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A single inhalation of 5-MeO-DMT in naturalistic setting is linked to psychological benefits (Study) Options
 
Bancopuma
#1 Posted : 4/16/2019 6:06:18 PM

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A fresh of the press paper on 5-MeO-DMT I thought may be of interest to some.

Study:

Uthaug, M.V., Lancelotta, R., van Oorsouw, K., Kuypers, K.P.C., Mason, N., Rak, J., Sulakova, A., Jurok, R., Maryska, M., Kuchar, M., Palanicek, T., Riba, J. & Ramaekers, J.G. (2019) A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms. Psychopharmacology, 1-14.

Full open access paper can be read and downloaded from here:

https://link.springer.co...onKeyC0uO-cInhZgCn-K1Mb0

Quote:
Abstract

BACKGROUND: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.

AIMS: The first objective of this study was to assess sub-acute and long-term effects of inhaling vapor from dried toad secretion containing 5-MeO-DMT on affect and cognition. The second objective was to assess whether any changes were associated with the psychedelic experience.

METHODS: Assessments at baseline, within 24 h and 4 weeks following intake, were made in 42 individuals who inhaled vapor from dried toad secretion at several European locations.

RESULTS: Relative to baseline, ratings of satisfaction with life and convergent thinking significantly increased right after intake and were maintained at follow-up 4 weeks later. Ratings of mindfulness also increased over time and reached statistical significance at 4 weeks. Ratings of depression, anxiety, and stress decreased after the session, and reached significance at 4 weeks. Participants that experienced high levels of ego dissolution or oceanic boundlessness during the session displayed higher ratings of satisfaction with life and lower ratings of depression and stress.

CONCLUSION: A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.
 

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Hotspur922
#2 Posted : 4/17/2019 2:24:50 PM

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good stuff, have yet to smoke the toad ooz but I'm sure one day I will lol
 
Praxis.
#3 Posted : 4/18/2019 2:46:26 AM

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I think this is an interesting idea for research but this study definitely lacked necessary control groups and doesn't come off as very objective to me.

For example, the researchers concluded that 5-MeO is associated with sustained benefits after a 4 week period, yet out of 75 total participants only 24 actually completed the assessment they're using as evidence for their findings. And again, out of 75 participants only 15 reported having no previous experience with 5-MeO, and the large majority of participants had previous experience with psychedelics in general.

Quote:
Overall, 75 participants agreed to participate in the study at baseline. Of those, 42 participants completed the test battery both before inhalation of the vapor from dried toad secretion containing 5-MeO-DMT (baseline) and within 24 h, while only 24 completed the test battery at the third and final assessment 4 weeks after intake. In total, 15 participants reported having had no previous experience with 5-MeO-DMT (whether this was a toad, synthetic, or plant was unspecified), while the majority (92.9%) had experience with other psychedelics (e.g., LSD, psilocybin, etc.).



Table 1 lists the reasons participants chose to participate, and in my opinion quite a few of the responses indicate bias towards reporting a positive experience. Some examples:

Quote:
To heal my soul.

Quote:
To connect with all that is, transcendence, downloading universal knowledge and understanding of self.

Quote:
Whatever the medicine wants to show me in this moment.



There's also a number of red flags surrounding the competency of the facilitators/researchers and potential conflict of interest.

Quote:
The facilitator was often assisted by another person, either with a background in coaching (i.e., a person trained in supporting clients in achieving a specific goal through providing training and guidance), or a person with no (clinical) background in psychology or in psychedelic-assisted therapy at all. These individuals (with or without background) had previous experience with 5-MeO-DMT (if this was a toad, synthetic form, or plant was not specified), and got involved at the sessions out of personal interest.


Quote:
It is worth noting that none of the session facilitators weighed the dose of dried toad secretion that they administered in the glass pipe, but instead, they relied on visual inspection when preparing the individual dosages. We therefore do not know the actual doses of dried toad secretion that were given during sessions to each participant. Some facilitators reported having administered around 20โ€“30 mg of dried toad secretion, while others reported to administer up to 100โ€“120 mg.


That last one was the final nail in the coffin for me. Sorry I hate to be that guy, but we have more eyes on us now than ever and I think it's important to present our arguments as objectively and legitimately as possible.
"Consciousness grows in spirals." --George L. Jackson

If you can just get your mind together, then come across to me. We'll hold hands and then we'll watch the sunrise from the bottom of the sea...
But first, are you experienced?
 
rOm
#4 Posted : 4/18/2019 7:12:25 AM

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Yeh this study worth what its worth, but for me too. one single Looooong inhalation in natural setting give me long lasting benefits, like physical energy and uplifted mood. I think, not sure, but think it fight off some antibiotic resistant bacteria too.. cause I did first big dose 100mg dried toad secretion and had a staph who was keep coming back to eat me alive. And I set as intentions to definitely get rid of this dangerous infection.
It never returned after the Toad.
In the secretions of amphibians, we know there are peptides that acts as powerful antibiotics.
Like in Kambo too.

Anyway, I haven't felt as good after one single inhalation of pure 5 MeO DMT.. maybve the added substance to the secretion are more responsible for that ?
LIke pislocybin synthetic VS psilocybe mushrooms. the major substance is often why you are drawn to experience it.. but the more subtle molecule have their medicianl benefits I believe.
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
RhythmSpring
#5 Posted : 4/18/2019 3:45:57 PM

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How bout a "well, duh!"?
From the unspoken
Grows the once broken
 
Bancopuma
#6 Posted : 4/19/2019 2:06:57 PM

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Hey Praxis,

Great analysis of the study's flaws. I admit I hadn't read it in depth when I shared it here and you of course make some very valid points regarding methodological issues. I've asked one of the study's authors to comment these. You raise some valid points, I don't think this study is trying to be a rigorous double blind placebo type affair, but an observational one (which all 5-MeO studies have been so far) in a naturalistic setting. But the issues you raise are valid.

I guess Bufo extract is more accessible than pure synthetic 5-MeO-DMT, but on ecological and ethical grounds, I worry that some people will read this and go after the toads (which have their problems as it is due to overharvesting) rather than seek out the pure synthetic molecule.

I suspect though, that despite the methodological flaws, that the beneficial effects observed are linked to the 5-MeO-DMT...the increases in life satisfaction, mindfulness and lower depression and anxiety rates post experience (and the strength of positive effects correlating with degree of ego dissolution experience) is in strong resonance with much more rigorous research conducted with psilocybin.

It is interesting to note that at the culmination of Strassman's pioneering DMT research, he noted little evidence of long-term therapeutic gains or benefits (this could have been partly study setting dependent however). One of the reasons for the differences in the perceived long-term effects between N,N-DMT and 5-MeO-DMT I think is tied to 5-MeO's much greater consistency and power when it comes to imparting experiences of ego dissolution than DMT...the strength of ego-dissolution has been correlated with degree of positive long term benefits and therapeutic gains post psychedelic experience in numerous studies.

Quote:
How bout a "well, duh!"?


Well this might be obvious to us, but that's preaching to the choir. Generating scientific evidence is an important means of getting information out there to the non converted.
 
Praxis.
#7 Posted : 4/20/2019 12:29:54 AM

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Bancopuma wrote:
I suspect though, that despite the methodological flaws, that the beneficial effects observed are linked to the 5-MeO-DMT...the increases in life satisfaction, mindfulness and lower depression and anxiety rates post experience (and the strength of positive effects correlating with degree of ego dissolution experience) is in strong resonance with much more rigorous research conducted with psilocybin.

For sure! I don't doubt for a minute the benefits they observed in the participants who completed the questionnaire are legitimate. I don't personally have experience with 5-MeO myself but if the general effects of other psychedelics are anything to go off I'm sure even a single puff can do a whole lot of good for someone.

I don't mean to be a stickler and I can appreciate the work that went into this, but I can also imagine a skeptic reading a paper like this and dismissing it entirely because of the methodology. A lot of folks already don't take psychedelic research seriously, so the impetus is on us to make sure our arguments are air-tight.


Quote:
It is interesting to note that at the culmination of Strassman's pioneering DMT research, he noted little evidence of long-term therapeutic gains or benefits (this could have been partly study setting dependent however). One of the reasons for the differences in the perceived long-term effects between N,N-DMT and 5-MeO-DMT I think is tied to 5-MeO's much greater consistency and power when it comes to imparting experiences of ego dissolution than DMT...the strength of ego-dissolution has been correlated with degree of positive long term benefits and therapeutic gains post psychedelic experience in numerous studies.

This is interesting, and part of the reason I'd like to try 5-MeO. I have had incredible experiences with N,N-DMT but it's not always consistent in its effects, and I feel like it hasn't had the same kind of deep long-term impact on my life as other psychedelics.
"Consciousness grows in spirals." --George L. Jackson

If you can just get your mind together, then come across to me. We'll hold hands and then we'll watch the sunrise from the bottom of the sea...
But first, are you experienced?
 
rOm
#8 Posted : 4/20/2019 8:44:42 AM

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not sure about each impact of each things, but yeh wild taods are stressed by pollution, by road trafiick which kills ten of thousand every year, and to either worng harvesting practice or over harvesting ( some toad are collected and milked somewhere else and then free very far away where they don't know and might possibly never have the time to feel a safe space before being killedf again from road traffick or polluted rivers... killer number one of toads are still pollution and road and this even if noone was milking any toad.
but yeh, people should go after synthetic 5 meo dmt before. also we got to find a tek to extract some from some source.
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
 
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