had shrooms datura and mescaline at the weekend a few times, was great, very LSD like, no nausea at all, not even any queasiness

I, on the contrary, get more stomach discomfort with D. stramonium seeds than without. They seem to shut down my digestive system, and I get LOTS of gas as a result. It is not very nice... Think I am going to try and use Mandrake instead.

shrooms + aniracetam, a 5HT2A allosteric modulator, for the win.

it intensifies the effects, as opposed to MAOIs, which prolong the effects.
and d. stromonium seeds just add a different effect altogether, giving the sensation that synergy is occurring.

You might want to try using Atropa belladonna seeds. Unlike Datura stramonium seeds, Atropa belladonna seeds contain almost no scopolamine at all. Datura stramonium seeds are mostly hyoscyamine, but contain enough scopolamine for it to have some effect. Datura inoxia contain scopolamine almost exclusively.

If scopolamine is the cause of the stomach discomfort, Atropa belladonna seeds should be the way to go for you. But maybe it's something else in Datura stramonium causing the stomach discomfort.

Look at this

The seeds are slightly more potent than Datura stramonium seeds by weight. You want to use about 20 mg of Atropa belladonna seeds to equal about 3 Datura stramonium seeds.

the fact that they slow down digestion is a HUGE turn off to me..I def dont want that.

Evening Glory, do you know if its hyoscyamine or scopolamine or both that's causing the discomfort? Have you tried Datura inoxia (contains scopolamine almost exclusively), and if so, does that also cause stomach discomfort?

All of the tropane alkaloids slow down digestion, that’s why they work to prevent nausea from psychedelics. I think scopolamine has this effect to the least amount, but is however better for motion sickness, so it should be more effective in combating the nausea of B. caapi and P. harmala, which is more of a motion sickness type of nausea.

Mescaline, LSD, psilocybin, etc., cause nausea by over-stimulating digestion via serotonin sites in the body, and that kind of nausea is relieved well with hyoscyamine or Dramamine which work by the same action.

You might just want to try a lower dose of Datura stramonium or Atropa belladonna seeds, in the range of 5-9 mg of seed. It could be you're just overly sensitive to the tropane alkaloids.

SWIM has done 3gr cubensis with 4 d. stramonium seeds, and well, it is a nice combo indeed.
I don't know if the seeds emproved the effect, maybe on the visual part slightly, but surely didn't had nausea or body discomfort at all.

Wow, thanks man! That really is interesting - I have been looking for other options high in hyoscyamine for a while. I have no idea if scopolamine is the reason behind my problems, or perhaps something completely else in the seeds, but I can easy check that with trying a few different varieties with these alkaloids. I will definitely try A. belladonna and report back, thanks again!

Do you by any chance have the raw data that you refer to with your dosage advice? I'm a sucker for facts...

The source for the belladonna alkaloid content was from a supplier. I'm not sure if I should post their link.

Colour Atlas of Poisonous Plants, by Dietrich and Pfander gives the following alkaloid contents:

Atropa belladonna
Leaves: 0.5
Seeds: 0.8
Fruit: 0.65
Root: 0.85
Flowers: 0.4

Datura stramonium
Leaves: 0.38
Seeds: 0.58
Fruit: 0.66
Root: 0.23
Flowers: 0.61

You might want to also look at this paper. It shows 87.6% hyoscyamine and only 1.9% scopolamine in the leaves of Atropa belladonna.

Great, thanks mate! Do you by any chance have any information on Mandrake? It is mainly hyoscyamine, right? I will for sure explore these wonderful plants (in extremely low doses, of course) in order to find one that suits me and everyone else where D. stramonium doesn't work as intended.

Sorry, I don't have good reliable information on Mandragora officinarum. There's a serious lack of studies on it. Some say it’s primarily hyoscyamine, but others say it’s a mix of scopolamine and hyoscyamine. So I’m not sure what to say about it. I'll keep looking for good data on this plant. If I find anything, I'll post an update.

Wow thanks all, SWIM recently tried piracetam and shrooms and had a great time. Very good combination. Next he will try aniracetam.