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New research shows a link between Salvinorin A and the DMN Options
 
Jagube
#1 Posted : 12/22/2020 11:08:31 AM

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Quote:
The Default Mode Network (DMN) is by now a familiar name in popular psychedelic circles. It’s a collection of brain areas that talk loudly to each other when we’re not doing any focussed tasks – basically when we’re daydreaming, thinking about ourselves, or conceptualising the past or future.

We know two important things about the DMN: it’s overactive in depression, and psychedelics can help to reset it. Studies have shown that classic psychedelics LSD and psilocybin can dramatically reduce the chatter of the DMN during a psychedelic experience, and allow it to re-form itself into a more stable network afterwards – correlating with decreased depressive symptoms. [..]

Now, new research has shown that Salvinorin A is also connected to the DMN. Twelve experienced psychonauts were given doses of Salvinorin A while in an MRI machine, which showed that the unique psychedelic reduced the connectivity of the DMN in a very similar way to LSD and psilocybin.


https://thepsychedelicsc...alvinorin-a-and-the-dmn/

Original paper: https://www.nature.com/articles/s41598-020-73216-8
 

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Cognitive Heart
#2 Posted : 12/22/2020 1:02:58 PM

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Incredible scientific report! Thank you for sharing. Love Thumbs up

I hope researchers can reduce their limitations in light of these findings. For anyone new to the default mode network or dynamical functions, start here: https://en.wikipedia.org/wiki/Dynamic_functional_connectivity
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Loveall
#3 Posted : 1/27/2021 12:58:28 PM

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Thanks Jagube.

One of the participants wrote a general audience press article on their experience:

https://www.vice.com/en/...esearch-salvinorin-a-mri
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Spiralout
#4 Posted : 1/27/2021 2:33:37 PM

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This doesn't surprise me. I imagine it's more a function of a novel shift in perception more than it is the chemical or activity that acts as a catalyst.
 
changaforchange
#5 Posted : 1/27/2021 3:10:08 PM

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thanks for this... I am actually taking Andrew Gallimore's Psychedelics and the Brain Master Course as we speak and it is touching the DMN towards the end.

quite interesting and useful stuff.
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