Hey Enoon. Thank you for the welcome! The only compound that I am currently aware of that is modified to be non-psychedelic with medicinal benefits is LSD. I'd have to look it up again, but a certain variation of LSD is not psychedelic at all yet still elicits the same medicinal benefits as psychedelic LSD for cluster headaches & migraines.
This is, however, a physical nature, not a psychological. Current antidepressants/antipsychotics, etc are only around 20% effective and at that take 4-6 weeks to have any noticable benefits. Why is this? Because it takes time for the brain to "change". Add cognitive based therapy or some other clinical psychology and this result increases to 80% effectiveness. Again, it is the physical nature of changing thoughts, patterns, and "mind-set" over time. Even us doctors fully understand that anti-depressent drugs do nothing unless they are aided with change. The drug may increase neurotransmitters but this only sets the stage for a good show. It is the script that creates the magic. In other words, you won't get better until you psychologically decided to and take physical action.
This is where psychedelics come into play. The psychedelic aspect is the "action". It is the "script". You take 50 milligrams of psilocybin and you are in for a good 6 hour therapy session where everything in your life is brought to the forefront for examination. What anti-depressant does that? In fact, this is exactly what clinical psychology is doing... just in a more politically correct way. Molecules don't have to be politically correct. If what you are doing in life is making things shitty... well the psychedelic experience shows you that you are fucking up. I don't believe in bad trips. I think bad trips are great experiences because it makes you question why your mind is doing this. It shows you your fears, anxieties, losses, worries, and so much more. Again, what counceling session or drug can come anywhere close to that.
This is just the outline too. What about the entities and other worlds you visit. The ideas of change and motivation evoked through these visions and experiences. I once had a trip where I was trying to plug my headphones into my computer and the cord was completely tangled... an absolute mess. Of course completely fucked... it was frustrating. But then I saw that it was truely only one knot making this disaster and once I unraveled that one knot, that one problem, everything straitened out. But it was the difficulty in realizing it was only that one knot that created the mess. This is essentially life too. It is usually one bump that fucks everything else up. Your too afraid, self conscious, lazy, whatever... If one could understand what their one knot is, maybe other problems would simply straiten out???
Now, tell me if I would have ever though of that obvious fact of life that stares us in the face every day if I was untangling my head phone while not tripping??? Maybe, but the examination of the situation was far deeper than I would expect anyone else to place into the context.
So to answer the question, in the realm of psychology I do not believe a non-psychoactive drug can be of any benefit for psychological change. It may aid, assist, enhance psychological change, but action in thought and life is absolutely required, in my opinion, to make that shift in your mind. Psychedelics greatly enhance the action of thought... and in turn create that thought into a virtual reality during the experience. A four hour trip can seem like an eternity. Coming out of it realizing what your missing in life and that it is only four hours later can really drive someone to make those positive changes and shifts that they want in life.
Hope this explains my perspective a little better and answers your question!
~Jez
Singularity already exists inside each of us. It isn't biology that is striving to singularity... but singularity that harnesses biology to live a life of greatness in the physical world. The secret is to find what your singularity wants and create it. This is what psychedelics show you!