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Magnolia trees could be active! Options
 
MaNoMaNoM
#1 Posted : 9/23/2013 12:08:47 AM

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Magnolia trees grow in the thousands around here.... Big grin
Googled magnolia real quick to see if there was anything interesting, and guess what!



QUOTES FROM WIKI:
"Magnolol is bio-active on GABAA receptors,
4-O-Methylhonokiol is a potent cannabinoid receptor type-2 (CB2) receptor ligand (Ki=50 nM),
Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.[6] Honokiol is a weak cannabinoid CB2 receptor ligand but the naturally occurring derivative 4-O-methylhonokiol was shown to be a potent and selective cannabinoid CB2 receptor inverse agonist and to possess antiosteoclastic effects.[7]
Honokiol is known to act on the GABAA receptors[9]"

wiki magnolia
wiki magnolol
wiki 4-O-methylhonokoil
wiki honokoil

SO, we should try some extraction on this... Any suggestions are greatly appreciated.
*ALL WAYS WITH LOVE
 
 
cannabinated
#2 Posted : 9/23/2013 2:52:06 AM

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Magnolia bark extract is used as a anxiety reducer, sleep aid, and nootropic. It is readily available in standardized extracts. I too got excited when I learned about this as magnolias are also common in my area.
It's ALL information.
 
benzyme
#3 Posted : 9/23/2013 3:33:06 AM

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there's a few magnolias at a local park, but I wouldn't get too excited.
those compounds could be pulled with amphipathic solvents.
"Nothing is true, everything is permitted." ~ hassan i sabbah
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The Day Tripper
#4 Posted : 9/23/2013 7:57:24 AM

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the nutritional extracts i've had from magnolia worked.

IDK how they were prepared, from what species of magnolia, or how much honokiol and other bioactive components were present, but it worked. It worked very well. If i can find the bottle, its a standardized dosage.

I'll see if i can find it.

Very good anxolitic that is far from habit forming ime.
"let those who have talked to the elves, find each other and band together" -TMK

In a society in which nearly everybody is dominated by somebody else's mind or by a disembodied mind, it becomes increasingly difficult to learn the truth about the activities of governments and corporations, about the quality or value of products, or about the health of one's own place and economy.
In such a society, also, our private economies will depend less upon the private ownership of real, usable property, and more upon property that is institutional and abstract, beyond individual control, such as money, insurance policies, certificates of deposit, stocks, etc. And as our private economies become more abstract, the mutual, free helps and pleasures of family and community life will be supplanted by a kind of displaced citizenship and by commerce with impersonal and self-interested suppliers...
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Mustelid
#5 Posted : 9/23/2013 8:41:31 AM

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It's almost like the Grateful Dead's song, Sugar Magnolia was a big hint.
 
MaNoMaNoM
#6 Posted : 9/24/2013 4:15:14 AM

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YES, it all makes sense now, lol!
Thanks everyone.
I had to look up amphiphile, and learned it describes a chemical compound possessing both hydrophilic (water-loving, polar) and lipophilic (fat-loving) properties..
Examples are alcohols with large R groups, such as diacyl glycerol (DAG), and oligoethyleneglycols with long alkyl chains.

Do you know of any commonly available amphipathic solvents?

Planning on doing an A/B, or whatever works best, eventually.
*ALL WAYS WITH LOVE
 
SKA
#7 Posted : 2/4/2014 11:57:02 AM
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The Day Tripper wrote:
the nutritional extracts i've had from magnolia worked.

IDK how they were prepared, from what species of magnolia, or how much honokiol and other bioactive components were present, but it worked. It worked very well. If i can find the bottle, its a standardized dosage.

I'll see if i can find it.

Very good anxolitic that is far from habit forming ime.


Interresting! In could sure use an Anxiolitic to reduce my social phobia which has been growing on me lately. Magnolias are widely sold at flourists & gardening stores.
I'll figure out which particulair magnolia is most desirble for this purpose and buy some of them this spring.

Also I remember a "hippie" classmate mention "people tripping on Magnolia" many years ago allthough I didn't take it all that seriously at the time as he presented merely as a rumour he had heard. But now I see there may be something to it.

ManomManom, thanks for sharing this! I too am wondering wether I can obtain some amphipathic solvents around here without having to order them from specialised chemistry sites...
 
 
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