A conjugate acid is a base that has had a hydrogen ion connected to it, a base that has become protonated.
For example:
When forming the fumarate salt of DMT, the DMT-freebase is the base that is receiving a proton from the fumaric acid, the fumaric acid and DMT base react and neutralize, forming the fumarate salt of DMT, and the conjugate base is what's left of the fumaric acid acid after it has protonated the DMT.
·An acid readily gives up a proton (H+)
·A base readily accepts a proton
The conjugate acid is the protonated base, and the conjugate base is what's left of the acid after its donated it's hydrogen ion (proton).
When you react an acid and a base, the deprotonated base accepts a hydrogen ion from the acid, which causes a neutralization of acidic or basic properties with the formation of a salt. The acid used determines the salt form, so HCL gives the hydrochloride, H2S04 gives the sulfate, acetic acid gives the acetate, and so on...
Quote:Acid–Base Reactions: Neutralization Reactions
When a strong acid and a strong base solution are mixed, a neutralization reaction occurs, and the products do not have characteristics of either acids or bases. Instead, a neutral salt and water are formed. Look at the reaction below:
HCl(aq) + NaOH(aq)H2O(l) + NaCl(aq)
The anion from the acid (Cl–) reacts with the cation from the base (Na+) to give a salt, and a salt is defined as any compound formed whose anion came from an acid and whose cation came from a base.
When a strong acid and a weak base are mixed, the resulting salt will be acidic; likewise, if a strong base and a weak acid are mixed, the resulting salt will be basic. If on the SAT II Chemistry test you are asked to determine if a salt formed in a particular reaction is neutral, acidic, or basic, first ask yourself, Which acid reacted with which base to form this salt? Next ask yourself, Was the acid strong or weak? and then, Was the base strong or weak? Consider K2CO3. K2CO3 is formed when the base, potassium hydroxide (which is strong since potassium is a 1A metal), reacts with the acid, H2CO3 (which is weak since it isn’t one of our six strong acids). Since this is a combination of a strong base and a weak acid, the salt formed will be basic.
http://www.sparknotes.co.../chapter6section6.rhtml
In chemistry A "free base" is the depronotated form of an amine.
So provided you have an amine, you can have its free base.
When you buy a medication and you see"HCL" after the name of the drug it means the free base of that compound was subjected to an acid base neutralization with hydrochloric acid forming the hydrochloride salt.
With cocaine, the freebase and the hydrochloride salt have special market relations, initially the freebase was being produced in one south American country from the coca plants, Then this free-base cocaine "paste" is shipped to another country to be formed into cocaine hydrochloride, which is the powder cocaine sold on the black market. Now, freebase cocaine producers, manufacturing from the coca plant, have recently learned how to produce the hydrochloride salt of cocaine from the freebase cocaine "paste", making shipping over borders for this process obsolete, placing countries like Peru as centers for cocaine production rather than countries like Columbia. When you "crack" cocaine, you are "breaking" the hydrochloride salt into its freebase form using NaHCO₃as a base.... most people think "freebase" is a method of smoking cocaine or other drugs on foil, this is nonsense, and while freebase compounds may be smoked on foil, the term is related to chemistry.
Any way...
Any amine can have free base and protonated forms...
-eg