DMT-Nexus member
Posts: 100 Joined: 15-May-2011 Last visit: 19-Oct-2011
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5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by a-adrenoceptor antagonists in rats 5-MeO-DMT-induced analgesia is blocked-brjpharm00312-0038.pdf A Methodology for Studying Various Interpretations of the N,N-dimethyltryptamine-Induced Alternate Reality paralleldmt.pdf Ayahuasca Healing Beyond the Amazon: The Globalization of a Traditional Indigenous Entheogenic Practice Ayahuasca+Healing+Beyond+the+Amazon+-+Preprint+2009.pdf Ayahuasca Tourism: A Cautionary Tale Ayahuasca_Tourism.pdf β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO) b-carboline in rue.pdf Cult-Hoasca: A Model for Schizophrenia. cult hoasca.pdf Entheogens and Existential Intelligence: The Use of Plant Teachers as Cognitive Tools CJE27-4-tupper.pdf Hallucinogens as a Discriminative Stimuli: Generalization of DOM to a 5-methoxy-N,N-dimethyltryptamine STIMULUS HALLUCINOGENS AS A DISCRIMINATIVE STIMULI.pdf Hyperbolic: Divining Ayahuasca Divining_Ayahuasca.pdf Pharmahuasca, Anahuasca and Vinho da Jurema: Human Pharmacology of Oral DMT Plus Harmine oral dmt plus harmine.pdf Plants as Teachers Among 4 Mestizo Shamans of Iquitos, Peru ethnopharmacology_plants_teachers.pdf Psychedelic Drugs: Steric Factors That Predict Psychotropic Activity PSYCHEDELIC DRUGS: STERIC FACTORS THAT PREDICT PSYCHOTROPIC ACTIVITY.pdf Psychological Effects of (S)-Ketamine and N,N-Dimethyltryptamine (DMT): A Double-Blind, Cross-Over Study in Healthy Volunteers Gouzoulis DMT ket 2005.pdf Steric and-Electronic Relationships among Some Hallucinogenic Compounds Steric and-Electronic Relationships among Some Hallucinogenic Compounds.pdf Suppressive Effect of Mitragynine on the 5-Methoxy-N,N-dimethyltryptamine-Induced Head-Twitch Response in Mice mitragynine-5meodmt-twitch.pdf The effect of selective 5-hydroxytryptamine uptake inhibitors on 5-methoxy-N,N-dimethyltryptamine-induced ejaculation in the rat The effect of selective 5-HT uptake inhibitors on 5-MeO-DMT-induced ejaculation in the rat-brjpharm00345-0020.pdf The Paradox of 5-Methoxy-N,N-Dimethyltryptamine: An Indoleamine Hallucinogen That Induces Stimulus Control Via 5-HT1A Receptors 5-meo-dmt.5ht1a.paradox.pdf Thieno[3,2-b]- and Thieno[2,3-b]pyrrole Bioisosteric Analogues of the Hallucinogen and Serotonin Agonist N,N-Dimethyltryptamine nichols-thienopyrroles.pdf Two things to keep in mind:
1) It is all lies.
2) There is no privacy on the Internet.
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DMT-Nexus member
Posts: 100 Joined: 15-May-2011 Last visit: 19-Oct-2011
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Attached is a text file containing the full title, authors, abstract, keywords, file name (not always identical to the one used in the post), and the number of the post where the file was uploaded, for all the articles in the posts above this one (#1 to #61) to this date. If you find any errors or omissions feel free to PM me with the correction. -Tse Two things to keep in mind:
1) It is all lies.
2) There is no privacy on the Internet.
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DMT-Nexus member
   
Posts: 1367 Joined: 19-Feb-2008 Last visit: 12-Jun-2016 Location: Pacific Northwest
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In vivo long-term kinetics of radiolabeled n,n-dimethyltryptamine and tryptaminehttp://www.ncbi.nlm.nih.gov/pubmed/21622895Quote:Abstract
N,N-dimethyltryptamine (DMT), a strong psychodysleptic drug, has been found in higher plants, shamanic hallucinogenic beverages, and the urine of schizophrenic patients. The aim of this work was to gain better knowledge on the relationship between this drug and hallucinogenic processes by studying DMT behavior in comparison with tryptamine.
METHODS:
(131)I-labeled DMT and tryptamine were injected into rabbits. γ-Camera and biodistribution studies were performed. Brain uptake, plasma clearance, and renal excretion were assessed for each indolealkylamine.
RESULTS:
DMT and tryptamine showed different behavior when brain uptake, residence time, and excretion were compared. Labeled DMT entered the brain 10 s after injection, crossed the blood-brain barrier, and bound to receptors; then it was partially renally excreted. It was detected in urine within 24 h after injection and remained in the brain, even after urine excretion ceased; up to 0.1% of the injected dose was detected at 7 d after injection in the olfactory bulb. In contrast, tryptamine was rapidly taken up in the brain and fully excreted 10 min after injection.
CONCLUSION:
To our knowledge, this is the first demonstration that exogenous DMT remains in the brain for at least 7 d after injection. Although labeled DMT and tryptamine behave as agonists for at least 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 2C receptor, trace amine-associated receptor, and σ-1 putative receptor targets, binding to the latter can explain the different behavior of labeled DMT and tryptamine in the brain. The persistence in the brain can be further explained on the basis that DMT and other N,N-dialkyltryptamines are transporter substrates for both the plasma membrane serotonin transporter and the vesicle monoamine transporter 2. Furthermore, storage in vesicles prevents DMT degradation by monoamine oxidase. At high concentrations, DMT is taken up by the serotonin transporter and further stored in vesicles by the vesicle monoamine transporter 2, to be released under appropriate stimuli. Moreover, the (131)I-labeling proved to be a useful tool to perform long-term in vivo studies.
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DMT-Nexus member
Posts: 119 Joined: 21-Jan-2011 Last visit: 19-Jul-2011
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Any chance someone could grab up: New aspects of intramolecular hydrogen transfer in some ortho-substituted aryl radicals Seemon H. Pines, Robert M. Purick, Robert A. Reamer, George Gal J. Org. Chem., 1978, 43 (7), pp 1337–1342 DOI: 10.1021/jo00401a011 Publication Date: March 1978 and A simple preparation of phenols from diazonium ions via the generation and oxidation of aryl radicals by copper salts Theodore Cohen, Albert G. Dietz Jr., Jane R. Miser J. Org. Chem., 1977, 42 (12), pp 2053–2058 DOI: 10.1021/jo00432a003 Publication Date: June 1977 It's been fun. Thanks for all the wisdom.
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Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos
Posts: 4661 Joined: 02-Jun-2008 Last visit: 30-Apr-2022
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Mydriasis wrote:Any chance someone could grab up:
New aspects of intramolecular hydrogen transfer in some ortho-substituted aryl radicals
Seemon H. Pines, Robert M. Purick, Robert A. Reamer, George Gal
J. Org. Chem., 1978, 43 (7), pp 1337–1342
DOI: 10.1021/jo00401a011
Publication Date: March 1978
and
A simple preparation of phenols from diazonium ions via the generation and oxidation of aryl radicals by copper salts
Theodore Cohen, Albert G. Dietz Jr., Jane R. Miser
J. Org. Chem., 1977, 42 (12), pp 2053–2058
DOI: 10.1021/jo00432a003
Publication Date: June 1977 There you go! Need to calculate between salts and freebases? Click here! Need to calculate freebase or salt percentage at a given pH? Click here!
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Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos
Posts: 4661 Joined: 02-Jun-2008 Last visit: 30-Apr-2022
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Entropymancer wrote:In vivo long-term kinetics of radiolabeled n,n-dimethyltryptamine and tryptaminehttp://www.ncbi.nlm.nih.gov/pubmed/21622895Quote:Abstract
N,N-dimethyltryptamine (DMT), a strong psychodysleptic drug, has been found in higher plants, shamanic hallucinogenic beverages, and the urine of schizophrenic patients. The aim of this work was to gain better knowledge on the relationship between this drug and hallucinogenic processes by studying DMT behavior in comparison with tryptamine.
METHODS:
(131)I-labeled DMT and tryptamine were injected into rabbits. γ-Camera and biodistribution studies were performed. Brain uptake, plasma clearance, and renal excretion were assessed for each indolealkylamine.
RESULTS:
DMT and tryptamine showed different behavior when brain uptake, residence time, and excretion were compared. Labeled DMT entered the brain 10 s after injection, crossed the blood-brain barrier, and bound to receptors; then it was partially renally excreted. It was detected in urine within 24 h after injection and remained in the brain, even after urine excretion ceased; up to 0.1% of the injected dose was detected at 7 d after injection in the olfactory bulb. In contrast, tryptamine was rapidly taken up in the brain and fully excreted 10 min after injection.
CONCLUSION:
To our knowledge, this is the first demonstration that exogenous DMT remains in the brain for at least 7 d after injection. Although labeled DMT and tryptamine behave as agonists for at least 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 2C receptor, trace amine-associated receptor, and σ-1 putative receptor targets, binding to the latter can explain the different behavior of labeled DMT and tryptamine in the brain. The persistence in the brain can be further explained on the basis that DMT and other N,N-dialkyltryptamines are transporter substrates for both the plasma membrane serotonin transporter and the vesicle monoamine transporter 2. Furthermore, storage in vesicles prevents DMT degradation by monoamine oxidase. At high concentrations, DMT is taken up by the serotonin transporter and further stored in vesicles by the vesicle monoamine transporter 2, to be released under appropriate stimuli. Moreover, the (131)I-labeling proved to be a useful tool to perform long-term in vivo studies. ^^ This article is a brilliant find! I hope to find some time and write a comprehensive review for laymen on that, because its implications are very important and interesting to just pass by unnoticed! Need to calculate between salts and freebases? Click here! Need to calculate freebase or salt percentage at a given pH? Click here!
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DMT-Nexus member
Posts: 14191 Joined: 19-Feb-2008 Last visit: 06-Feb-2025 Location: Jungle
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7 days in the brain??? thats impressive!
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Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos
Posts: 4661 Joined: 02-Jun-2008 Last visit: 30-Apr-2022
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endlessness wrote:7 days in the brain??? thats impressive! Yup, that's insane! Need to calculate between salts and freebases? Click here! Need to calculate freebase or salt percentage at a given pH? Click here!
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DMT-Nexus member
Posts: 180 Joined: 24-Oct-2010 Last visit: 12-Oct-2015
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DMT-Nexus member
Posts: 119 Joined: 21-Jan-2011 Last visit: 19-Jul-2011
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Thanks infund! It's been fun. Thanks for all the wisdom.
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Skepdick
Posts: 768 Joined: 20-Oct-2009 Last visit: 26-Mar-2018 Location: Norway
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Infundibulum wrote:
^^
This article is a brilliant find!
I hope to find some time and write a comprehensive review for laymen on that, because its implications are very important and interesting to just pass by unnoticed!
Looking forward to the review!
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omnia sunt communia!
Posts: 6024 Joined: 29-Jul-2009 Last visit: 25-Feb-2025
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GAS-LIQUID CHROMATOGRAPHIC RETENTION INDICES OF 131s SUBSTANCES OF TOXICOLOGICAL INTEREST ON SE-30 OR OV-1 STATIONARY PHASE Wiki • Attitude • FAQThe Nexian • Nexus Research • The OHTIn New York, we wrote the legal number on our arms in marker...To call a lawyer if we were arrested. In Istanbul, People wrote their blood types on their arms. I hear in Egypt, They just write Their names. גם זה יעבור
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Stiletto Stoner
Posts: 1132 Joined: 18-Nov-2008 Last visit: 15-Mar-2015 Location: Blazin'
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Drying of Organic Solvents: Quantitative Evaluation of the Efficiency of Several Desiccants D. Bradley G. Williams and Michelle Lawton Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa J. Org. Chem., 2010, 75 (24), pp 8351–8354 DOI: 10.1021/jo101589h http://pubs.acs.org/doi/abs/10.1021/jo101589hGot GVG ? Mhm. Got DMT ? Pandora wrote:Nexus enjoys cutting edge and ongoing superior programming skills of the owner of this site (The Traveler), including recent switching to the .me domain name. I'm still, I'm still Jenny from the block Simon Jester wrote:"WTF n00b, buy the $100 vapor pipe or GTFO" Ignorance of the law does not protect you from prosecution
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DMT-Nexus member
Posts: 14191 Joined: 19-Feb-2008 Last visit: 06-Feb-2025 Location: Jungle
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That link doesnt work. Im not sure if you were asking for it or if the link you posted should have the full file.. Anyways, its attached here. Unfortunately it does not talk about the drying of solvents with methods such as used here (magnesium sulphate, etc). The publication is about molecular sieves and silica or alumina. Very interesting nonetheless! So im attaching: Desiccant efficiency in solvent drying. A reappraisal byapplication of a novel method for solvent water assay David R. Burfield, Kim-Her Lee, and Roger H. Smithers J. Org. Chem., 1977, 42 (18 ), 3060-3065 which does talk about some stuff like calcium chloride, magnesium sulphate, etc
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DMT-Nexus member
Posts: 14191 Joined: 19-Feb-2008 Last visit: 06-Feb-2025 Location: Jungle
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Can anybody try to find this paper; Agurell, S.; Holmstedt, B.; Lindgren, J. E. (1968 ) Alkaloid content of Banisteriopsis rusbyana. Am J Pharm 140:148-151 http://www.ncbi.nlm.nih.gov/pubmed/5698439
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Stiletto Stoner
Posts: 1132 Joined: 18-Nov-2008 Last visit: 15-Mar-2015 Location: Blazin'
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endlessness wrote:That link doesnt work.
Does too  It points to the abstract. Would appreacite if you can access it. Got GVG ? Mhm. Got DMT ? Pandora wrote:Nexus enjoys cutting edge and ongoing superior programming skills of the owner of this site (The Traveler), including recent switching to the .me domain name. I'm still, I'm still Jenny from the block Simon Jester wrote:"WTF n00b, buy the $100 vapor pipe or GTFO" Ignorance of the law does not protect you from prosecution
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DMT-Nexus member
Posts: 14191 Joined: 19-Feb-2008 Last visit: 06-Feb-2025 Location: Jungle
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its attached in that post you quoted from me 
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Stiletto Stoner
Posts: 1132 Joined: 18-Nov-2008 Last visit: 15-Mar-2015 Location: Blazin'
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endlessness wrote:its attached in that post you quoted from me Uh-huh. Got GVG ? Mhm. Got DMT ? Pandora wrote:Nexus enjoys cutting edge and ongoing superior programming skills of the owner of this site (The Traveler), including recent switching to the .me domain name. I'm still, I'm still Jenny from the block Simon Jester wrote:"WTF n00b, buy the $100 vapor pipe or GTFO" Ignorance of the law does not protect you from prosecution
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Kalt und Heiß, Schwarz und Rot, Kürper und Geist, Liebe und Chaos
Posts: 4661 Joined: 02-Jun-2008 Last visit: 30-Apr-2022
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As requested by inmotion: A Character Analysis of the Secondary Products of the Porpidiaceae (Lichenized Ascomycotina) Need to calculate between salts and freebases? Click here! Need to calculate freebase or salt percentage at a given pH? Click here!
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DMT-Nexus member
Posts: 473 Joined: 07-Aug-2011 Last visit: 10-Jan-2014
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An interesting article on chiral resolutions mentioning a very simply prepared stationary phase. Thanks shaolin for grabbing this for me
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