Injury-Triggered Blueing Reactions of Psilocybe “Magic” Mushrooms Options
#1 Posted : 12/1/2019 9:18:04 PM


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Article attached.

It seems like they identified an enzyme (PsiL) that oxidizes the -OH group, and after that dimers form, followed by dimers and larger groups.

Interested in any opinions. I believe some of these dimers had been proposed before (I remember endlessness mentioning them in chat). I think this is the first time they are verified (?). Cheers.
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#2 Posted : 12/1/2019 10:35:16 PM

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Great that they've confirmed the structure I suggested - not necessarily to the scientists involved - 12 years ago Big grin (I have evidence!) and the enzymology ices the cake nicely.

dimers form, followed by dimers and larger groups.
*trimers, tetramers. With the higher oligomers they've taken the idea further than my suggestion. It's not unexpected to see that the additional cross-linking takes place in the positions they found.

All-in-all, a good piece of work that answers a long-standing question.

The attached structures were drawn in 2007. (It's the 5,5-dimer that forms first and cross-linking occurs in the 2 and 7 positions, using the conventional tryptamine numbering scheme. The numbering scheme used in the paper is different as it was more convenient for their C-13 NMR study of the dimerisation kinetics.)
downwardsfromzero attached the following image(s):
2dimer.jpg (10kb) downloaded 30 time(s).
5dimer.jpg (10kb) downloaded 29 time(s).
7dimer.jpg (10kb) downloaded 29 time(s).
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