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ehum.....DMT and the Pineal. Options
 
Infundibulum
#121 Posted : 11/19/2013 8:47:53 PM

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DisEmboDied wrote:
My question to Dr. Barker:

"But does the paper mean that DMT is also being synthesized or produced by the pineal?..."


His response:

"Yep."



BS.

Nowhere in their paper did they present evidence that it is being synthesized in the pineal. And accordingly, nowhere did they say that is is being synthesized; they did however pondered at the possibility.

Obviously, if in the publication the authors were saying as freely as in your communication with Dr. Barker that the paper means "that DMT is also being synthesized or produced by the pineal" they'd be scalded with boiling oil by reviewers. Or if they did when their manuscript was initially submitted for review, such claims must have been criticized and removed by reviewers.

I am concerned about Barker's response because it shows that he's quick to jump at conclusions about his data and that he's being uncareful to pass his misunderstood opinion (which unfortunately comes by a credible person as he is) to laymen.



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DisEmboDied
#122 Posted : 11/19/2013 10:38:45 PM

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Unfortunately, Infundibulum, I agree with you. Once I re-read the paper, it simply showed that DMT is found in the pineal, in fact it is found all throughout the body. Something is up with this, I need to get him to clarify, hmmmmm......
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
universecannon
#123 Posted : 11/20/2013 12:39:44 AM



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I would email Barker this thread (and the one infund linked, with further discussion) and ask him why they think this shows its produced by the pineal? It would be interesting hearing their answer.



<Ringworm>hehehe, it's all fun and games till someone loses an "I"
 
Infundibulum
#124 Posted : 11/20/2013 9:39:17 AM

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universecannon wrote:
I would email Barker this thread (and the one infund linked, with further discussion) and ask him why they think this shows its produced by the pineal? It would be interesting hearing their answer.

Yes, that is a good suggestion.



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DisEmboDied
#125 Posted : 11/21/2013 10:48:29 PM

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Dr. Barker is a good guy, and he does not at all mind responding to e-mails or talking about it, I have even been to his office a couple of times. Just Google him and e-mail him anytime, I swear it is cool. I am awaiting his response about pineal production....
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
DisEmboDied
#126 Posted : 11/22/2013 3:04:21 AM

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His latest response:

"The pineal is a secretory gland and the enzyme
that makes DMT is in the pineal"


My after response:

"Is there anyway to demonstrate that?

Not trying to give you a hard time man, just want to be excited and make sure I understand what I think I understand Pleased"
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
benzyme
#127 Posted : 11/22/2013 5:01:17 AM

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ask him for a photo of a western blot and microarray, to show evidence of cDNA-bound enzyme isolated from pineal gland cells.
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
Infundibulum
#128 Posted : 11/22/2013 7:05:43 AM

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I think a western blot would suffice, or even a proper immunohistochemical experiment in pineal glands using antibodies against INMT. Mind you, the very same thing has been done and was reported in a poster by cozzi and ruoho a few years ago (also mentioned in the very first post of this thread by joedirt), but there are numerous problems with the latter

1. They used macaque monkey pineal sections probed with INMT antibody raised against human INMT. The human epitope their INMT antibody recognises has very poor homology with macaque INMT. This is a recipe for disaster in immunohistochemistry.

2. Their immumo pictures did not have controls like no primary antibody controls

3. Their inmt signal was completely all over the place, completely patternless. Not what you expect ffrom immunohistochemistry

4. The cozzi et al poster is a poster, i.e. not a peer reviewed study. And since it is unpublished and also with the data presented therein so open to numerous criticisms, how can dr barker cite such findings in their recent study is beyond me. This is bad citation and bad science overall...

I wonder what dr barker has to say regarding the above points

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DisEmboDied
#129 Posted : 11/22/2013 6:44:30 PM

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His latest response:

"Yeah. We’ll be looking at CSF to see if it is being secreted."

I will ask him about the above.
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
DisEmboDied
#130 Posted : 11/28/2013 3:32:12 AM

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He says it is safe to assume at this point. That is all.
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
benzyme
#131 Posted : 11/28/2013 3:57:01 AM

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Rolling eyes
what the heck does that mean?

it's also safe to assume that humans are responsible for the increase in global warming.
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
Infundibulum
#132 Posted : 11/28/2013 12:02:26 PM

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I find his Dr Barker's responses worrisome. But maybe that's because in his email communications with DisEmboDied he was aiming to address the questions of a layman, not tight criticism from a colleague (not that this is excuse, but anyway).


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DisEmboDied
#133 Posted : 11/29/2013 11:23:21 PM

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Well, I believe that Dr. Barker knows what he is doing and where he and Strassman are going with this. He probably can see the result, but just can't quite prove it yet, not quite yet, technically. He knows that I am not a hardcore scientist such as himself, so are conversations are indeed less formal. He is just excited to talk to someone as interested in this stuff as he is. I have degrees in psychology and philosophy and so he likes to here that perspective from me since he is all about numbers. I will be in love when that result finally comes through without a doubt that the pineal produces and excretes DMT directly into our brains!
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
benzyme
#134 Posted : 11/29/2013 11:32:34 PM

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not holding my breath, they're more likely to confirm
presence and expression of the inhibitory enzyme Strassman
mentioned in a 1990 monograph.
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
DisEmboDied
#135 Posted : 12/4/2013 4:06:39 AM

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This is the original place where I found out about the paper:

http://www.cottonwoodresearch.org/dmt-pineal-2013/
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
benzyme
#136 Posted : 12/4/2013 4:10:58 AM

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hooray for enlightened rodents Very happy
"Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
 
dreamer042
#137 Posted : 12/4/2013 4:19:45 AM

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DisEmboDied, any word from him about when they are gonna try comparing this baseline information to rats that are sleeping or at night or in other states of consciousness?

This is indeed a rich area of research that everyone is on the edge of their seats wondering about. Would love to know more, do they need any grad students? Laughing
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DisEmboDied
#138 Posted : 12/9/2013 4:15:09 PM

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"hooray for enlightened rodents!" -love that!

Actually, he does need a graduate student, his former grad student, who did his Dissertation on ayahuasca, has graduated and moved on...I am talking about for Dr. Barker, I don't know for the rest of Cottonwood...For Barker, one must have extreme mathematical/science skills, not really psychology/philosophical skills alone, as he is a chemist primarily. His last grad student first had a Master's in Neuroscience from Tulane. But he needs a new one, so apply! He works at LSU, his page is

http://www.vetmed.lsu.edu/cbs-update/Barker.htm
Meditate before you venture, take it seriously, use it as medicinal—it is good psychotherapy if needed. Realize that you, the Earth, others, and the Universe are all one and the same process. Then take that knowledge back to become, as you already are, one with nature. Eternity in every moment. Divinity in every particle. All is one organism.



 
The Neural
#139 Posted : 12/10/2013 3:34:28 PM

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DisEmboDied wrote:
For Barker, one must have extreme mathematical/science skills, not really psychology/philosophical skills alone, as he is a chemist primarily.

Just to clarify, psychology requires advanced mathematical, statistical and scientific skills. Otherwise we are talking about psychotherapy.

What you don't understand, you can make mean anything. - Chuck P.

Disclaimer and clarification: This member has been having brief intermittent spells of inattention. It looks as if he is daydreaming in place. During those distracting moments, he automatically generates fictional content, and asks about it in this forum for feedback. He has a lot of questions, and is a pain in the arse.
 
User 18517
#140 Posted : 12/24/2013 6:42:23 AM
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Pineal calcification is real, for the record.

https://www.google.com/search?q=pineal+gland+calcify+autopsy
 
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