red bulb I found at grocery store in hardware section for five dollars when normally doing this.

1. eight grams weighed out on folded over paper plate, then hammered in between plate on concrete with hammer.

2. then the hammered mush was further ground in coffee grinder.

3. mush sitting in one half pint tall jar. (these jars can be found in canning section of stores)

4. 2 oz (60ml) of cold sherry wine added to mush and transferred to fridge for 20 minutes, shook hard every 5 minutes. (Shake hard three times or every 5 minutes during the 20 minute soak)

5. after 20 minutes in fridge observe course debris at bottom.

6. after 20 minutes in fridge, then filtered thru a cotton ball in a funnel, press on cotton ball using straw when dripping stops to get all remaining light colored wine solution out.

7. observe wine solution dripping thru cotton ball, solution is light colored and free of nauseating to the stomach and intestines debris!

8. closeup of 1st cotton ball in funnel after filtration, it took out ALOT of dark colored debris that is nauseating to stomach and intestines.

9. closeup of first cotton ball used for filtration, super dirty black at top 1/3rd portion.

10. first cotton ball changed out half way thru process, as it clogged, then replaced with a 2nd cotton ball to filter out remaining liquid which was in the funnel.

11. The end! 1.5 oz liquid collected from starting 2.0 oz, put back into fridge until use. Heavy nutty flavor, 100 percent free of nauseating to the stomach and intestines debris. All the actives remain in solution while the debris has all been eliminated. Prepare for a very euphoric and lucid visual trip with deep insights...combines extremely well with other entheogens as well.

12) Wine solution when dabbed on cue tip and touched to paper plate, glows bright blue

13) Her, underground house DJ

Pics appear to be posted backwards, no matter how I re-list them, 1st photo at very right, then in sequence from right to left. Very bottom photo of screen = step #2 the coffee grinder.

Stay true to yourself, Love, Peace and Music
http://www.friskyradio.com

In closing: morning glory compared with HBWR:

Please keep in mind that HBWR has high levels of ergometrine, causes cramping and vasoconstriction, ergometrine levels in morning glory for comparison is very low. Also, HBWR has no history of Shamanic use, whereas morning glory seed usage goes back several hundreds of years. HBWR only has history of medicinal use. HBWR also has high levels of LSA, very sedating and not really all that psychedelic at all. But yes, all studies published after 2011 indicate that no LSH has been found yet in HBWR.

Interestingly, when a boy was found dead at the bottom of his apartment building (he jumped out, apparently this really does happen), they detected levels of LSH or Lysergic acid Hydroxyethylamide in his blood, he had also been drinking heavily and taking HBWR seeds that night. Here is the actual toxicology study:

https://pubmed.ncbi.nlm.nih.gov/20018470/
hxxps://pubmed.ncbi.nlm.nih.gov/20018470/

Remember, LSH is just a labile (unstable) adduct of LSA + acetaldehyde which can remain stable in acidic solutions, for example: outside the body in ph=4.0 cold fresh just opened sherry wine solution (under 70 degree F so the acetaldehyde does not boil off), and sherry is high in acetaldehyde. And you have to seal off the wine with a ten dollar wine preservation canister of inert argon gas (from *mazon with enough gas to last years of sealing) you shoot into the bottle, before placing back into the fridge, to keep the acetaldehyde from decomposing to vinegar via oxidation. Keep cold at all times. Whether this forms outside the liver as well as within is a whole nother discussion.

This is the paper that shows the alkaloid content of HBWR is vastly different from the alkaloid content of morning glory: Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs—ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62–71.

No high levels of stimulating LSH, agroclavine, elymoclavine, chanoclavine, penniclavine found in HBWR seeds, only in morning glory seeds. A 2014 forensics paper from Paulke found no LSH in HBWR seeds, but only found LSA & iso-LSA (83-84%) & ergometrine (10-17%) & rest minimal: lysergol, elymoclavine & chanoclavine.

Sandgrease: "HBWR has more of a sedative effect compared to MG."

Nogal: "HBWR is more body related while MG seeds have effects more similar to LSD."

Pic 1: The Aztec & Mayan extracted the morning glory seeds into wine and alcoholic solutions, 2016 Polish morning glory pics.

Pic 2: Steps in the wine morning glory extraction, pics listed from end to beginning in reverse order.

Pic 3: LSA adducts

Pic 4: Left: old 1970's morning glory data, right: new 2016 Polish mg study data

Pic 5: Eleusis ruins where the sacred psychoactive entheogenic Kykeon was drunk by initiates in ancient Greece, Eleusis participants, top: LSH compared to LSD, bottom: morning glory alkaloids, right: paspalum grass infected with claviceps paspali ergot which grows on the famous Rarian plain adjacent to Eleusis contains the same alkaloid profile as the sacred Aztec & Mayan morning glory.

Attached 1: 2016 Polish morning glory study.pdf

Attached 2: Austin 1994 Tryptophan analogues form adducts by cooperative reaction with aldehydes and alcohols.pdf

Attached 3: The Theoretical Synthesis and in silico Modelling of Lysergic Acid Biscinnamylidene Amide from the Adduct Formation of d-Lysergic Acid Amide and Cinnamaldehyde, 2022.
 
ava69
#9 Posted : 5/2/2021 1:49:17 AM

DMT-Nexus member


Posts: 330
Joined: 24-Apr-2021
Last visit: 02-May-2022

part 9: 20 minute visionary visit from a dead Aztec Shaman


This is how I got into growing morning glory, thought would share as I feel it was more a message from the Aztec Shaman, also goes to show the visual power of high dose LSD made from ergot alkaloids, this really happened.

Over 12 years ago, girlfriend and I both dropped 10 hits each of super old 15 year old decomposed acid given to us by a dear friend, he had stored it in between the pages of a book all that time without using a baggie, when held in front of blacklight, only around 60% of each blotter glowed, rest decomposed. It had a sick feeling for the first 2 hours, but then it worked and skyrocketed us to a higher divine plane, it was very strong.

She and I both saw the exact same vision for 20 minutes straight which had formed out of the shadows cast by the fake Christmas tree lights onto the wall--a 20 minute "schooling" by an ancient powerful & spiritually prominent Shaman from Aztec era --- I have never had an experience like that ever again to this day--it was a once in a lifetime opportunity.

The Shaman sat on a living chair made of spirit animals (birds, jaguars, otters, pumas, macaws, toucans) that morphed into other animals constantly, to the left and right of him were centaurs (half animal below, half naked female above), the great Pyramid of the Aztec capital behind him, and he showed me the rise and fall of several civilizations throughout time--and what is even more amazing--is that we both saw the exact same vision.

The Shaman wore a huge beautiful headdress made of feathers and the detail of the 20 minute animated vision was beyond 4k, and extremely detailed--it was also the vision in which I saw snakevines behind the centaurs, and before the Shaman left us at the end, he motioned to me with his eyes to look to the right of the living room out the window into the patio area where I had an empty garden plot--he was trying to tell me to plant entheogenic plants in the plot--that spring, summer & fall I grew morning glory in that plot on a large wide & tall wooden trellis cemented into the ground.

His point in showing me the rise and fall of the different civilizations was that I believe he was trying to tell me that "if humanity is to survive, the only hope is a Spiritual Solution".

In conclusion, post #8 continued here, ends here:

Below (1-6) from 1975 paper "Extraction and Identification of Clavine and Lysergic acid alkaloids from morning glory", see end of post #8 at top for latest "2016 attached 12 page paper", valuable morning glory study on LSH & other alkaloid levels found in morning glory from 3 different vendors, all levels very similar, collected from heavenly blue mg from 3 different regions located far apart.

The attached 2016 Polish morning glory study at end of post #8 (is somewhat similar to the 1975 study) except it shows penniclavine and LSH to be the 2 highest alkaloids, with the other alkaloids filling in the lower percentage.

hxxps://kb.osu.edu/bitstream/handle/1811/22310/V075N4_198.pdf?sequence=1
https://kb.osu.edu/bitst...75N4_198.pdf?sequence=1

1) elymoclavine = approx 17% of heavenly blue mg = 1957 paper from Yui Takeo showed that when animals were injected with elymoclavine, that they were stimulated MORE than when they were given LSD.

2) agroclavine = approx 25% of heavenly blue mg = 1957 paper from Yui Takeo showed than when animals were injected with agroclavine, that they were stimulated MORE than when they were given LSD.

3) chanoclavine = approx 7% of heavenly blue mg = 1957 paper from Yui Takeo showed that when animals were injected with chanoclavine, that they were stimulated just as much as when given LSD.

4) penniclavine = approx 25% plus of the heavenly blue mg = 1957 paper from Yui Takeo showed that when animals were injected with penniclavine, that they were stimulated just as much as when given LSD.

5) D-Lysergic acid hydroxyethylamide (LSH) = approx 25% plus of the heavenly blue mg. If the seeds are not frozen & stored properly, then over time LSH decomposes to LSA (Lysergic acid amide). So the seeds may contain a makeup of 1/2 LSH to 1/2 LSA a long while later, like retail rack seeds as the LSH decomposes over time.

6) Ergometrine = approx 5% of the heavenly blue mg.

From the 1957 paper:
Quote:
All members of the excitor group produced in all test animals a syndrome of central sympathetic excitation and elicited a stimulation of spontaneous activity. In this group, elymoclavine, was the most potent stimulant and next come agroclavine, triseclavine, penniclavine, and LSD which are almost equipotent, as judged by the degree of symptoms exhibited in the same dose. The arousal effect of elymoclavine or agroclavine on reserpine-sedation was superior to that of LSD.

Animal experiments have shown that elymoclavine, lysergol, LSD and several other ergot alkaloids such as agroclavine, triseclavine, penniclavine, lysergine and lysergene have excitory effects on the central nervous system (Note 1: Yui & Takeo, 1957) as well as lysergic acid hydroxyethylamide (LSH) which also excites the central nervous system in animals (Note 2: Glasser, 1961).

The effects of agroclavine are similar to those of elymoclavine and LSD on rabbits (Yui & Takeo, 1957), indicating that the effect of agroclavine may well be psychoactive in humans as well. It also seems likely that agroclavine, triseclavine, penniclavine, lysergine and lysergene and lysergic acid hydroxyethylamide (LSH) will be psychoactive in humans.

LSH = D-Lysergic acid hydroxyethylamide in the seeds, we know it is similar to LAE-32 in TIHKAL, in which human experiments were done, at 1.5mg it was stimulating & "LSD like".

Glasser in 1961 noticed animals also became stimulated when injected with LSH. Dr. Glasser said some of the mice even stood on their hine legs and pressed on the noses of the mice in front of them, very peculiar.

Animal tests all point to LSH being an active psychedelic and it is indeed the closest thing to LSD found in nature, far closer than d-ergine. Owsley claims Hoffman himself told him that LAOH is very LSD-like.

It was Gröger who first discovered LSH in the seeds, published in his 1963 paper "Über das Vorkommen von Ergolinderivaten in Ipomoea-Arten". Later also Hofmann then extracted it from the seeds. It probably was in 1967, as Heim wrote in his work from August 1967 that Hofmann said he recently extracted it from the seeds (personal communication, as they knew each other very well).

LSD----------------------------------------CH2CH3-----CH2CH3.....chemical formula (C20 H25 N3 0)

LAE-32-----------------------------------------H------CH2CH3.....chemical formula (C18 H21 N3 0)

d-lysergic acid hydroxyethylamide-----------H---------CHOHCH3....chemical formula (C18 H21 N3 02)

Penniclavine-----------------------------------------------------chemical formula (C16 H18 N2 O2)

Notes:
(1) The above experiments with mice, rabbits, cats and dogs who were injected with elymoclavine, agroclavine, chanoclavine alkaloids from morning glory can be found in "Neuropharmacological studies on a new series of ergot alkaloids" "Elymoclavine as a potent analeptic on reserpine-sedation" by tohoru Yui and Yuji Takeo, Hyg 911/LSD 494, Jap. J. Pharmacol. 7, 157 (1957). Jap. J. Pharmacol 7, 157-161 (1957).

(2) LSH experiments on animals: A. Glasser, Nature 189, 313 (1961)

(3) This is the paper that shows the alkaloid content of HBWR is vastly different from the alkaloid content of morning glory: Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW. Identification of legal highs—ergot alkaloid patterns in two Argyreia nervosa products. Forensic Sci Int. 2014;242:62–71.

No high levels of stimulating LSH, agroclavine, elymoclavine, chanoclavine, penniclavine found in HBWR seeds, only in morning glory seeds. A 2014 forensics paper from Paulke found no LSH in HBWR seeds, but only found LSA & iso-LSA (83-84%) & ergometrine (10-17%) & rest minimal: lysergol, elymoclavine & chanoclavine.

We know that MG has centuries of Shamanic use, while HBWR has no history of Shamanic use. HBWR only has history of medicinal use.

Sandgrease: "HBWR has more of a sedative effect compared to MG."

Nogal: "HBWR is more body related while MG seeds have effects more similar to LSD."

4) Aum_Shanti, 2019, "In fresher seeds there's mainly LSH (in relation to LSA). Only in old seeds, the LSA is dominant. This is because the fungi on the plant can only biosynthesize LSH (not LSA), and LSA is then a decomposition product of LSH over time. The fungi on the vines biosynthesize:

from tryptophan-->chanoclavine-->agroclavine-->elymoclavine-->lysergic acid-->ergometrine-->LSH, which then decomposes over time into LSA."

(5) Psychotomimetics of the Convolvulaceae pg 93: "This particular plant seems to have been more important to the Aztecs in divinity then Peyotl or Teonanacatl, two of their other classical sacred plants."

(6) Jonathan Ott "Pharmacotheon": "Ololiuhqui was far more prominent as an entheogen here in Mesoamerica than those mushrooms; the mushrooms are mentioned only here and there by a few competent chroniclers; yet almost an entire book was devoted to denouncing mainly the ololiuhqui idolatry. The annals of the Inquisition contain many times more autos de fe for ololiuhqui than for mushrooms."

(7) 2016 Polish morning glory study which finds 3x higher amounts of LSH in fresher MG seeds direct from grower/producer vs retail: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830885/ LSA is a decomposition product of LSH over time (see attached pics from study).

2016 Polish MG study:
Quote:
Alkaloids abundance in all 3 HB cultivars is comparable, with most significant difference for LSH (Lysergic acid hydroxyethylamide), which varies from 0.54 to 1.71 compound to IS ratio.

As has been demonstrated in this study, LSH is a labile compound, and therefore the variances in its concentration may be due to different age and storage conditions of the seeds rather than difference in plant metabolism. Indeed, seeds IT-HB2, which express highest concentration of LSH, were bought directly from the producer, whereas seeds IP-HB1 were purchased in retail stores.

[8] Researchers showed in 1961 that Claviceps paspali produces high amounts of LSH in culture: "Production of a new lysergic acid derivative (LSH or Lysergic acid hydroxyethylamide) by a strain of Claviceps paspali, Stevens & Hall".

Possible likely entheogen candidate used to serve hundreds of initiates at Eleusis in ancient Greece: this is where the Eleusian Mysteries were held, at the Eleusis Telesterion (initiation Hall for initiates...all men, women & slaves were invited) in ancient Greece.

Chemist Peter Webster wrote that fresh Greek claviceps paspali infected paspalum grass which grows adjacent to Eleusis in the famous Rarian Plane contains the exact same alkaloids as found in the fresh Aztec & Mayan morning glory. Albert Hofmann wrote that Claviceps paspali due to it's similar makeup to the Mexican morning glory could also have been the likely entheogen used at Eleusis to serve hundreds of people.

(9) Krystle Cole from the book "Lysergic":
Quote:
"Isn't Ergot what Socrates used to take at Eleusis?" I thought it was kind of cool to be taking something that the founders of our democracy used to take, but that our current democracy has made illegal.

LSD chemist Todd Skinner replied "Yes". Todd had prepared 6 jugs of ergot wine and stored them for many years.

Krystle Cole's "ergot wine" experience (several pages long) in the book "Lysergic", reported that she saw constantly rotating holographic Sanskrit or Arabic & Zodiac symbols, floating in a circle around Todd's head.

(10) sample morning glory wine trip report from Erowid: Morning Glory & Alcohol by Psychopsilocybin:
https://erowid.org/experiences/exp.php?ID=95057
hxxps://erowid.org/experiences/exp.php?ID=95057
I would only note that she or he should have most likely extracted the seeds from the start immediately into the wine instead of extracting into the water first...then adding to wine later, as this will cause the LSH to first decompose to LSA in neutral water or water that is not acidic.
ava69 attached the following image(s):
Aztec Shaman vision.JPG (155kb) downloaded 3,317 time(s).
 
Mitakuye Oyasin
#10 Posted : 5/3/2021 1:56:23 AM

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That is fascinating. I had never heard of HPBCD before now. The molecular arrangement and the fact that is forms a cone that substances can be 'hidden' in is really interesting. I wonder if this could be beneficial to other psychoactive substances than DMT. Thanks for sharing.
Let us declare nature to be legitimate. All plants should be declared legal, and all animals for that matter. The notion of illegal plants and animals is obnoxious and ridiculous.
— Terence McKenna


All my posts are hypothetical and for educational/entertainment purposes, and are not an endorsement of said activities. SWIM (a fictional character based on other people) either obtained a license for said activity, did said activity where it is legal to do so, or as in most cases the activity is completely fictional.
 
Loveall
#11 Posted : 5/3/2021 1:45:08 PM

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Hi, thanks for the research and tests.

I have limited time to answer, so please excuse the lack of links and mistakes/commissions - I'm going off memory alone.

1) I believe someone by the name of Inmotion had a DMT/HPBCD complexation thread. Someone tested it and in their experience the resulting powder was too bulky/not practical.
2) Why use a 1 to 1 molar ratio? As I understand it % complex and permeability increases with HPBCD as the complex is in equilibrium with the separate molecules. As HPBCD is increased, permeability reaches an optimal point since at some time excess empty HPBCD starts getting in the way (the salvinorin complexation thread discusses this and has some data and examples from the literature for some molecules).
3) We had some success making salvinorin/HPBCD buccaly/orally active here at the nexus, but reproducing it was spotty. Zebbie had success and strong effects buccaly using the green gunk from wa acetone salvia extraction (made powdery with some form of starch).

I wonder what would happen if spent salvia (from chilled acetone leftovers) was extracted with room temp acetone to get the green gunk and make the starchy powder that worked for Zebbie. Them mix that with DMT and test for buccal activity.

Also, as you may already know, FB harmalas are buccaly active on their own at 20mg in my experience (there are threads on that too).

Cheers and thanks again.
[center]💚🌵💚 Mescaline CIELO TEK 💚🌵💚
💚🍃💚 Salvinorin Chilled Acetone with IPA and Naphtha re-X TEK💚🍃💚
 
ava69
#12 Posted : 5/3/2021 4:37:48 PM

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Part 10: One way to make tetrahydroharmine

Personal note: I may be a long term chemist, but I developed this many years ago so that anyone can do this at home. I actually went into a trance state after a death and received the information from a divine source on how to do this, as I was stuck at one point for weeks on end with no solution. No fancy chemicals or equipment needed like TIHKAL THH Synthesis. Due to the hundreds of Spiritual centers in South America needing these plants, Caapi is increasingly being harder to find. You can do this with normal coffee filters and cotton ball stuffed in a funnel. Tetrahydroharmine (THH): she is as valuable as mescaline, can't do without her. Diamondlike shimmering in her beauty.

Note: I only do this around 3 times in a lifetime, so I have enough THH to last a lifetime, as I tend to use 300mg at least x 3 times a month. It's a lot of hard work extracting the rue. The harmaline to THH part is easy.

Professor8 said in 2012 here:
Quote:
A while back I read a very good explanation of the different effects of Harmalas that has stuck with me. I believe it was 69ron that said: ‘Harmine is the Coffee of the harmalas & Harmaline is the Weed and when it comes to THH (tetrahydroharmine) you have The Light.'

While very similar in molecular structure, THH has a completely different personality to Harmine & Harmaline. Calling it The Light of the harmalas is very appropriate. IMHO, it is the Holy Grail of The Harmalas. I have found Harmine very, very helpful in Meditation & Yoga. It energises your Light Body and allows you to see your Chakras & Auric fields; very helpful in a biofeedback sorta way.

Personally, Harmaline is too heavy & stony for me but I do respect its power and personality, kinda like a big shaggy & lovable dog.
I'm more in the camp with professor8, unfortunately I have a low nausea threshold, and those who know me know I always avoid anything (harmaline) with even the slightest hint of nausea producing potential personally.

Tetrahydroharmine or THH ranks very high on the "periodic psychedelic table" among all the known entheogens for inducing realistic way beyond 4k monochrome teaching visions for hours...adding even small amounts of DMT brightens and colorizes the visions, example: reptiles, birds & animals such as serpents/snakes/toucans/parrots/jaguars with patterning show their respective associated colors. Many times I have viewed multi-colored serpents, birds & jaguars several times over hour long CEV periods, serpents are the manifest spirit of Ayahuasca.

THH in the caapi also seems to strongly activate the right hand hemisphere of the brain-- the side that performs tasks that have do with creativity and the arts, feelings, visualizations, imagination, holistic thinking & intuition, empathy, spirituality & connectedness. Researchers found that the right side of the brain lit up in brain scans of people who took LSD, mescaline, or mushrooms. This includes tetrahydroharmine. The world is largely moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development.

Read study reference 1 below, and you will see that Vegetal Ayahuasca (made by the UDV, Santo Daime, Shuar Indian) contains zero to extremely low amounts of harmaline (less than 15mg), but contains as much tetrahydroharmine as it does harmine. Somehow, over their day's long cooking process perhaps using vitamin C (hydrogen doner) in the cooking, the THH would attain levels found as harmine in the plants. All of the Santo Daime Ayahuasca contained zero mg of harmaline: https://en.wikipedia.org/wiki/Tetrahydroharmine

Page 154 of "Various Alkaloid Profiles in Decoctions of Banisteriopsis Caapi, 2005":
Quote:
The average ratio of THH to harmine in the vegetals (traditional brews) was consistently near 1:1, from all sources (table 2), while this ratio was closer to 1:5 in a large survey of source plant material. It is presently unclear whether harmaline is being chemically reduced to THH during the acidic process of decoction.

Dr. Callaway wrote in "The Entheogen Review":
Quote:
However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União do Vegetal members who had consumed ayahuasca for 10+ years). In short, yes, there seems to be important activity from THH.

Be-ware cheap China made THH as a handful of people have reported it does not glow blue under blacklight, but green, indicating the process was not carried out to completion, harmaline contamination, incomplete synthesis. I recommend making your own or quality sources.

Once you get to the end of your rue extraction, where you dissolve your rue hcl or rue salt in 120 degree F water in a pyrex dish on your stir mantel with stir bar spinning (the rue dissolves fast and easy in slightly hot water from the stove) and precipitate the harmine from the harmaline, you want to slowly bring the ph of the water up to exactly 7.0 with drops (often many milliliters) of 10% janitorial strength ammonium hydroxide (from hardware store)...remember to keep the stir bar spinning...at 7.0 only the harmine will fall out, collect over vacuum filter...then raise ph to 7.5 or 8.0 (your preference) and collect a small middle fraction, which you will want to set aside as it is a mix of some harmaline with some harmine...keep this fraction to add back in the future on a rainy day when you do another rue extract...now collect the 3rd fraction, which is the harmaline only at ph = 7.5 or 8.0 and above (your choice). Temperature of solution (120, 100, 90 or 80 degree F water as it has been sitting a while) also affects PH you collect at to a slight degree, so keep this in mind.

Once your done precipitating your harmine (1st) and your middle fraction (2nd) and in the end, get to precipitating the harmaline only (3rd), you can raise the PH to as high as 10 with a little bit of added ammonium hydroxide (add several milliliters), and your harmaline will all precipitate very quickly. Don't worry you can't overdo the addition of the ammonium hydroxide when precipitating the harmaline, it's completely safe. Ammonium hydroxide has a natural ph of around 10.0, so you can't overdo the addition of it.

The big box stores do not carry the 10% janitorial strength ammonium hydroxide but I am able to find it at an old mom and pop hardware store near the lake where I live, and it can be ordered on line. It comes in 1 gallon containers for a few dollars.

It's only important that you reach the target ph on the Apera Instruments ph20 ph meter for an instant, then you will notice the ph meter readings drop slightly as the spin mantel becomes saturated with your precipated crystals, now is the time to filter and collect. There are easy to observe color changes in the solution as the crystals precipitate, you will notice these as well. For example, once you hit target PH of 7.0 using many drops or milliliters of ammonium hydroxide, the dish will fill with precipiated harmine freebase crystals, but the meter readings will often then drop down to around 6.8 or 6.7 or so. This is normal as the spinning solution becomes saturated. Let it continue to spin for several more minutes, then collect. If it is spinning too slow, spin it for a bit with a spoon for a few seconds to help it all mix better.

Always rinse your freebase harmine and harmaline crystals with hot water when done filtering them on the vacuum filter, then spread them out on a pyrex dish to dry under a fan overnight, then weigh them the next morning.

Details: I dissolve the rue hcl extract into around 120 degree F water on a stir mantel, and as the stir mantel spins....add milliliters (many, many drops) of 10% ammonium hydroxide to precipitate only the harmine 1st, then a very small middle fraction (harmine + harmaline), then a final fraction which is only harmaline. I prefer using Excellent PH meter: Apera Instruments ph20 ph meter.

Now once you have your harmaline freebase...

1) place 10.5 grams of harmaline in a 1 liter pyrex cup style glass
2) add 900ml vinegar
3) add 40g zinc dust in the pyrex glass too, use 40g zinc dust per each 10.5 grams of harmaline. You will see tiny hydrogen bubbles rise to the surface like champagne.
4) place beaker solution on a magnetic stirrer with stir rod and spin entire solution slowly
5) spin for 1.5 hour, then let solution sit for 1 hour without spinning so the zinc dust can settle to the bottom. The solution will have turned from a beginning dark green color to a transparent like golden color after it sits 1 hour after the 1.5 hour spin. Use the end of a cotton q tip to place in solution and dab on paper plate in front of blacklight, the smear will now glow light blue when transition is done...

6) Remember, once done with spin, let the solution sit for 1 hour, most (99.5%) of the zinc dust will settle to bottom, then filter solution above the zinc over a #101 9cm filter disc fitted to a vacuum flask with vacuum trap in series with your vacuum pump, this will give you a transparent golden color liquid, use this solution for next step.

Throw away any zinc dust you just collected on filter disc (be careful, don't throw zinc on top aluminum foil in garbage or it will smoke due to hydrogen loaded zinc, best to put used zinc in a baggie with water to keep it moist, keep away from aluminum).

The pump/vacuum filter flask & filter disc will remove 100% of any zinc dust. so in other words, filter pyrex beaker solution (takes out the zinc dust) over a #101 9cm filter disc fitted inside a vacuum filtration flask hooked up to a vacuum pump, with a small vacuum trap in series, in-between the filtration flask and the pump. A good pump is JB platinum DV-142N 5 CFM heavy duty vacuum pump.

Cool you are left with a 100% clear transparent with just a touch of golden very light yellow color with no zinc dust at all...now add (80ml of 10% janitorial ammonium hydroxide per 2g of harmaline)...so this means add 400ml of the 10% ammonium hydroxide to your solution...you will immediately see the thh crash out of solution as a white powder, place mason jar in fridge for at least 3 hours, the crystals will all be seen at bottom of mason jar. I like to let jars sit in fridge overnight then collect the THH at the bottom of the jars early the next morning. As you have already done quite a bit of work the 1st day.

7) you will collect 7.5 grams THH freebase on the filter disc sitting in your vacuum filtration flask once you pour fridge cold solution over a #101 9cm filter disc in your vacuumm pump, rinse THH with some hot or cold water. put filter disc of thh in a pyrex tray, scrape off and dry under fan.

8] always this will happen: exactly 75% is the yield, as I don't know why this is so...but it's a great yield still. Even in TIHKAL, the yield was similar, right at 75% as well.

9) The more zinc you use, the faster the reaction progresses, so 35 to 40g zinc means the reaction is finished by 1.5 hour.

I've looked at the #101 filter after filtration, hardly anything at all on it, truly only less than 1% of the zinc dust remains to be filtered after sitting for 1 hour.

If you don't have a vacuum pump/filtration setup: Personally, I believe the cotton ball in a funnel to be one of the greatest inventions of all time--and think it would work just fine for filtering out the remaining less than 1% zinc dust, remember 99.5% of the zinc dust falls to the bottom already after sitting for 1 hour after the spin mantel is turned off. What you are filtering is actually the less than 1% of zinc dust from the very bottom after sitting that gets kicked up back into the solution as you are decanting it off. 2 people here have said the cotton ball stuffed in funnel does indeed work to remove any lingering (less than 0.5%) zinc dust, and said their resulting THH worked fine.

p.s. I also saw an episode of "Ancient Aliens" in which they discovered remnants of zinc dust inside one of the chambers, and they believe the Egyptians were making hydrogen gas using zinc and vinegar, speculating that the great pyramid was some sort of power generating device.

igorcarajo said:
Quote:
On the topic of THH I wonder what happens if instead of separating the harmine from harmaline and then adding zinc to the harmaline to convert it to THH, one would add zinc to the harmine/harmaline mix. Would the harmaline convert to THH and the harmine remain intact?

Great question igorcarajo. I don't recommend doing it that way as when harmine is reacted with teeny tiny hydrogen gas bubbles whether from zinc in vinegar or any other method (I've done this before to see what happens) it does remain as harmine but the harmine will give off a strange smell or odor indefinitely as if the reaction has some minor unknown influence on the alkaloid. It will even change the color of the harmine from it's very dark natural brown to a light tan shade. Even 300mg of pure THH made from harmaline has zero nausea, but this "weird harmine" subjected to hydrogen gas may cause nausea. Even left out in open air, it will continue to "stink the very faint strange odor". You also will not know how much harmine is mixed in with the THH making it impossible to dose correctly. The harmine when used this way also seems to impart a strange side effect of occasional minor drainage down the throat of flim, don't recommend the resulting "weird harmine". It's best not to have large amounts of harmine mixed in with the harmaline during the conversion to THH. It's not much work to separate the harmine from the harmaline with extreme purity using 10% janitorial ammonium hydroxide found at some hardware stores. Keep in mind harmine and THH both glow blue when a bit is dabbed onto a cue tip pre-wetted with vinegar and smeared on a paper plate and held under blacklight. Harmaline glows greenish.

Downwardsfromzero said:
Quote:
Without an actual chemical analysis we can only speculate what might happen when harmine is present during the harmaline/zinc reduction. Dimerisation or a similar coupling reaction is possible, where the harmine can trap a radical anion of the partially reduced harmaline. Perhaps the product of this kind of reaction is what has the nauseant effect. Emetine is a dimeric isoquinoline alkaloid although that doesn't necessarily count for anything. There are other kinds of dimeric alkaloids that do other things, and I would note that for emetine there are myocardiac toxicity risks. The main point still stands, being that if unknown dimeric or other oligomeric alkaloids are being formed in the harmine/harmaline reduction mixture we are dealing with unknown toxicity risks and this is something best avoided.
Excellent analysis downwardsfromzero.

https://www.sciencedirec...istry/tetrahydroharmine
hxxps://www.sciencedirect.com/topics/medicine-and-dentistry/tetrahydroharmine

"Hallucinogenic Plants in the Mediterranean Countries"
Ioannis D. Passos, Maria Mironidou-Tzouveleki, in Neuropathology of Drug Addictions and Substance Misuse, 2016

From above article: "The content of dried seeds of the plant in harmine is about 4.3% w/w, 5.6% in harmaline, 0.6% in harmalol, and 0.1% in tetrahydroharmine."

There is less than 0.1% THH in rue seeds (next to nothing), but THH is the 2nd largest alkaloid in Caapi used in traditional Ayahuasca. You will need to convert the harmaline you extract from the rue seeds directly into tetrahydroharmine using the procedure here, uses all over the counter chemicals, same yield as TIHKAL (75%) but TIHKAL THH synthesis uses hard to obtain chemicals, some of which only chemist are able to obtain. The procedure on this post is a process I developed myself many years ago so that anyone can do this at home. All you need is vinegar, 10% janitorial ammonium hydroxide from your local mom and pop hardware store, and zinc dust from pyrotechnic places. If you don't have a vacuum pump, this post explains how you can use a cotton ball stuffed into a funnel instead.

The particular rue seeds I get from India have extremely large amounts of harmaline compared to the harmine, and that's fine by me, as I purposely order only these only, as I prefer lots of harmaline...that way I can convert it all to tetrahydroharmine. Rue seeds from the middle east I've noticed contain more harmine than the Indian seeds. Depends where you get your seeds from, and in what season they were harvested, these two factors both affect the percentage of harmine to harmaline.

When I precipiate the full 274g rue salt amount, I typically end up with 40grams of harmine fb (ph=7.0), 8g middle fraction (mix of harmine with some harmaline fb at ph=7.1 to ph=7.5) and 158g harmaline fb (above ph=7.5, all falls out quickly at ph=10.0)

This is something I only do a couple times in a lifetime, as it's a lot of hard work, and takes a very long time. Most people will only extract a small amount of rue seeds, and for good reason. I like to get it all over with at one time so I can have enough for a lifetime.

Like downwardsfromzero once remarked when he does this, rue stains all over the place, same here, my workbench turns yellow and green stains, lots of work and cleaning dishes, changing out vacuum pump oil when you are finally done, etc. But it's all worth it when you're done. My wife has me go over every inch of the floor from the garage to the kitchen and wipe up every drop of rue stain on the floor while my dog follows me to make sure I get it all, as I make endless trips between both rooms to clean jars, get water, manske boils, etc.

Post #1 details the experiences using this very pure THH which I have used literally around a hundred times, which few people have tried. I've used this pure THH for a decade, it's simply divine and quite incredible, I value it as highly as I do mescaline.

Like L-dreamer states, with the sublingual HPBCD DMT: no delirium, very clear and crisp, zero dizziness, zero nausea, when combined with 35mg sublingual harmine and 300mg oral very pure tetrahydroharmine taken 45 minutes before: perfect experience, intensely beautiful and clear just like mescaline. No words to describe. For music lovers like myself, it is a joy to listen to music for hours on end, sounds heavenly just like high dose cactus tea. Profound music enhancement, open eyed beauty infinite, abundant neon colors, the most beautiful teaching Ayahuasca visions, the divine spiritual insights gained are worth the admission alone.

Dirt cheap experience compared to the rare and expensive cactus which I also love dearly. 90mg HPBCD dmt sublingual + 35mg sublingual harmine (both at exact same time under tongue) + 300mg pure oral THH taken 45 minutes before is like 600mg of mescaline. Intensely beautiful experience.

--> Taking 200mg of oral harmine + 300mg of oral THH + the sublingual HPBCD DMT taken 1 hour later is an experience so incredible and strong, still no nausea and dizziness for me:

In my trip diary that June night, I documented this oral harmine + oral THH + 90mg sublingual HPBCD dmt around 1 hour later as the most powerful sublingual experience of my life. Not only was there no dizziness or nausea but no anxiety as well, very impressed. For reasons posted by Dr. Narang on post #1, the sublingual HPBCD DMT was many factors more powerful than any dosage of oral HPBCD DMT. It was many factors stronger, around x5 times. It was so powerful that I saw curtains of neon-colored visuals in the open doorway when I looked to my right. Everything in all directions was surrounded by brilliant neon-colored rainbow reflections, the euphoria and music enhancement was very powerful.

Open-eyed beauty was beyond belief, divine and infinite. The tracers were so powerful, that they went on forever like a hall of mirrors into the distance, and instead of there just being multiples of my hands when I waved them, there were beautiful colored fractals inside the tracer smears. One hour after the sublingual HPBCD DMT started to work, it was still as strong visually & transcendence wise as when it started. Only at the 1.5 hour point did the DMT ween down in strength several levels.

The 200mg of harmine was so powerful, that I continued by taking a 2nd dose of sublingual HPBCD DMT again 2 hours later after the 1st dose, and it again worked just as strong as the first dose. With closed eyes were seen brightly colored Ayahuasca visions, in my diary I noted that I saw close to a hundred rapidly changing visions from Egyptian scenery to elaborate art carvings in stone, way beyond 4k in detail. This resulted in a +5 strength Shulgin level journey with life changing consequences.

The harmine having a half-life of from 1 to 3 hours, did not die off until around 5 hours later, so each time I took a re-dose of sublingual HPBCD DMT for the evening, it continued to work very strongly. I highly recommend this approach, and plan to use the oral harmine again with the oral THH many times again in the future, but only using the HPBCD DMT sublingually as noted above. Take care, all the best...peace, love and music.

Pic 1: One way to make tetrahydroharmine

Pic 2: Dissolve your rue hcl extract into warm 120 degree F water so it all dissolves, drop in two high precision PH meters, start the spin mantel, and add drops of 10% hardware store ammonium hydroxide until you reach ph=7 when the harmine only will fall out, ph 7.1 to ph 7.9 = small middle fraction of harmaline mixed with harmine, put away and save for a rainy day when doing another extraction to add back in, ph 8.0 and above = all the harmaline only.

Pic 3: 75 grams of pure tetrahydroharmine, will last me a lifetime, more valuable to me than any gold, never depart with. Pure THH glows blue under blacklight when a bit dabbed onto vinegar soaked cue tip and smeared on plate under blacklight.

In order to create the 75g very pure THH that will last me a lifetime, here a few pics of the end stage. Just follow the "Tao of rue extraction" here, or something similar to get to the ending stage where you then precipitate pure harmine & pure harmaline following instructions here.

pic 4: 274 grams rue salt, 200 grams of this rue salt was used to precipitate the below alkaloids, rest put away.
pic 5: 23g pure harmine fb precipitated at ph=7.0
pic 6: not shown: 5g middle fb precipitation (ph=7.1 to 7.5 is a small precipitation of harmine with some harmaline mix), put away to save for a rainy day when you do another rue extract, to add back in, to further separate.
pic 7: 116g pure harmaline fb precipitated above ph=7.5.
pic 8: 75g very pure tetrahydroharmine fb made from 100g of the harmaline fb (around 75% yield, similar to yield in TIHKAL, which was also 75%). But the conversion uses all over the counter chemicals (ammonium hydroxide, vinegar, zinc dust) unlike the TIHKAL synthesis.

Pics for welcome guests (post #13): https://mycotopia.net/to...ly-active-under-tongue/
Pics for welcome guests (post #36): https://mycotopia.net/to...ive-under-tongue/page-2

Attached: (June 2005). "Various alkaloid profiles in decoctions of Banisteriopsis caapi" (PDF). Journal of Psychoactive Drugs.
 
ava69
#13 Posted : 5/4/2021 7:08:32 AM

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Loveall said:
Quote:
2) Why use a 1 to 1 molar ratio? As I understand it % complex and permeability increases with HPBCD as the complex is in equilibrium with the separate molecules. As HPBCD is increased, permeability reaches an optimal point since at some time excess empty HPBCD starts getting in the way (the salvinorin complexation thread discusses this and has some data and examples from the literature for some molecules).
ava69 attached the following image(s):
HPBCD complex to DMT suggested molar ratio.JPG (36kb) downloaded 4,106 time(s).
 
Loveall
#14 Posted : 5/5/2021 1:32:40 PM

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Do you have any references to backup the statement that most studies use a 1:1 drug/cyclodextrin ratio?

What I have come across is that usually it is not 1:1 (see example table below).

Attaching a paper that systematically goes over what affects the ratio/preparation (complexation efficiency).

Also, both FB and salt drug forms complex with HPBCD as I understand it.

Setting all that aside, I think you have a promising experimental claim. I'll try to replicate it at some point. If it works I would test higher HPBCD ratio also, let the experimental results see if there is a modulation/improvement.
[center]💚🌵💚 Mescaline CIELO TEK 💚🌵💚
💚🍃💚 Salvinorin Chilled Acetone with IPA and Naphtha re-X TEK💚🍃💚
 
ava69
#15 Posted : 5/5/2021 3:08:40 PM

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Loveall, thanks for response and hope to hear from you in future should you try an experiment. Thanks for your table. Your table indicates even higher molar ratio examples of "host drug to HPBCD, or rewritten as drug:CD molar ratio" as the first sentence in your table indicates.

Loveall said:
Quote:
Also, both FB and salt drug forms complex with HPBCD as I understand it.

HPBCD only forms inclusion complexes with non-polar compounds. With a hydrophobic interior and hydrophilic exterior, cyclodextrins form complexes with hydrophobic compounds. Hydrophobic molecules are usually nonpolar, like freebase DMT for example. Hydrophobic literally means “the fear of water”

HPBCD is a new technology that allows freebase nonpolar drugs like DMT to be trapped by the cyclodextrin inner hydrophobic cavity which is composed of an inner "non-polar trap", and "outer polar cavity or hydrophilic exterior cone" which allows the normally water insoluble DMT to be made 100% water soluble.

As mentioned earlier, only a portion or "tail end" of DMT molecule needs to be trapped in the HPBCD cone...I wonder if more than one DMT molecule can trap itself inside "just one single HPBCD molecular cone"? Maybe downwardsfromzero has an answer.

If so, I can see how much less HPBCD can be used. The DMT molecule is very small compared to the inner HPBCD cone. Using much less HPBCD would prove a valuable experiment.

Notice the authors of the ofloxacin HPBCD study not only used a 1:1 molar ratio like I copied, but they also "kneaded" or mashed the HPBCD into the host drug with their hands, just like I did with the HPBCD placed on top the DMT in the spoon with many drops of water...I used the end of a spoon and my muscles to crush and mash or knead it all together back and forth on the spoon into a sticky glob for 2 minutes.

Girl & boy caught in waterpark tornado funnel ride, picture host drug being caught in HPBCD cone.
ava69 attached the following image(s):
40.JPG (174kb) downloaded 3,622 time(s).
 
Jagube
#16 Posted : 5/5/2021 6:34:14 PM

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downwardsfromzero wrote:
This combined with the HPBCD complexation results (which we really ought to replicate and confirm) makes me wonder whether there are saccharides in leaf brews which perform a similar effect to HPBCD. There is still so much scope for really interesting research here - thanks for posting.

I've seen anecdotal reports of quidded D. cabrerana leaf being active.
 
ava69
#17 Posted : 5/7/2021 11:51:54 AM

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The reason I put this in the Pharmahuasca experience section...is that the combination of the two (oral THH taken 1 hour earlier) and sublingual under the tongue DMT + 35mg sublingual harmine fb for 15 minutes results in the "full monty", will give you an experience like strong cactus tea or true Ayahuasca, the full mind expansion transcendence. This is what a lot of people don't understand, is that Ayahuasca is teamwork between the various alkaloids.

DMT according to two studies posted in part 2 does not block serotonin on it's own, but THH does (like ibogaine, cactus, LSD, mushrooms), serotonin blocking results in stimulation and the breaking down of the survival filters or barriers in the mind, the combination of the two results in not just 20% receptor stimulation from the DMT alone, but 100% receptor stimulation, as 5-ht1a inhibition (serotonin blockage) makes up over 80% of brain 5-ht according to LSD scientist Dr. Nichols. Tetrahydroharmine has also been shown to agonize the A2A-A2C receptors, just like mescaline, they have numerous receptorome similarities.

You will notice with the combination of the two that music sounds incredible, closed eye visions are seen like those of "true Ayahuasca" described in "Antipodes of the Mind" by Benny Shanon, or cactus tea. Open eyed beauty is profound, impossible neon colors not seen on this earth become apparent.

Out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.
 
ava69
#18 Posted : 5/8/2021 2:12:07 PM

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redgreenvines said:
Quote:
well you can mix me up a batch
I would love too! But since I can't just buy some HPBCD powder, dirt cheap.

Ferdinando said:
Quote:
mescaline is a second
Full bodied cactus tea from 1 x 12" bridgesii or 2 x 12" medium thickness to 1 x 12" large thickness San Pedro is my absolute favorite, have done over 200 times now over many, many years...totally bad ass. The 250 to 300mg oral THH + 60 to 90mg on up sublingual HPBCD DMT ranks in the same, both equally VERY bad ass. I keep a trip diary over a period of many years. I've done Ayahuasca x 70 times now. Bridgesii is more stable in it's good alkaloid content, whereas san pedro can vary from no activity, to some activity, to good activity.

Tyrannicalrex said:
Quote:
I'm about to try cactus/mesc extraction HcL more than likely. I have a couple kilos of MHRB, probably a lifetime supply, lol. I could get 36 grams of DMT from them give or take.
Tell you what, just cut the cactus down the sides (de-core it), cut into chunks, peel the skin off each chunck, and boil the pieces for 1 hour, then strain thru a strainer and drink--so easy and kicks much ass--full bodied complete spectrum. Also, so glad to hear you have a lifetime supply of MHRB.
 
ava69
#19 Posted : 5/9/2021 9:54:57 PM

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part 11: From the archives of dmt world: How to easily extract 2.3g DMT from 170g bark using a 2 liter Erlenmeyer flask


From the archives of dmt world, pre-runner to dmt Nexus forum:
Quote:
Super easy instructions for 2.3g DMT from 170g bark all in one day using a 2 Liter erlenmeyer flask and long glass pipette with rubber bulb on end for the pulls (zero drip).

Yields 2.3g DMT from 170 gram powdered bark: all 4 pulls are using 90ml naptha on 170g powdered bark mixed into 1.8 liter lye water (1.5 x 150g bark = use 225g lye dissolved into the 1.8 liter 150 degree hot water.) Just heat up 1.8 liter of water in a big pyrex pot on stove and use thermometer to pull if off when it reads 150 degree F.

Slowly sprinkle lye using safety goggles and long chemical resistant gloves that go up each arm, and stand back as far as possible...(the hot water will fizz but not boil up) into your pyrex pot of hot water. After each sprinkle, stir the water a bit with a super long metal spoon. It will "growl" a bit as it fizzes, but this way it dissolves very fast into already hot water.

Pour this lye water into your 2 Liter erlenmeyer flask using a large automotive funnel. Add 170 grams of finely powdered bark, and use a long chopstick or similar to mix it all together.

Use (.53 x 170g bark = 90ml naptha pull for each of the 4 pulls). An erlenmeyer flask makes it easy to do pulls using a long glass pipette, as the top of flask is tapered, so all the naptha collects at the top for easy pull.

Use an electronic thermometer to check the temp of the Lye water bark mix, when the lye water cools down from 150 degree F to around 120 degree F, then it's time to add your 90ml of naptha, make sure your 2L flask is sitting on a mitten or similar...this makes it easy to swirl your flask to mix the contents, make sure you are using the proper rubber stopper number 9.5 to seal the top of your flask once you turn it upside down then right side up to mix the contents as well.

Do a combination of swirling and a couple of upside down then right side up turns of the 2L flask, then once right side up, let the rubber stopper out, and let the stopper just barely sit in the flask (not tight), so gasses can exit. After 1/2 hour, all the 90ml of naptha will migrate & collect at the top of the tapered erlenmeyer flask...use your long glass pipette to collect the naptha, that's it! very easy, no mess, and the tapered erlenmeyer flask and glass pipette with round rubber plunger at the end makes it easy to collect the naptha at the top without collecting any lye water by accident.

No need to do a sodium carbonate clean on it, it's plenty clean already.

More notes:

Erlenmeyer flask tapers towards the top, makes extractions easier using a glass pipette, as all the naptha collects in a narrow band tapered area near the top.

Yield from 170g finely powdered bark using a 2 Liter erlenmeyer flask with 9.5 number stopper:

1st pull far left, dish + coffee filter = 1668mg
2nd pull in middle, dish + coffee filter = 517mg
3rd pull to far right = 155mg
4rth pull close to nothing
3 pulls get majority of it all (95%)
total = 2340mg

1) For 170g bark, use 1.8 Liter 150 degree water, when water, lye and bark all dissolved, liquid will all come up exactly to the 2,000 ml line on the flask.
2) 170g bark x 1.5 = use 255 grams lye
3) use 3 x 90ml naptha pulls, each 90ml naptha addition will rise 1.5" or so above 2L line on flask for easy collection using a long glass pipette.
4) allow 30 minutes for each naptha pull to rise to top for collection, this will ensure it all rises. Do pulls one after another, around 1.5 hour beginning to end, then you are done with 3 pulls.

The pre-heated water with mixed lye keeps liquid/naptha warm...keep a 60 watt lamp bulb with reflector close or pointed to back of flask the entire time, so each of 3 pulls are around 125 degree F when measured with electronic thermometer.

It's very important to let your dishes with lids sit undisturbed for a long while, dishes sit in freezer for 12 hours during day (11am till 11pm), then overnight for 8 hours.

Pics for welcome guests (post #15): https://mycotopia.net/to...lly-active-under-tongue/
 
ava69
#20 Posted : 5/11/2021 10:08:37 PM

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L-dreamer said:
Quote:
Had another try today.
Ava was not kidding with the images of beautiful women. Today I had a vision of a naked blonde with the body of a literal Goddess opening my mind's eye like you would a zipper at the beggining. The perfection of the female form in full display with a glistening astral skin. And it wasn't any libido increase, just a sense of witnessing beauty. This effect is so peculiar to me, ava mentioned about certain adrenergic receptors that THH touches like mescaline does, but I could not find a source on how these receptors are actually involved in "Aesthetic perception"

L-dreamer you can find a book that explains receptorome psychedelic theory in James Kent book "Psychedelic information theory." Your visions of naked blonde Goddess beauty is very common in my own sublingual Ayahuasca visions as well, many times I've witnessed naked female forms, a spiritual beauty quality like artwork or music in all her divine perfection.

L-dreamer, I also had an experience last night that blew my mind, have not used dmt in 2 months, I found 30mg of sublingual HPBCD complexed harmine to be very powerful, yesterday, took 300mg very pure THH orally 45 minutes before, then 90mg HPBCD DMT on a spoon (90mg dmt complexed to x7 or 630mg plain HPBCD in 10 drops very hot water) mixed with only 30mg HPBCD complexed harmine freebase (30mg harmine complexed to x6 or 180mg HPBCD in 3 to 4 drops very hot water), held both under tongue at exact same time for 15 minutes, it all dissolved...

Instructions for how to complex the harmine and the dmt on post #1 under "Reference: Full instructions for sublingual or the one-shot HPBCD DMT Ayahuasca (your choice)"

...for 2 hours I had the most powerful experience, like 600mg of mescaline, CEV's of morphing and spinning colored geometrics, open eyed beauty so over the top, watched 4k movies, actresses looked like dazzling, glowing super-colorful cartoon versions of themselves the entire 2 hours. Neon color saturation so powerful it spilled over on to every corner of the house and walls, the entire walls then filled with neon colors that flashed and morphed into other colors, these neon colors then broke up into fine lines like laser beams and pasted themselves across the entire front wall, it was mesmerizing...intense open eyed beauty, no words to describe, music enhancement so powerful...

Best of all, super deep head space, very strong mescaline like spiritual euphoria or ecstasy, profound spiritual insights, an infinite source of love, creative energy & wisdom. I found no need to re-dose more of the sublingual dmt, such a powerful journey..intense afterglow all night and next day.

...I kept saying how is this possible with only 30mg sublingual harmine...but it has the power of at least x6 or 180mg oral harmine, zero nausea, zero dizziness, like high dose mescaline, extremely visual. The geometrics turned into full-fledged Ayahuasca visions when I closed my eyes for long periods of time, saw interlocking artwork made out of stone that solved ancient puzzles, like Puma Punku, breathtaking Egyptian myths laid out before my eyes, I saw thoth (Egyptian man with the head of an ibis) with multicolored beak, Egyptian women in overflowing beauty, elaborate architecture rapidly changing, so incredibly beautiful. So in other words, give only 30mg harmine a chance.

Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.

pic1: 300mg oral very pure THH + 30mg sublingual HPBCD complexed harmine + 90mg sublingual HPBCD complexed DMT

pic2: closeup 300mg oral very pure THH + 90mg sublingual HPBCD DMT to which was added 30mg sublingual HPBCD complexed harmine


Part 14: THH + mushrooms report from JKW


Quote:
Just wanted to let you know that I finally tried 3 grams of cubensis with 180 mg of THH, and all I can say is WOW! Intense and beautiful like I've never had before, with a definite DMT edge to it.

I've always been a hard-head, needing 4.5+ grams to get anywhere interesting. I've done up to 9 grams, and never got near this intensity.

Just wanted to thank you for the tip. This is the way for me to go form now on.
I look forward to combining THH with DMT.

All the best, and take care.


Part 15: Multiple encounters with death and depression


This is the story of how HPBCD DMT came about: the plants taught this to me. I did not discover it. I have taken Ayahuasca over 70 times and cactus tea x 200 times. Ayahuasca seems to want to propagate herself all over the globe by any means possible, and if that means using the latest pharmacology advancements such as HPBCD, then so be it. The planet is in crisis, and Ayahuasca wants to help reverse the insane rapid destruction.

Daniel Pinchbeck "How Soon is Now":
Quote:
The human race is careening toward extinction: rising acidity of the oceans threatens coral reefs, habitat destruction, non-native species (predatory fish, bullfrogs, fungus, pathogens), climate change (alters temperature and water levels), pollution and diseases (especially chytridiomycosis, caused from the chytrid fungus) all have been shown to contribute to worldwide amphibian declines.

We clear forest that are full of trees even though we continue to pump CO2 into the air even though we know it's heating up the ozone and melting ice caps; we clear forests that are full of trees that could potentially help clean that co2 out of the air, the Amazon rainforest is the lungs of the planet, but miles of it are slashed & burned every week so that cattle can graize there instead to make hamburgers, and massive soybean cultivation. We throw away plastic water bottles, and worst of all, we feed into the corporate systems that keep this destruction going.

I don't know about you, but I don't use soybeans for anything, don't eat hamburger or steaks, only fish, chicken & turkey daily, as a bodybuilder this keeps me lean daily.

On my 70th Ayahuasca journey using the very last of my stored away Hawaiian psychotria, she showed me a vision of my "lost 1kg container of HPBCD". I had put it away 12 years ago, as I bought it from a sports supplement supplier, once pro-hormones became illegal, I carelessly abandoned the container in a place I could care less about.

Ayahuasca has a long standing traditional reputation of helping people find lost personal items like rings, necklaces, etc. through visions. She once helped me find a set of important spoons that I had misplaced many years ago as well. She showed me they were buried in a drawer under forgotten clothes many years old. I once saw a vision of a beautiful woman in medieval times searching for a lost ring in her home, Ayahuasca showed me that it was at the very top of a cubbard in her kitchen.

All that time the HPBCD container was lost, she showed me that it was in my garage buried in a container along with plumbing parts. That night I dug it out of the container and put it in my closet for use the next day. She also showed me a vision of the mimosa tree or shrub, I put 2 and 2 together, and knew what she was telling me...to experiment with HPBCD complexed DMT, and so that is what I did. She already knew that I had experience making sublingual HPBCD pro-hormones, as I had learned it from chemist Patrick Arnold.

I had run out of Hawaiian psychotria, and it had been extinct for the past 3 years, perhaps diverted to all the numerous Ayahuasca centers in South America. I needed a high power alternative.

A little bit about me...

Becoming a shaman is often just as much of a curse as it is a blessing. Shamans are chosen by the Spirits at birth, but it is not until later in life (usually in their 20’s) that the shaman is struck down. The striking down of a shaman is to dismember them as a person and to have them reborn into something else.

The word Shaman means "to know". I am not a shaman, but have been thru alot of the near-death experiences Shaman's have gone thru, lost both our twin girls in womb, so have no children, my beloved pet Shitzu died at only age 4 from continuous bladder stones for 6 months, we did everything together...he was unable to pee so many times, we had to rush him to vet, where he was put down. He visited both of us in a dream 2 days later to tell us he was doing great in Heaven with a big smile on his face.

Have nearly died several times, once was hit head on by a truck when driver ran a yield sign, barely survived with numerous injuries. The hospital caught all my fractured ribs but did not diagnose my collapsed lung, so when I got home, drifted into shock in the middle of the night, wife called an ambulance and was rushed to a better hospital where they immediately diagnosed the lung condition and treated me for it.

Once took alot of acacia bark with Ayahuasca instead of the normal Hawaiian psychotria I use, and went into a serious serotonin syndrome shock, for an hour and a half I sweated my ass off sitting in the bathtub, I told my wife goodbye while my dog watched in a sad state...by some miracle pulled out of it, believe it was the high levels of maoi's in the acacia that interacted with the rima's in the Ayahuasca, bad combination. My forehead was pouring sweat for 1.5 hours, was in severe shock and trembling, and knew I was gonna die.

Lost everything in a 100 year severe flood, my home and all my belongings, had just gotten married to my beautiful wife and all the newlywed gifts perished...right after that we moved to an apartment complex, and 5 months later all our belongings again perished as they burnt to the ground after a disgruntled teen threw a lit blunt into the apartment complex after his girlfriend dumped him.

Had it not been for the policeman banging on the door of the apartment, we would have surely burned in the flames, as we were on the 3rd floor & asleep as I worked 2nd shift at the time. We ran down the steps in only our bare feet and suffered smoke inhalation.

Have been thru some near-death experiences similar to a Shaman, who lives on the outskirts of society. Music, lifting weights, walking in nature with my dogs, going to the waterpark with a season pass every summer, and reading the Holy Bible all keep my spirits up.

Some of you have contacted me via messenger to let me know that you would like to experience this for other reasons than the visions, to help with treating depression. I will tell you this, yes, Ayahuasca can help to cure not only anger issues, melancholy, drug abuse & addictions, but also depression. She is also able to grow brand new neurons in the brain every time a journey is taken, she has cured people of all sorts of afflictions and ailments, even severe depression. I feel an afterglow for a couple days after a journey, and this refreshed serotonin reset often lasts for a couple weeks.

Celebrities who have battled major depression: Dwayne Johnson "the Rock", Katy Perry, Jon Hamm, Lady Gaga, Michael Phelps, Kristen Bell, Bruce Springsteen, Gwyneth Paltrow, Ashley Judd, Naomi Judd, Ryan Phillippe, J.K. Rowling, Sheryl Crow, Terry Bradshaw, Buzz Aldrin, Tipper Gore, Wayne Brady, Jim Carrey, Robin Williams, Brittany Murphy.

Beyond Happiness And Unhappiness, An Interview With Spiritual Teacher Eckhart Tolle:
https://www.thesunmagazi...ppiness-and-unhappiness
hxxps://www.thesunmagazine.org/issues/319/beyond-happiness-and-unhappiness

Oprah Talks to Eckhart Tolle:
https://www.oprah.com/sp...-talks-to-eckhart-tolle
hxxps://www.oprah.com/spirit/oprah-talks-to-eckhart-tolle

Eckhart Tolle is one of my favorite writers. He is the author of "The Power of Now, a guide to Spiritual Enlightenment" & "A new Earth, Awakening to your Life's purpose".

Banisteriopsis caapi alkaloids, plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro:
https://www.nature.com/a...cles/s41598-017-05407-9
hxxps://www.nature.com/articles/s41598-017-05407-9

A Happier You, by Eckhart Tolle:
Quote:
The greatest goal you can set this year is to make peace with your life, no matter your circumstances. These 10 powerful insights from Eckhart Tolle will get you started.

Oneness with All Life by Eckhart Tolle

Don't seek happiness. If you seek it, you won't find it, because seeking is the antithesis of happiness. Happiness is ever elusive, but freedom from unhappiness is attainable now, by facing what is rather than making up stories about it.

The primary cause of unhappiness is never the situation but your thoughts about it. Be aware of the thoughts you are thinking. Separate them from the situation, which is always neutral, which always is as it is. There is the situation or the fact, and here are my thoughts about it. Instead of making up stories, stay with the facts. For example, "I am ruined" is a story. It limits you and prevents you from taking effective action. "I have 50 cents left in my bank account" is a fact. Facing facts is always empowering.

See if you can catch the voice in your head, perhaps in the very moment it complains about something, and recognize it for what it is: the voice of the ego, no more than a thought. Whenever you notice that voice, you will also realize that you are not the voice, but the one who is aware of it. In fact, you are the awareness that is aware of the voice. In the background, there is the awareness. In the foreground, there is the voice, the thinker. In this way you are becoming free of the ego, free of the unobserved mind.

Wherever you look, there is plenty of circumstantial evidence for the reality of time—a rotting apple, your face in the bathroom mirror compared with your face in a photo taken 30 years ago—yet you never find any direct evidence, you never experience time itself. You only ever experience the present moment.

Why do anxiety, stress, or negativity arise? Because you turned away from the present moment. And why did you do that? You thought something else was more important. One small error, one misperception, creates a world of suffering.

People believe themselves to be dependent on what happens for their happiness. They don't realize that what happens is the most unstable thing in the universe. It changes constantly. They look upon the present moment as either marred by something that has happened and shouldn't have or as deficient because of something that has not happened but should have. And so they miss the deeper perfection that is inherent in life itself, a perfection that lies beyond what is happening or not happening. Accept the present moment and find the perfection that is untouched by time.

The more shared past there is in a relationship, the more present you need to be; otherwise, you will be forced to relive the past again and again.

Equating the physical body with "I," the body that is destined to grow old, wither, and die, always leads to suffering. To refrain from identifying with the body doesn't mean that you no longer care for it. If it is strong, beautiful, or vigorous, you can appreciate those attributes—while they last. You can also improve the body's condition through nutrition and exercise. If you don't equate the body with who you are, when beauty fades, vigor diminishes, or the body becomes incapacitated, this will not affect your sense of worth or identity in any way. In fact, as the body begins to weaken, the light of consciousness can shine more easily.

You do not become good by trying to be good, but by finding the goodness that is already within you and allowing that goodness to emerge.

If peace is really what you want, then you will choose peace.

Excerpted from Oneness with All Life by Eckhart Tolle.


What we are beginning to discover is this: The HPBCD "encapsulated and trapped DMT" seems be forming enhanced modes of transport and delivery of DMT similar to how oral psychotria leaf gives an experience that is much more powerful and all encompassing and colorful than using normal plain DMT crystals.

The experiences from the Hawaiian psychotria brew Ayahuasca tea are always +5 on the Shulgin scale for myself in over 70 Ayahuasca sessions, while multiple experiments with several people in the Clearlight sessions found the DMT extracted crystals gave only mild experiences (+3 max) even when using doses up to 100mg. They also found the leaf brews to be +5 Shulgin level in strength & all encompassing.

Even used doses of oral dmt crystals at doses from 70 to 120mg a dozen times years ago, and found them all mild as well (+3 Shulgin scale) compared to the VERY strong Hawaiian psychotria experiences (30 to 35 gram tea), just like mind-blowing Jungle Ayahuasca.

Clearlight:
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Experiments that involved several people found the leaf brew form superior to extracted actives, the leaf brews were very strong and powerful & clairavoyant (+5 Shulgin scale), while the extracted actives were mild (+3 Shulgin scale) at best, even up to 100mg. Again, this is poorly understood.

However, the HPBCD complexed DMT seems to greatly alter the transport, absorption & digestion of DMT freebase crystals, resulting in powerful experiences sublingually so far, even resulting in oral powerful Ayahuasca similar to those brews using actual Hawaiian psychotria leaf in them.

downwardsfromzero wrote:
Quote:
This combined with the HPBCD complexation results (which we really ought to replicate and confirm) makes me wonder whether there are saccharides in leaf brews which perform a similar effect to HPBCD. There is still so much scope for really interesting research here -thanks for posting.

This is indeed fascinating downwardsfromzero, thanks for that keen observation on the sacchardies, perhaps they do function similar to HPBCD? Note: this procedure will work with any freebase molecule that is poorly water soluble, it does not work with already water soluble compounds or salts.

Jagube said:
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I've seen anecdotal reports of quidded D. cabrerana leaf being active.
Excellent observation Jagube.

69ron posted 8/12/2009:
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People are getting pleasant DMT effects from sublingual Virola calophylla resin. I don't think it has that much DMT in it. So why does the resin work so well when DMT is so hard to use sublingually?

HPBCD DMT is very strong...have used 60mg of it sublingually under tongue for 15 minutes along with 35mg sublingual freebase harmine at exact same time and experienced rapid heartbeat & pulse, tryptamine body rush & buzz, dilated pupils, music sounded incredible, had cev's and open eyed euphoria and profound beauty. 5 hours of Ayahuasca visions. I took 300mg of tetrahydroharmine 1 hour earlier so it was more like a true Ayahuasca experience, but no nausea, and re-dosed more 60mg HPBCD DMT every 1.5 hour x twice re-dose for a 4.5 hour total long experience with super-long afterglow well beyond this.


Part 15 continued: 80mg DMT complexed to 560mg HPBCD oral Ayahuasca report


The experiment was a success...I took the 80mg freebase DMT complexed to (x7) or 560mg of HPBCD (use x8 or 640mg if using the more common 2-HPBCD to keep at a 1:1 molar ratio) all kneaded/crushed using end of another spoon, use your muscles, scrape & crush it back and forth well...all mixed on a spoon for 2 minutes with 0.500 milliliter (10 drops) of VERY HOT near boiling water from a nearby coffee mug.

1300 g/mol HPBCD to 188 g/mol DMT freebase = 1:1 molar ratio
1500 g/mol 2-HPBCD to 188 g/mol DMT freebase = 1:1 molar ratio

Both work exactly the same.

What I do is heat up a bit of water in a coffee cup in microwave & draw up drops of it using pipette. I read using hot water speeds & aids the mixing of the HPBCD to host drug. Then heat bottom of spoon up for around 20 seconds with a bic lighter, just until the edges of the liquid on the spoon begin to bubble, then pull flame away, mix solution a few more seconds, this ensures complete dissolution.

I added the 0.5ml spoon full HPBCD DMT solution to 1oz of 120 degree hot water...this then immediately turned into 100% transparent water when it hit the hot liquid in the pyrex cup...This was stored in fridge until use...then when I was ready, the 1oz clear transparent liquid HPBCD DMT water solution, once re-heated up in pyrex pot on stove, to this was then added 200mg harmine + 250mg THH and also 150mg of pure ascorbic acid (vit C) to help dissolve the freebase harmine + thh.

Or you can just take pre-made capsules of your harmalas at the exact same time you drink the 1oz HPBCD DMT hot water tea to avoid the taste of the harmine and THH.

I gulped it down in one shot...there was virtually no taste! I think the HPBCD completely masked the taste of the nasty DMT...I was shocked...took it all together at same time at 3:30, I'm writing this 3 hours later.

It came on exactly like 30 grams of hawaiian psychotria! there was no difference between this and the leaf brew, again I was shocked...it gripped me powerfully, heavy tryptamine buzz and high frequency. The THH already imparts a body frequency buzz + DMT tryptamine buzz = amazing amplified body frequency.

A vibrating neon colored fortress like a magnetic field surrounded me in the room, it shined off of every object similar to a UV blacklight glow...this neon visual vibration appeared all around me, given off by everything around me. The vibrational frequency field reminded me of the tractor beam in Star Trek when they would transport. I've experienced this same phenomena with past journeys involving 30 to 35 grams of potent Hawaiian psychotria...but never with plain freebase DMT or DMT salts before, only again with this HPBCD DMT.

I had to remain in one spot sitting as it was so strong for 1 hour straight, the walls in the room filled with 3-D ish like honeycomb orange & brown geometrics that appeared to bulge slightly off the surface, like the inside of a bee hive, neon colors were abundant, heavy tracers...the beauty all around me was infinite, beautiful CEV's (spinning and dancing or constantly morphing geometrics) and OEV...I was amazed to say the least.

In conclusion, I am impressed with this route of administration via sublingual or oral.
During the oral Ayahuasca journey (200mg harmine + 250mg THH + 80mg DMT complexed to 560mg HPBCD) for the first hour, all objects glowed or shined as if in caught in a neon colored magnetic transporter beam.
ava69 attached the following image(s):
zzz 300mg oral very pure THH plus 25mg sublingual harmine plus 90mg sublingual HPBCD DMT.JPG (126kb) downloaded 545 time(s).
zzz closeup 300mg oral very pure THH plus 90mg sublingual HPBCD DMT to which was added 25mg sublingual harmine (2).JPG (225kb) downloaded 541 time(s).
 
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