Does anybody here have any idea of why DMT doesn't work on me? Before u go jumping the gun of course I've tried everything possible I've tried every dose I've tried every way but injection I've tried every kind I've tried set and setting I've tried meditation I've tried complete detox of all drugs for at least 6 months nothing will work why

Sounds unfortunate. Just to eliminate one obvious question, would it be possible to attach a picture of the DMT you are using?

I live in the city and don't notice a difference in intensity of experience whether I'm at home or in the woods. It may be more apt to assume that certain settings prime our reception of the experience in certain ways. I wonder if your setting at home stifles the set of your mind from receiving the experience.

One love

It could also be that DMT us just weird

But you're right it's hard to know. I find it best to temper our conclusions and remain open

One love

I don't know if it has ever been investigated but theoretically some genetic mutations can code for structurally different serotonin receptors and/or glutamate receptors and this could result in unresponsiveness to psychedelics. Since serotonergic psychedelics have very similar action mechanisms, if you can't feel any effect from other psychedelics as well your genetics could probably be involved.

A paper published in July found that genetics play a role in the effects of psychedelic therapy. 5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics. I've seen this thing quoted in various news articles in the past months.

However, from everything I've seen in research so far, there does not seem any genetic disposition to not feel psychedelics at all. I think there is probably something else causing the lack of effects. There are, of course, the obvious things like the effective dose being too low, maybe because the traveler has a problem with their technique (this has happened to me). Another idea might be the traveler might have been on SSRIs for years - I am pretty sure I have seen some research suggesting that long-term SSRI use leads to a significant reduction in 5-HT2A receptors (I cannot find that study right now, so take that with a grain of salt).

My assumption is that if one takes a sufficient _effective_ dose of a classical psychedelic, they will end up feeling the effects.

Love,
Bob

Without a more detailed description of each of the things you've tried I'd say it's a bit hard to comment. Fink's question is pertinent too - what exactly is this DMT that you've been using? And since it seems clear that you're experienced with other drugs, may I ask what those were, specifically?

It may not be DMT or a very weak extraction. Did you extract it yourself or bought it from someone? Did your friends had the same product and how was their experience?

I have a friend who DMT doesn't work for.
All he gets is slight visuals , nausea and then gets sleepy and starts yawning.

Do you have a history of substance abuse at some point in your life?

Do you eat sweet stuff?

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does this stop DMT working? i do not eat much sweet stuff at all so i would not have noticed, but this both surprises me and doesn't surprise me at the same time

I eat my fair share of sweets and haven't noticed a difference, granted I have a hypersensitivity anyway.

One love

I am just trying to find a correlation My friend gets nauseous if he eats more than a half of a candy, so he doesn't eat sweets at all. I thought maybe it is related somehow.

ah okay, that is good to hear. it would be very disappointing if that was the case

Terence McKenna has said 1 in 20 don't feel the effects of dmt.

It could be a number of issues:
1.You have a bad supply(of course this is very dependent on how you acquired it)
1a.(There are some extractions that can yield ...subpar product, and if your initial product is an unreliable amount due to impurities it can be hard to gauge how much you are actually taking)
2.It could be the method of intake, there are many options in this field and I am by no means an expert lets just say if flame is directly touching....you are doing it wrong.
3.It tends to expand your mind's processing, to process much more at once.(I am not speaking of the action itself but the longer term effects), So perhaps your mind is already expanded and when you seek a new high when you are already at the top of the cliff, you are SoL.(because the only way from there is to learn to fly or go back down)
4. Tolerance, this is a touchy subject because some times you think you are immune to the effects because of your frequent usage and then you end up in another world. I assume your 6 month detox included DMT, if not then trying it over and over will just make it less effective.
5. It could even be the source you are using mimosa vs acacia for example you may find better results in one than another.


(side note: I don't think sugar intake has a huge impact, if any)

Has anybody else tried the DMT that you are using? Are you sure that it is correctly extracted and works on humans?

Have you tried different batches of DMT?

What dosages have you attempted?

Unfortunately, a miniscule portion of the population is simply immune to psychedelics such as DMT. Others may just require very large doses. With that said, it is extremely unlikely that you fit into the former category. I would presume that another factor is at play here.

has it been shown in a controlled environment that 1 in 20 people do not have effects? or even that it does not work on some people? or is this just an observation from Terence McKenna?
i do not know much about Terence McKenna but as far as i know he did not do controlled research using proper methods. i could be wrong though, i haven't looked much into his work.

would these two points not just result in low yields? so you would still have high quality product (over 99% pure) but small amounts of it?
unless you are getting contaminants in your work, of course, but i think it is unlikely that your contaminants would look like DMT.
if it is just a small yield then it should not be a problem.

When re-exing a low purity product, as I'm sure you know already, it is possible to end up with less than half the weight you think you had. So a 20mg hit of impure DMT could be weaker than even a threshold experience. People have showed me their DMT in the past and it looks like 90% solidified yellow-brown gunk. I think that is what was implied.