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From Wikipedia, the free encyclopedia:
"
gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless oily liquid with a weak characteristic odor and is soluble in water. GBL is a common solvent and reagent in chemistry and is used as an aroma compound, as a stain remover, as a superglue remover, as a paint stripper, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol."
GBL overdose can cause irrational behaviour, severe sickness, coma and death.[7]
Metabolism takes place in stomach and blood plasma. Both the duration and onset of GBL are shorter than of GHB. Otherwise, effects are similar to GHB, although weight for weight GBL is significantly more powerful due to being absorbed faster and its higher bioavailability, meaning dosage must be lowered accordingly. If taken undiluted by mouth, GBL can cause esophageal and gastro-intestinal irritation. It is possible for oral ingestion of GBL to cause nausea and other similar problems, possibly more so than with GHB.
Dangers
GHB (gamma hydroxybutyrate) and GBL (gamma butyrolactone) are substances which are often used as recreational drugs. GHB has two effects, at low doses it has a euphoric effect (which is why it is sometimes referred to as liquid ecstasy). GHB also has a sedative effect[8] and at higher doses it can cause unconsciousness.[9]
There have been news reports of several deaths associated with GBL.[10]
Addictiveness
Frequent use of GHB/GBL, even when taken long-term and in moderate doses, does not appear to cause significant physical dependency in the greater majority of its users. In many people, quitting or temporarily abstaining from use of the drugs is achieved with minimal or no difficulty. However, when consumed in excessive amounts with a high frequency of dosing, physical and psychological dependence can develop.[11][12]
Frequent use of alcohol (which induces similar effects) can directly translate to physical and usually psychological addiction, where the heavy user can suffer painful and even life-threatening withdrawals.
There are some reports of GHB/GBL users adopting a '24/7' dosing regime.[13] This is where the user has become tolerant to the effects of the drug, increasing the dosage and frequency of dosage simply to avoid withdrawal symptoms.
For those users who do report withdrawal symptoms upon quitting the use of GHB/GBL, symptoms seem to depend on the dosage and the length of time the drug was used for. Light to moderate users often experience insomnia and sleep-related problems, whereas heavy, prolonged use can cause severe withdrawal symptoms similar to Benzodiazepine withdrawal syndrome (BWS).
Dose
A milliliter of pure GBL metabolizes to the equivalent 1.65g of NaGHB, the common form, so doses are measured in the single milliliter range, either taken all at once or sipped over the course of a night. GBL has a distinctive taste and odour, described as being comparable to stale water, synthetic melon aroma or burnt plastic. This differs significantly from GHB, which is described as having a decidedly "salty" taste.[14]
"This is an interesting post started by wiccan_seeker on another forum.
I wonder what melatonin would turn into
A few good QUOTEs from the thread:
Detection of gamma-butyrolactone (GBL)
as a natural component in wine
by
Vose J, Tighe T, Schwartz M, Buel E.
Vermont Forensic Laboratory,
Waterbury 05676, USA.
J Forensic Sci 2001 Sep;46(5):1164-
ABSTRACT
The compound gamma-butyrolactone (GBL) was found in extracts from samples of unadulterated wines. This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 microg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. These results illustrate the need to carefully examine an allegedly adulterated sample's matrix before determining a sample was laced with GBL.
Started a batch today with the following recipe:
3.8 L Pasteurized Apple Juice (not from concentrate with ascorbic acid)
1 cup fresh Ginger tea
12 grams MSG
1/4 packet wine yeast (Lalvin D47)
That is approximately a 3g/L concentration.
if i had to explain it id say MSG, an amino acid, can be fermented into GHB, and this happens because the yeast is already fermenting the sugar in the solution into ethanol and co2, and the MSG is fermented into the corresponding GHB along with it.
Part of the original post was the idea that this can also produce tryptophol from tryptophan. It by itself is nothing of importance (could be used as a sleep aid) but more importantly it can be converted to DMT. The only real references I can find on tryptophol -> DMT are just theoretical though and the reaction conditions seem a little harsh for DMT synth but it does open up possibilities.
Hell, there are no end to the potentially novel alcohols that could be produced by this method.
Ampakines and other peptide drugs come to mind
It should be safe to assume that by general rule, all amino acids should go through this metabolic pathway when added to a fermentation mash.
Quote:
MisterMuscaria said:
Just outta curiosity, could a "prison ghb" be made by adding a pack of ramen noodle seasoning to your typical jail hooch?
Interestingly, probably yes
Although from what I found it looks like only 500mg per pack. Could use 8 packs for a gallon of hooch and get 1g/L of ghb.
Quote:
C_T said:
so if ghb distills at like 205c, why couldn't this be a very simple test, distill of the alc at 78.3 degC, then boil down whats remaining to a concentrate.
best of both worlds?
GHB doesn't actually distill, GBL does. GBL forms an azeotrope with water (just like alcohol does) and distills well below 205c. If you try to separate it by fractional distillation some could come over with the water/alcohol azeotrope.
A more efficient way to isolate GHB in salt form as stated by teefizzle:
Basify the mixture to convert all GBL to NaGHB
Distill off the ethanol and a lot of the water
Acidify the mixture to convert it back to GBL
Distill off the GBL and the rest of the water as an azeotrope
Basify the mixture with NaOH to convert to NaGHB in water
Evaporate the water to yield NaGHB powder/paste
*ALL WAYS WITH LOVE