Most Syrian rue seeds contain harmine as their main alkaloid, followed closely by harmaline. But this is not always the case. Some Syrian rue seeds actually contain harmalol as their main active alkaloid. Very few places sell harmalol and those that do either charge a fortune for it, or only sell large quantities.

SWIM once had some pure harmalol long ago. He tried it stand alone, and found it sort of resembled psilocybin, but without the visual effects. It was pretty short acting. SWIM did not test it much. It was very pricey. He only had a few doses of it to play with.

Has anyone else had any experience with pure harmalol? Is this alkaloid of any practical use as an MAOI, or potentiator of other psychoactive alkaloids?

I for one am VERY interested in these lesser know compounds!

I'm really curious about all the trace compounds in Diplopterys and Virola species, as well as the beta-carbolines from Caapi and Syrian Rue and stuff.

Good work 69ron!

Has no one else tried harmalol?

It's seems like this subject is really uninteresting to others. There are such few posts in this thread after it being here for several days. No wonder few vendors sell it.

I personally would like to see more work on harmalol. In SWIM’s limited experience, it was very pleasant and very short acting. If it could be used as an MAOI, it might be able to produce a short 1 hour ayahuasca experience. SWIM would like that very much.

The problem is that SWIM cannot afford to buy harmalol these days. He can barely make it to the end of the month with all the bills he has to pay.

I’ve seen a few extraction techs that extract harmalol. But they are not easy. Just extracting peganum harmala is a pain in the ass because of all the mucilage present which clogs filters like crazy. SWIM would rather buy it, but doesn’t see any affordable source for it.

Harmalol is a phenolic alkaloid like bufotenine and psilocin. It’s very water soluble and doesn’t come out when you salt the harmala alkaloids from rue. It stays dissolved. You have to do an A/B to get it, but then you also get the nasty alkaloids of rue. Separating them from the harmalol is a challenge.

EDIT: I've attached images of harmalol, harmine, harmaline, and finally THH, in that order.

Dagger, if you ever get hold of any please post about it. I would love to see someone else's take on harmalol's effects.

Just order some from a different chem. company. Its unscheduled, and there are plenty of suppliers in china who'll indescrepantly take your credit card and not give two hoots about whether you are a company or not.
As a side note, I just asked a few friends and it seems that this series can all be got at with NaBH4 reduction, in methanol. So you could start with harmine and make your own harmaline, thh, or harmalol.
Watching closely, 69Ron Thanks for the tip-off. What is it about haramlol that you desire? How are the effects different from harmala, harmine, tetrahydroharmine? (i.e whats the trend across the series)

russian olive(Eleagnus angustifolia) is an excellent source for the -ol beta-carbolines containing Harmol,Harmalol and Tetrahydroharmalol in the inner bark. I am interested in the tetrahydroharmalol to see if it is similar to THH-ine.
I will be recieving an amount of spring bark around march and will be working on an extraction algorithym beginning with attempting a F/B precip as with rue or caapi.
SB

sorry, i should have been clearer. that was advice not a status-update. Otherwise I would have said *I just ordered*...

There were loads when I googled

SWIM bucked up and just ordered some.

*prints receipts, prepares to watch online banking closely, crosses fingers*

will update the day he gets it.

edit: hmmm, via further research SWIM found that though it isn't in the US, harmalol is schedule III in Canada.... hope it is for amounts >1g....

It’s hard to say. SWIM experienced it only a few times. It wasn’t enough to really get a good feel of it. Its feel was similar in ways to psilocybin but not psychedelic. It seemed to peak really fast, after about 30 minutes, or something like that. It was short acting, maybe 1-2 hours, and felt nothing like the other harmala alkaloids.

SWIM’s memory of the experiment is vague. He didn’t take good notes on it. He’d like to try it again and take better notes, but it’s way too pricey.

for anyone whos interested in harmalol, or sperate harmala alkaloids I suggest build a cromatography
setup and run your harmala extract through that, and isolate harmalol.

This may have been mentioned already, I haven't had time to read this whole thread, but isn't Harmaline the main alkaloid in S.Rue?

It is B.Caapi that has Harmine as it's main alkaloid, followed by THH & then a small amount of Harmaline.

Correct?


WS

Hey Warren,

Syrian rue has both harmine and harmaline in good amounts. Harmine is usually more, SWIM has seen rue with 2/3 harmine and 1/3 harmaline, his latest extraction however gave 90% harmine and just 10% harmaline.

So judging just by the ratios in rue, harmine appears to be the main one!

What column would you suggest? Which adsorbent do you recommend and which elution buffers do you suggest for the separation of the harmala alkaloids?

border patrol destroyed it. They considered it "an amphetamine" what ignorant ignoramuses

To prevent oxidation, store the material air-tight, without any light, and as cold as possible. Put it in a concealer free of any air, and store it in the freezer.

i could be wrong but i think i remember reading that tobacco contains decent amounts of harmalol and norharman(?)

Very cool! Are you planning to try it anytime soon?

Fuming hydrochloric acid (35+ %) at 140C does not sound easy, this suggests high pressure. Don't boil concentrated HCl without precautions like a fumehood.. from the top of my head: at 1 atm HCl 35% boils at 120C.

The 'ols are very under-investigated indeed Ron! I'm verrry interested in the effect of harmalol on smoked/oral DMT.

SWims been asking this question for a long time... this is very worthy of investigation. Harmalol is in a lot of plants as swim recalls... and its true the invasive species russian olive has much in it... Russian olive could be a new and really goo d source for this if its effective and helpful in the great work. There needs to be more effective plants out there that are good at providing the beta carbs... IMHO...