Quote:5-MeO-DMT is regarded as an endogenous psychotoxin, and elevated concentrations of 5-MeO-DMT and its analogs in body fluids might be associated with psychotic disorders such as schizophrenic psychosis [12-19].
This is pretty significant. This is an endogenous psychotoxin, and this has often been said for N,N but to hear the same thing about the toad "venom" of the
b. alvarius spp. is important. It's an interaction between the minds of various plants and animals, which is actually amazing.
Strassman's works on the topic often rave about this sort of thing in a rather woo-woo kind of way, but I mean when you dip into this stuff, you get kind of excited about it. It's an amazing chemical.
It calls it a neurotoxin and it is in the strictest sense. It causes extreme levels of serotonin in the brain which causes all sorts of hallucinations and visual effects because it plays rough with all kinds of neuro-electrical systems that are responsible for the impulses that handle visual data, cause respiration and many other regulated processes. This is rather obvious by analyzing the effects of the drug qualitatively.
Quantitatively, tryptamines and other indolamines (of which all of the -DMTs are), these drugs have high affinities for sigma receptors like 5HTP-1,2A/B receptors.
Quote:5-MeO-DMT has high affinity for the serotonin 5-HT1A receptor, and it is 4- to 10-fold more potent than N,N-dimethyltryptamine (DMT) in human subjects [25, 26]. Unlike its chemically and pharmacologically related drugs, such as 5-hydroxy-N,N-dimethyltryptamine (bufotenine), DMT, 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) and α-methyltryptamine (AMT) that all have been Schedule I controlled drugs for years, 5-MeO-DMT was not a federally controlled substance in United States until August 2009 when the Drug Enforcement Administration issued a notice intending to place 5-MeO-DMT into Schedule I of the Controlled Substances Act [20].
Incidentally, this 5HT agonism is the key mechanism of action in SSRI-class serotonergic psychoactives, and is responsible for its medical use. Why this indole ring structure has been outlawed everywhere seems obvious-- serotonin toxicity is a malady that shouldn't be tampered with lightly. And yet some of us do at our own risk and often our own detriment because we play with madness, hallucination and psychosis until we literally lose our minds.
I'm interested to find out more on the topic of other herbal 5HT-[] agonists like St. John's Wort which as I've learned today contains hypericin. It's proposed that it is responsible for its 5HT-1A agonism, I think.
I'm still reading. More on this to come.
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