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Panaeolus Cyans vs Psilocybe Cubensis Options
 
downwardsfromzero
#81 Posted : 1/18/2023 5:06:21 PM

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Bancopuma wrote:
Serotonin doesn't pass the blood-brain barrier, [...]

Hey doubledog, growing Pan cyans is definitely a little more fiddly than growing Pan cyans, with tweaks to substrate and fruiting conditions required, but the basic process is the same, and growing them certainly shouldn't be considered as very difficult.

Would ingested serotonin contribute to nausea, though? Kind of contra to the increased smoothness idea, I know - I suppose it depends on the relative kĭs of psilocin and serotonin at the 5HT3 receptor (or whichever).

And presumably you mean "... more fiddly than growing natalensis... "?




“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
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dithyramb
#82 Posted : 1/19/2023 8:53:29 AM

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Perhaps it does not need to cross the blood brain barrier to have an effect?
The consciousness of plants is a constant source of information for medicine, alimentation, and art, and an example of the intelligence and creative imagination of nature. Much of my education I owe to the intelligence of these great teachers. Thus I consider myself to be the “representative” of plants, and for this reason I assert that if they cut down the trees and burn what’s left of the rainforests, it is the same as burning a whole library of books without ever having read them.

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Bancopuma
#83 Posted : 1/19/2023 2:32:31 PM

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downwardsfromzero wrote:
Bancopuma wrote:
Serotonin doesn't pass the blood-brain barrier, [...]

Hey doubledog, growing Pan cyans is definitely a little more fiddly than growing Pan cyans, with tweaks to substrate and fruiting conditions required, but the basic process is the same, and growing them certainly shouldn't be considered as very difficult.

Would ingested serotonin contribute to nausea, though? Kind of contra to the increased smoothness idea, I know - I suppose it depends on the relative kĭs of psilocin and serotonin at the 5HT3 receptor (or whichever).

And presumably you mean "... more fiddly than growing natalensis... "?


Given the amount of serotonin receptors in the gut, definitely feasible for some kind of interaction on that front. Ha yes and you're right, that's indeed what I meant - have edited for clarity, thanks Thumbs up

Quote:
Perhaps it does not need to cross the blood brain barrier to have an effect?


Possibly, but I'm not sure through what mechanism it would have a noticeable effect without impacting the serotoninergic system that the psilocybin is also working on. If there is serotonin knocking around in the fungus, by extension that means there will also be serotonin precursor compounds present which could be bioactive to some degree, so I don't think their potential influence should be overlooked even if the serotonon itself might not be exerting an influence.
 
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