I take a huge dose of the MAOI-A Parnate (Tranylcypromine); 160mg per day. (I carry nefidepine everywhere of course). No matter the dose of Ketamine*, LSD, Psylocybin Mushrooms, Fly Agaric, Opium, Mescaline that I take, I feel no effects, how could this be? What should I do to remedy it? All conventional contraindication warnings, though appreciated, are not necessary. Please feel free to speculate.

*At a high dose of Ketamine I ran into two creatures talking to one another (no visual), one of which excitedly talked through/to me for 20 min or so,in a sort of "electronic" language. Not at all like any DMT creatures I've met. (though I've only had 5 breakthroughs)

Can you help me with this dire dilemma fellow Nexians?

I heard that it's not the MAOI itself, but that everyday use of MAOIs has such an effect on serotonin that psychedelics are obstructed.

Wow, thank you. I don't know where else I would have got that piece of information. I hope if I stop the MAOI (going to try, starting this week by substituting HGH for it) the necessary aspects of the serotonin system regenerate.