With all of the information popping up lately about the therapeutic use of Psilocybin to treat anxiety, depression, so on and so forth, as in an article like this http://reset.me/story/five-mind...ut-psilocybin-mushrooms/ Im curious as to the dosage used.

A quote from a study I found on "treating negative emotion" says "This study assessed the effects of acute administration of the hallucinogen psilocybin (.16 mg/kg) versus placebo on amygdala reactivity to negative stimuli in 25 healthy volunteers using blood oxygen level-dependent functional magnetic resonance imaging"

Since 2-5g is your standard range for a full on psychedelic experience, Im curious if they supply a super small dose of psilocybin so that there is NO psychedelic effect. Do they administer like 0.25g say? Or do they administer a proper dosage for a full on trip to allow the therapeutic benefits?

For someone weighing 75kg, that would be 12mg of psilocybin, which would be about half a full dose.

The study I think you are referring to was a 2011 cross-university one conducted in the UK (link: http://www.pnas.org/cont...1119598109.full.pdf+html )

According to the paper, 2mg of psilocybin was injected, which the paper states is comparative to 15mg taken orally. Using some info from wiki (http://en.wikipedia.org/wiki/Psilocybin) I reckon that's about a 1.5g of dried dose.

On an anecedotal note, I've used psyches to treat depression in the past. I find the sort of dose I need to start untying those mental knots would be around 3g dried, 300-400ug LSD, or 500mg+ mescaline.

I recently did some work with a friend who wanted to address some issues within himself. We started with about 4g of dried material, per person.

After the Session, he felt a noticicable difference in his attitude. His Co workers, who I spoke with a week after the mushies, said that he had a much brighter attitude, and was not as negative in the work place.

That was his first experience with psychs. He wants to go for round two.

I'm a little indifferent. I feel like it should not be my duty to encourage such a path due to legal status of these compounds. At the same time, I've bettered myself, and I would not want to stand in the way of another person bettering themselves - if that's the path they choose

Very interesting. Arcologist 12mg is like 1/200th of a "normal dose" at least of dried shrooms. is that speaking in terms of extracted psilocybin thats been injected?? 12mg seemms low. What am I missing?

So depending on method of administration, thats whatreally determines dose? And it seems like those of you with experience go for the full on experience and consume standard sized doses.



Me personally, a year ago I was totally content with being 25 and still living home because I thought I was ahead of the curve seeing how many 30-33 year olds I know still living home, I figured meh I have time. I graduated college about 3 years ago as a psych major and criminal justice minor, and had very little direction though I did have a good job , nothing career worthy though. My job was not college degree related, I was essentially forced through college by my parents because they related success with a stupid degree, but because they themselves never went to college and are very unsuccessful people, they thought by me going through college would give me a greater chance at "success".

I lost that job about 8 months ago, and was unemployed for 3 months. The time I spent jobless gave me a ton of insight as to the fact that it was time to grow up, time to apply myself and get what I truly deserve and that the only limitation is the self. That time period too was when I first experimented with DMT and Id say it's been the most insightful part of my life thus far.

Growing up I was very athletic, I am extremely smart (I really want to situate myself in the theoretical physics field) but lacked applying myself 100% and simply coasted by high school and college at 85% capacity, I never had problems having plenty of friends. I dont suffer from anxiety or depression, I suffer from overly-coddled only child disorder haha. My family is not wealthy by any means, but growing up they ALWAYS went out of their way to give me everything and anything I wanted that they never had and because of this I am impulsive and lack drive because I simply expect someone to hand me every thing. Not to the extent I used to, but with my current start of my new career, I still find myself saying "Eh, Ill do it tomorrow" or "I'll call them later".

As much growing up as Ive done in the past 6 months, I have plenty more to go. All of the self-realizations I have had have been great, but I still feel I need to get over the hump and help rid my self further of my negativity and rid myself of being content with coasting thru life and leaving every thing til later. I'd love to get myself into meditation practices and have been studying on how to do so so I may practice normally. This is why I think psilocybin could be useful to me because it may assist in furthering my pursuit for being fully independent on my transition away from my negativity and immature, impulsive ways. I do also have cacti on standby because I'd love to try mescaline with a good friend of mine who has extensive use with lsd, rc's, and shrooms. He tried DMT one day with me, and he even said it was the most wild 6 minutes he ever had.


I have no plans on trying LSD or any RC's, Id prefer to stick with what earth put here.

When the studies refer to a dose of 12mg, they are referring to pure psilocybin. 20mg of pure psilocybin is considered by many to be a full dose. IIRC, the average dried psilocybe cubensis contains about 1% psilocybin/psilocin. So 20mg pure psilocybin would be equivalent to approximately 2g fully dried mushroom material.

Here's a study that I have reviewed


http://www.hopkinsmedici.../GriffithsPsilocybin.pdf

The folks at Johns Hopkins found that 20mg of pure psilocybin was the optimal dose that maximized the potential for mystical experiences but minimized the risk of a 'bad trip' or psychotic reaction. Anything lower than that tended not be intense enough, and everything above that was too much.

I don't have access to the actual paper, but here's a pretty good rundown by Mother Jones:
http://www.motherjones.c...rooms-safe-still-illegal

Lately I find this statement kind of silly (not trying to be mean). We still don't know all the chemicals that are created naturally. For all we know there is an LSD tree somewhere. And earth also put opiates here so...

When human trials are done with substances they always use pure synthesized versions. And the amounts are in per kg measurements (patients body weight in kg).

Interesting to know as I find 2g dried shrooms to be the sweet spot for me. Controllable enough to keep negativity at bay yet strong enough to still be able to go deep and become aware of connections with the things I forget about from time to time.

The 4th of July is around the corner. I think a mushroom trip is in order.

Thanks Entheogenerator! That was what I'd figured.

And thank you Nathaniel and Acacia.

2g is what I was planning on going with, after consulting the Shroomery's Magic Mushroom Calculator While there are a lot of variables, it's a very interesting calculator. Specifically where it breaks down 5 different levels of trip, 1 being the slightest and lowest dose and 5 being a high dose (about 5-6g dried of cubensis) so far beyond the realm of imaginable possibility that youre simply one with the universe and you also are the universe at the same time haha.

Anarchy I simply mean by the fact that LSD at this point is more lab created than say mescaline, and shrooms and even DMT coming from plant/tree based life.

I like the idea of cacti and shrooms because they're truly a living part of our planet. When we find LSD in a tree, I'd be a little more eager to try it. The idea of a synthetic, lab drug to me reminds me too much of big pharma and doesnt sit well with me. The body is meant to dance with nature, as the body is nature. I dont even take advil for aches and pains.

Well that's sort of what I mean. Lab grade lsd is much different than Tylenol. I just find it silly to associate two things that are not the same thing.

As far as we know synthetic dmt is the same thing as a pure dmt product. I understand your view and I'm not attacking, this is just an observation.

But ya, 2g is absolutely amazing. Works great when taken with a few close friends, or alone. Can be fairly visual for me and gives a new level to my emotions. Music feels great. An extra gram just increases all of it and is also a good dose.

That sounds truly fantastic.

On this chart, where would you say it falls? Id certainly like to be somewhere in a midway of Level 2 and 3. A level 3 trip on the calculator comes out to 2.38g of cubensis in average batch of cubensis and a level 2 trip is 1.35. So I figured exactly 2g of dried would be just about a level 3.

Level 1
This level produces a mild "stoning" effect, with some visual enhancement (i.e. brighter colours, etcetera). Some short term memory anomalies. Left/right brain communication changes causing music to sound "wider".

Level 2
Bright colors, and visuals (i.e. things start to move and breathe), some 2 dimensional patterns become apparent upon shutting eyes. Confused or reminiscent thoughts. Change of short term memory leads to continual distractive thought patterns. Vast increase in creativity becomes apparent as the natural brain filter is bypassed.

Level 3
Very obvious visuals, everything looking curved and/or warped patterns and kaleidoscopes seen on walls, faces etc. Some mild hallucinations such as rivers flowing in wood grained or "mother of pearl" surfaces. Closed eye hallucinations become 3 dimensional. There is some confusion of the senses (i.e. seeing sounds as colors, etcetera). Time distortions and "moments of eternity".

Level 4
Strong hallucinations, i.e. objects morphing into other objects. Destruction or multiple splitting of the ego. (Things start talking to you, or you find that you are feeling contradictory things simultaneously). Some loss of reality. Time becomes meaningless. Out of body experiences and e.s.p. type phenomena. Blending of the senses.

Level 5
Total loss of visual connection with reality. The senses cease to function in the normal way. Total loss of ego. Merging with space, other objects, or the universe. The loss of reality becomes so severe that it defies explanation. The earlier levels are relatively easy to explain in terms of measureable changes in perception and thought patterns. This level is different in that the actual universe within which things are normally perceived, ceases to exist! Satori enlightenment (and other such labels).

I've been thinking about this a lot lately. I'm still not decided as to where I stand on the matter, but I find it interesting that some people are very adamant about only taking drugs that are known to occur in nature without human intervention.

And on that note, did you know that GHB (Gamma-Hydroxybutyric acid) is a naturally-occurring compound found in wine, beef, citrus fruits, and the bodies of most animals including humans?? I was kind of amazed when I learned this the other day. I do not know much about GHB. It is not something that has ever sparked my interest and I have no first-hand experience with the compound, but I guess I always kind of just assumed that it was man-made. Just a little fun fact for ya!

I personally find between 1-2g to be helpful in resetting or de-stressing myself for some more medicinal benefit. Or even starting at that point and then re-dosing a little more during the time period to extend it.

Studying chemistry a little bit (just enough to follow the reactions and hopefully understand the end result) for different things has lightened my concerns for using chemicals to extract or "make" a substance. I still dont want crazy things in my body but a reaction can totally negate a certain chemical for instance or minimally it is not in the final product. Anyways...I found GHB to be a very natural feeling and useful substance until it turned into abuse, like just about everything, too much is not good. It is interesting to read up on.

I have dealt with and am dealing with depression and anxiety for a long time. Currently I am not taking anti-depressants in the regular sense but since finding out about natural dessicated thyroid vs. the thyroxine they give for an underactive thyroid (which i have) and using 5-HTP for the 2 issues, it has become really manageable. I am very excited about having mushrooms again too for their benefits.