Mentioned this in my intro essay, but wanted to discuss it more specifically. I've had trouble breaking through despite smoking increasing amounts.

Any information on DMT's interaction with specific psychiatric medications? For example I am on the following:

- Lamictal (mood stabilizer)
- Wellbutrin (atypical anti-depressant, not SSRI or MAOI)
- Abilify (atypical anti-psychotic)
- Klonopin


I have tried fasting from the Wellbutrin, since it has affected the efficacy of MDMA in the past, but it didn't seem to help much.

Anyone have experiences with this issue themselves?

Good morning Nailpolished!

Thats some combination of meds you're on!

I am familiar with your concoction and the most probable cause of your difficulty breaking through is Aripiprazole.Its a fairly novel anti-psychotic particularly with regards to its variable agonist/antagonist properties at the 5 HT (serotonin) receptors.

I think youre other meds take a bit of a backseat with regards to your difficulties.At least with Wellbutrin, you should find it easier to give up cigarettes should you be a smoker!!

I dont know anything about your history but if you were in the UK, a combination like this would be used in the more difficult cases of bipolar disorder.

You also need to be careful about stopping your meds for the obvious reason of your mental well-being but benzos like clonazepam cannot be stopped abruptly if you have been on it for some time.Same applies to lamotrigine as the risk of withdrawal seizures from both of these is significant.

Lastly I would strongly advise being INCREDIBLY cautious in your endeavors to break through as a relapse in your mental health is too high a price to pay for the experiences you seek.Take care!

I don't know anything specific other than most psychedelics are not recommend for use, if also taking most prescription anti depressants. One major reason being because psychedelics often affect serotonin, and anti depressants also affect serotonin in some way. For some reason, combing two drugs that act on the same neurotransmitter can be very bad. That's the basic theory...... I guess you'll need something more specific.

Wow... That is one extreme combo!! I will seriously encourage you to rethink using DMT, or any psychedelics for that matter. With your psychiatric condition(s), you may be at high risk of developing further conditions from such use. Please step careful.

Nevertheless, the cause of your problems breaking through are undoubtedly the aripiprazole (Abilify). It acts as an antagonist at 5HT-2A receptors, which means that it binds to the receptor without activating it. The effect of DMT and other psychedelics is because they act as agonists at the same receptor, which means that they bind to the receptor and activates it.

Aripiprazole's action on these receptor is exactly the opposite of the psychedelics. When you are on aripiprazole, you are effectively blocking the ability of psychedelics to function, because the 5HT-2A receptors already have a substance bound to them. Aripiprazole is also the cause of your problems with MDMA, as it binds to the serotonin transporter just as the MDMA would do if nothing else was already there. This action effectively blocks or at least significantly reduce the efficiency of MDMA.

The clonazepam (Klonopin) is also likely to play a role, as benzodiazepines are known to reduce the efficiency of psychedelics. The other medications might also have something to do with your problems getting intense effects, but the real problem here is the aripiprazole and to a lesser extent the clonazepam.

Again, I urge you to rethink the use of psychedelics. You don't want to mess any more with your mind, it might lead to some very bad effects. The nature of a DMT breakthrough is hard enough to cope with for people without any psychiatric conditions. I would instead encourage you to seek psychiatric therapy (not just treating the symptoms with a cocktail of drugs) in order to hopefully do something about your condition(s).

If you find a good treatment program, you might be able to someday get off this terrible cocktail of intense drugs. But please do not stop taking any of them before consulting professional medical opinion from at least two different professionals.

I wish you very much good luck!

What they all said ^

and please check the health and safety section

Wise words as usual coming from Evening Glory.