benzyme wrote:Evening Glory wrote: In short, this means that both the substrate and the enzymes needed for the reactions are found in the pineal gland.
It does, however, not mean that DMT is in fact synthesized there. All we know is that it is naturally occuring in the body, and that the pineal gland could be the organ responsible.
the mRNA for INMT is missing from the pineal gland.
can't make products if the genes necessary for protein expression are not there.
That would actually make more sense benzyme, why would you want INMT produced in the pineal, when its an organ directly linked to the blood supply of the brain?
That would result in the pineal spreading a continuous flow of DMT into brain tissue, rendering the person in a constant DMT/Dreamlike trip.
No, rather you would want INMT produced in the lungs, while in the right conditions it meets tryptamine, which is produced in the CNS.
There are high concentrations of Monoamine Oxidases in the lung tissue aswell to keep this balance in check.
Evening Glory wrote: Yeah, it's a wonderful paper! I especially took note of this: "INMT mRNA was present in the rank order of lung > liver > brain (Thompson and Weinshilboum, 1998 )."
Does this rationale not present a possible mechanism? It would be easier to regulate DMT which enters the brain if INMT was produced outside the brain.
The hardest thing of all is to find a black cat in a dark room, especially if there is no cat.
-Confucius
"Under the skin of our lives; somewhere deep and early, forgotten, we all share the same dreams"