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The TRANSDERMAL DMT Thread Options
 
roninsina
#81 Posted : 10/31/2021 5:07:26 AM

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IridiumAndLace wrote:
(Apologies for the double post)

Well folks, I have another result, albeit definitely not the one I hoped for. I did a skin sensitivity test, identical to the last test, with a 1 cm² pad containing just emu oil and nerolidol. After 7 hours I removed the patch, and... No reaction. I couldn't smell any nerolidol left in the patch, and my skin was just fine.

Meanwhile, the red rectangle on my other arm is less inflamed and fading slowly, but still clearly visible. Hydrocortisone had no effect.

From this, I'm forced to the unfortunate conclusion that it was the DMT freebase that was the cause of the irritation, NOT the nerolidol as previously thought. (My DMT is very pure, so I don't believe extraction byproducts were the cause.) This spice was pretty dilute, so I'm concerned that a stronger concentration of DMT would rapidly increase the severity of the irritation.

Not sure where to go from here, since freebase DMT in a patch appears to be a bad idea. One option is to try the "lotion" approach, applying a thin layer of DMT-laden carrier as an oil, cream, gel, or even a spray over a broad area to lessen the irritation at any one particular site. The other option is to see if a salt of DMT can permeate the skin, and if it causes the same irritation that FB does.

Since I've never worked with DMT fumarate, I might try an alcohol-based delivery method going forward myself, probably in gel form. Gonna have to think this one through a bit.


Just a shot in the dark, but calcium acetate forms a gel with ethanol. It can be made by combining lime and vinegar or can be purchased inexspensively as a nutritional supplement.

Also, I’ll still see if I have the same reaction as you did and try nerolidol with and without dmt. Maybe, as you say, a salt would work better.

Edit: PubChem lists the molecular weight of dmt fumarate at 304 so well below the purported limit of 500 daltons for transdermal administration.
"We dance round in a ring and suppose,
while the secret sits in the middle and knows." Robert Frost

 

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Ruffles
#82 Posted : 10/31/2021 5:44:48 PM
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Quote:
From this, I'm forced to the unfortunate conclusion that it was the DMT freebase that was the cause of the irritation, NOT the nerolidol as previously thought.


Has your freebase been cleaned with acetone or IPA after freeze precipitation?

Couldn`t some small amount of NPS be trapped inside freebase crystals and be acting on your skin, specially in longer contact times?

Most NPS are strong skin irritants, although they would also help with disrupting barriers to absorption (which really is another cause of irritation).

Sublingual fumarate tastes horribly of whatever NPS as it is precipitated out of it in the first round, irritates the mucosa somewhat. Once you reprecipitate on IPA or acetone the taste becomes bearable like bitter salt and little to none irritation occurs.
 
ava69
#83 Posted : 11/14/2021 6:58:54 PM

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Hi roninsina & Ruffles & everyone, great work! read the whole thread. I've worked with a transdermal formula, but found waiting nearly 1.5 hour for it to work weakly, just too long to wait. But below is a sublingual formula that works very well, in case interested.

Anyhow, rom my end, complete instructions and pictures all updated for 1-1-2022 on sublingual HPBCD DMT & summary of over 44 sublingual experiences in a year's time, these experiences all much stronger than oral DMT by many factors. Zero nausea, zero dizziness, zero anxiety or un-easy feelings, deep head space, highly visual, strong open eyed and CEV's of spinning & dancing geometrics & real Ayahuasca visions, incredible music enhancement, way over the top open eyed beauty, neon colorful & highly euphoric, see trip reports bottom of post #1...will continue to use for the rest of my life, highly recommend:
https://www.dmt-nexus.me...spx?g=posts&t=96861

From post #1:

My procedure:
1) place 60mg of DMT onto a spoon
2) add 1:1 molar ratio of host drug to HPBCD powder, this means 1:7 mg ratio DMT to HPBCD, use a 1:8 mg ratio DMT to HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
3) this means 60mg dmt placed on spoon, then add 420mg of HPBCD on top DMT, use 480mg HPBCD if you are using the 2-Hydroxypropyl-β-cyclodextrin.
4) add 10 drops of very hot near boiling water to the mix from a nearby microwaved coffee mug for DMT doses of 90mg or below, use 12 drops of boiling hot water to mix DMT doses over 90mg (such as 100 to 120mg). 60mg DMT = +3 Shulgin level strength, 90 to 120mg = +5 Shulgin level life changing strength.
5) Knead or crush the HPBCD powder into the dmt using the end of a spoon for 2 minutes, scrape & mix everything back and forth hard using your muscles. This is how scientist pre-pare these complexes by kneading.
6) Hold a lighter under the spoon with flame around an inch or less away to heat up spoon for around 15 seconds or so to 110 degree F or more, so that complete dissolution or dissolving takes place, after heating up, mix the contents a little bit more before using.
see pics.
6) Take 150 to 300mg tetrahydroharmine orally around 45 minutes before. Place 35mg of freebase harmine under your tongue. Then place bottom of your tongue onto HPBCD complexed DMT spoon, the HPBCD DMT glob will all adhere as HPBCD powder forms sticky complexes. Be sure to take the 35mg harmine and HPBCD DMT under tongue all at the exact same time in order to activate the DMT strongly.

Hold under tongue for 10 to 12 or 15 minutes depending on dosage, press down with bottom of tongue the whole time to trap sticky liquid complex in the sublingual mucosa. Be sure to use bottom end of tongue to lick any off spoon that is left behind, you want to get it all.

At end of 15 minutes, spit out any saliva into a cup instead of swallowing. Gently relieve any saliva during the 15 minute period as comfort dictates by leaning your head forward and spitting into a cup, but keep your tongue pressed down any time you relieve saliva. There is a mild to moderate sting felt but it's so worth enduring for the effects in 22 minutes. The sting does not bother me at all. The tongue is completely fine afterwards (no burn), and it's as if nothing happened the next day.

For guests who can't log in, go here to Mycotopia: botanicals to see pics: https://mycotopia.net/to...ly-active-under-tongue/

Pic 1: 300mg pure white tetrahydroharmine taken 45 minutes earlier orally, 35mg brown freebase harmine taken sublingually at same time (under tongue) as 90mg DMT complexed to (90 x 7 = 630mg HPBCD, use 90 x 8 = 720mg if using the more common 2-HPBCD) in 10 drops of boiling hot water.

Pic 2: Notice Bic lighter, dropper, mug of microwaved boiling hot water, 90mg DMT was added to spoon with (90 x 7 = 630mg plain white HPBCD) and crushed + mixed well for 2 minutes on the spoon (scraping all together back & forth hard using your muscles) using the end of another spoon in 10 drops of boiling hot water, then lighter held under spoon for 15 seconds or so to complete the dissolution of the DMT into the HPBCD. After heating up, mix the contents a little bit more before using.

Pic 3: Notice how well the DMT dissolved or complexed into the HPBCD. Make sure your 35mg harmine fb is under your tongue 1st, then place your tongue onto spoon, the sticky HPBCD complexed DMT will all adhere, get ready for a very strong journey that begins in 22 minutes, and lasts for 90 minutes, at which time you can re-dose more sublingual harmine + HPBCD DMT up to 2 more times, each dose just as strong as 1st dose, for a 4.5 hour long journey with super-long afterglow beyond that. No need to ever take more THH as it has a half-life of 10.5 hours with peak at 5.25 hours.

ava69 attached the following image(s):
sublingual HPBCD DMT pics.PNG (704kb) downloaded 5 time(s).
 
roninsina
#84 Posted : 11/30/2021 3:44:22 AM

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Just wanted to say I don’t have any intention of ghosting this thread. I suppose it’s possible the OP and others in this thread were experiencing placebo effects, but I’m going to guess there was either unreacted freebase in suspension or the greases and soaps they generated were somehow metabolized and active.

That being said, as IridiumandLace mentioned, and is implied in the article linked by twitchy, either a salt form dissolved in water and perhaps carried in some additional medium or freebase dissolved in alcohol with a carrier would be more optimal.

I haven’t had appropriate set and setting if this were to meet with success, and do not foresee so before the first of the year, so I will reserve this space for uninteresting results and make another post if results merit so.
"We dance round in a ring and suppose,
while the secret sits in the middle and knows." Robert Frost

 
IridiumAndLace
#85 Posted : 12/3/2021 8:33:09 PM

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roninsina wrote:
Just wanted to say I don’t have any intention of ghosting this thread.


Yeah, same here. I had to set this idea to the side for now while I attend to other matters (life, etc).

I did have a small opportunity for an impromptu test the other day, when I accidentally spilled some DMT-saturated heptane on my skin. It was hot so I'm glad it was only a small amount, and it left a sheen of xtals on my skin. Just for fun I got a couple drops of clean propylene glycol and spread it out over the area; half an hour later the PG and xtals had disappeared.

The result was.... Nothing noticeable at all. I'm sure I got only a few mg, but it also didn't leave me with a mark like my previous test. When I get a chance I might explore the "DMT lotion" idea further.
 
ava69
#86 Posted : 12/8/2021 1:26:20 PM

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I've worked with a transdermal formula, but found it weak, and had to wait 1.5 to 2.0 hour for it to work weakly.
 
ava69
#87 Posted : 12/24/2021 1:45:39 PM

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Just wanted to say, love this thread, keep up great work.
 
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