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Pictorial Iboga TA extraction Options
 
justine
#21 Posted : 12/12/2011 12:10:43 PM

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Great job rom! I'd go for the FASI salting Smile
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rOm
#22 Posted : 12/12/2011 12:57:29 PM

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I do now a quick water wash...
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
justine
#23 Posted : 12/12/2011 6:28:02 PM

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Anyway I'm not even sure that iboga TA alkaloids are salts, they might just be free bases so in the end if this tek is
as efficient as the one used by iboga TA suppliers it would be very interesting financially since 40g costs 130€ at ibogaworldand and got you a solid 8g while 4g TA costs more
than 180€ from the same supplier, it's incredible what they charge for extracting Rolling eyes That must be really easy money for them...
To see the world in a grain of sand, and to see heaven in a wild flower, hold infinity in the palm of your hands, and eternity in an hour.
- William Blake
 
rOm
#24 Posted : 12/14/2011 1:33:00 PM

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In this picture, we have the resulting liquid that now may be discarded, and the solids, TA in their freebase form.

The water wash part was just :

- Add de-ionised water to this extract, mix it and filtering it through coffee filter or vacuum system.
- The collecting solids are freebase so they don't dissolve in water.
The yield is now reduced to 3,2 grams (see picture).
- The yellow liquid is the impurities dissolved in water (see picture again).

So this number is now more in line with the 5 to 10% alcaloids in rootbark.
rOm attached the following image(s):
IMG_2168.JPG (1,668kb) downloaded 634 time(s).
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
rOm
#25 Posted : 12/14/2011 1:34:24 PM

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Next step, bioessay !
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
GratefulDad
#26 Posted : 12/14/2011 3:49:45 PM

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The HCl salts are much more stable and will keep their potency if one is going to store them for later use. If one wants a more complete TA with all the alkaloids, I would suggest doing the Acetone/HCl step, then just evaporating the acetone from the crystals (rather then separating the crystals from the acetone to dry), as this will leave the other alkaloids in, while the alkaloids that will form a salt with HCl stay in HCl form. This will at least allow the most important alkaloids to remain much more stable, making for a more potent extract, especially if it's to be stored for any length of time.
 
rOm
#27 Posted : 12/14/2011 5:51:03 PM

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SALTING :

The Freebase TA, weighed 3,2 grams was dissolve in acetone.

We know Ibogaïne, Ibogaline, Ibogamine bounds to hydrochloric acid but other alcaloids don't.
So, to preserve a fuller spectrum, we decided to salt with HCL but to save the other alcaloids left behind in acetone, in order to add them to the HCL salts.

The hydrochloric acid was added to acetone iboga freebase dissolved.

We see some alcaloids crushing.

This acetone acid solution will be let in fridge overnight to further salt.
rOm attached the following image(s):
IMG_2169.jpg (2,176kb) downloaded 610 time(s).
IMG_2171.jpg (2,368kb) downloaded 616 time(s).
IMG_2173.jpg (2,334kb) downloaded 608 time(s).
IMG_2174.jpg (2,193kb) downloaded 609 time(s).
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
endlessness
#28 Posted : 12/14/2011 5:57:27 PM

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Thanks for continuing the work rOm! might i ask, where do you have the info about the alkaloids that dont bind to HCl? What other alkaloids are they?
 
rOm
#29 Posted : 12/15/2011 11:36:27 AM

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The present investigation of Tabernanthe iboga root records the isolation of twelve compounds, which includes not only the four known alkaloids ibogamine, ibogaine, tabernanthine and iboluteine but also iboquine, desmethoxyiboluteine, the hydroxyindolenine derivatives of ibogaine and ibogamine, voacangine, gabonine, kisantine and kimvuline. Of these, the latter three have not been described previously. The current interest in Tabernanthe iboga initiated a more detailed investigation of the alkaloidal content of the root. Emphasis was placed both on the preparation of the major alkaloids in a state of high purity and on the isolation of the greatest possible number.

Source is here:

http://www.puzzlepiece.o...iterature/dickel1958.txt
Smell like tea n,n spirit !

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rOm
#30 Posted : 1/17/2012 1:27:21 PM

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250 mg of this TA was bioessayed. The effects are very clean and somewhere equal in potency to 2 grams of this rootbark.
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
samomi
#31 Posted : 1/20/2013 6:51:14 PM

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Good day!
Thank you, rOm and GratefulDad and other nexians for these extraction teks!Thumbs up


Could you please answer some questions of mineConfused

0. So how much vinegar/HCl4.0 should be added for pulls (on 40g bark: rOm - ~30ml, GD - ~200ml - quite a big difference or the HCl step accounts for it...)?
1. Why in rOm's tek to do 2 pulls with vinegar and then 2 pulls with HCl - why not only vinegar or only HCl?
2. Why in rOm's tek the pH of HCl solution for pulls should be 4.0? ('cause the crystals will precipitate?)
3. Will in GratefulDad's tek this procedure
Quote:
1: You now, take your acetone and add 15-18 mls of acetone per gram of freebase TA extract (brown freebase powder), and soak freebase in the filter with it. You can stir around the precipitate in the filter (again be careful not to poke a hole in it), and wash it two or three times with the SAME acetone. Do not go over 18 mls per gram of brown TA freebase, but be sure to soak as much color from the solid as possible. The filter should contain any bark crud, and any other impurities, when finished.
significantly (to say >1%) decrease the yield?

Hope the Q's are not too stupid Embarrased
believe in nexus
 
lowjackal
#32 Posted : 2/19/2014 3:13:55 PM

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You have any pics of the PTA after acetoned and filtered?
"Keep your friends close and your enemies dismembered."
Lowjackal original quote
 
Jees
#33 Posted : 2/19/2014 9:55:57 PM

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TA extract, PE extract, these abbreviations, what do they stand for please? Searched google and wiki here, could not find anything close to it. Thanks!
 
Red Eclipse
#34 Posted : 2/19/2014 11:06:32 PM
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Jees wrote:
TA extract, PE extract, these abbreviations, what do they stand for please? Searched google and wiki here, could not find anything close to it. Thanks!



TA stands for total alkaloid (aka full spectrum)
 
Jees
#35 Posted : 2/20/2014 11:12:57 AM

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Red Eclipse wrote:
...TA stands for total alkaloid (aka full spectrum)

Thanks, it seems "PE (extract)" means Plant Extract, I thought TA and PE referred to specific extraction tecs, was clearly searching to far for an explanation Pleased
 
rOm
#36 Posted : 2/20/2014 1:09:34 PM

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lowjackal wrote:
You have any pics of the PTA after acetoned and filtered?


No, but I plan on really digging this whole Iboga culture and extraction a lot more.

Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
Jox
#37 Posted : 6/10/2014 2:39:08 AM

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Hi all,

This sounds like a good tek. I did with ammonia, but it is not good for two reasons, it smells to much and in building situation it is not good. Second the TA forms on top and separation is hard.

NaOH is great idea but I didn't see washing off with H2O? As in this tek I assume that it will be highly NaOH contaminated?

Would washing dissolve some of the alkaloids like in harmala extractions.

Thanx
JoX
 
endlessness
#38 Posted : 6/11/2014 9:28:19 AM

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http://www.ibogaine.desk.nl/review-dotf.html

according to this, freebase ibogaine is insoluble in water so in theory washing it with a bit of water should remove NaOH and not lose significant amounts of alkaloids.

As mentioned by pm, just talking theory here, I have no experience with ibogaine extraction. Maybe someone else can chime in.
 
rOm
#39 Posted : 7/21/2014 1:34:43 PM

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Hey Jox,
I have washed the freebase in water and the numbers got down by half. Before washing thr FB with water we got 8 grams raw TA, after rincing we got 3,8 grams of TA.

It is very important to think about cleaning the product, as these strong freebase are very toxic.
I would call for an safer alternative freebase such as sodium carbonate next time I make TA.
White distilled vinegar or glacial acetic acid as acid and sodium carbonate as freebase.

Kind regards,

rOm
Smell like tea n,n spirit !

Toke the toke, and walk the walk !
 
Jox
#40 Posted : 7/21/2014 3:12:21 PM

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Hi rOm,

Do you think by washing TA with water you washed out some active ingredients. I do remember that TA is not soluble in water and endlessness got us a link for reference.

Neutralising vinegar with sodium carbonate, asks for a lot of the base, maybe do one step with NaOH, filter and re dissolve with vinegar and get freebase with s.carbonate.

But I still think that washing with water is OK.

What do you think?
 
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