Intraterrestrial
Posts: 300 Joined: 25-Oct-2009 Last visit: 21-Jul-2021 Location: Where past, present, and future collapse
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Thanks for the find.  So from quickly scanning through it DMT binds to the sigma-1 receptor, but opiates do not. I find this odd as the anesthetic effects of DMT are so powerful, more powerful than any opiate I have taken. It must block pain receptors? "That which I avoid I will become a slave to, that which I confront I will master."
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DMT-Nexus member
  
Posts: 3555 Joined: 13-Mar-2008 Last visit: 19-Aug-2020 Location: not here
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What cells are sigma 1 receptors expressed in? Is it only neuronal tissue? If so any information on where they are localized.
All this is suggesting to me that dmt's effects like the effects of most drugs are mediated by a few different receptors. Would be cool to see what receptors mediate what response with in vivo selective antagonist studies.
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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they say lung, adrenals, pancreas...interestingly, the same tissues INMT is expressed "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 830 Joined: 20-Jan-2009 Last visit: 07-Jun-2017
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antrocles wrote:it makes me beyond happy to know that i have such intelligent "family" on this board....truly....although my degree is in kinesiology, brain chemistry was only shallowly and briefly skimmed over. i had no aptitude for it. i enjoy beyond measure, however, reading you guys batting this stuff around. rock on!
love and gratitude! No need to put family in parenthesis  You lock the door, and throw away the key
There's someone in my head but it's not me
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DMT-Nexus member
Posts: 1139 Joined: 14-Jul-2008 Last visit: 01-Apr-2017 Location: USA
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Sigma receptors are expressed through-out the entire body. They are found in very high levels through-out most CNS areas and the periphery. Also many many diverse agents (endogenous and exogenous) bind to sigma receptors. Literally it may be easier to list what doesn't bind to sigma-1...., not really but you know what I mean it is notoriously promiscuous. Regarding distribution sig-1 has a "slightly" more limited distribution than sig-2 but is still widely expressed. Highest levels are found in the cerebellum and motor association regions. It is likely that sigma receptors play a key role in cellular physiology rather than as neurotransmitter receptors involved in rapid information processing.
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