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The Mescaline Extraction Thread Options
 
Kash
#181 Posted : 5/9/2013 1:00:43 AM

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If precipitating hcl crystals out of solution you require very fine filter paper most likely, as they pass right through Whatman grade #1 filter papers. #1 filter paper and coffee filters are fine for filtering scraped up hcl crystals from an evaporated salting, though SWIM usually just decants away the liquid. Hope this helps.
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joshisom
#182 Posted : 6/2/2013 3:13:32 AM
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so to clarify STB with cactus seems to provide good results?
 
Spiralout
#183 Posted : 9/24/2015 11:57:26 AM

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Ello all,

I'm trying to decide which way to go about extracting cacti. I don't have access to toulene but I can get MEK and xylene. For acids I can get vinegar, citric acid and I'm guessing HCL but I believe the fumes from HCL are harmful? Was thinking of adding cacti to water with a splash of vinegar and doing a few pulls like that (essectially like making tea) and then reducing and filtering, then basing with sodium hydroxide (don't think mescaline is sensitive to high PH) and then pulling a few times and either salting with vinegar (but it looks like acetic mescaline is hard to handle) or citric acid ( don't knowmuch about that).

This will also be to test a cacti's relative potency as I don't plan on seperating the mescaline fromother alkaloids.

Any and all comments or advice much appreciated; thanks. <3
 
DansMaTete
#184 Posted : 9/24/2015 6:10:27 PM

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It seems you're going in the right direction.

Few things :
A good tek is Kash's A/B Mescaline Extraction

First step, Freeze&thaw the fresh cactus or the hydrated powder (or chips). I prefer chips (dry or fresh cacus cut in small bits) as it's easier to filter compared to powder (or fresh crushed) and it seems there's not mescaline left after extraction.

Second step, A pressure cooker is very efficient to water extract (3x30min). It saves lots of time compared to boil in a pan. Warning, first boil, be sure to boil with no cover until it doesn't foam anymore otherwise it could clog the pressure release valve (or repaint your kitchen)

I prefer to filter before reducing and you can decant after reducing but the mud leftover still contain mescaline so i extract from this mud.

Xylene (as good as toluen) is to pull freebase from the alkaline soup and you can use MEK to clean x-tals in a final step if you want to separate them from other alkaloids.

I salt with HCl and there is no problem with fume as you need only a really small quantity. Plus, if there is too much HCl after salting, it will evap leaving non contaminated mescaline at the end.

Have fun with extraction !
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1ce
#185 Posted : 9/24/2015 7:03:30 PM

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Kash wrote:
If precipitating hcl crystals out of solution you require very fine filter paper most likely, as they pass right through Whatman grade #1 filter papers. #1 filter paper and coffee filters are fine for filtering scraped up hcl crystals from an evaporated salting, though SWIM usually just decants away the liquid. Hope this helps.


I've found a few things while working with tryptamine that work equally well with mescaline HCL. It's first a good idea to dehydrate the solvent completely. Then once gas is passed through the solvent, distilling off the solvent to leave the salt and recrystallizing from alcohol works great. Or if distilling off the solvent becomes an issue, add water (if solvent is immiscible) and evaporate the water layer.

 
blue.magic
#186 Posted : 6/25/2017 3:17:44 PM

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What do you think about these ideas on "dry" extraction:

- use dry cactus powder when possible, having just two phases (liquid, solid) to avoid emulsions completely
- use acids and bases that evaporate (HCl, ammonium hydroxide), so none is left in the plant material
- liquid separation is avoided, filtering is performed instead


The extraction would go like this:

01 ) blend the fresh cacti with a bit of acid to ensure alkaloids are in their salt form
02 ) dry (or better: freeze-dry) the cacti to remove all the water and possibly the acid as well
03 ) grind the dried cactus into fine powder
04 ) de-fat the cactus powder with NPS, stir, decant, filter, completely evaporate the solvent from the powder
05 ) basify the cactus powder using ammonia solution, stir, decant, filter, completely evaporate the ammonia solution
06 ) pull with NPS, stir, decant, filter (keep the solvent this time)
07 ) clean NPS with AC, filter with Celite - this may remove tiny particles then went through filter as well as discoloration
08 ) determine alkaloid content by titration (?) or guess based on dry weight and cactus species
09 ) salt out alklaloids with aqueous HCl solution (DI water used) - same as in Kash's Tek
10 ) evaporate the water, scrape crude alkaloid mix
11 ) cold MEK wash - same as in Kash's Tek
12 ) purify with cold acetone wash OR run a chromatographic column
13 ) salt out purified mescaline OR evaporate the solvent (preferrably in a rotary evaporator)


Ideas are taken from this document on general alkaloid extraction.
 
downwardsfromzero
#187 Posted : 10/24/2017 3:14:20 PM

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Some thoughts - I missed this when it first appeared.
Quote:
05 ) basify the cactus powder using ammonia solution, stir, decant, filter, completely evaporate the ammonia solution
Mescaline freebase readily forms a carbonate in contact with the atmosphere. Does M carbonate decompose when treated with NPS?

Quote:
06 ) pull with NPS, stir, decant, filter (keep the solvent this time)
Which part do you propose to extract with the NPS? The strained cactus solids or the residue from the evaporated ammonia solution?


Quote:
12 ) purify with cold acetone wash OR run a chromatographic column
The Nexus would certainly benefit from a bit more practical focus on preparative chromatography. Dry flash springs to mind - pretty simple and forgiving, and performed in a fritted filter funnel rather than an actual column.
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Cactus Man
#188 Posted : 5/19/2018 1:27:52 AM
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Does anyone here feel like there is a limit to how many pulls you can reuse the same xye for?

Didnt feel like this question was important enough for its own thread.
 
TGO
#189 Posted : 5/19/2018 1:47:36 AM

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Cactus Man wrote:
Does anyone here feel like there is a limit to how many pulls you can reuse the same xye for?

Didnt feel like this question was important enough for its own thread.


On reusing non polar solvents

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DansMaTete
#190 Posted : 5/19/2018 1:47:40 AM

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If there is a limit i didn't find it. And i used the same xylen, again and again and again ...









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Elrik
#191 Posted : 5/19/2018 6:31:43 AM

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Same here.
My bottle of cactus xylene has done 20 pulls, give or take a few, and its not gummed up, cloudy, or giving less pure mescaline.
It might help that I defat my teas with paraffin before basing. Paraffin picks up enough stuff that it only lasts two defats before I run the risk of it getting hard to remove after hardening. So sacrificing paraffin might be extending the life of my xylene.
 
Cactus Man
#192 Posted : 5/19/2018 12:37:03 PM
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Thanks for the replies everyone! Gonna keep on pullin till she just wont pull no more!
 
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