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Get DMT by taking MAOI + tryptophan + L-methionine = DMT in brain = trip Options
 
greenmoss
#1 Posted : 10/27/2015 7:32:04 PM

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Quicksilver wrote:
> I'm curious as to what peoples experiences are with mixing smart drugs
> with psychedelics and other drugs like LSD, shrooms, MDMA, or pot.


MAOI + tryptophan + L-methionine (+ B12 + B6 + folic acid) = DMT

See Alexander Shulgin's new book 'TIHKAL'. This is a must for anyone
interested in psychedelics, it is destined to become a classic. I will
quote directly (without permission, sorry) where it describes the
chemistry and effects of tryptamine:


Experience report:
I took 500mg of l-tryptophan + 500mg of l-methionine + half oz of passionflower extract + (b6 + b12 + folic acid to help with synthesis) I added 20mg of melatonin, because I heard it could help out.


After about 30 minutes after ingesting the effects felt like salvia until i fell asleep. I tripped in my sleep often waking up. The next day my mind seem clearer.


page 283.
Quote:

..... Almost forty years ago a researcher in the National institute
of Mental Health, in Maryland, discovered an enzyme in rabbit lung
that could transfer a methyl group to a tryptamine from the amino
acid donor, S-adenosyl-methione. With this system, sorotonin gave
N-methylsorotonin, N-methylsorotonin gave bufotenine, trptamine gave
N-methyltrptamine, and N-methyltrptamine gave DMT. What a fabulous
black box that would make. Get two enzyme preparations, one that can
methylate S-adenosyl-homocysteine to S-adenosyl-methionine and
another that can regenerate S-adenosyl-homocysteine by transferring
the methyl group to an available amine. Two catalysts in a chamber
heated to 37 C, with a spigot adding tryptamine at the top, and
another releasing DMT out the bottom. That's the science - I'll leave
the details to the engineers.


page 582.

Quote:
(with 15 g, orally with 150 mg iproniazid) "this was a daily
treatment given to schizophrenic patients, tryptophan along with an
antidepressant which is a monoamine oxidase inhibitor. Most showed
marked changes such as an elevation in mood, an increased
involvement with other people in their ward, and an increased
extrovertism. A separate study of this composition with the addition
of the amino acid L_methionine produced in about half of these
patients a toxic or deliriod state."

...... Tryptophan, a natural and nutritionally essential amino-acid,
is a centrally active intoxicant and sleep provider in man. It is
converted metabolicaly to tryptamine, which is a little bit
psychedelic. When administered with methionine (another amino-acid
know to methylate things) it produces methylated tryptamines, the two
best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine
(DMT). The effects that result are hard to categorize, reflecting the
the diagnostic state of the patient. But something happens. In short,
tryptophan, alone or in combination with MAO inhibitors or methyl
donors, is a fabulous tool for exploring brain function...........

A quick Web search turned up some useful information relating to
methionine (again without permission):

The Cognitive Enhancement Research Institute
S-adenosylmethionine (SAM)

One of the essential metabolic functions of the body is active methyl
donation (cycle A). The active methylation donor is S-adenosyl-
methionine (SAM), which is produced from methionine by the addition
of ATP (adenosine triphosphate). After the methyl group has been
donated (reaction 3), homocysteine remains. Because homocysteine has
pro-oxidant properties (elevated levels are associated with cardio-
vascular disease), it must be detoxified. Two separate mechanisms
exist both of which are serine dependent. In the first (reaction 1),
homocysteine is re-methylated by methyltetrahydrofolate (Me-THF, or
"activated" folic acid) back to methionine, and the SAM cycle is
closed. Under most circumstances, this should be the dominant
pathway. In the second mechanism (reaction 2), homocysteine is
combined with serine to form cystathionine which is split back apart
(slightly differently) to yield cysteine and homoserine. This
reaction depends on the enzyme cystathionine beta-synthase which
opens up the SAM cycle and results in loss of methionine (and
accumulation of cysteine).

The restoration of the SAM cycle is not solely dependent on
increasing serine levels. The folate cycle (cycle B) is essential to
close the SAM cycle and keep methionine available for producing SAM.

The folate cycle not only requires folic acid, but also vitamins B6
and B12, and NADH (a vitamin B3-containing reducing agent). NADH is
now available as a dietary supplement in the US.


So it appears that to be safe methionine should be taken in combination
with vitamins B12, B6 and folic acid. Again on the down side I have read
that methionine has GI side effects such as nausea.

A safe MAOI could be Peganum harmala extract (harmine). With the
exception of tryptophan all the other ingredients are available from
health food stores.

Fat Freddie
 

Good quality Syrian rue (Peganum harmala) for an incredible price!
 
332211
#2 Posted : 10/27/2015 9:36:05 PM

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i love how people find ways to work around the law.

thumbs up for our bodies, the most complicated chemical synthesizers ever created.
 
greenmoss
#3 Posted : 10/31/2015 3:29:41 PM

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Quote:
Tryptophan is the amino acid metabolized into 5-HTP, from which serotonin and subsequently melatonin can be produced.

Melatonin appears to inhibit the tryptophan 2,3-dioxygenase (TDO) enzyme, which directs tryptophan away from production into 5-HTP by enhancing its catabolism.Inhibition of TDO via melatonin can enhance the amount of bioavailable tryptophan, independent of supplementation.

(This means it Melatonin stops the conversion of L-tryptophan being converted to Kynurenine pathway. This is good because it means L-tryptophan can convert either into 5-HTP producing more serotonin and or making it easier to convert to tryptamine)



NB:
Quote:
Tryptophan, a natural and nutritionally essential amino-acid,
is a centrally active intoxicant and sleep provider in man. It is
converted metabolicaly to tryptamine, which is a little bit
psychedelic. When administered with methionine (another amino-acid
know to methylate things) it produces methylated tryptamines, the two
best studied being N-methyltryptamine (NMT) and N,N-dimethytryptamine
(DMT).

The effects that result are hard to categorize, reflecting the
the diagnostic state of the patient.

But something happens. In short,
tryptophan, alone or in combination with MAO inhibitors or methyl
donors, is a fabulous tool for exploring brain function...........
 
benzyme
#4 Posted : 10/31/2015 5:45:17 PM

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there is nothing in those precursors/substrates mentioned to inhibit the production of serotonin, which is the preferred pathway in vivo; increasing melatonin concentration in plasma does inhibit serotonin production via feedback inhibition, but it doesn't facilitate tryptamine methylation.

also, once a functional group is added to the 5-position, there is no removing it... no going from 5-HTP to DMT.

the metabolic synthesis looks cute on paper, especially to organic chemists...however, enzymes are finicky catalysts (very substrate-specific, they prefer certain substrates over others), and follow first-order kinetics. concentration drives the reactions...to a point, where increasing conc. does nothing but inhibit. further complicating matters are other substrates present in cytosol.

doing what shulgin suggested in tihkal may give a little brain tingle, but probably nothing like a vaped experience. maybe a mild aya buzz.
"Nothing is true, everything is permitted." ~ hassan i sabbah
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