Sinomenine from Sinomenium Acutum Options
#1 Posted : 8/1/2020 6:02:10 AM

DMT-Nexus member

Posts: 558
Joined: 24-Jan-2009
Last visit: 20-Sep-2020
Location: beside you in time
I have read studies about it being a novel analgesic and evidence for it being an NMDA antagonist. Compare the molecule with dextromethopran. Could this possibly be a better analog of DXM for reaching those states?

A listing online for this states:
..3g+ sample of Sinomenium Acutum containing 99% pure Sinomenine. This is frequently used in TCM for it's purported pain relieving effects. I will add additional details in the near future. Feel free to reach out to me with any questions!

Here are two forum threads about it with no conclusions made:

Moderator wrote:
Minor edit in quoted description. Sales lingo, etc.
PsilocybeChild attached the following image(s):
Wire 2020-07-31 at 1_16 AM.png (667kb) downloaded 54 time(s).

Have doubts about your samples? Get trusted results by having your samples tested.
#2 Posted : 8/2/2020 6:25:32 AM

DMT-Nexus member

Posts: 558
Joined: 24-Jan-2009
Last visit: 20-Sep-2020
Location: beside you in time
Dextromethorphan (DXM) molecule for comparison
PsilocybeChild attached the following image(s):
Screenshot from 2020-08-02 01-24-43.png (12kb) downloaded 36 time(s).
#3 Posted : 8/3/2020 5:59:14 PM

No way ticket

Chemical expertSenior Member

Posts: 5031
Joined: 30-Aug-2008
Last visit: 26-Sep-2020
Location: square root of minus one
The geometry of sinomenine vs. that of DXM is rather different. Dashed bonds are below the plane of the picture. Wedge bonds project out of the plane. I've attached a side-by-side comparison of the two molecules and a 3-d rendering of each. Crucially, the nitrogen atom is positioned very differently in each respective case. I would predict that sinomenine displays neither an antitussive nor a dissociative effect, at least not at sensible doses.
downwardsfromzero attached the following image(s):
DXM vs Sinomenine.jpg (7kb) downloaded 20 time(s).
DXM vs Sinomenine flipped.jpg (7kb) downloaded 20 time(s).
DXM3dVDW.jpg (7kb) downloaded 20 time(s).
Sinomenine3dVDW.jpg (8kb) downloaded 20 time(s).
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
Users browsing this forum

DMT-Nexus theme created by The Traveler
This page was generated in 0.012 seconds.