If you did produce 4-OH-5-MeO-DMT in the mushrooms, wouldn't that then make those mushrooms legal?

If you were to do this, and grow mushrooms from those spores, would the next generation of mushrooms produce 4-OH-5-MeO-DMT instead of 4-OH-DMT?

Nope. As Global said, this won't prevent the mushrooms from making psilocin and psilocybin.


No. Giving the mushroom some 5-MeO-DMT to eat will in no way give the mushroom the genetics to make its own 5-MeO-DMT. If your mom ate bananas while she was pregnant, would this give you the ability to spontaneously produce bananas?

I haven't talked to anyone who has successfully cultivated 4-HO-5-MEO-DMT using this method nor have I read about anyone who has successfully done it.

4-Hydroxy-5-methoxy-N,N-dimethyltryptamine would be a fascinating compound to explore. The reason it's not in TIKHAL is that it is virtually unknown. The only report of it in the chemical literature was a paper published by Marc Julia's group at the Pasteur Institute in 1965. They reported the synthesis and physical properties of the compound but to my knowledge it has never been explored in any way. The synthesis is quite a frightening thing. It starts with ortho-vanillin and takes approximately 10 steps to get to the 4,5-HO-MeO-DMT. I'm not surprised that no one has pursued the compound.

However there is a very interesting study that took place in Leipzig about 15 years ago. Jochen Gartz, a mushroom explorer whom I know quite well, has done some fascinating studies with Psilocybe species by raising them on solid media containing strange tryptamines that are alien to the mushroom. Apparently the enzymes that are responsible for the 4-hydroxy group of psilocin are indifferent to what it is they choose to 4-hydroxylate. He has taken things like DPT or DIPT and put them in the growth media and the fruiting bodies that came out contain 4-hydroxy-DPT or 4-hydroxy-DIPT instead of psilocin. In fact, he has a patent on the process. These active compounds are made by the mushroom so they really are natural and yet they never have been observed in nature. I'll give you even odds that if you put spores of a psilocybe species on cow droppings loaded with 5-MeO-DMT you would come out with mushrooms containing 4,5-HO-MeO-DMT. This way you avoid a 10 step synthesis by growing a psychoactive mushroom that contains no illegal drug.