OOOOK. Previous post was deleted, soo let me just say that, THIS POST HAS NOTHING TO DO WITH MDMA OR MDA. IF YOU ARE HERE TO COMMENT ABOUT HOW SAFROLE IS ISOSAFROLE IS A BLAH BLAH BLAH, LEAVE PLEASE SO THAT WE MAY LEARN SOMETHING. THANKS YAH'LL =]

https://www.dmt-nexus.me...osts&t=9745&p=2

This is an old discussion about a cold water tea extraction of sassafras. The poster 69ron, states that SWIM made a cold water extraction with the plants rootbark, and noticed the presence of an unknown/unresearched alkaloid. There was a problem however, the cold water extract didn't rid the plant material of its oils, containing a specific oil, maybe safrole, which seemed to lower its potency as an alkaloid. SWIM then decided to rinse/soak the plant material in an acetate, removing the oils from the plant material, without removing the alkaloid/s. Then he proceeded with the cold water extraction. VWALA! Alkaloid supremacy achieved =]

What Tim,the raging bullratman, wants to know is how can REMOVE the oils, without the use of acetate, or any other harsh chemicals. I've taken basic chemistry back in school and math was bogus and so was playing puzzle pieces, and he's not very knowledgeable about it either. So I cant help him. We are but simple kitchen herbalists =]

Also distilling the oil or boiling it in general WILL destroy the desired unknown alkaloid.

ehhh???anyone?

69ron made a lot of interesting and hopeful but often unbacked or dubious claims. What is the evidence there is an alkaloid of interest, and how do we know its safe in any way? It may be toxic, or it may be there's no alkaloid of interest.

Searching on google scholar, all I can find is this:

http://agris.fao.org/agr...E/XE77079.xml;XE7705023

so now one would have to find pharmacology/toxicity and solubility info on those alkaloids.

Why are you so interested in sassafras? There are so many other plants out there with safer profile of known alkaloids with known pharmacology and very interesting effects, or others more unstudied but with more extensive history of human usage and anecdotal evidence that indicates safety, etc.

Please be safe

Why does one take the unknown road to get home rather than the one one is used to?

Thanks Endless for the post and for checkin out my post ;]

I understand that impulse, im known to always go off the beaten track, but I don't ingest the unknown road

Just want people to be safe out there, no offense meant! Be well!

because he's not after alkaloids, like he incorrectly asserts. he's in search of propenyl-benzodioxole derivatives, which get reductively aminated to yield the alkaloids of interest.

*isn't fooled*

"home" would be the Nook. this isn't the Nook.

*edit*
after taking a look at 69ron's post, he mentions people doing A/B on sassafras, and correctly
mentions that the result of this would not be safrole (safrole does not have an amine to protonate/deprotonate). thus, the alkaloid may be some [tetrahydro]benzylisoquinoline derivative

interesting...according to the fiki, aporphine is a 5HT7 antagonist. so are DMT and LSD.

http://en.wikipedia.org/wiki/5-HT7_receptor

=] no offense taken, thanks endless, lovin you to!

Really? You dont think that cinnamolaurine is the main focus here?

the first time i made sassafras tea i thought i felt the most amazing orgasmic feelings, that was two years ago, since i have achieved no effects. ive made a post where i attempt to do it again, and i simply got a very mild pressure on my temples, and nausea. i dont see much use in continuing this.... i personally think 69ron was doing some great research until he started talking about propyl and allybenzenes... anyway keep experimenting and let us know if you get positives effects

Safrole is a potential carcinogenic.

I dont know if different sassafras plant concoctions have been analysed but I'd be wary.

And please benz and others, lets not turn this thread even a little into the direction of synthesis of scheduled compounds.

There's about as much info indicating that safrole is toxic as there is indicating that one can consume moderate amounts on a regular basis and lead a long, healthy life as many cajuns I know do. The area is still very grey and tainted with opinion on most fronts, so it seems to me the most important thing to note about this spectrum of psychoactives is the good ol' advice: "Start slow, be responsible and when you get the message, hang up the phone"

Safrole preparations can often bring about very strong psychoactive and physical effects. Most often these effects aren't noticed or cause stress in the user, but when used with preparation and purpose, small doses of safrole/sassafrass can be just INCREDIBLE and very maleable and usable. Also: there are relatively few substances that deliver this particular type of energy in a predictable fashion and without causing very tiring brain and body damage, or additional potentially unwanted psychoactive effects. Other chemicals like this tend to be very stimulating or psychedelic, while sass is calm, clean and gentle (but oh so powerful).

This isn't any good reason to go chomping down the stuff wholesale, but rather I'm just pointing out that there are many very good reasons to use this plant and that the benefits can very much be worth the risk if the user knows how to use the drug to its maximum potential and slightest detriment.

Happy Trails and Much Luv
Hg

Are you saying its for sure not carcinogenic? Can you please explain your critique to the studies/data? For example this:
Safrole and oesophagus cancer
Safrole toxicity and interaction with CYP
Safrole and hepatocellular carcinoma
DNA adducts derived from safrole and related compounds (cant find full paper)

If not, then are you saying that somehow a user can consciously avoid cancer? If so, how? Or are you implying increased cancer risk is "worth it" for the benefits?

When you say the "benefits can be worth the risk", seems you are already deciding for others instead of letting them decide for themselves.

a minor constituent of sassafras, containing both benzodioxole and tertrahydroquinoline
structures, so it would behoove you to implement a means of separating
it from the other benzodioxoles

so then the acetate wash might rid itself of the benzodioxoles? Leave the tertrahydroquinline?

*Edit*

BTW was looking for an alternative to using acetate, something more simplr maybe?

Loving the thread title. <3

No, I am not saying that it is or is not carcinogenic or toxic. No, I won't explain with studies or data because I'm assuming you're bright enough to think for yourself, do your own research and make your own decisions as an intelligent individual. The burden of proof is not on me and you're not obligated to read or believe what I post. I am not going to spend my time scouring the internet for your edification.

It is the god-given right of every living being to consume what he, she or it pleases.

Please stop putting words in my mouth, I don't care to put up with that... I am not making decisions for anyone or saying that one should use the substance. I'm saying that many people do use the substance in moderation to great benefit and live long healthy lives. The came can be said for cigarettes and other potentially deadly substances. Petty picking on people who offer a point of view other than your own is not harm reduction.

Telling other humans what they should and should not eat, asking them to justify their thoughts and opinions, and abstracting words in order to start ridiculous arguments seems such a sorry waste of time that divides people and causes stress. In my opinion it would be kind of you not to alienate others and spread tension.

You can drop the self-righteousness (and the abrasiveness that accompanies so many of your posts, as you yourself acknowledge).

The attitude states:


This means that the burden of proof IS on you, especially when you choose to post statements that could adversely affect the health and well being of individuals who follow your claims/advice. It is NOT "petty picking on" to request that someone back up their statements with a valid source (or not make such statements).

You've been here for a while and I would expect you to understand that we take harm reduction quite seriously. In my opinion, it would be kind of you to adhere to the attitude of this site, which you have chosen to register on of your own free volition.

Kinda the reason I posted this ^^^

Just do a cold water extraction on an oz of bark and filter. Saves you the trouble of defatting the safrole with acetone. I can verify sassafras is active, very similar to the mental head-space of MDMA. The first time I drank sassafras tea was quite memorable... as were other times when a large amount was consumed. I tend to get effects from making tea traditionally as well, much more subtle in nature but seems to combine well when mixed with herbs such as muira puama & catuaba.

I used to actually chew sassafras root bark that was harvested by a friend of mine, I would chew it with coca & kratom leaf and the sassafras noticeably reduced any edge caused by the stimulating chews. My guess is that sassafras is a universal serotonin releaser with a mild stimulant action. It feels sort of like 5-htp but a little different, more energized love euphoria while 5-htp reminds me of a more of a peaceful feeling. Similar but unique.

Thank you Heretic