Yeah sort of. What can happen is that some plant material might have more fats and impurities than others, but that can always be cleaned up later on with a re-x or re-a/b if its not as clean as you want. Also experimenting with FASA/FASI salting is a good way to bypass plant impurities and crash out the alkaloids, check out BLAB and other such info in the wiki and forum.
As for which amount, if youre extracting from DMT, I think 75-100g is a good amount to extract for first times.. for other plant sources will depend how potent they are. Just consider that you should extract around at least 10-20 doses otherwise it might not be worth it.
As for expecting decent result, if the plant material has alkaloids and you do the extraction properly, youll get all/most of what is there. If plant material is bad, you cant expect good result and doesnt matter what you do it will still be bad. If you do bad technique, it depends how bad you do.
