DMT-Nexus member
Posts: 1045 Joined: 12-Mar-2010 Last visit: 11-Jun-2024 Location: Urf
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downwardsfromzero wrote:In the area of native usage the occasional death from iboga root powder doses is not unheard of. I'm pretty sure this is on the ethnopharmacological record. It would be nice to have a thread specifically discussing this aspect of the matter since this thread is targetted on the pure tabernanthalog compound.
I would personally get an EKG done before embarking on any deeper exploration of iboga in whatever form. Mind you, I am getting on a bit. Maybe a wrinkle and a grey hair or two. I appreciate your kindness in asking me to start my own thread about this. I just felt the need to chime in since it seemed that the premise of the experiments was that of necessity--because there weren't any reasonably safe ways to get the benefits from iboga. I still believe the experiments are unnecessary, but I'll continue my perspective-sharing in another thread. From the unspoken
Grows the once broken
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Boundary condition
 
Posts: 8617 Joined: 30-Aug-2008 Last visit: 07-Nov-2024 Location: square root of minus one
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You're very welcome - it raises an interesting point of discussion and between us all we should be able to find a lot of good data. Maybe you know, I have a foot in both camps, having a firm grounding in chemistry alongside some powerful plant and nature spiritual/mystical experiences. Horses for courses, you might say. I tend not to say as much about the spiritual and mystical stuff because my trained vocabulary is on the other side of the fence. βThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work." β Jacques Bergier, quoting Fulcanelli
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Boundary condition
Posts: 8617 Joined: 30-Aug-2008 Last visit: 07-Nov-2024 Location: square root of minus one
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Shizballs wrote:downwardsfromzero wrote:PS - considering this is technically a RC you ought to post some safety information to go with it. Them's the rules. Of course. The pharmacological screening results are attached. Cameron et al. wrote:
The effects of TBG (10 ΞΌM) on a wide range of targets was assessed by Eurofins Discovery. Assays were conducted in duplicate and the results were averaged. Targets with β₯50% inhibition are highlighted in blue. Exact n values for each experimental condition are reported in Supplementary Table 1. Specific statistical tests, information on reproducibility and exact P values are reported in Methods and in Supplementary Table 1.
Something that initially concerned me was inhibition of both the serotonin transporter and MAO-A. It is common knowledge on here that MAOI + SSRI is a potentially lethal combination, so I was extremely careful to start with very low doses below 5 mg and work my way up. I'm guessing that the actual MAO inhibition is much lower in vivo because I haven't experienced even minimal serotonin syndrome symptoms. Thanks. While you can't post in the actual RC or Nootropics sections yet, maybe (with a little luck) you'll be able to soon, so it seems pertinent to show you this message regarding such things: https://www.dmt-nexus.me...aspx?g=posts&t=40448What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity  )? βThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work." β Jacques Bergier, quoting Fulcanelli
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Research & Development
Posts: 451 Joined: 12-Mar-2019 Last visit: 25-Oct-2024
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endlessness wrote:This paper names 2 examples of rootbark-related deaths and 2 more of total alkaloids-related death and another that could be total alkaloid or rootbark (plus a bunch of pure ibogaine-related deaths). This is from 2012, there might be more cases since then if you search a bit. Dang, reading through this scares me out of ever wanting to try Ibogaine as I'm a big drinker who is prehypertensive. A lot of deaths in that paper related to opiate use, cocaine use, methadone etc. But some we're just from myocarditis and myocardial infarction, proving that Ibogaine really raises your blood pressure. What a terrible way to go. 🌳👨β🔬🌳 - My A/B Hot Plate TEK - 🌳👨β🔬🌳 🍜🍜🍜 - Don't Heat Your Naphtha, Heat Your Soup! - 🍜🍜🍜 β΄β΄β΄ - White Spice vs Yellow Spice - 🌟🌟🌟 "You are an explorer, and you represent our species, and the greatest good you can do is to bring back a new idea, because our world is endangered by the absence of good ideas. Our world is in crisis because of the absence of consciousness." - Terence McKenna 🙌 "Dang, that's really impressive for a first extraction. Those xtals are nicely resolved." - Benzyme 🙌
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DMT-Nexus member
Posts: 35 Joined: 07-Jun-2019 Last visit: 16-Nov-2023 Location: Bompton
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downwardsfromzero wrote:While you can't post in the actual RC or Nootropics sections yet, maybe (with a little luck) you'll be able to soon, so it seems pertinent to show you this message regarding such things: https://www.dmt-nexus.me...aspx?g=posts&t=40448What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity )? Thanks, I'll have a look. downwardsfromzero wrote:What do you find to be the subjective benefits of TBG? Any downsides, perhaps (other than lack of psychoactivity )? I've used ibogaine VERY extensively through the years. It helps a lot with getting back to being productive when I am in a low point. It's hard to say atm but it does seem to have the same effect as ibogaine but it seems to be a little less potent. It's hard to give a definitive review right now due to other pharmacology interfering but I did seem to get a benefit. Downsides are few aside from nonpsychoactivity. I did notice that any doses after the morning have interfered with sleep which was surprising. Other than that, very little to say. Gonna need to experiment more with a cleaner slate.
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