..just to agree and disagree with everyone:
an individual's level of MAO (A or B) inhibition is not simply a function of the amount of a particular known MAOI ingested, but also related to the total amount of amines in their system (from foods drugs, which are chewing up available MAO) and possible accumulative effects of other MAO substances (e.g. foods/herbs rich in flavonoids)
as quoted in Tyramine interaction poll thread,, from
"Therapeutic Applications of Selective and Non-Selective Inhibitors of Monoamine Oxidase A and B that do not Cause Significant Tyramine Potentiation" by Youdim MB, Weinstock M. Neurotoxicology. 2004 Jan;25(1-2):243-250.:
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Quote:..However irreversible MAO-A inhibitors continue to induce a cheese reaction...The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin...The consequence of these findings were the development of reversible MAO-A inhibitors (RIMA), moclobemide and brofaromin...with limited tyramine potentiation..
..the hypertensive crisis caused by irreversible MAOIs is extreme, but we can't totally discount other kinds of reactions in individuals between (reversible) RIMAs and tyramine..
there are other potentially toxic amines in seasame-soy-chicken which could cause problems, depending on individual meal and person..
..the poll suggests about 15-30% of respondents get some kind of interaction
Tyramine interactions poll/discussion here..
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..it's still worth noting, though:
Quote:RIMAs still have highly dangerous and sometimes fatal interactions with many common drugs; in particular, they can cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant or stimulant, common migraine medications, certain herbs, or even most cold medicines (including decongestants, antihistamines, and cough syrup).
wikipedia.