I'm currently on Citalopram and Olanzapine. Citalopram is a SSRI and a anti depressent. Olanzapine ssri and an anti depressant similair to prozac.

I'm in a good headspace right now. Thanks to meditation and probably prescription drugs. When I do do dmt I will start at a low sub breakthrough dosage and evaluate how I feel in the week(s) after that. Building up or building down as I see fit. I'm just wondering if it is a physically dangerous combination.

As long as you're smoking pure spice and not mixing any MAOIs in there, and you feel like you're in the right headspace, I don't believe they would make a bad combo. I just don't think you'd want to have a feeling of intoxication from them.

Sorry to contradict without a definite answer, but I'm near sure I heard that SSRI medication used in combination with drugs that can alter seratonin activity can result in seratonin syndrome which is potentially fatal. And as far as I am aware, DMT can alter seratonin activity. Perhaps I have this wrong, but better to be sure to rule this out before continuing.

yeah just a month ago a member posted his bad report about one of theese syndrome,he thought he was dieing must be very carefull with ssri with substance that influence the ways of the serotonine..you could die due to this syndrome

swim did not know it could be toxic in combination with dmt , swim in the past has done ssri prozac exactly and his muhsroom and lsd trips where much milder if affects alot the experiencie but i thought that dmt would act alike that like a milder experience

A lot of people think they are dying when using psychedelics, this doesnt mean they were in danger...

Corpus_Callosum should give us a better medical advice here but im pretty sure SSRI's and dmt/psychedelics is not really a dangerous combination (but MAOI or amphetamines such as MDMA can be very dangerous to mix with that! Im talking about only vaporized dmt or other 5-ht2a classic oral psychedelics).

Check this older discussion, specially Evening Glory and bufoman's posts:

https://www.dmt-nexus.me...spx?g=posts&t=12292

Citalopram is an antidepressant of the SSRI class;olanzapine is not an antidepressant per se- its actually an anti-psychotic medication which is used as an add-on in certain depressives.

Whats the underlying diagnosis thats been attached to your problems?

The combination of SSRIs and FB vaporised DMT ie with no MAOI is not physically hazardous; you may find that the olanzapine reduces the effects of DMT by virtue of its anti-psychotic effect (mediated through dopamine receptors).

Probably the most important issue is your present state of wellness (or otherwise) and the effect that something as profound as vaporised DMT can have on your mental state subsequent to the experience.Hence the importance of the underlying diagnosis and the extent of the problems youve previously had.

The danger doesn't arise from anything that can just "alter seratonin activity". MAOIs for example inhibit the MAO that keep seratonin in check and balanced so as a result there can be an unbalanced flood of seratonin. This is not the case with freebased DMT without MAOIs. And yeah, in terms of the anti-psychotic medication, that should simply block or reduce DMT's effects, but shouldn't be hazardous. I'm pretty sure mushrooms for example can "alter seratonin levels" and yet if you go to the hospital on a freakout, the first thing they'll give you is xanax which I believe is an SSRI (if not antidepressant). In terms of the user who posted his bad report, there was probably a case of intoxication with the SSRI he was using or he may have had a poor "set" (as in set and setting) which could have lead to the negative experience.

If someone were to present at an ER having freaked out on a conventional psychedelic, the treatment options depend on how 'disturbed' the poor tripper was.A mildish freakout may just require some reassuring words; a more pronounced freakout would merit a benzo (of which xanax is a modern derivative).A full-on freakout with no discernible links to the consensus reality would probably get a benzo with a dose of anti-psychotic such as chlorpromazine/haloperidol.

Buspirone is the only anxiolytic sedative which goes badly with MAOIs.