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Journal: 50 Sublingual HPBCD DMT Ayahuasca journeys over a years time Options
 
L-dreamer
#401 Posted : 4/24/2022 7:52:26 AM

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Posts: 106
Joined: 20-Sep-2020
Last visit: 29-Jun-2022
starway7 wrote:

ive found that a ..[reversable MAOI] like rue.. increased my visuals with spice ..slowed the trip down enough to navagate and recall better..

Maybe your THH isnt too good?,,,

no need to worry, the THH I have is 100% legit. It's just that sublingual DMT requires harmine or harmaline (sublingual or oral) to activate from my testing. At this point I am trying to see how exactly it works and what kind of harmalas are needed. Sublingual DMT isn't like vaped DMT where you don't need harmine or harmaline IMO.
The reasons I know my THH is legit are:
- had actual visions on it+DMT+ sublingual harmalas (even 35 mg can work). Visions of incredibly beautiful women (think Greek goddesses archetypes) are for me one of the hallmarks of THH
- enhances music
- leads to slight dizziness at that dosage but no actual nausea
- powerful mood enhancement for days after I have taken it: less anxiety, and less neuroticism
 

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ava69
#402 Posted : 4/24/2022 1:23:05 PM

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Posts: 359
Joined: 24-Apr-2021
Last visit: 29-Jun-2022
Yes, as L-dreamer states: the Sublingual Ayahuasca will only work if you include around 30mg sublingual harmine at the same time under tongue as your sublingual DMT. It has the power of x6 or 180mg oral harmine and is necessary to activate the DMT, without it there is no experience.

---> Short overview:

2 minute easily formed HPBCD DMT liquid on a spoon: very bioavailable sublingually under tongue. HPBCD or hydroxypropyl beta cyclodextrin makes the DMT not only very water soluble but studies show it increases penetration into the sublingual mucosa under the tongue by up to 400% as it is a potent polysaccharide derived from the enzymatic degradation of natural corn starch. HPBCD traps the DMT inside it's molecular cone like a tornado. The HPBCD complexed DMT all adheres to bottom of tongue once you place your tongue onto spoon as it forms sticky complexes like sugar. It also outperforms DMT salts orally by many factors in personal trials, combo with tetrahydroharmine, Ayahuasca.

I've used sublingual Ayahuasca around 50 times in a year's time if you count the number of times I've re-dosed in an evening, which is usually twice more, as I like a 4.5 hour total long experience with long afterglow well beyond that.

The sublingual Ayahuasca absorbs in 15 minutes under tongue and starts to work in 1/2 the time of an oral dose, or 22 minutes instead of waiting 45 minutes, but lasts as long as an oral dose or 1.5 hour. I keep a trip diary journal and record all my experiences. It can be used as often as once a week, there is zero tolerance...will continue to use her weekly for the rest of my life, absolute favorite. Ayahuasca is a feminine teaching spirit.

The most recent experiences I've had (300mg oral THH taken 45 minutes before + 30mg sublingual harmine + 150mg sublingual DMT at the exact same time under tongue for 15 minutes) feel like 600mg of mescaline for 1.5 hour, but only a fraction of the cost of the rare and expensive cactus. Sublingual Ayahuasca is a great way to stay psychedelic for the rest of your life.

300mg oral THH + 30mg sublingual harmine + 60mg sublingual DMT feels like 300mg mescaline
300mg oral THH + 30mg sublingual harmine + 90mg sublingual DMT feels like 400mg mescaline
300mg oral THH + 30mg sublingual harmine + 120mg sublingual DMT feels like 500mg mescaline
300mg oral THH + 30mg sublingual harmine + 150mg sublingual DMT feels like 600mg mescaline

I've taken bridgesii and Peruvian torch cactus tea over 200 times in a decade, and this THH based sublingual Ayahuasca is extremely similar to a mescaline experience: crystal clear clarity, energizing, extremely visual & VERY trippy, incredible music enhancement, highly euphoric, deep head space, divine spiritual experience.

I now save my home grown bridgesii for use only when I go to the waterpark, to enjoy all morning and afternoon outdoors...former beach and deep water waterpark lifeguard. We get a pass and go every summer at least once a week with my wife, her sister and teenagers, it's right down the road. We enjoy being out in nature to escape working for a corporation long-hours which I equate to an air-conditioned ant hill.

With the sublingual Ayahuasca: zero nausea, zero dizziness, zero anxiety, no weirdness or terrifying vibes like oral Ayahuasca can have in the beginning. There is something about DMT moving through the stomach that makes the experience eerily weird imho (I've taken oral Ayahuasca x 70 times over a decade), but with the sublingual Ayahuasca, pure euphoria and bliss, highly recommend.

---> Complete 4 page summary:

part 1. 12 reasons why you should always include pure THH or tetrahydroharmine in your Ayahuasca
part 2. Complete instructions for sublingual or the one-shot HPBCD DMT Ayahuasca (your choice) along with first April 2021 Sublingual Ayahuasca journey with 2 more re-doses at each 1.5 hour point: hundreds of colored teaching visions during the 5 hour experience & music sounded phenomenal the whole time, just like high dose cactus tea. +5 strength Shulgin level life changing experience
Part 3. L-dreamers early experiences
part 4. Latest 4-22-2002 sublingual Ayahuasca journey, another +5 strength Shulgin level life changing experience, most incredible neon colored geometrics I've ever seen in my life for 1 hour that evolved into Egyptian cat women and Indian goddesses with mind-blowing music enhancement the whole time:

300mg pure THH taken orally 45 minutes before
30mg sublingual HPBCD harmine
150mg sublingual HPBCD dmt

---> Part 1: 12 reasons why you should always include pure THH or tetrahydroharmine in your Ayahuasca:

Personal note: I may be a long term chemist, but I developed a method (post #12) many years ago so that anyone can make tetrahydroharmine at home. I went into a trance state after a death and received the information from a divine source on how to do this, as I was stuck at one point for weeks on end with no solution. No fancy chemicals or equipment needed like TIHKAL THH Synthesis. Due to the hundreds of Spiritual centers in South America needing these plants, good older Caapi is increasingly being harder to find. You can do this with normal coffee filters and cotton ball stuffed in a funnel. Tetrahydroharmine (THH): she is as valuable as mescaline, can't do without her. Diamondlike shimmering in her beauty.

In brews analyzed by the UDV, Santo Daime and Shuar Indian, THH levels were at the same high levels of harmine in the plant. Somehow, over their day's long cooking process perhaps using vitamin C (hydrogen doner) in the cooking, the THH would attain levels found as harmine in the plants. Harmaline levels often found zero but always very low (0 to 15mg levels) in a typical brew. Just google tetrahydroharmine wikipedia and read the studies attached at bottom.

1. Post #12 of this paper: shows how to convert harmaline to pure THH in 1.5 hour for the first time (very fast) with 75% yield. TIHKAL THH entry also achieved 75% yield. Post also shows how to check the blue glow under blacklight to make sure it is pure.

Note: THH is NOT an MAOI, she (feminine teaching spirit) is a psychedelic SRI or serotonin reuptake inhibitor just like the following psychedelic serotonin reuptake inhibitors: mescaline, LSD, shrooms, ibogaine.

Make sure your THH is pure and not contaminated with unconverted harmaline (which is a RIMA/maoi). Dab some THH on a wet vinegar soaked cue tip, rub on paper plate, hold under blacklight, if it glows blue you have THH, if any green glow, you have unconverted harmaline in it, keep in mind harmine also glows blue too though. Be-ware cheap China made THH as a handful of people have reported it glowing green and not blue, harmaline contamination, incomplete synthesis. I recommend making your own or quality sources.

1. Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.

2. She is in the same beta-carboline family as ibogaine. She is the 2nd highest alkaloid in Caapi. She has a 10.5 hour half-life with peak at 5.25 hours.

3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.

4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin.

5. THH has numerous similarities to mescaline, she is like the beta-carboline version of mescaline, few people have used her over 100mg. I have seen the receptorome chart for THH vs. mescaline. She not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors A1-A3 associated with beauty and aesthetic enhancement, just like mescaline. Beauty enhancement is "over the top" when THH is included, she is diamondlike shimmering in her beauty.

Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.

6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, when 2 cups are drank by some of the more advanced members for evening at the vegetals (UDV, Santo Daime, Shuar Indian) people are consuming around 300mg of THH.

7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. The combo of THH + DMT is like listening to music on high-dose cactus tea, heavenly.

8. This pure THH at 300mg all by herself is extremely visual, she's an isomer of a hormone like substance made in the brain naturally.

9. The entry in TIHKAL for 300mg THH is completely wrong, where the unexperienced person compares it to the effects of 100mg harmaline. She is nothing at all like harmaline, and like 69ron once said about the person's comment in TIHKAL, he or she would not be able to tell their ass from their elbow. I agree, what complete nonsense.

10. professor8 (found here from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
Quote:
Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.

11. Trips (from here on 12/2/2011):
Quote:
As to how the THH altered the experience -> I find rue extract+DMT to be very similar to mushrooms. I found the THH added to the rue+DMT to shift the experience to a state much closer to that provided by LSD. It was more clear, more energetic, more focused, and when confusion struck it was definitely more "acid-like".

Espiridion:
Quote:
Tetrahydroharmine is much more like mescaline.

The world is moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development: empathy, spirituality, connectedness. Compounds like tetrahydroharmine in Caapi could be said to improve emotional intelligence, a smart-nutrient for the right side of the brain.

At 300mg of THH all by itself, there are heavy open-eyed tracers like lightening flashes, and hours of teaching closed eye visions that start with colored sparkles and fireworks (red, green, yellow, blue) that dart around and progress into full-fledged way-beyond 4k visions with eyes closed that are not only static but often animated like slow and high speed movies, but all one monochrome color like green or blue for me, when you add DMT, the visions then become colored and patterning on animals for example will display their associated colors, DMT also adds on to or builds on top the THH visions, expanding them, but the teachings and insights & visions are credited to the Vine:

12. Gayle Highpine (Ayahuasca researcher):
Quote:
The vine carries the content of the message, the teaching, and the insight. The purpose of drinking Ayahuasca is to receive the message the vine imparts.

Professor8 said in 2012 here:
Quote:
A while back I read a very good explanation of the different effects of Harmalas that has stuck with me. I believe it was 69ron that said: ‘Harmine is the Coffee of the harmalas & Harmaline is the Weed and when it comes to THH (tetrahydroharmine) you have The Light.'

While very similar in molecular structure, THH has a completely different personality to Harmine & Harmaline. Calling it The Light of the harmalas is very appropriate. IMHO, it is the Holy Grail of The Harmalas. I have found Harmine very, very helpful in Meditation & Yoga. It energises your Light Body and allows you to see your Chakras & Auric fields; very helpful in a biofeedback sorta way.

Personally, Harmaline is too heavy & stony for me but I do respect its power and personality, kinda like a big shaggy & lovable dog.
I'm more in the camp with professor8, unfortunately I have a low nausea threshold, and those who know me know I always avoid anything (harmaline) with even the slightest hint of nausea producing potential personally.

Tetrahydroharmine or THH ranks very high on the "periodic psychedelic table" among all the known entheogens for inducing realistic way beyond 4k monochrome teaching visions for hours...adding even small amounts of DMT brightens and colorizes the visions, example: reptiles, birds & animals such as serpents/snakes/toucans/parrots/jaguars with patterning show their respective associated colors. Many times I have viewed multi-colored serpents, birds & jaguars several times over hour long CEV periods, serpents are the manifest spirit of Ayahuasca.

THH in the caapi also seems to strongly activate the right hand hemisphere of the brain-- the side that performs tasks that have do with creativity and the arts, feelings, visualizations, imagination, holistic thinking & intuition, empathy, spirituality & connectedness. Researchers found that the right side of the brain lit up in brain scans of people who took LSD, mescaline, or mushrooms. This includes tetrahydroharmine. The world is largely moving in the direction of the Left Brain: technology and science. What the world needs is to move in the direction of Right Brain development.

Read study reference 1 below, and you will see that Vegetal Ayahuasca (made by the UDV, Santo Daime, Shuar Indian) contains zero to extremely low amounts of harmaline (less than 15mg), but contains as much tetrahydroharmine as it does harmine. All of the Santo Daime Ayahuasca contained zero mg of harmaline: https://en.wikipedia.org/wiki/Tetrahydroharmine

Page 154 of "Various Alkaloid Profiles in Decoctions of Banisteriopsis Caapi, 2005":
Quote:
The average ratio of THH to harmine in the vegetals (traditional brews) was consistently near 1:1, from all sources (table 2), while this ratio was closer to 1:5 in a large survey of source plant material. It is presently unclear whether harmaline is being chemically reduced to THH during the acidic process of decoction.

Dr. Callaway wrote in "The Entheogen Review":
Quote:
However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União do Vegetal members who had consumed ayahuasca for 10+ years). In short, yes, there seems to be important activity from THH.


---> Part 2: My very first April 2021 sublingual trip report that started all this:

Note: Be sure to always take from 150 to 300mg very pure THH orally around 45 minutes before. You can put it in an empty capsule. Normal Caapi based Ayahuasca always contains an average of 150mg THH per cup. When 2 cups are drank for the evening by more advanced members of the UDV, Santo Daime, Shuar Indian, or advanced members like myself, people are consuming 300mg of THH.

No need to ever re-dose more of the oral tetrahydroharmine or THH as she (feminine teaching spirit) has a half life of 10.5 hours with peak at 5.25 hours.

Always complex the 30mg harmine freebase to HPBCD as well, this makes it very water soluble and increases penetration into the sublingual mucosa under the tongue by many factors, and also completely masks the harmine freebase taste. Normal un-complexed freebase harmine absorbs poorly. I've tested how fast it can absorb under the tongue by itself, only a few minutes it works so well. But always take it at the exact same time as the HPBCD DMT under tongue, mix it into the HPBCD DMT spoon and take it all at once under tongue for the most powerful experience, just as the Shaman's do: all at once.

Depending on total HPBCD harmine + HPBCD dmt dosage, it can all absorb in as little as 10 minutes, for higher doses I give it 15 minutes under tongue, it all completely absorbs. Spit out all the built up saliva at the end of 15 minutes into a cup, all of the sublingual Ayahuasca ingredients should have easily absorbed by then....but if at any point during the 15 minutes you build up too much saliva, and you feel it become too uncomfortable, simply tilt head forward and gently relieve any built up saliva but always keep tongue pressed down to hold any remaining ingredients in the sublingual mucosa under tongue at all times.

There is a mild to moderate sting felt while you do this, and it doesn't bother me at all, as it is so worth enduring for 10 to 15 minutes for the phenomenal spiritually divine experience that begins 22 minutes after you begin all this (the sublingual experience begins in 1/2 the time or 22 minutes instead of 45 minutes like the oral) but still lasts 1.5 hour with super long afterglow. You can re-dose up to two more times, and it continues to work just as strong as the first dose, so long as you continue to use 30mg harmine along with each re-dose of dmt.

--> On my very first 300mg oral THH taken 45 minutes earlier + sublingual 60mg HPBCD DMT fb (60mg DMT complexed to x7 or 420mg HPBCD in 6 drops boiling hot water) combined with sublingual 30mg HPBCD harmine fb (30mg harmine complexed to x6 or 180mg HPBCD in 3 drops boiling hot water) held under tongue at exact same time journey with 2 sublingual re-doses at each 1.5 hour mark (had not used dmt in several months):

...all the way till 5am in the morning I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.

I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea.

I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.

All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."

...all of these visions were brightly colored due to the sublingual DMT/harmine and oral THH combo all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 70 times, cactus 200 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw that first night.

The visions inspired me to buy a book on the Aztec myth of "Quetzalcoatl, the serpent of precious feathers", as I feel somehow this entity is a "teacher to mankind". I saw the brightly colored serpents many times in the 5 hours of visions, and now I understand why they are so commonly reported in Ayahuasca journeys.

They seem to possess divine knowledge that humans were not supposed to have been privileged to, but the serpents gifted this knowledge to humankind.

Recently found a 1.5 hour video on Amazon prime entitled "Ancient Alien Origins" which is all about this ancient alien flying serpent or dragon entity which is found in all religions of the world & "BAM, Builders of the Ancient Mysteries".

Also, see "Alien gods" 2019 on amazon prime, another great video all about this winged serpent, giver of knowledge, culture, music, art, civilization to mankind, first appearing around some 5000 years before Christ. The snake was equated to wisdom & healing, even in the Bible.

Return of the Serpent & of Eden:

https://earthmedicine201...of-the-serpent-of-eden/
hxxps://earthmedicine2015.wordpress.com/2016/01/29/return-of-the-serpent-of-eden/

Reference: Full instructions for sublingual or the one-shot HPBCD DMT Ayahuasca (your choice):
1) place 60mg of DMT onto a spoon (60mg for beginners)
2) add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 8 drops of very hot near boiling water to the mix from a nearby microwaved coffee mug for DMT doses of 90mg, use 10 drops of boiling hot water to mix DMT doses of 120mg. Use 12 drops of hot water for 150mg DMT. You will want to use less drops of hot water (1 drop per 12mg DMT) for higher doses of DMT so it will fit comfortably below the tongue. 60mg DMT = +3 Shulgin level strength, 90mg DMT = +4 Shulgin level life strength. 120 to 150mg DMT = +5 Shulgin level life changing experience.
5) Knead or crush the HPBCD powder into the dmt using the end of another spoon for 2 minutes, scrape & mix everything back and forth hard using your muscles. This is how scientist pre-pare these complexes by kneading.
6) Hold a lighter one inch away from under the spoon to heat up spoon for 20 seconds, then pull flame away, this aids the final complete dissolution or dissolving of the 2 ingredients after heating up a slight bit, mix the contents 10 seconds more before using, just as bodybuilder chemist Patrick Arnold recommended and taught for sublingual pro-hormone mixing. See pics.

7) --> For one-shot Ayahuasca: Refer to post #381 with 6 pics, simply dunk spoon of HPBCD DMT into 30ml (one-shot) of 125 degree F water from microwave when ready to drink for the evening, stir a few seconds...it dissolves instantly, and leaves a transparent color it dissolves so well, and also completely masks the nasty DMT freebase taste as it goes down...then stir in around 160mg harmine fb and 150 to 300mg tetrahydroharmine freebase, add around 100mg of 100% pure vitamin C powder so the freebase harmalas can dissolve, stir a bit, then drink all at once as the Shaman's do for the most powerful journey: https://www.dmt-nexus.me...ts&t=96861&p=20

8] --> For sublingual Ayahuasca: Place 30mg harmine freebase on a spoon, cover it with x6 or 180mg HPBCD to keep at a 1:1 molar ratio of harmine to HPBCD. Use x7 or 210mg HPBCD if using the more common 2-hydroxypropyl beta-cyclodextrin. Add 3 drops of boiling hot water from a nearby microwaved coffee mug, mix and mash it all together hard using muscles for 2 minutes on the spoon using the end of another spoon.

--> General rule for sublingual use: use 1 drop of boiling hot water from a nearby microwaved coffee mug for each 10 to 12mg of dmt freebase, or each 10mg of harmine freebase you are mixing and mashing on a spoon using the end of another spoon. Example: Use 5 to 6 drops of very hot water from a medicine pipette to mix 60mg of dmt with x7 or 420mg HPBCD on a spoon using the end of another spoon. Use 8 to 9 drops of very hot water to mix 90mg of dmt with x7 or 630mg HPBCD. Use 3 drops of very hot water to mix 30mg harmine with x6 or 180mg HPBCD.

Then mix this HPBCD complexed harmine into your HPBCD complexed DMT...then place bottom of tongue onto the spoon of harmine and DMT complex, it will all adhere, as HPBCD forms sticky complexes....be sure you took 150mg to 300mg of pure THH orally 45 minutes before....hold this harmine/dmt HPBCD sublingual complex under tongue for 10 to 15 minutes depending on dosage, it will all absorb, experience begins in 22 minutes once you start all this, or 1/2 the time of an oral dosage...but the experience still lasts 1.5 hour or the same time as an oral dosage with super long afterglow. You can re-dose up to two more times and each dose will be as strong as the first for a 4.5 hour total long experience.

---> Part 3: L-dreamer's early experiences:

L-dreamer said:
Quote:
My few experiences have consisted of about 60 mg of freebase DMT dissolved in 500 mg of HPBCD, with 250-300 mg of THH, and about 35 mg of sublingual harmala/harmaline.

From the start I want to say that sublingual DMT with oral THH is everything I wanted ayahuasca/pharmahuasca to be. And I think it is also the best way for someone to be introduced to DMT.
Where do I start with the pros:
- no nausea at all, even if you take sublingual harmine/harmaline with it. It is such an odd and pleasant feeling to not have to fight constant nausea and vomit inducing dizziness. I literally don't have to worry about having a handy throwup bucket like I did with typical oral DMT
- just the right kind of duration, it never overstays it's welcome, in about an hour you will get whatever you had to receive. No need for a bedridden 2+ h long comedown
- crisp, clear headspace. Previous oral DMT experiences have always given me this pinch of delirium and sleepiness to my mental state. But with this combo and I am fully present in it
- no come-up anxiety, the transition is gradual and smooth
- the DMT visuals are there, and in one experience they seemed even more glowing, or with actual real-life landscapes or persons assembling before my vision instead of the usual DMT geometry
- your body will love to move to the music you are listening
- let's say you accidental swallow the DMT solution or the saliva build-up becomes unbearable - you will still have a pharmahuasca experience with less if not any nausea. And also this form of oral DMT seems to absorb way better than a typical pharmahuasca
- you need less DMT than the typical pharmahuasca
- if you aborted the experience (saliva build-up that you spit out) you will now in about 25-30 minutes for sure, and then you can try again with the same DMT dosage, it won't stack like in pharmahuasca where it can sometimes take even 2 hours to enter fully

I still can't believe people aren't all over this method, especially beginners. It is so versatile and maybe even "comfortable". It is worth experimenting only on it for me, goodbye throw bucket and tissues next to my bed, goodbye retching and holding in the taste of earthy vomit, goodbye 5 hour long sedation and diziness that takes up your entire day.

I predict in a short time sublingual DMT will have it's separate section on the Nexus.
L-dreamer's cotton ball sublingual method, page 18, post #42: https://www.dmt-nexus.me...ts&t=96861&p=18

---> Part 4: 4-22-2002 sublingual Ayahuasca journey today:

300mg pure THH or tetrahydroharmine taken orally 45 minutes before
30mg HPBCD harmine
150mg HPBCD dmt

Today, I'm taking 300mg THH or tetrahydrohamine 45 minutes before, then 30mg of harmine freebase complexed to x6 or 180mg HPBCD in 3 drops boiling hot water from a nearby microwaved coffee mug, along with 150mg dmt freebase complexed to x7 or 1050mg HPBCD in 12 drops boiling hot water from the mug.

1) Stirred, mashed and mixed the 30mg harmine along with the 180mg HPBCD for 2 minutes on a spoon using the end of another spoon in the 3 drops hot water, it complexes very fast due to the dust-like crystal size of harmine, it appears to work in only 30 seconds.

2) Then stirred, mashed and mixed the 150mg dmt along with the 1050mg HPBCD in 12 drops hot water on a spoon using the end of another spoon for 2 minutes, using muscles to crush or knead it hard together back and forth...then held lighter 1" away from under bottom of spoon for 20 seconds, then mixed contents 10 more seconds...this 20 second light heating really aids the complete dissolution or dissolving of the 2 ingredients. Like a tornado, the dmt is trapped inside the HPBCD cone. This makes it not only very water soluble, but studies show this enhances penetration into the sublingual mucosa under the tongue by up to 400%.

Dr. Narang:
Quote:
"with sublingual" or "under the tongue" better than buccal, gingival & palatal, absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa is only 100 to 200 microns thick.

Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.
I use 30mg HPBCD complexed harmine fb sublingually along with the sublingual HPBCD complexed DMT, 30mg sublingual has the power of x6 or 180mg oral harmine.

3) Then I added the 150mg HPBCD DMT to the spoon of 30mg HPBCD harmine, or vice versa, and mixed it all together, made sure I took 300mg pure THH 45 minutes before, then put the spoon of HPBCD harmine/dmt under tongue, it all adheres as HPBCD forms sticky complexes (like sugar) and held for 15 minutes. The 30mg sublingual harmine works really great for activating the DMT.

Update 3pm: I took 300mg THH 45 minutes before, then the harmine/dmt complex held under tongue for 15 minutes...mind blowing experience...with eyes closed for an entire hour I witnessed the most incredible evolving dancing kaleidoscopic geometrics I've ever seen, way beyond anything I've ever seen before: thousands of fine intricate geometries....and all incredible neon yellow, pink, green, blue, violet...at some points the geometries evolved into Egyptian cat women and Indian goddesses. I was blow away, I had music playing, mind blowing music enhancement...so heavenly...

With open eyes, incomprehensible "over the top" infinite beauty everywhere, everything glowed with an intense inner divine light, diamond like shimmering...the movie playing had actresses who looked like glowing, dazzling super colorful cartoon versions of themselves.

This felt like 600mg of mescaline, +5 Shulgin level experience, incredible deep head space and profound spiritual insights.

Best part: zero nausea, zero dizziness, zero anxiety. Pure euphoria and bliss. I will continue to use this weekly for the rest of my life.

Pic1: top to bottom: 300mg pure THH to take orally 45 minutes before, 30mg harmine, 180mg HPBCD to complex to the harmine, 150mg dmt, 1050mg HPBCD to complex the dmt.

Pic2: a spoon holding the sublingual 30mg HPBCD complexed harmine along with a spoon holding the 150mg HPBCD dmt. I add the dmt to the harmine spoon, mix it all together, then hold both under tongue at exact same time, just as the Shaman's do for the most powerful experience.

Artwork courtesy of Jillian Evelyn, "Beyond the mold"...she is one of my favorite artists. Juxtapoz & Hi Fructose 2 favorite art mags. My grandmother was a lifetime oil painter and taught me to oil paint at an early age, thus my love for art. She had rooms full of art, and even painted dragons on the bedroom wall, and cowboys in the bathroom. Some of her paintings can be seen on page 3, post #44: https://www.dmt-nexus.me...sts&t=96861&p=3

Pics for welcome guests: https://mycotopia.net/to...rneys-over-a-years-time/
ava69 attached the following image(s):
zzz 5000 (2).JPG (225kb) downloaded 1,052 time(s).
zzz 5001 (2).JPG (183kb) downloaded 1,051 time(s).
 
ava69
#403 Posted : 4/24/2022 6:26:54 PM

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Dr. Narang:
Quote:
"with sublingual" or "under the tongue" better than buccal, gingival & palatal, absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa is only 100 to 200 microns thick.



ava69 attached the following image(s):
zzz sublingual mucosa only 100 to 200 microns thick.JPG (61kb) downloaded 942 time(s).
 
physics envy
#404 Posted : 4/25/2022 5:27:06 AM

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Follow up from a previous oral experience...

A few months ago I used 60mg of DMT complexed with 2hpbcd orally along with 275mg LIFTMODE "THH", 150mg harmine, and 125mg Vitamin C.

I've been wanting to try the same experiment but without the complexation to see if the experience was similar or not.

I finally had a chance to try to experiment this weekend, though it wasn't as similar to the original as I was hoping. I didn't realize I'd have the chance until late in the evening, and I only had 1.5 hours after a somewhat heavy meal (previously I had closer to 3 hours after dinner).

Also, I usually eat a piece of bread about 10 minutes after drinking the dmt to initiate digestion. This time, I only ate a few crackers about 5 minutes after drinking.

My results were that the trip didn't kick in until nearly 2 hours after drinking (it was 35 minutes last time). Also, the visions were much harder to see - though they were there.

I would say this experience was about 1/2-3/4 as strong as the last one when I had complexed the dmt.

Also, I could not sleep for several hours after it wore off this time.

So it turned out to not be a very good experiment for comparison. My takeaway, though, is that the HPBCD probably does increase the efficiency of the dmt so the less can be used with this ROA, but for me the HPBCD probably increases the strength by 1.5-2x at most over non-complexed dmt. But unless I just decide I don't want to risk using HPBCD in the future, I'll likely use it every time as I only do this trip a few times a year and I have a bottle full of HPBCD to use up.
Salvia quid enthusiast
 
ava69
#405 Posted : 4/27/2022 5:53:41 PM

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Thanks for the link https://www.dmt-nexus.me...p;m=1147725#post1147725 to your detailed harmaline experiences downwardsfromzero, I read that in the new members section a while back, great detail! I have 3 papers from Dr. Naranjo on harmaline attached on post #3 under:

300mg tetrahydroharmine (THH) teaching visions all by herself, see post #3:
https://www.dmt-nexus.me...spx?g=posts&t=96861
He died recently, and will be sorely missed.

Yes, as L-dreamer states on top post, THH use not only results in realistic Ayahuasca visions when combined with DMT and sublingual harmine, and strong music enhancement, but also leaves you in an upbeat glowing mood for days afterwards, and happy to hear physics envy that the oral HPBCD complexed DMT is at least 1.5 to x2 times stronger for you, thanks for reporting. Good to see you again.

Today 4-27-2022 sublingual Ayahuasca journey:

300mg THH or tetrahydroharmine taken 45 minutes earlier
35mg HPBCD harmine
150mg HPBCD DMT

I'm doing this one time to check the tolerance 5 days later. I normally wait always at least 7 days.

1) 35mg harmine was covered with x7 or 210mg HPBCD, 3 drops boiling hot water from a microwaved coffee mug was added, mixed and mashed back and forth hard using muscles, this is how scientist prepare these complexes, by kneading. 35mg sublingual harmine has the power of x6 or 210mg oral harmine.

2) 150mg DMT was covered with x7 or 1050mg HPBCD, 12 drops boiling hot water from the mug was added, mixed and mashed hard using muscles for 2 minutes. Then held lighter 1" away under spoon for 20 seconds to heat up a slight bit, then mixed contents 10 seconds more. This light heating aids in the final dissolution or complexing of the 2 ingredients, just as bodybuilder chemist Patrick Arnold recommended and taught for mixing sublingual pro-hormones, he had millions of dollars in sales with his company Ergopharm which sold sublingual HPBCD complexed pro-hormones for 10 years until the Gov't made pro-hormones illegal as the sublingual HPBCD pro-hormones worked as well as steroids: https://thinksteroids.co.../ask-patrick-arnold-11/

3) 300mg of pure THH was taken at 12pm (45 minutes earlier), the 150mg HPBCD DMT was added to the 35mg HPBCD harmine, mixed together then placed bottom side of tongue onto spoon, sticky complex all adhered, held for 15 minutes at 12:45pm.

Note: I always DRY THE BOTTOM of my tongue/sublingual mucosa with a tissue before applying the sublingual Ayahuasca--it really works well for helping to keep the complex under tongue comfortably without any excess saliva water.

Update 4pm: This worked very well! with closed eyes watched 45 minutes of some of the best morphing neon colored geometries I've ever seen--completely different from the ones in the last trip. Amazing how nothing ever repeats from trip to trip, always new and beautiful. Very deep head space...phenomenal beauty with open eyes and incredible music enhancement. Rainbow colored reflections surrounded everything which glowed intensely with an inner divine light. Will continue to use her weekly for the rest of my life...absolutely love it! Felt very similar to 600mg of mescaline. Zero nausea, zero dizziness, zero anxiety, pure euphoria and bliss again. This all absorbed very well under tongue.

I prefer the 35mg harmine over the 30mg harmine, the extra additional strength pays off. Sublingual harmine & oral tetrahydroharmine both work together to activate the trip & prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neurons of the brain.

Option 2: You can even take 200mg of harmine orally 1 hour before with the THH, and once you start to feel the harmine, then take the sublingual HPBCD DMT, it works this way too very well, see post #2. You can even take a HPBCD DMT re-dose 1.5 hour later as the oral harmine has a half life of 1 to 3 hours, and continues to work to prevent the DMT from being destroyed by MAO in the mitochondria of the neurons of the brain. I've done this before, one of the most powerful experiences I've ever had.

Note: I actually normally prepare the harmine and dmt HPBCD complex on ONE SINGLE SPOON, by putting the 35mg harmine + 150mg DMT + (210 + 1050mg HPBCD = 1260 total HPBCD) with 3 + 12 = 15 total drops hot water added for mixing...but I am using 2 spoons in order to illustrate the complexing process. It's easier to form everything together on one spoon as it's pretty sticky, and hard to transfer one spoon's ingredients to the other for mixing. I highly recommend you do the same if you duplicate this.

pic 1: top to bottom: 300mg pure THH taken 45 minutes earlier, 35mg harmine fb, 35 x 7 or 210mg HPBCD to complex the harmine in 3 drops boiling hot water, 150mg dmt fb, 150 x 7 or 1050mg HPBCD to complex the DMT in 12 drops boiling hot water.

pic 2: 35 mg sublingual HPBCD harmine on a spoon and 150mg sublingual HPBCD DMT on a spoon.

Artwork courtesy of Jillian Evelyn "Beyond the mold" and Hanna Faith Yatta "the convulsively beautiful paintings of Hanna Yatta"

Pics for welcome guests (post #6): https://mycotopia.net/to...a-years-time/?p=1500882
ava69 attached the following image(s):
zzz 700 (2).JPG (128kb) downloaded 898 time(s).
zzz 701 (2).JPG (102kb) downloaded 911 time(s).
 
physics envy
#406 Posted : 4/28/2022 3:21:18 AM

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Hi Ava,

At what point in this thread did you first mention complexing the harmine? I must have overlooked that until this last post. You've probably covered this, but did you notice a difference?
Salvia quid enthusiast
 
ava69
#407 Posted : 4/28/2022 12:28:24 PM

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Hi physics envy. At top of this page, post #402. I've compared the normal non-complexed harmine to the complexed harmine, the complexed harmine (35mg harmine fb covered with x6 or 210mg HPBCD with 4 drops boiling hot water mixed and mashed for 2 minutes on a spoon) not only masks the harmine freebase taste, but it absorbs many factors better into the sublingual mucosa compared with normal harmine which absorbs poorly. Studies show HPBCD increases drug penetration by up to 400% into the sublingual mucosa under the tongue, give this a shot, you should notice a significant difference in strength of it's ability to activate the DMT, extremely powerful.
 
physics envy
#408 Posted : 4/29/2022 6:59:42 AM

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Thank you, Ava!

However, the underside of my tongue seems extremely sensitive to the complexed DMT and I am done with that ROA...I'll roll the dice with the oral method going forward over 3 days of tongue repair ;-)

But I'll try complexing the harmine before my next oral attempt and see how that goes as an experiment.

Salvia quid enthusiast
 
ava69
#409 Posted : 4/29/2022 11:34:13 AM

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This is my last post, as I spend most of my spare time at the gym, beach & waterpark down the road over the summer. In my 20's while going thru school, was a certified lifeguard instructor & deep water lifeguard over the spring and summers for the beach & local waterpark, something I enjoyed a lot, water spirit here. Beach, waterpark & parks are my 3 favorite places, love walking with my dog on the seawall or the local parks anytime I am off, lift weights 3 times a week, and run at least 20 minutes on days I don't lift.

Hi physics envy. Closing note: no need to complex the harmine if you are using it orally. Works fine by itself normally. I remember you saying you extract your DMT using pickling lime instead of NaOH, I use NaOH and naptha to extract (post #19). I don't know if the resulting DMT makes a difference. Make sure you are using a long glass pipette with rubber bulb on end to extract and a 2L erlenmeyer flask, this way when you pull your naptha, it all collects in a narrow band near the top of the flask, and the no-drip pipette ensures you don't accidentally get any pickling lime (your case) or sodium hydroxide (my case) in your extracted DMT, or this will surely burn the bottom of your tongue.

From a personal standpoint: the bottom of my tongue is completely fine afterwards and its as if nothing happened the next day. There is no way I would have continued to use this sublingually over 50 times if it left even any kind of scarring or discomfort immediately afterwards under the tongue. Seriously, bottom of tongue & sublingual mucosa is 100% fine afterwards.

The complexing of the DMT not only improves absorption by up to 400% into the sublingual mucosa but helps to mask the taste and sting of the DMT freebase as it is absorbed into the sublingual mucosa, but there is still a mild to moderate sting when doing this, does not bother me at all for 15 minutes as it is so worth the very strong & divine 1.5 hour experience that results. However, everyone is different. You can always use this orally if that is your preference: skip to page 20 for one-shot HPBCD DMT Ayahuasca, masks taste & increases absorption many factors, with pics: https://www.dmt-nexus.me...ts&t=96861&p=20

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017:
Quote:
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes. Cyclodextrins at high doses can increase drug permeability by direct action on mucosal and intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7]. Cyclodextrins are absorbed poorly via mucosal membranes but can improve complexed drug absorption by up to 400% sublingually.

The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27]. The α- and β-cyclodextrins do not cross the intestinal barrier in significant amounts and are fermented by gut bacteria or excreted whole; γ-cyclodextrins are metabolized by mammalian α-amylases into linear oligosaccharides. Consequently, cyclodextrins in food or otherwise consumed orally or applied sublingually do not usually enter the circulation in significant amounts (Frijlink et al., 1990), and thus are very safe.

Chemist Patrick Arnold taught me how to complex HPBCD to pro-hormones for sublingual use in my 20's, same method I use for sublingual HPBCD DMT. I've also been a bodybuilder & chemist all my life. Bodybuilder chemist Patrick Arnold had millions of dollars in sales with his company Ergopharm which sold sublingual HPBCD complexed pro-hormones for 10 years until the Gov't made pro-hormones illegal as the sublingual HPBCD pro-hormones worked as well as steroids: https://thinksteroids.co.../ask-patrick-arnold-11/

MESO-Rx, "Ask Patrick Arnold #10", April 15, 1999 By Patrick Arnold:
Quote:
Sublingual hydroxypropylbetacyclodextrin (HPBCD) complexed testosterone has a very high bioavailabilty however as the peak blood levels are seen rather quickly (20 to 40 minutes). These peaks are quite high however and the drop off is substantially gradual as in the EMU study testosterone levels of greater than 60% over baseline were still measured after 2 hours.

Straight testosterone or prohormones do not have very good absorption under the tongue. When complexed with cyclodextrin the properties change to enable it to absorb extremely well. It would be a long and detailed explanation but that is the jist of it.

Pic 1: HPBCD tornado cone traps the DMT freebase inside and Ergopharm's hot selling cyclodiol powder, HPBCD complexed 4-androstenediol (4-AD), when used sublingually, converted into testosterone at a rate of 95% via enzyme activity once it quickly entered the bloodstream from the sublingual mucosa.

Pic 2: Serpents are the manifest Spirit of Ayahuasca, saw brightly colored serpents many times over my first 300mg oral THH taken 45 minutes earlier + 35mg sublingual HPBCD complexed harmine + 60mg sublingual HPBCD complexed DMT (both held under tongue at exact same time for 15 minutes) with another sublingual re-dose two more times at each 1.5 hour point resulted in hundreds of colored teaching visions & powerful music enhancement over the 5 hour total trip, trip report on post #402.

Top left: Egyptian Goddesses Isis (Cobra) & Serapis: depicted as Sacred Serpents

Top middle: Shipibo Ayahuasca Tapestry: The Vase representing the Amazonian Medicine, The Serpents that of the Grandmother Spirit of Ayahuasca

Top middle: Cosmic Serpent: Book by Jeremy Narby

Top right: Mayan ruins

Bottom left: Priestess of Quetzalcoatl

Bottom middle: Aztec Serpent Moon Goddess (Coyolxauhqui). Other Aztec Serpent Symbols include: Quetzalcoatl (Feathered Serpent), Xiuhcoatl (Fire Serpent), Mixcoatl (Cloud Serpent), and Coatlicue (She with Serpent Skirt)

Bottom right: Kundalini Serpent Pathway

Bottom right: Shiva & Shakti: Siddhi Level of Divine Masculine & Feminine Balance, similar to the Caapi vine (female Spirit) which is supported by the masculine tree so she can reach for the Heavens.

Pics for welcome guests [post #8]: https://mycotopia.net/to...-a-years-time/?p=1500937
ava69 attached the following image(s):
HPBCD and Erogopharm's cyclodiol.JPG (94kb) downloaded 727 time(s).
serpents are the manifest Spirit of Ayahuasca.JPG (114kb) downloaded 725 time(s).
 
ava69
#410 Posted : 5/21/2022 1:40:36 PM

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For new people: I would recommend 60mg for a +3 Shulgin strength. This is the beginning dose, remember this works for 1.5 hour, the 60mg is needed to provide the horsepower for the long duration. 12 reasons why you should always include from 150 to 300mg oral THH at least 45 minutes before with your sublingual Ayahuasca on post #402 at top of this page 21.

Sublingual Ayahuasca Journey #57 (5-20-2022)

Yesterday 5-20-2022, at 3pm, I used 300mg pure THH orally 45 minutes before, then 30mg harmine mixed with 120mg dmt all on a single spoon with (30 x 7 = 210mg HPBCD) + (120 x 7 = 840mg HPBCD) = 1050mg total HPBCD mixed and crushed back and forth on the spoon for 2 minutes using the end of another spoon with 10 drops boiling hot water, placed bottom side of tongue onto spoon, it all adhered as HPBCD forms sticky complexes, studies show HPBCD complexed freebase drugs increase absorption sublingually x 400 percent, held under tongue for 15 minutes, viewed incredible CEV's for 1 hour...

....this time the geometries skipped and went straight to realistic visions: I viewed incredibly beautiful women morphing into other beautiful women, all neon colored, these women changed into nearly 20 different women, completely naked and with animated face changes, infinite beauty, mind blowing CEV's...like the most incredible cartoon renderings of the most beautiful women, they even had geometric swirling pastels on the surface of their bodies...completely blown away. I usually use this at least once a week, just incredible. When I say animated, these women smiled and blew kisses and moved into all different positions...like watching a movie. They made intimate eye contact and communicated via physical motions. This was a +5 Shulgin level experience, this felt like direct communication and receiving of important artistic creative feelings and insights into the feminine domain.

I recorded this journey as one of the most visual of my entire life, never have I seen an hour's worth of beautiful women morphing into other women, with swirling geometric pastel patterns on their naked bodies, communicating physically, this is an artist's dream come true, way beyond 4k, visual detail astounding. I had headphones on, and the music sounded as if I had taken a strong bridgesii cactus tea (18" of bridgesii or around 500mg of mescaline), profound music enhancement, just heavenly, powerful spiritual insights, infinite open eyed beauty and neon colors splashed on all the walls, very powerful experience, it was so strong I started to feel the sublingual harmine/dmt starting to work in only 10 minutes, incredible blast off, lasted 1.5 hour with very strong trip, with 1 full hour of powerful closed eye visions as stated above. Zero nausea, zero dizziness, zero anxiety, fast comeup, had not used THH or DMT in two weeks, this may explain the powerful realistic visions.

The harmine and dmt needs to be taken mixed together and held under tongue at the EXACT SAME TIME, just as the Shaman's do for the most powerful experience, the harmine also helps masks the mild sting of the HPBCD DMT, it is actually comfortable under the tongue, and the sting becomes extremely mild with the harmine helping to mask.

For me, with every sublingual Ayahuasca journey, a higher level of consciousness is awake at one with being, beyond thought and the mind: the realization that all the things that truly matter - the spiritual, beauty, love, creativity, joy, inner peace - arise from beyond the mind, each journey awakens me and teaches me how to access this level of consiousness in everyday practice, to be the observer of the thinker, to rise above thought, a sense of stillness and peace, to be fully present in the moment, to feel the subtle emanation of joy arising from deep within: the joy of Being.

Artwork courtesy Chuck Sperry, F. Scott Hess & Jillian Evelyn (beyond the mold)

Pics for welcome guests (post #10): https://mycotopia.net/to...neys-over-a-years-time/

Pic1: top to bottom: 300mg pure white tetrahydroharmine (THH) taken orally x 45 minutes before, 30mg harmine freebase, 120mg DMT freebase, 1050mg total HPBCD to complex the harmine (30mg harmine x 7 = 210mg HPBCD + 120mg dmt x 7 = 840mg HPBCD, total = 1050mg HPBCD) in 10 drops boiling hot water from a nearby coffee mug all on a single spoon.

Pic2: 30mg harmine + 120mg DMT + 1050mg HPBCD all getting ready to be mixed and mashed together on a single spoon for 2 minutes using 10 drops boiling hot water from a nearby microwaved coffee mug. Also shown at top: 300mg pure white THH in a weigher which was taken orally x 45 minutes before hand.

Pic3: This is the 30mg harmine + 120mg DMT + 1050mg HPBCD all mixed together for 2 minutes in 10 drops boiling hot water, mixed and mashed it hard back and forth using muscles, this is how scientist prepare these complexes, by kneading...then held lighter 1" away under spoon for 20 seconds, then mixed contents x 10 seconds more after light heating...this light heating guarantees the final complexing of all the ingredients, then placed tongue onto spoon, it all adhered, held for 15 minutes in sublingual mucosa, started to work strongly in only 10 minutes. Took 300mg pure tetrahydroharmine or THH orally 45 minutes before beginning the sublingual. This resulted in +5 Shulgin level life changing strength journey, extremely visual & music enhancing.

Pic4: 4 of my 12" home grown bridgesii, I grow an entire patio full of these which get morning sun only. I drink the tea of 2 of these when I go to the waterpark, all of outdoors looks like a fairy tale land full of neon colored bikinis, phenomenal psychedelic experience all morning and afternoon long. No words to describe. The 5-20-2022 trip above using 300mg oral THH + 30mg sublingual HPBCD complexed harmine + 120mg sublingual HPBCD complexed DMT feels very similar to 18" of bridgesii tea or 500mg of mescaline for 1.5 hour with super long afterglow, and it's easy to re-dose more of the sublingual harmine/dmt if you choose at every 1.5 hour point x 2 more times for a 4.5 hour long strong trip. No need to ever re-dose more of the tetrahydroharmine as it has a 10.5 hour half life with peak at 5.25 hours.

Pic5: The late great DM Turner on the mescaline experience. I've taken purified mescaline around 50 times in doses from 300 to 600mg, and bridgesii cactus tea over 200 times in a decade. The oral 300mg THH + sublingual 30mg harmine + sublingual 120mg dmt feels very similar to a high dose 500mg mescaline experience. Easy to handle, crystal clear clarity, euphoria, profoundly beautiful and extremely visual, infinite open eyed beauty, powerful music enhancement and profound spiritual insights with a special feeling like Heaven is smiling down on you, just like DM Turner describes.
ava69 attached the following image(s):
zzz 200 (2).JPG (172kb) downloaded 632 time(s).
zzz 201 (2).JPG (123kb) downloaded 616 time(s).
zzz 204 (2).JPG (102kb) downloaded 605 time(s).
zzz smaller bridgesii (2).JPG (229kb) downloaded 586 time(s).
zzz DM Turner on mescaline.JPG (314kb) downloaded 592 time(s).
 
L-dreamer
#411 Posted : 5/23/2022 12:25:53 AM

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Writing this post 30 minutes after another sublingual DMT experience. Someone was asking me why am I hoarding grams of DMT. And the reply is that I want to have as many sublingual DMT experiences.
Finally got the pure harmine and the difference is night and day from the harmaline. Way more sharper thought space without the tinges of delirium harmaline brought me, I'm not going back.
I tried two times pharmahuasca but I puked two hours in each time, so the experiences ended way sooner.

I will say that the pharmahuasca is more suited, at least in the dosages I take the DMT with, for self-assessment. It just makes me think about me, my life, and my relationships with others. A lot of times there is barely any fancy light show going on but I am fed spikes of what I feel are insight, that stay with me long after the experience is over. One of the trips dealt with the theme of my parents and brothers, the blood lineage that ties us and the affection that binds a family in cohesion.
Sublingual DMT on the other hand is way more euphoric, sharp and energetic. Pharmahuasca is the boring tea you have to sip that does not taste good, while sublingual DMT is that can of energy drink you just want to gulp in one go.
I have a vape mod but I can honestly say that I am too scared to smoke DMT in any significant dosage. And the lack of harmalas gives the pure DMT landscape a vibe that I consider too chaotic and useless, like those post-modern "pain-t(h)ings" were people just smear paint and call it a day.

Dosage: 120 mg of DMT (without the RE-x), 50 mg of sublingual harmine, 300 mg of THH an hour before. The HPBCD was added according to the instructions of ava
Held the cotton with the liquid for 8 minutes, all the saliva built up was spit into a cup after. I have to say that, like ava mentioned, the harmine added to HPBCD alleviated the DMT sting a bit.
Comeup began as soon as I put my sleep mask on. What followed could be described as a display of a dance show. Walls of different chambers were morphing and dancing to the music I was listening. They changed into different body parts such as legs and arms (all with womanly proportions) and were in an perpetual fluidity. Plenty of women figures under disguise, at some point I saw a roman chamber with a white statue morphing. Near the end of the trip a vision of a forest sprang up.
The trip duration was literally to the length of this playlist I was listening during.
https://www.youtube.com/...Vbbt8AsJtlgsjV0H9Vmhrbk

10/10 would recommend again

Now I'll want to test:
- if the intensity is different if I abstain from harmalas, especially THH. So for 3 weeks I won't take any more harmalas. Which if I think about it is significant, since I am taking for months a big dosage of harmalas every 1 or two weeks
- if the intensity will increase if I Re-x my DMT. Tested a 500 mg batch I have and once I poured naphta over it a slimy bright orange oily gunk quickly formed at the bottom.
 
starway7
#412 Posted : 5/26/2022 2:21:22 PM

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how visual is your ..[sublingual DMT experience ?]

With vaped.. [sp] ..you can get.. strong visual halucinations like..colors .. rainbows...time windows..cosmic carniviles..entitys...?

Or.. is your sublingual experiamnce..more of a ....[lighter visionary experiance?]..or headspace thing.. where your visions are more in the form of...memory..thoughts..and emotion......


these are booth visionary in their own way...but the first... is heavy eye candy...

just asking..which of these ..[two types of experiances]...does sublingual give you?

AVA69...always said his sublingual experiances were always very visual.... solid colors...and nice eye candy.. almost every time! but that may be because of the high quality THH he said he has..

there may be a way to simply enter your brains stored memorys by using the molecule as a ..[chemicle pass key].. in a self induced state of meditation..

Ive also suspected that salvias.. [salvorian A] .. could be that.. pass key..because of experiances ive had with it some time back...
 
L-dreamer
#413 Posted : 5/26/2022 5:07:23 PM

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starway7 wrote:
how visual is your ..[sublingual DMT experience ?]

it is the eyecandy visual type, the "show me the pretty lights" kind.
 
starway7
#414 Posted : 5/27/2022 12:58:21 AM

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L-dreamer wrote:
starway7 wrote:
how visual is your ..[sublingual DMT experience ?]

it is the eyecandy visual type, the "show me the pretty lights" kind.



L-dreamer..have you ever tryed the .. [DMT with harmine only?]....[ without THH!].. ..? just to see if the visual trip would still work/..


Just wondering how much ...[the THH]... had to do with the visions? could it work without the THH?



[Straight dmt]..for me... usually doesnt absorbe sublingually by itself very well...AVA was always using [HPBCD ..powder]... with it sublingually to help it work better sublingually..



I have some... [lift mode].. THH] but im not shure of its purity...it glows /..[yellow green] under a black light?

Does your THH glow..a yellow greenish color]... under black light?

I think reasonably pure.. THH.. should glow a ....pale blue.... under black light...


So i ask....are you also using ...[HPBCD]... powder in your sublingual dose?]] the HPBCD is something AVA is always using in his dosage....
 
L-dreamer
#415 Posted : 5/28/2022 10:23:48 AM

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starway7 wrote:

So i ask....are you also using ...[HPBCD]... powder in your sublingual dose?]] the HPBCD is something AVA is always using in his dosage....


yes, always using HBPCD when doing DMT sublingually
I have not tried DMT with harmine only.
I had another sublingual DMT try last night, and compared with the previous one a week ago, it lacked the more visionary aspect and beauty of it. The experience resembled more my pharma trips when I did them without THH before I started incorporating it. Last night I added WAY more harmine: 120mg orally with 300 mg THH an hour before. I also added 110 mg of harmine sublingually with the goal of eventually swallowing the DMT and harmala mix after it sat under tongue so that I don't lose any actives. But the taste was too bad so I just spit the entire thing after it got under my tongue. Now because of the high dose of harmine everything became WAY more speedy. Was listening to music and it had the sped up effect, thoughts seem to be racing. I checked my pulse and I was very calm, the mental chatter was dissociated from the body high and relaxation. Overall the experience lacked a certain "magic" I had a week ago, it could be that the harmine overpowered the THH. DMT effects wore in an hours, after which I was in the harmala trance. Fell asleep at t:1h30 minutes and woke up at t:5 hours with solid harmala tracers still present

It probably sounds incredibly false to say this since I have not seen this mentioned everywhere, but maybe some features that THH adds (full 3D visions, amazing geometries glowing with neon that feed your eyes, entities) to the trip give a tolerance that requires at least two weeks to go away, and repeatedly chasing the experience leads to nowhere in my experience
 
starway7
#416 Posted : 5/29/2022 12:06:44 AM

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L-dreamer wrote:
starway7 wrote:

So i ask....are you also using ...[HPBCD]... powder in your sublingual dose?]] the HPBCD is something AVA is always using in his dosage....


yes, always using HBPCD when doing DMT sublingually
I have not tried DMT with harmine only.
I had another sublingual DMT try last night, and compared with the previous one a week ago, it lacked the more visionary aspect and beauty of it. The experience resembled more my pharma trips when I did them without THH before I started incorporating it. Last night I added WAY more harmine: 120mg orally with 300 mg THH an hour before. I also added 110 mg of harmine sublingually with the goal of eventually swallowing the DMT and harmala mix after it sat under tongue so that I don't lose any actives. But the taste was too bad so I just spit the entire thing after it got under my tongue. Now because of the high dose of harmine everything became WAY more speedy. Was listening to music and it had the sped up effect, thoughts seem to be racing. I checked my pulse and I was very calm, the mental chatter was dissociated from the body high and relaxation. Overall the experience lacked a certain "magic" I had a week ago, it could be that the harmine overpowered the THH. DMT effects wore in an hours, after which I was in the harmala trance. Fell asleep at t:1h30 minutes and woke up at t:5 hours with solid harmala tracers still present

It probably sounds incredibly false to say this since I have not seen this mentioned everywhere, but maybe some features that THH adds (full 3D visions, amazing geometries glowing with neon that feed your eyes, entities) to the trip give a tolerance that requires at least two weeks to go away, and repeatedly chasing the experience leads to nowhere in my experience



quote..
yes, always using HBPCD when doing DMT sublingually..



so it appears you need ...[HPBCD] with the spice..to make it work sublingually?

Because [spice] doesnt work sublingually very well by itself i find...

have you ever tryed spice sublingually without HPBCD powder? what was results?


I have ..HPBCD [.cyclodextrin]...[powder..but hesatate to use it... because of on line info ..that claims the powder can damage your ... hearing??/ and i already have tinitus...

not trying to scare anyone.... but its good to be aware of these on line claims..

AVA 69 is aware of this but claims its perfectly safe to use?..

dont know how true this claim is/?

β-Cyclodextrin is poorly absorbed following oral administration in animals and humans. It is hydrolysed to maltose and glucose by the gut microflora and endogenous amylases in the colon; consequently, β-cyclodextrin levels in tissues and serum are low (< 1%). β-Cyclodextrin has a low acute oral toxicity.Dec 7, 2016

Re‐evaluation of β‐cyclodextrin (E 459) as a food additive -https://efsa.onlinelibrary.wiley.com › doi › j.efsa.2016.4628


they also claim its ..perfectly safe!.. to use as a food additive ?....

but there are other claims that it can effect ones hearing negativly?
 
ava69
#417 Posted : 5/29/2022 12:27:23 PM

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Thanks for your beautiful detailed reports L-dreamer.

Part 1: below is all about tetrahydroharmine and why she (feminine spirit) is so important to Ayahausca. Note: THH is NOT an MAOI, she (feminine teaching spirit) is a psychedelic SRI or serotonin reuptake inhibitor just like the following psychedelic serotonin reuptake inhibitors: mescaline, LSD, shrooms, ibogaine. She is in the same beta-carboline family as ibogaine and is the best kept secret in the psychedelic world.

Part 2: below is the receptorome chart and explains how DMT does not block serotonin, but 5-meo-dmt, LSD, mescaline, ibogaine, shrooms, bufotenine, THH all block serotonin, and why this is important...important teamwork when THH (which blocks serotonin) is combined with DMT (which does not block serotonin).

Part 3: below is why HPBCD is completely safe when used sublingually or orally with studies.

Starway7, please do not spread false information. There is nothing I dislike more. HPBCD is completely safe when used sublingually or orally, what you are reciting is when researchers injected mega doses of HPBCD directly into the brain of cats during a research study to slow the progression of an un-curable cholesterol disease called Niemann-Pick disease. Niemann-Pick is a rare, inherited disease that affects the body's ability to metabolize fat (cholesterol and lipids) within cells.

The researchers directly injected 4000mg per kilogram weight of the animal into the brain. This is in the range of 20,000 to 30,000mg of HPBCD directly into the brain via injection. This is called intrathecal injection. They did this same mega-dose brain injection into the cats day after day for an entire week, using 14 total MEGA intrathecal injected brain doses!

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017 (attached paper):
Quote:
Cyclodextrins are absorbed poorly via mucosal membranes but can improve complexed drug absorption by up to 400% sublingually. Cyclodextrins in food or otherwise consumed orally or applied sublingually do not usually enter the circulation in significant amounts (Frijlink et al., 1990), and thus are very safe.

I do not like trolling, and it appears that is what you are doing. You keep asking the same questions page after page, going all the way back to page 10, time and again referring to smoking dmt, this is the pharmahuasca subsection, not the smoked dmt area, if your point is to start another page 22, then it is headed that way. And by the way, what is with the double space? it just eats up more empty space. I am happy for you that you love smoking DMT, but I am from the Ayahuasca school, and only use these entheogens as they have been used traditionally for hundreds of years. Without the THH, the teaching is absent, the insight and the messages, THH is in the same betacarboline family as ibogaine, she is very important, she is the 2nd highest ingredient in Vegetal prepared Caapi based Ayahuasca, often found in the same levels as harmine...advanced members of the UDV, Santo Daime, Shuar Indian or people like myself are consuming around 300mg THH when they consume 2 cups of traditional Ayahuasca...more on this below:

Gayle Highpine (Ayahuasca researcher):
Quote:
The vine carries the content of the message, the teaching, and the insight. The purpose of drinking Ayahuasca is to receive the message the vine imparts.

Tetrahydroharmine or THH ranks very high on the "periodic psychedelic table" among all the known entheogens for inducing realistic way beyond 4k monochrome teaching visions for hours...adding even small amounts of DMT brightens and colorizes the visions, example: reptiles, birds & animals such as serpents/snakes/toucans/parrots/jaguars with patterning show their respective associated colors. Many times I have viewed multi-colored serpents, birds & jaguars several times over hour long CEV periods, serpents are the manifest spirit of Ayahuasca.

Daniel Pinchbeck "Breaking Open the Head" (Daniel also states in his book, that Ayahuasca is his favorite entheogen):
Quote:
For many people, Ayahuasca-a slowed-down low-res interface of the DMT flash-seems to convey strong messages from the natural world, of nature as sentient energy and spirit matter, of the need to protect the planet we have been given.

Yage whispers that human beings are meant to be gardeners of this reality, journeyers, storytellers and singers, weavers of the sacred. DMT, on the other hand, conveys no overt human or humane message.

Graham Hancock, "Supernatural", pg 428:
Quote:
My experience with smoked DMT was qualitatively different from the realms and beings Ayahuasca introduced me to. For whereas the Ayahuasca worlds seemed rich, luxurious, and abundant in the transformations of organic and supernatural life, DMT brought me to a world--or to some aspect of a world--that appeared from the outset to be highly artificial, constructed, inorganic, and in essence technological.

Gayle Highpine (Ayahuasca researcher):
Quote:
In the western world, Ayahuasca acquired a new definition: It was now, by definition, the combination of Banisteriopsis caapi and a DMT-containing plant. Ayahuasca became, by definition “orally active DMT.” The first anthropologist to adopt the new definition seems to have been Luis Eduardo Luna in 1984. Luna spent time with Terence McKenna, absorbing his perspective, before beginning his fieldwork. Since then, anthropologists have increasingly adopted this definition and filtered their observations through it. The preeminence of the Ayahuasca vine in the indigenous Amazonian world became the elephant in the living room of Ayahuasca studies, with a tacit agreement to pretend it doesn’t exist.

The leaves were Ayahuasca’s “helpers,” I was told, and their purpose was to “brighten and clarify” the visions. The vine is like a cave, and the leaf is like a torch you use to see what is inside the cave. The vine is like a book, and the leaf is like the candle you use to read the book.

The vine is like a snowy television set, and the leaf helps to tune in the picture. There was a subtle attitude that the need for strong leaf was the sign of a beginner: An experienced ayahuasquero could see the visions even in low light.

Ayahuasca vine is not visionary in the same way as DMT. Visions from vine-only brews are shadowy, monochromatic, like silhouettes, or curling smoke, or clouds moving across the night sky. It is because their visions are usually monochromatic that vines are classified by the color of vision they produce: white, black, blue, red (in my experience, dark maroon).

Snakes, the most common vision on Ayahuasca, are considered the manifest spirit of the vine. Vine visions can be hard to see; in fact, the “visions” may not be visual at all, but auditory or somatic or intuitive. But the vine carries the content of the message, the teaching, and the insight.

The leaf helps illuminate the content, but the teachings are credited to the vine. Vine visions are “frequently associated with writing, to a code that is present in visions…or in the ‘books’ where the spirits keep the secrets of the forest.” (Calavia Saez 2011:135).

The vine is The Teacher, The Healer, The Guide. The purpose of drinking Ayahuasca is to receive the message the vine imparts. This is why it is the vine, not the leaf, that is classified by the type of vision it gives. “For them the vine is, in truth, a living guide, a friend, a paternal authority” (Weiskopf 2005:104).

Psychedelia, page 61:
Quote:
A traditional saying among Ayahuasqueros is that the jungle vine brings powerful realistic visions, but that the chacruna brings light to these visions. According to the view of Western research, this is not the case; essentially the entire psycho-activity resides with the chacruna leaves DMT content.

Espiridion:
Quote:
Tetrahydroharmine is much more like mescaline.

professor8 (found here from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
Quote:
A while back I read a very good explanation of the different effects of Harmalas that has stuck with me. I believe it was 69ron that said: ‘Harmine is the Coffee of the harmalas & Harmaline is the Weed and when it comes to THH (tetrahydroharmine) you have The Light.'

While very similar in molecular structure, THH has a completely different personality to Harmine & Harmaline. Calling it The Light of the harmalas is very appropriate. IMHO, it is the Holy Grail of The Harmalas. I have found Harmine very, very helpful in Meditation & Yoga. It energises your Light Body and allows you to see your Chakras & Auric fields; very helpful in a biofeedback sorta way.

Personally, Harmaline is too heavy & stony for me but I do respect its power and personality, kinda like a big shaggy & lovable dog.

Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.

Psychedelia, page 61:
Quote:
Ayahuasca researcher Luis Eduardo Luna recently observed that when surveying tribal lore praising the jungle vine, he could find no traces of similar mythology around the two most common plant admixtures; psychotria viridis or diplpterys cabrerana, even though these DMT plants to a Westerner would appear much more important than the harmala alkaloids of the B. caapi liana.

Page 154 of "Various Alkaloid Profiles in Decoctions of Banisteriopsis Caapi, 2005":
Quote:
The average ratio of THH to harmine in the vegetals (traditional brews) was consistently near 1:1, from all sources (table 2), while this ratio was closer to 1:5 in a large survey of source plant material. It is presently unclear whether harmaline is being chemically reduced to THH during the acidic process of decoction.

Dr. Callaway wrote in "The Entheogen Review":
Quote:
However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União do Vegetal members who had consumed ayahuasca for 10+ years). In short, yes, there seems to be important activity from THH.

Make sure your THH is pure and not contaminated with unconverted harmaline (which is a RIMA/maoi). Dab some THH on a wet vinegar soaked cue tip, rub on paper plate, hold under blacklight, if it glows blue you have THH, if any green glow, you have unconverted harmaline in it, keep in mind harmine also glows blue too though. Be-ware cheap China made THH as a handful of people have reported it glowing green and not blue, harmaline contamination, incomplete synthesis. I recommend making your own or quality sources.

1. Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.

2. She is in the same beta-carboline family as ibogaine. She is the 2nd highest alkaloid in Caapi. She has a 10.5 hour half-life with peak at 5.25 hours.

3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.

4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin.

5. THH has numerous similarities to mescaline, she is like the beta-carboline version of mescaline, few people have used her over 100mg. I have seen the receptorome chart for THH vs. mescaline. She not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors A1-A3 associated with beauty and aesthetic enhancement, just like mescaline. Beauty enhancement is "over the top" when THH is included, she is diamondlike shimmering in her beauty.

Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.

6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, when 2 cups are drank by some of the more advanced members for evening at the vegetals (UDV, Santo Daime, Shuar Indian) people are consuming around 300mg of THH.

7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. The combo of THH + DMT is like listening to music on high-dose cactus tea, heavenly.

8. This pure THH at 300mg all by herself is extremely visual, she's an isomer of a hormone like substance made in the brain naturally.

9. The entry in TIHKAL for 300mg THH is completely wrong, where the unexperienced person compares it to the effects of 100mg harmaline. She is nothing at all like harmaline, and like 69ron once said about the person's comment in TIHKAL, he or she would not be able to tell their ass from their elbow. I agree, what complete nonsense.


Part 2: Receptorome chart

This is why I kindly suggest giving this a try: taking the DMT with either tetrahydroharmine (as found in true Ayahuasca) or 5-meo-dmt (both which block 5-ht1a serotonin day to day survival filters in the brain):

Thomas S. Ray, Psychedelics and the Human Receptorome (2010):

http://journals.plos.org...71/journal.pone.0009019
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max or "off the charts", 0.00=min
Quote:
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty & new ideas)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)

2011 Thomas S. Ray study: Breadth of Receptor Binding, 4.00=max, 0.00=min
Quote:
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (these serotonin filters/gates/barriers/doors make up >80% of brain 5-ht & are broken down when 5-ht1a is agonized)

This study from Mol Pharmacol. 1988 Feb;33(2):178-86. backs up the above study from Thomas S. Ray:

Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. https://www.ncbi.nlm.nih.gov/pubmed/2828913
Quote:
5-HT1A agonist: All the tryptamine derivatives substituted in position 5 of the indol were potent agonists [5-HT, 5-CT, 5-MeO-N,N-DMT, 5-methoxytryptamine, and bufotenine (5-ho-DMT)],

whereas tryptamine, N-methyltryptamine, and N,N-dimethyltryptamine (DMT) were poor agonists.

Dr. Nichols (Heffter.org LSD paper):
Quote:
LSD has very strong potency in blocking the action of serotonin. LSD is strongly "anti-serotonin". The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist. 5-ht1a makes up >80% of brain 5-ht receptors

An example of the importance of adding the serotonin reuptake inhibition properties of 5-meo-dmt for example to dmt (which has poor 5-ht1 reuptake properites on it's own) is shown below. This is the same way the snuff's are used in the amazon, as they naturally combine dmt with additives which cause the reuptake of 5-ht like bufotenin for example.

Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":

DMT + tiny amounts of 5-meo-dmt [perhaps similar theoretically to Amazonian snuffs which have a makeup of 7.4% bufotenin (potent 5-ht1a agonist), 0.04% 5-MeO-DMT (potent 5-ht1a agonist) & 0.16% DMT (poor potency as 5-ht1a agonist):
Quote:
As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.

--> With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.

Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.

As we go thru day to day life, the 5-ht1a brain serotonin filters (gates, or day to day survival filters as I like to call them) which make up over 80% of brain 5-ht are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world": https://en.wikipedia.org/wiki/Mind_at_Large

Aldous Huxley held that psychedelic drugs could disable filters which inhibit Mind at Large from reaching the conscious mind. In his books, Huxley explores the idea that the human mind filters reality, partly because handling the details of all of the impressions and images coming in would be unbearable, partly because it has been taught to do so. He believes that psychoactive drugs can partly remove this filter, which leaves the drug user exposed to Mind at Large.

5-ht1a inhibition by entheogens (in green above) theoretically cause this filter system to be lifted, and the infinite mind to manifest in combination with oral dmt with the tetrahydroharmine providing the 5-ht1a inhibition & additional adrenal system agonization (A2A thru A2C), just as bufotenine in snuff's provide the 5-ht1a inhibition combined with the dmt in the snuff's, resulting in a 3 hour experience ie both examples of Teamwork on how these entheogens are used traditionally in the Amazon.

Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. In other words, tetrahydroharmine and Ibogaine reverse the serotonin transporter. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor.

Tetrahydroharmine is a serotonin reuptake inhibitor, it is an SRI found in caapi. In other words, both are strong serotonin reuptake inhibitors which inhibit over 80% of brain 5-ht at 5-ht1a.

Crude example: We come to a red light and stop as the filter systems in our brain have conditioned us to stop in order to survive, and go only when the light turns green. Without this filter, and the infinite mind only in place, we might stop at the red light and admire it for it's beauty for long periods of time instead.

Part 3: why HPBCD is completely safe when used sublingually or orally with studies

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017:
Quote:
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes. Cyclodextrins at high doses can increase drug permeability by direct action on mucosal and intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7]. Cyclodextrins are absorbed poorly via mucosal membranes but can improve complexed drug absorption by up to 400% sublingually.

The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27]. The α- and β-cyclodextrins do not cross the intestinal barrier in significant amounts and are fermented by gut bacteria or excreted whole; γ-cyclodextrins are metabolized by mammalian α-amylases into linear oligosaccharides. Consequently, cyclodextrins in food or otherwise consumed orally or applied sublingually do not usually enter the circulation in significant amounts (Frijlink et al., 1990), and thus are very safe.

From "Discussions" pages 55-56 of Niemann-Pick disease study:
Quote:
In humans, intravenous administration of up to 3 grams (3,000mg) HPBCD in healthy volunteers was well-tolerated and doses of 16 grams (16,000mg) HPBCD per day given with itraconazole did not result in hearing abnormalities (4). The authors could not find examples of doses of 1000 mg/kg and higher being used in human patients although these are being proposed to treat patients with NPC disease. The authors are aware of no previous study examining the effect of HPβCD on auditory function and yet we were able to determine an effect on hearing using a small number of normal cats and cats with NPC disease.

Our data show that 1000 mg/kg had no effect on the BAER response when given weekly for 14 doses between the ages of three and 16 weeks of age. Doses of 4000 mg/kg body weight resulted in an increase in hearing threshold only after repeated dosing and doses of 8000 mg/kg body weight resulted in significant increases in hearing threshold in both normal cats and cats with NPC disease following the administration of a single dose.

Point 1: We are only using 1,050mg HPBCD to complex 30mg harmine + 120mg DMT (30 x 7 + 120 x 7 = 210 + 840mg HPBCD) = 1050mg HPBCD. HPBCD is derived from the enzymatic degradation of corn starch.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct 9, 2017: Page 11 of 16:
Quote:
According to the data in section 2 one can conclude that below 20 mg/kg/day no serious adverse effects are to be expected for all routes of administration (nasal, rectal, dermal, sublingual, ocular) and no statement is deemed necessary.

Above 20 mg/kg/day, cyclodextrins may show some activity, and because there are insufficient safety data in children below two years old, it is advisable to inform about the quantity of cyclodextrin in the product and that for use in children below two years old, a doctor’s recommendation is needed.

Above 200 mg/kg/day cyclodextrins may theoretically cause problems in the digestive system when given orally, and cause mild renal toxicity when given parenteral, which information can be given. Depending on the amount, cyclodextrins may influence the Cyclodextrins used as excipients permeability of tissues and therefore the bioavailability of active substances given topically (nasal, rectal, dermal, sublingual, ocular).
This is exactly the way I use the HPBCD sublingually, when I complex 120mg DMT to (x7) or 840mg of HPBCD and complex 30mg harmine to x7 or 210mg HPBCD, and I re-dose again at the 1.5 hour point, I am using around 2000mg of HPBCD for the evening. I weigh 100kg, so I am using at or less than 20mg/kg/day or 2000mg per day. This always gives me a 3 hour long +5 Shulgin level strength experience with super-long afterglow. Very similar to 500mg plus of mescaline when used with 300mg of pure tetrahydroharmine (THH) taken orally around 45 minutes before. Very powerful experience, my absolute favorite for use at home [along with bridgesii cactus tea which I also cherish just as highly, but drink only before I go to the waterpark, mescaline was made for outdoors].

Point 2: The sublingual route results in up to 400% increase in absorption of complexed freebase drugs, but the HPBCD itself is poorly absorbed, only about 0.1 to 3% is absorbed orally, and the HPBCD is poorly absorbed sublingually (under the tongue) even though it increases the complexed drug absorption under the tongue by up to 400% via polysaccharide actions on the sublingual mucosa.

Point 3: Again, we are not using mega dose 20,000 to 30,000mg HPBCD direct brain injections like the un-curable Nieman Pick disease study on cats, every day brain injections for an entire week, or 14 total mega-doses like the cat Nieman Pick study. This is COMPLETELY different, this is oral or sublingual use, huge difference.

Point 4: I had my hearing checked (spent $200) at the local ear, nose, throat doctor for shits and grins, and my hearing was completely normal after using HPBCD sublingually over a year's time, used over some 50 times. I posted the results way back around page 15.

Point 5: Patrick Arnold sold HPBCD complexed pro-hormones for sublingual use for 10 years, and made millions of dollars in sales they worked so will, never any complaints of hearing loss. He only stopped selling it because the Government made pro-hormones illegal as they worked as well as steroids. See post #409 for more on this with pics of his hot selling "Cyclodiol", and description from chemist and bodybuilder Patrick Arnold on how it worked so well with bloodwork studies, he was granted patents on this revolutionary discovery.

As a life long chemist myself (and bodybuilder) I am simply applying his method to freebase DMT, resulting in yet another revolutionary discovery: the powerful strong absorption of DMT (along with 30 to 35mg sublingual HPBCD complexed harmine to activate) via the sublingual mucosa, in combination with 300mg oral tetrahydroaharmine taken 45 minutes before, simulating oral Ayahuasca for 1.5 hour but without all the nausea, dizziness, anxiety & weird feelings that can often accompany oral Ayahuasca. I've taken oral Ayahuasca over 80 times in a decade, and vastly prefer the Sublingual Ayahuasca: just as powerful but without all the above mentioned symptoms I could do without.

Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.
I use 30mg to 35mg HPBCD complexed harmine fb sublingually along with the sublingual HPBCD complexed DMT, 30mg sublingual has the power of x6 or 180mg oral harmine. 35mg sublingual HPBCD complexed harmine is also very strong and has the power of x6 or 210mg oral harmine.

Dr. Narang:
Quote:
The absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa under tongue is only 100 to 200 microns thick.
 
starway7
#418 Posted : 5/29/2022 4:48:10 PM

DMT-Nexus member


Posts: 455
Joined: 08-Sep-2018
Last visit: 30-Jun-2022
Location: colorado
Ava...

I am not spreading false info on HPBCD...

I only put what ive read many times on line about the stuff,,

This info .. [solidly exists].. on line! ..read it ..page after page!... talking about the risks of using HPBCD
on hearing.....

Its a long known fact ..that DMT does not work sublingually very well by itself...

If HPBCD makes it work sublingually for you great...But i havent seen any proof that it does from any one else ?Confused ..as ive tryed your method several times and nothing ever happened..

Please!..... any one out there thats tryed AVA 69s sublingual method ?.like to hear from
[JUST ONE PERSON].. that it works as well as you claim it does .. please report your sucess!!

i would love for your method to work!!..but it hasent worked for me!.. and many others!... not to the degree of success you have reported...

I would like to hear..[..just ONE REPORT!]... of real sucess with this method?...besides yours..that it works sublingually as well as you claim it does......

Info on line page after page suggests that HPBCD .. [[MAY].. .. be a risk to hearing... and thats all i put..so dont blow a gasket..and make acusations without proof.. ...

have a nice day..




Highlights. β-Cyclodextrin used to treat Niemann-Pick disease causes hearing loss. In adults, β-Cyclodextrin, a cholesterol chelator, only killed adult outer hair cell. β-Cyclodextrin killed all postnatal cochlear and vestibular hair cells and neurons.

Hydroxypropyl-β-cyclodextrin causes massive damage to the ...https://www.sciencedirect.com › science › article › abs › pii







The susceptibility of cochlear outer hair cells to cyclodextrin is ...https://actaneurocomms.biomedcentral.com › articles
by Y Zhou · 2018 · Cited by 7 — Though promising in alleviating neurological symptoms, HPβCD causes irreversible hearing loss in NPC1 patients and outer hair cell (OHC) ...

Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with ...https://www.ncbi.nlm.nih.gov › articles › PMC5676048
by MA Crumling · 2017 · Cited by 54 — Despite the potential health benefits, use of HPβCD has been linked to significant hearing loss in several species, including humans.
Missing: harms ‎| Must include: harms

Hearing Loss and Otopathology Following Systemic ... - PubMedhttps://pubmed.ncbi.nlm.nih.gov › ...
by S Cronin · 2015 · Cited by 29 — However, recent evidence shows that 2-hydroxypropyl-β-cyclodextrin (HPβCD) causes severe hearing loss in mice, selectively killing outer hair ...
People also ask
Does cyclodextrin cause hearing loss?
Is beta cyclodextrin harmful?
Is 2-hydroxypropyl-β-cyclodextrin safe for humans?
What is iatrogenic hearing loss?
Feedback

(PDF) Hearing Loss and Otopathology Following Systemic ...https://www.researchgate.net › publication › 277958431_...
Jun 9, 2015 — However, recent evidence shows that 2-hydroxypropyl-β-cyclodextrin (HPβCD) causes severe hearing loss in mice, selectively killing outer ...

2-Hydroxypropyl-β-Cyclodextrin Raises Hearing Threshold in ...https://www.researchgate.net › publication › 42807165_2...
We evaluated the efficacy of HPbetaCD in the feline model of NPC disease and recognized a dose-dependent increase in hearing threshold associated with therapy ...

Safety and Efficacy of Intravenous Trappsol Cyclo (HPBCD) in ...https://clinicaltrials.gov › show › NCT02912793
Samples of Cerebrospinal fluid (CSF) are also taken by lumbar puncture during and following the first treatment dose. Patients will also have their hearing ...

Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 ...https://clinicaltrials.gov › show › NCT01747135
Hydroxypropyl beta cyclodextrin (HPBCD) is being tested for a disease called ... They will also have neurological tests, including tests of hearing, ...

Cyclodextrins in Drug Delivery Systems and Their Effects on ...https://www.mdpi.com › pdfPDF
by Á Haimhoffer · 2019 · Cited by 62 — hydroxypropyl-β-cyclodextrin (HPBCD) was found to be effective in vitro in ... ototoxicity and hearing loss was recorded in all patients.

Hydroxypropyl-β-cyclodextrin causes massive damage to the ...https://cyclodextrinnews.com › 2020/10/28 › hydroxyp...
Oct 28, 2020 — Cyclodextrin News, Hydroxypropyl beta-cyclodextrin, HPBCD, hearing loss, mice, rats, cochlear hair cells.
Missing: harms ‎| Must include: harms

Use of cyclodextrins in diseases and disorders involving ...https://patents.google.com › patent
26: Activation of TFEB by HPbCD: ΗΡ-β-CD has been shown to activate ... Plot of hearing thresholds for individual mice reveals minute variability across ...
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ava69
#419 Posted : 5/29/2022 6:42:03 PM

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Posts: 359
Joined: 24-Apr-2021
Last visit: 29-Jun-2022
Stop Stop Stop
"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct, 2019, available on-line free, simply google:
Quote:
Due to it's bulky nature, HPBCD is absorbed poorly via mucosal membranes, but the HPBCD complexed drug absorption is increased up to 400% into the sublingual mucosa under the tongue via polysaccharide absorption enhancement activity.
Most of the water soluble bulky HPBCD itself (1300g/mol) ends up in the saliva you spit out after 15 minutes into a cup while you are holding the drug complex under the tongue...while the low molecular weight (188g/mol) DMT is released by the HPBCD into the sublingual mucosa. The HPBCD not only makes the DMT water soluble but greatly increases the pentration due to polysaccharide penetration enhancement "opening up of tight junctions" in the sublingual mucosa as studies show, allowing the DMT to cross from the sublingual mucosa into the bloodstream and cross the blood brain barrier as the potent freebase.

Starway7, if you read the 6 studies you just posted above on post #418 notice this from one of your studies for example:
Quote:
Injections were delivered at up to 10,000 mg/kg body weight (b.w.), with controls given a comparable volume of sterile 0.9 % NaCl. The majority of animals were tested at either 3000 mg/kg (SQ Low) or 6000 mg/kg (SQ high).
Notice how the researchers are once again using MEGA DOSES of injections to treat in all the studies you posted Niemann Pick disease: 10,000 mg/kg body weight is nearly 45,000mg injected for a 4.5kg cat, and 4000mg/kg body weight is nearly 18,000mg injected for a cat, or 320,000mg injected for an 80kg human....again we are not using doses anywhere near that (only 1,000mg HPBCD to complex the 30mg harmine + 120mg freebase DMT), and the sublingual under the tongue HPBCD is poorly absorbed but the complexed drug absorption is increased up to 400% into the sublingual mucosa via polysaccharide activity, just as the European Medicines union writes above. We are not using injections of any kind whether they be sublingual under the skin into the neck or intrathecal directly into the brain, as all the above posted studies you cite. Even water is toxic if you drink enough. It looks like you didn't read any of the studies you posted, just copy and paste.

From "Discussions" pages 55-56 of Niemann-Pick disease study:
Quote:
In humans, intravenous administration of up to 3 grams (3,000mg) HPBCD in healthy volunteers was well-tolerated and doses of 16 grams (16,000mg) HPBCD per day given with itraconazole did not result in hearing abnormalities (4). The authors could not find examples of doses of 1000 mg/kg and higher being used in human patients although these are being proposed to treat patients with NPC disease. The authors are aware of no previous study examining the effect of HPβCD on auditory function and yet we were able to determine an effect on hearing using a small number of normal cats and cats with NPC disease.

Our data show that 1000 mg/kg had no effect on the BAER response when given weekly for 14 doses between the ages of three and 16 weeks of age. Doses of 4000 mg/kg body weight resulted in an increase in hearing threshold only after repeated dosing and doses of 8000 mg/kg body weight resulted in significant increases in hearing threshold in both normal cats and cats with NPC disease following the administration of a single dose.
The researchers directly injected 4000mg per kilogram weight of the animal into the brain. This is in the range of 20,000 to 30,000mg of HPBCD directly into the brain via injection. This is called intrathecal injection. They did this same mega-dose brain injection into the cats day after day for an entire week, using 14 total MEGA intrathecal injected brain doses! As some of the newer studies site Starway7, it is unfortunate that researchers decided to go ahead and use these injected MEGA-DOSES on humans with Niemann Pick disease regardless. In my opinion, they should not have gone there.

Another thing, the reason your HPBCD complexed DMT never worked, is because you mention way back that you never included the sublingual harmine along with it in order to activate it, without the harmine, there is no trip. As Dr McKenna states, "The harmine not only activates the DMT but prevents it from being deaminated or "zapped" by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron."

By saying this does not work, you not only attempt to disrespect myself but L-dreamers beautiful experiences as well, and you plainly ignore the bloodwork studies done by chemist Patrick Arnold on sublingual HPBCD complexed freebase pro-hormones. Had they not worked, his company Ergopharm would not have had millions of dollars in sales for 10 years and bloodwork studies to back it all up, see reference under "references" below from Chemist Patrick Arnold for proof.
 
ava69
#420 Posted : 6/2/2022 4:21:12 PM

DMT-Nexus member


Posts: 359
Joined: 24-Apr-2021
Last visit: 29-Jun-2022
Complete summary of all pages, or entire topic, contents 1-6:

1. HPBCD is completely safe when used sublingually or orally with studies
2. Latest Sublingual Ayahuasca Journey #57 (5-20-2022)
3. References from Dr. McKenna, Jamie, Dr. Narang & Chemist Patrick Arnold on how HPBCD increases sublingual penetration absorption of DMT into the sublingual mucosa under tongue by up to 400%.
4. References: 12 Reasons why you should always take from 150 to 300mg pure tetrahydroharmine or THH orally around 45 minutes before applying the sublingual HPBCD complexed 30mg harmine + 60 to 150mg DMT mixed together & held under tongue for 15 minutes.
5. How to complex the harmine and DMT to the HPBCD in only 2 minutes, very easy, done on a spoon.
6. My first Sublingual Ayahuasca Journey #1 (4-23-2021)

1. HPBCD is completely safe when used sublingually or orally with studies:

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct, 2019, available on-line free, simply google:
Quote:
Due to it's bulky nature, HPBCD is absorbed poorly via mucosal membranes, but the HPBCD complexed drug absorption is increased up to 400% into the sublingual mucosa under the tongue via polysaccharide absorption enhancement activity.
Most of the water soluble bulky HPBCD itself (1300g/mol) ends up in the saliva you spit out after 15 minutes into a cup while you are holding the drug complex under the tongue...while the low molecular weight (188g/mol) DMT is released by the HPBCD into the sublingual mucosa. The HPBCD not only makes the DMT water soluble but greatly increases the penetration due to polysaccharide penetration enhancement "opening up of tight junctions" in the sublingual mucosa as studies show, allowing the DMT to cross from the sublingual mucosa into the bloodstream and cross the blood brain barrier as the potent freebase.

"Cyclodextrins used as excipients" pdf, European Medicines Agency, Oct, 2019:
Quote:
Cyclodextrins can be used to reduce or prevent gastrointestinal and ocular irritation, reduce or eliminate unpleasant smells or tastes. Cyclodextrins at high doses can increase drug permeability by direct action on mucosal and intestinal membranes and enhance drug absorption and/or bioavailability. These effects are possibly caused by solubilisation of membrane lipids through inclusion complexation with cyclodextrins and the ability of cyclodextrins to cause perturbation of membrane integrity. However, unlike detergents, cyclodextrins solubilize membrane components without entering into the membrane, therefore the perturbing effects of cyclodextrins are mild and reversible [7]. Cyclodextrins are absorbed poorly via mucosal membranes but can improve complexed drug absorption by up to 400% sublingually.

The oral bioavailability of cyclodextrins is very low in adult animals and humans (0.1–3%), except for RM-β-CD, which has a bioavailability of 12% in rats. Because of their bulky and hydrophilic nature only insignificant amounts of cyclodextrins are absorbed from the gastrointestinal tract by passive diffusion [33, 27]. The α- and β-cyclodextrins do not cross the intestinal barrier in significant amounts and are fermented by gut bacteria or excreted whole; γ-cyclodextrins are metabolized by mammalian α-amylases into linear oligosaccharides. Consequently, cyclodextrins in food or otherwise consumed orally or applied sublingually do not usually enter the circulation in significant amounts (Frijlink et al., 1990), and thus are very safe.

Method 1: Remember, for this to work at all, you must include from 30mg harmine freebase complexed to x6 or 180mg HPBCD, or 35mg harmine freebase complexed to x6 or 210mg HPBCD under the tongue (has the power of x6 or 180 to 210mg oral harmine), along with your 60 to 150mg HPBCD complexed DMT. Instructions on content #5. Method 2: Or you can take 200mg of oral harmine around 1 hour before, when you begin to feel the harmine working, then apply the HPBCD complexed DMT under tongue. See post #2 of this thread for complete Method 2 trip report.

As a life long chemist myself (and bodybuilder, this is my current pic at 220lbs, 12% bodyfat in profile avatar wearing cactus t-shirt) I am simply applying chemist & bodybuilder Patrick Arnold's proven method described in references #3 below with supporting blood work to freebase DMT, resulting in yet another revolutionary discovery: the powerful strong absorption of DMT (along with 30mg sublingual HPBCD complexed harmine to activate) via the sublingual mucosa, in combination with 300mg oral tetrahydroharmine taken 45 minutes before, simulating oral Ayahuasca for 1.5 hour but without all the nausea, dizziness, anxiety & weird feelings that can often accompany oral Ayahuasca, and it's easy to sublingual re-dose again at the 1.5 hour point should you desire. I've taken oral Ayahuasca over 80 times in a decade, and vastly prefer the Sublingual Ayahuasca: just as powerful but without all the above mentioned symptoms I could do without.

Spend most of my spare time at the gym, beach & waterpark down the road over the summer. In my 20's while going thru school, was a certified lifeguard instructor & deep water lifeguard over the spring and summers for the beach & local waterpark, something I enjoyed a lot, water spirit here. Beach, waterpark & parks are my 3 favorite places, love walking with my dog on the seawall or the local parks anytime I am off, lift weights 2 to 3 times a week, and run at least 20 minutes on days I don't lift.

Thanks to the sublingual Ayahuasca, now save my home grown bridgesii cactus for use only when I go to the waterpark, drinking the tea made from 1.5 to two 12" bridgesii (depending on thickness). Mescaline was made for outdoors. We get a pass and go every summer at least once a week with my wife, her sister and teenagers, the waterpark is right down the road. Enjoy being out in nature to escape working for a corporation long-hours which I equate to an air-conditioned ant hill.

2. Latest Sublingual Ayahuasca Journey #57 (5-20-2022):

300mg oral THH + 30mg sublingual harmine + 60mg sublingual DMT feels like 300mg mescaline
300mg oral THH + 30mg sublingual harmine + 90mg sublingual DMT feels like 400mg mescaline
300mg oral THH + 30mg sublingual harmine + 120mg sublingual DMT feels like 500mg mescaline
300mg oral THH + 30mg sublingual harmine + 150mg sublingual DMT feels like 600mg mescaline

For new people: I would recommend 60mg for a +3 Shulgin strength. This is the beginning dose, remember this works for 1.5 hour, the 60mg is needed to provide the horsepower for the long duration. 12 reasons why you should always include from 150 to 300mg oral pure THH around 45 minutes before with your sublingual Ayahuasca in references below, content #4.

Yesterday 5-20-2022, at 3pm, I used 300mg pure THH orally 45 minutes before, then 30mg harmine mixed with 120mg dmt all on a single spoon with (30 x 7 = 210mg HPBCD) + (120 x 7 = 840mg HPBCD) = 1050mg total HPBCD mixed and crushed back and forth on the spoon for 2 minutes using the end of another spoon with 10 drops boiling hot water, placed bottom side of tongue onto spoon, it all adhered as HPBCD forms sticky complexes, studies show HPBCD complexed freebase drugs increase absorption sublingually x 400 percent, held under tongue for 15 minutes, viewed incredible CEV's for 1 hour...

....this time the geometries skipped and went straight to realistic visions: I viewed incredibly beautiful women morphing into other beautiful women, all neon colored, these women changed into nearly 20 different women, completely naked and with animated face changes, infinite beauty, mind blowing CEV's...like the most incredible cartoon renderings of the most beautiful women, they even had geometric swirling pastels on the surface of their bodies...completely blown away. I usually use this at least once a week, just incredible. When I say animated, these women smiled and blew kisses and moved into all different positions...like watching a movie. They made intimate eye contact and communicated via physical motions. This was a +5 Shulgin level experience, this felt like direct communication and receiving of important artistic creative feelings and insights into the feminine domain.

I recorded this journey as one of the most visual of my entire life, never have I seen an hour's worth of beautiful women morphing into other women, with swirling geometric pastel patterns on their naked bodies, communicating physically, this is an artist's dream come true, way beyond 4k, visual detail astounding. I had headphones on, and the music sounded as if I had taken a strong bridgesii cactus tea (18" of bridgesii or around 500mg of mescaline), profound music enhancement, just heavenly, powerful spiritual insights, infinite open eyed beauty and neon colors splashed on all the walls, very powerful experience, it was so strong I started to feel the sublingual harmine/dmt starting to work in only 10 minutes, incredible blast off, lasted 1.5 hour with very strong trip, with 1 full hour of powerful closed eye visions as stated above. Zero nausea, zero dizziness, zero anxiety, fast comeup, had not used THH or DMT in two weeks, this may explain the powerful realistic visions.

The harmine and dmt needs to be taken mixed together and held under tongue at the EXACT SAME TIME, just as the Shaman's do for the most powerful experience, the harmine also helps masks the mild sting of the HPBCD DMT, it is actually comfortable under the tongue, and the sting becomes extremely mild with the harmine helping to mask.

For me, with every sublingual Ayahuasca journey, a higher level of consciousness is awake at one with being, beyond thought and the mind: the realization that all the things that truly matter - the spiritual, beauty, love, creativity, joy, inner peace - arise from beyond the mind, each journey awakens me and teaches me how to access this level of consiousness in everyday practice, to be the observer of the thinker, to rise above thought, a sense of stillness and peace, to be fully present in the moment, to feel the subtle emanation of joy arising from deep within: the joy of Being.

3. References from Dr. McKenna, Jamie, Dr Narang, chemist Patrick Arnold:

Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.

Jamie, posted : 11/23/2012 8:29:28 PM:
Quote:
You can't compare sublingual or oral either..20-30mg sublingual harmine is enough to activate sublingual DMT and cause effects on it's own. 20mg sublingual is probably comparable to 200mg oral.
I use 30mg to 35mg HPBCD complexed harmine fb sublingually along with the sublingual HPBCD complexed DMT, 30mg sublingual has the power of x6 or 180mg oral harmine. 35mg sublingual HPBCD complexed harmine is also very strong and has the power of x6 or 210mg oral harmine.

Dr. Narang:
Quote:
The absorption of drugs through the sublingual route is 3 to 10 times greater than oral route and is surpassed by hypodermic injection. Sublingual mucosa under tongue is only 100 to 200 microns thick.

MESO-Rx, "Ask Patrick Arnold #10", April 15, 1999 By Chemist & bodybuilder Patrick Arnold:
Quote:
Sublingual hydroxypropylbetacyclodextrin (HPBCD) complexed testosterone has a very high bioavailabilty however as the peak blood levels are seen rather quickly (20 to 40 minutes). These peaks are quite high however and the drop off is substantially gradual as in the EMU study testosterone levels of greater than 60% over baseline were still measured after 2 hours.

Straight testosterone or prohormones do not have very good absorption under the tongue. When complexed with cyclodextrin the properties change to enable it to absorb extremely well. It would be a long and detailed explanation but that is the jist of it.
DMT is very similar to pro-hormones, poor absorption under tongue, but when complexed to HPBCD, it absorb's extremely well, studies show up to 400% increased penetration. Chemist Patrick Arnold taught me how to complex pro-hormones in my 20's: https://thinksteroids.co.../ask-patrick-arnold-11/

4. References: 12 reasons why you should always include from 150 to 300mg pure THH or tetrahydroharmine in your Ayahuasca:

Personal note: I may be a long term chemist, but I developed a method (post #12) many years ago so that anyone can make tetrahydroharmine at home. I went into a trance state after a death and received the information from a divine source on how to do this, as I was stuck at one point for weeks on end with no solution. No fancy chemicals or equipment needed like TIHKAL THH Synthesis. Due to the hundreds of Spiritual centers in South America needing these plants, good older Caapi is increasingly being harder to find. You can do this with normal coffee filters and cotton ball stuffed in a funnel. Tetrahydroharmine (THH): she is as valuable as mescaline, can't do without her. Diamondlike shimmering in her beauty.

1. Dennis Mckenna Ph.D:
Quote:
Thus, tetrahydroharmine may prolong the half-life of DMT by blocking it's intraneuronal uptake, and hence, its inactivation by MAO, localized in mitochondria within the neuron.
In my experience, THH doubles the half-life of DMT, so when used sublingually or orally, you get a full strong 90 minutes out of it with long afterglow.

2. She is in the same beta-carboline family as ibogaine. She is the 2nd highest alkaloid in Caapi. She has a 10.5 hour half-life with peak at 5.25 hours.

3. DMT only colors are subdued and dark, but THH brightens the DMT visuals: out of this world impossible bright neon colors are a trait of high dose oral tetrahydroharmine + moderate dose 60 to 70mg+ sublingual or oral HPBCD DMT: neon red-greens, neon orange-blues, neon purple-yellows.

4. DMT does not block serotonin on it's own, but THH does...this results in not only stimulation but euphoria in combo with the DMT: and real Ayahuasca visions become apparent...important teamwork. Ibogaine, LSD, mescaline, shrooms, 5-meo-dmt, bufotenin in Amazonian snuffs, all block serotonin, THH blocks serotonin.

5. THH has numerous similarities to mescaline, she is like the beta-carboline version of mescaline, few people have used her over 100mg. I have seen the receptorome chart for THH vs. mescaline. She not only blocks serotonin like mescaline, but agonizes all 3 adrenal receptors A1-A3 associated with beauty and aesthetic enhancement, just like mescaline. Beauty enhancement is "over the top" when THH is included, she is diamondlike shimmering in her beauty.

Actresses on TV will look like dazzling glowing super-colorful cartoon versions of themselves (just like with high dose cactus tea) only if you include the THH. Researchers have called THH the "tryptamine of the beta-carboline world" and rightly so.

6. THH is found in average 150mg in a cup of Caapi based Ayahuasca tea, when 2 cups are drank by some of the more advanced members for evening at the vegetals (UDV, Santo Daime, Shuar Indian) people are consuming around 300mg of THH.

7. Music will only sound bad-ass incredible if you include from 150mg to 300mg oral THH with your sublingual or oral DMT. The combo of THH + DMT is like listening to music on high-dose cactus tea, heavenly.

8. This pure THH at 300mg all by herself is extremely visual, she's an isomer of a hormone like substance made in the brain naturally.

9. The entry in TIHKAL for 300mg THH is completely wrong, where the unexperienced person compares it to the effects of 100mg harmaline. She is nothing at all like harmaline, and like 69ron once said about the person's comment in TIHKAL, he or she would not be able to tell their ass from their elbow. I agree, what complete nonsense.

10. professor8 (found here from 11/1/2010 he writes like a poet w/special powers of imagination & expression):
Quote:
A while back I read a very good explanation of the different effects of Harmalas that has stuck with me. I believe it was 69ron that said: ‘Harmine is the Coffee of the harmalas & Harmaline is the Weed and when it comes to THH (tetrahydroharmine) you have The Light.'

While very similar in molecular structure, THH has a completely different personality to Harmine & Harmaline. Calling it The Light of the harmalas is very appropriate. IMHO, it is the Holy Grail of The Harmalas. I have found Harmine very, very helpful in Meditation & Yoga. It energises your Light Body and allows you to see your Chakras & Auric fields; very helpful in a biofeedback sorta way.

Personally, Harmaline is too heavy & stony for me but I do respect its power and personality, kinda like a big shaggy & lovable dog.

Tetrahydroharmine (THH) has the ability to raise your vibration in a most powerful, yet subtle way. It brings a crystalline prismy texture to spice and adds a super clear watery dimension to Aya, like looking down through 10meters of shimmering Caribbean Sea on clear blue day. It brings a dimension of pure light to the entheogenic experience and encourages entities & intelligences of only the Highest Order. If one is not accustomed to perceiving these experiences with a spiritual perspective most of the nuances & subtleties THH brings on are overlooked and remain unseen and one would better enjoy Harmaline as a house painter chooses a roller over a brush, its about preference & choice.

11. Espiridion:
Quote:
Tetrahydroharmine is much more like mescaline.

12. Gayle Highpine (Ayahuasca researcher):
Quote:
The vine carries the content of the message, the teaching, and the insight. The purpose of drinking Ayahuasca is to receive the message the vine imparts.

At 300mg of THH all by itself, there are heavy open-eyed tracers like lightening flashes, and hours of teaching closed eye visions that start with colored sparkles and fireworks (red, green, yellow, blue) that dart around and progress into full-fledged way-beyond 4k visions with eyes closed that are not only static but often animated like slow and high speed movies, but all one monochrome color like green or blue for me, when you add DMT, the visions then become colored and patterning on animals for example will display their associated colors, DMT also adds on to or builds on top the THH visions, expanding them, but the teachings and insights & visions are credited to the Vine.

Tetrahydroharmine or THH ranks very high on the "periodic psychedelic table" among all the known entheogens for inducing realistic way beyond 4k monochrome teaching visions for hours...adding even small amounts of DMT brightens and colorizes the visions, example: reptiles, birds & animals such as serpents/snakes/toucans/parrots/jaguars with patterning show their respective associated colors. Many times I have viewed multi-colored serpents, birds & jaguars several times over hour long CEV periods, serpents are the manifest spirit of Ayahuasca.

THH in the caapi also seems to strongly activate the right hand hemisphere of the brain-- the side that performs tasks that have do with creativity and the arts, feelings, visualizations, imagination, holistic thinking & intuition, empathy, spirituality & connectedness. Researchers found that the right side of the brain lit up in brain scans of people who took LSD, mescaline, mushrooms or THH.

Read study reference 1 below, and you will see that Vegetal Ayahuasca (made by the UDV, Santo Daime, Shuar Indian) contains zero to extremely low amounts of harmaline (less than 15mg), but contains as much tetrahydroharmine as it does harmine. All of the Santo Daime Ayahuasca contained zero mg of harmaline: https://en.wikipedia.org/wiki/Tetrahydroharmine

Page 154 of "Various Alkaloid Profiles in Decoctions of Banisteriopsis Caapi, 2005":
Quote:
The average ratio of THH to harmine in the vegetals (traditional brews) was consistently near 1:1, from all sources (table 2), while this ratio was closer to 1:5 in a large survey of source plant material. It is presently unclear whether harmaline is being chemically reduced to THH during the acidic process of decoction.

Dr. Callaway wrote in "The Entheogen Review":
Quote:
However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União do Vegetal members who had consumed ayahuasca for 10+ years). In short, yes, there seems to be important activity from THH.


5. How to complex the harmine and DMT to the HPBCD in only 2 minutes, very easily done on a spoon:

Full instructions for sublingual or the one-shot HPBCD DMT Ayahuasca (your choice):
1) place 60mg of DMT onto a spoon (60mg for beginners)
2) add 1:1 molar ratio of host drug DMT (188g/mol) to HPBCD (1300g/mol) powder, this means 1:7 mg ratio DMT freebase to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin. For harmine freebase, 212g/mol or 1:6mg ratio harmine to HPBCD. The HPBCD is only able to complex freebase drugs, not the salt or hcl.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 8 drops of very hot near boiling water to the mix from a nearby microwaved coffee mug for DMT doses of 90mg, use 10 drops of boiling hot water to mix DMT doses of 120mg. Use 10 to 12 drops of hot water for 150mg DMT. 10 drops usually still works well for 150mg DMT. Just experiment a bit. You will want to use less drops of hot water (1 drop per 12mg DMT) for higher doses of DMT so it will fit comfortably below the tongue. 60mg DMT = +3 Shulgin level strength, 90mg DMT = +4 Shulgin level life strength. 120 to 150mg DMT = +5 Shulgin level life changing experience.
5) Add 30 to 35mg harmine freebase to your spoon of HPBCD DMT, add x 6 or 180mg HPBCD for 30mg harmine. Add x 6 or 210mg HPBCD for 35mg harmine, add 2 to 3 more drops of hot water to complex the harmine.
6) Knead or crush the HPBCD powder into the dmt & harmine using the end of another spoon for 2 minutes, scrape & mix everything back and forth hard using your muscles. This is how scientist pre-pare these complexes by kneading.
7) Hold a lighter one inch away from under the spoon to heat up spoon for 20 seconds, then pull flame away, this aids the final complete dissolution or dissolving of the 3 ingredients after heating up a slight bit, mix the contents 10 seconds more before using, just as bodybuilder chemist Patrick Arnold recommended and taught for sublingual pro-hormone mixing.

8] --> For one-shot Ayahuasca: Refer to post #381 on page 20 with 6 pics: https://www.dmt-nexus.me...ts&t=96861&p=20 simply dunk spoon of HPBCD DMT into 30ml (one-shot) of 125 degree F water from microwave when ready to drink for the evening, stir a few seconds...it dissolves instantly, and leaves a transparent color it dissolves so well, then stir in around 160mg harmine fb and 150 to 300mg tetrahydroharmine freebase, add around 100mg of 100% pure vitamin C powder so the freebase harmalas can dissolve, stir a bit, then drink all at once as the Shaman's do for the most powerful journey.

Note: DRY THE BOTTOM of tongue/sublingual mucosa with a tissue before applying.

6. My first Sublingual Ayahuasca Journey #1 (4-23-2021) that started all this:

Note: Be sure to always take from 150 to 300mg very pure THH orally around 45 minutes before. You can put it in an empty capsule. Normal Caapi based Ayahuasca always contains an average of 150mg THH per cup, 2 cups Ayahuasca contain 300mg THH.

No need to ever re-dose more of the oral tetrahydroharmine or THH as she (feminine teaching spirit) has a half life of 10.5 hours with peak at 5.25 hours.

Depending on total HPBCD harmine + HPBCD dmt dosage, it can all absorb in as little as 10 minutes, for higher doses I give it 15 minutes under tongue, it all completely absorbs. Spit out all the built up saliva at the end of 15 minutes into a cup, all of the sublingual Ayahuasca ingredients should have easily absorbed by then....but if at any point during the 15 minutes you build up too much saliva, and you feel it become too uncomfortable, simply tilt head forward and gently relieve any built up saliva but always keep tongue pressed down to hold any remaining ingredients in the sublingual mucosa under tongue at all times.

There is a mild sting felt while you do this, but the added harmine sublingually helps to make the sting very mild...works to mask a bit...and it doesn't bother me at all, as it is so worth enduring for 10 to 15 minutes for the phenomenal spiritually divine experience that begins 22 minutes after you begin all this (the sublingual experience begins in 1/2 the time or 22 minutes instead of 45 minutes like the oral) but still lasts 1.5 hour with super long afterglow. You can re-dose up to two more times, and it continues to work just as strong as the first dose, so long as you continue to use 30mg harmine along with each re-dose of dmt.

--> On my very first 300mg oral THH taken 45 minutes earlier + sublingual 60mg HPBCD DMT fb (60mg DMT complexed to x7 or 420mg HPBCD in 6 drops boiling hot water) combined with sublingual 30mg HPBCD harmine fb (30mg harmine complexed to x6 or 180mg HPBCD in 2 to 3 drops boiling hot water) held under tongue at exact same time journey with 2 sublingual re-doses at each 1.5 hour mark (had not used dmt in several months):

...all the way till 5am in the morning I was seeing closed eye visions of slow and high speed movies...I saw brightly colored serpents, dungeons I traveled thru, many Mesoamerican pyramids, women of incredible beauty, Japanese landscapes, dancing geometrics, many different animals on a rotating globe, walking on the planet-like globe as it spun, hundreds of visions like slow and high-speed movies over the course of many hours.

I wore headphones and listened to music the whole time, as the music sounded just like if I had taken a very strong cactus tea.

I saw the interiors of many magnificent homes, exposed like a camera flash went off, then off to the next home interior, bizarre alien looking creatures, I saw ancient ruins but they were seen as they were before they fell apart. All sorts of architectural wonders appeared that I could not make out exactly what time period they were from.

All the visions were enchanting & manifested incredible beauty. The multi-colored beautiful serpents kept appearing several times in different forms, as if they have some prominence to do with it all, two of them had shining skin covered in gold scales and intertwined like DNA, reminds me of the Aztec quetzalcoatl myth, the "serpent of precious feathers."

...all of these visions were brightly colored due to the sublingual DMT/harmine and oral THH combo all night long..it was one of the most powerful psychedelic experiences of my life...and I've taken Ayahuasca x 70 times, cactus 200 times, etc...I have never had over 5 hours of non-stop CEV visions anything close to what I saw that first night.

The visions inspired me to buy a book on the Aztec myth of "Quetzalcoatl, the serpent of precious feathers", as I feel somehow this entity is a "teacher to mankind". I saw the brightly colored serpents many times in the 5 hours of visions, and now I understand why they are so commonly reported in Ayahuasca journeys. They seem to possess divine knowledge that humans were not supposed to have been privileged to, but the serpents gifted this knowledge to humankind.

Recently found a 1.5 hour video on Amazon prime entitled "Ancient Alien Origins" and "Alien gods" 2019 on Amazon prime which is all about this ancient alien flying serpent or dragon entity which is found in all religions of the world & "BAM, Builders of the Ancient Mysteries".

Return of the Serpent & of Eden:

https://earthmedicine201...of-the-serpent-of-eden/

Pic1: top to bottom: 300mg pure white tetrahydroharmine (THH) taken orally x 45 minutes before, 30mg harmine freebase, 120mg DMT freebase, 1050mg total HPBCD to complex the harmine (30mg harmine x 7 = 210mg HPBCD + 120mg dmt x 7 = 840mg HPBCD, total = 1050mg HPBCD) in 10 drops boiling hot water from a nearby coffee mug all on a single spoon.

Pic2: 30mg harmine + 120mg DMT + 1050mg HPBCD all getting ready to be mixed and mashed together on a single spoon for 2 minutes using 10 drops boiling hot water from a nearby microwaved coffee mug. Also shown at top: 300mg pure white THH in a weigher which was taken orally x 45 minutes before hand.

Pic3: This is the 30mg harmine + 120mg DMT + 1050mg HPBCD all mixed together for 2 minutes in 10 drops boiling hot water, mixed and mashed it hard back and forth using muscles, this is how scientist prepare these complexes, by kneading...then held lighter 1" away under spoon for 20 seconds, then mixed contents x 10 seconds more after light heating...this light heating guarantees the final complexing of all the ingredients, then placed tongue onto spoon, it all adhered, held for 15 minutes in sublingual mucosa, started to work strongly in only 10 minutes. Took 300mg pure tetrahydroharmine or THH orally 45 minutes before beginning the sublingual. This resulted in +5 Shulgin level life changing strength journey, extremely visual & music enhancing.

Pic4: 4 of my 12" home grown bridgesii, I grow an entire patio full of these which get morning sun only. I drink the tea of 2 of these when I go to the waterpark, all of outdoors looks like a fairy tale land full of neon colored bikinis, phenomenal psychedelic experience all morning and afternoon long. No words to describe. The 5-20-2022 trip above using 300mg oral THH + 30mg sublingual HPBCD complexed harmine + 120mg sublingual HPBCD complexed DMT feels very similar to 18" of bridgesii tea or 500mg of mescaline for 1.5 hour with super long afterglow, and it's easy to re-dose more of the sublingual harmine/dmt if you choose at every 1.5 hour point x 2 more times for a 4.5 hour long strong trip. No need to ever re-dose more of the tetrahydroharmine as it has a 10.5 hour half life with peak at 5.25 hours.

Pic5: The late great DM Turner on the mescaline experience. I've taken purified mescaline around 50 times in doses from 300 to 600mg, and bridgesii cactus tea over 200 times in a decade. The oral 300mg THH + sublingual 30mg harmine + sublingual 120mg dmt feels very similar to a high dose 500mg mescaline experience. Easy to handle, crystal clear clarity, euphoria, profoundly beautiful and extremely visual, infinite open eyed beauty, powerful music enhancement and profound spiritual insights with a special feeling like Heaven is smiling down on you, just like DM Turner describes.

Pic6: Dr. Narang: "Sublingual mucosa under tongue 100 to 200 microns thick, 3 to 10 times better than oral absorption."

Last pic: each 3ml syringe with storage cap is back filled (remove plunger from syringe) from spoon full of HPBCD complexed 30mg harmine and 150mg DMT for storage in a freezer, defrost by dunking in a coffee cup full of hot water when ready to use.

Artwork courtesy Chuck Sperry, F. Scott Hess (dreamtime), Jillian Evelyn (beyond the mold), Soey Milk (inflorescence, woman meditating).

Pics for welcome guests (post #14): https://mycotopia.net/to...rneys-over-a-years-time/
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