just curious
Posts: 67 Joined: 26-Dec-2010 Last visit: 09-Mar-2016
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Thanks corpus callosum! That is a great and useful description of the variety of different cell types beyond neurones most directly involved in brain functioning. (The support staff, if you will, for the neurones) I would like to clarify your last point that "Any neurogenesis taking place in the CNS (ie making 'new' NEURONS) will be taking place as a result of the maturation of pre-existing stem cells rather than a de novo process." Actually, there is evidence that the progenitor (stem) cells in certain regions of the brain actually do divide as they differentiate/mature. So yes, any neurogenesis is the result of the maturation of pre-existing stem cells, but it seems that part of that process includes mitotic division. I am ignorant as to what is considered a de novo process of cell division, so this point may or may not contradict what you wrote. ( http://www.jneurosci.org/content/22/3/629.short)
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DMT-Nexus member
Posts: 206 Joined: 12-Jul-2010 Last visit: 15-Oct-2024
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Saw this on youtube the other day...almost posted haha. Then I figured someone else would.
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DMT-Nexus member
 
Posts: 1952 Joined: 17-Apr-2010 Last visit: 05-May-2024 Location: somewhere west of here
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InfiniteFacticity wrote:Thanks corpus callosum! That is a great and useful description of the variety of different cell types beyond neurones most directly involved in brain functioning. (The support staff, if you will, for the neurones) I would like to clarify your last point that "Any neurogenesis taking place in the CNS (ie making 'new' NEURONS) will be taking place as a result of the maturation of pre-existing stem cells rather than a de novo process." Actually, there is evidence that the progenitor (stem) cells in certain regions of the brain actually do divide as they differentiate/mature. So yes, any neurogenesis is the result of the maturation of pre-existing stem cells, but it seems that part of that process includes mitotic division. I am ignorant as to what is considered a de novo process of cell division, so this point may or may not contradict what you wrote. ( http://www.jneurosci.org/content/22/3/629.short) Nice link!  The purpose of my post was to clarify the issue of 'brain cells', a vague term (IMO), and to point out that 'growing new brain cells' could suggest to the casual reader that the process under discussion may involve new cells appearing without a progenitor source. Good stuff is neuroscience.  I am paranoid of my brain. It thinks all the time, even when I'm asleep. My thoughts assail me. Murderous lechers they are. Thought is the assassin of thought. Like a man stabbing himself with one hand while the other hand tries to stop the blade. Like an explosion that destroys the detonator. I am paranoid of my brain. It makes me unsettled and ill at ease. Makes me chase my tail, freezes my eyes and shuts me down. Watches me. Eats my head. It destroys me.
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DMT-Nexus member
Posts: 131 Joined: 06-Nov-2012 Last visit: 04-Oct-2014 Location: Hyperborea
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Good to have a doctor in the house, Corpus! I thought (I'm no neuroscientist) that the main requirement for building new brain cells was sugars.
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DMT-Nexus member
Posts: 524 Joined: 12-May-2010 Last visit: 22-Nov-2024 Location: canada
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that is pretty remarkable "science never proves anything; you can never duplicate an event precisely at the same moment in time as the initial event. science can only show correlation from the evidence and data derived from it." -benzyme
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DMT-Nexus member
Posts: 57 Joined: 20-Oct-2010 Last visit: 02-Mar-2020 Location: Mother Earth
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I love this. It is fine if it is a thesis from some intern, its evidence. And cheers to corpus callosum for the head-y break down. Lovin' you nexus for trying to figure out this mystery and show the positivity of this wonderful set of molecules. NowHere.
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DMT-Nexus member
Posts: 2147 Joined: 09-May-2009 Last visit: 28-Oct-2024 Location: the shire, England
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Fantastic thread, thanks so much for sharing that and for all the good info, amazing! As well as psilocybin, ibogaine, ketamine, cannabis, exercise and fasting have all been implicated with neurogenesis to some degree.
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DMT-Nexus member
Posts: 2147 Joined: 09-May-2009 Last visit: 28-Oct-2024 Location: the shire, England
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The paper on this is attached for anyone interested. Catlow, B.J., Song, S., Paredes, D.A., Kirstein, C.L. & Sanchez-Ramos, J. (2013) Effects of psilocybin on hippocampal neurogenesis and extinction of trace fear conditioning. Experimental Brain Research.
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DMT-Nexus member
Posts: 290 Joined: 15-Jun-2011 Last visit: 01-Jun-2020
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Thanks for the article Bancopuma. Haven't read that one yet. Awesome stuff. All these posts are on behalf of Stimpy, my yellow bullhead. He is an adventurous fish, and I feel his exploits are worth sharing...so much so, I occasionally forget that HE is the one who does these things. Sometimes I get caught in the moment and write of his experiences in the first person; this is a mistake, for I am an upstanding citizen who never does wrong. Stimpy is the degenerate.
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DMT-Nexus member
Posts: 113 Joined: 24-May-2011 Last visit: 29-Sep-2013 Location: Intn Waters
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1.5mg/kg, that would obliterate your mind...
That's 120mg for a 80KG adult. Poor little mice. I hope that their receptors don't bind well with psilocybin.
Threshold 3 - 4 mg
Light 4 - 8 mg
Common 6 - 20 mg
Strong 20 - 40 mg
Heavy 35 + mg
Am I missing something?
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