A forum member who's name escapes me mentioned somewhere before that actives of rue are mostly or entirely contained in shells of seeds therefore grinding is unnecessary. Being sceptical of the claim and assuming great alkaloid loss 5g of seed was boiled to determine if sufficient MAO inhibition will be achieved for purposes required, and compare how it would feel to a standard 3g dose. It worked great and was stronger - although impossible to say that it would feel like a regular dose of 5g would. Taste and smell were greatly improved however. It was as bitter but lacked a certain flavour of nastiness that ground syrian rue has.

Given how cheap rue is, it seems to me that an extraction on whole seed is something worth trying because rigorous filtering process(or decanting) would no longer be needed. Less smell too - boiling ground rue in vinegar is quite a process to endure If the forum member is correct, alkaloid content wont be reduced, or if it will it won't be by much, I guess up to 10% is acceptable. A pure speculation - but what if Manske step won't be needed ? What if only a trace of vasicine and vasicinone makes it in this way ? It would be interesting to see how the process would be different this way. Any ideas or input on this idea, or perhaps its been done already ?

I've done extraction boiling non-ground seeds with yields very comparable to those with ground seeds. All my rue extractions were low but I think it was like

1st - 1.4% ground
2nd - 1.8% ground
3rd - 1.7% non-ground

Have several grams in tinctures so haven't tried it since then though.

I tested ground vs non ground and non-ground yield was significantly smaller. Dont remember the exact numbers though.

Funny thing is someone else (infundibulum) tested the same thing using a coffee expresso machine to extract from the rue, and he says yields were not significantly different from ground vs non-ground. So what we need is more people doing side-by-side tests to confirm or disconfirm either way.

Interesting, will report with the results myself.

I never grind when doing oral rue, just take 3-4grams boil it gentle in some acidic water for 30mins and drink with very little nausea and always full maoi effect.

Personally i think rue is alot easier than caapi when it comes to nausea and stomach problems, although caapi is much more therapeutic for me.

There is also this thread around i cannot seem to spot at the moment showing differences in yield by utilising a pressure cooker (bigger yiels). Personally i would suggest taking extra steps to maximise yields : grinding can be counter productive as far ar filtering goes, but give a go at microwaving the seeds and/or boiling them in pressure cooker.

Here is the thread but...its not of much use anymore https://www.dmt-nexus.me...aspx?g=posts&t=18985

Ι hope Mydriasis puts it back together because it was a really nice post

After a few experiments it seems that unground rue suits me better. Mostly due to consistency after A/B(I do Manske first). It comes out really fine and powdery. While ground extraction produces more stink(neighbours can smell it), and most importantly requires clean-up after A/B, perhaps even multiple A/Bs or Manske's to have a comparable end-product. Yields are similar, although inconclusive due to small # of trials.

Overall much less hassle when working with unground syrian rue.