I really think it is all about "How to work with it, and for what purposes."
I had good conversation with a Huichol about this a while ago, this was the context:
The Wirikuta desert is under attacked by open mining, mostly companies of Canada having bought the rights to shred open the desert surface (bye bye peyote) and process the minerals what lead to "poisoning" of the water. Universal story but here's the point out of the eyes of the Huichol ceremonies:
The ceremonies are done NOT for personal advantage, but are the mechanics that actual and factual keeps nature in balance and running. Nature forces pivoting on the ceremonies. Take the ceremonies away and the whole nature of the earth is compromised. THAT is the real threat. Western people do not know, recognize, see, believe this to be true, and use peyote for personal purposes. This makes deep sorrow in the heart of the Huichols. Therefore I think the Major speaks his words. They really believe Peyote gave instructions what to do with it, how to do, when to do, etc, and any other use is not respecting the will of the peyote,
and they are afraid for the consequences.
Their "holy trinity": Deer - Peyote - Kauyumari (the first God living in Wirikuta desert).

We are all free to call their approach BS or superstitious religion and have it our way nonetheless. But note that far away from Huicoles, very same, identically lines of thought live among the Kogi indians of Colombia, they also truly are convinced that their (Coca - aya) ceremonies run nature/balance on the globe. Coincidence?
Having a genuine Huichol ceremony tomorrow night, doing so I will respect their ways.
The sample was granted to spread along with their concerns, they really ask our help.