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Is Salvinorin B psychoactive? Options
 
dithyramb
#1 Posted : 6/16/2021 9:03:55 PM

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If so, how would you describe it? Perhaps it has a special synergy with salvinorin A?

I have not been able to find information on the effects of Salvinorin B so far. There are a few species of sage with very high amounts in my country.
 

Good quality Syrian rue (Peganum harmala) for an incredible price!
 
downwardsfromzero
#2 Posted : 6/17/2021 3:29:51 PM

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Salvinorin B is the deacetylated version of salvinorin A. The main reason why salvinorin A is not orally active is because it gets hydrolysed - deacetylated - in the stomach. One impact salvinorin B might have on the salvinorin A experience is by slowing the breakdown of salvinorin A through equilibrium effects.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
dithyramb
#3 Posted : 6/17/2021 4:19:43 PM

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So it might have some sort of potentiating role then?

Thanks.
 
dithyramb
#4 Posted : 6/17/2021 7:45:30 PM

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I thought the main reason Salvinorin a is not orally active is because of poor bioavailability/intestinal absorption?
 
downwardsfromzero
#5 Posted : 6/17/2021 9:01:11 PM

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Well, people on here were growing thyme-leaved sandwort as a prospective adjunct to Salvia divinorum for its carboxylesterase inhibition capabilities, and there's Twig Harper's Salvia syrup which contains, among other things, Nigella sativa oil with a view to enabling oral activity through a similar means - perhaps by improving absorption or bioavailability as well, I'd need to look at that more carefully.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
RoundAbout
#6 Posted : 6/18/2021 6:30:13 PM

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I don't think so. The binding affinities are out there in the literature if you look (IIRC).

It would be easy to go from Sal B to Sal A if it wasn't for heroin. Unfortunate coincidence.
 
dithyramb
#7 Posted : 6/18/2021 9:13:40 PM

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Here are photos I took during my nature walk today:

1) Salvia cryptantha - 50 micg/g Salvinorin A + 400 micg/g Salvinorin B

I actually know somebody who was traumatized from hallucinations from drinking an excessive amount of the tea.

2) Salvia verticillata. This is actually a close relative of Salvia divinorum. 30 micg/g Salvinorin A + 20 micg/g Salvinorin B.

3) My beloved Wild Rue :-)

Considering the active dose of Salvinorin A, both species of sage could possibly be practical to work with if utilized with full efficiency.

All biological information from https://pubmed.ncbi.nlm.nih.gov/28722248/
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dithyramb
#8 Posted : 6/18/2021 9:49:56 PM

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Is there information on how much Salvinorin B is in S. divinorum?
 
downwardsfromzero
#9 Posted : 6/19/2021 11:40:18 AM

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dithyramb wrote:
Is there information on how much Salvinorin B is in S. divinorum?

Presumably in the various papers detailing the analyses that also led to the discovery of salvinorin A. Subsequent research papers detailing S. divinorum analyses will probably reference the original paper. The PubChem/PubMed entry for the original paper will list papers that reference it, through a "referenced by" button.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
dithyramb
#10 Posted : 6/20/2021 7:00:07 PM

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It seems Salvinorin B is a k opioid agonist, just much weaker than Salvinorin A.

And if I understood the second source correctly, Salvinorin B has potent anticancer activity.

https://www.google.com/u...amp;cshid=1624198568532

https://www.researchgate...stry_of_Salvia_divinorum
 
dithyramb
#11 Posted : 6/26/2021 8:08:30 PM

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I had tried quidding S. cryptantha before without success.

Today I tried quidding S. verticillata for the first time. 5g dried leaves gave me the numbness in the head and jaws feeling of Salvia divinorum... İf a significant experience can be achieved, it probably would take around ten times this amount.

And speaking of numbness in the head... This year I discovered a different psychedelic sage species... Salvia verbenaca. This is very strange as it is a well known species used for medicinal and culinary purposes, but it consistently gives me a strong psychedelic effect, reminiscent of both S. divinorum and psilocybin mushrooms. I can tell it is not Salvinorin A, but has a pronounced "reset" effect similar to S. A. Apparently different salvia species with different psychedelic effects from different diterpenes are known to exist. I can describe the effect as a strong silencing of the mind similar to tropanes, enhanced connection to nature, colorful, playful, and sexual. I didn't feel like allying it so far because it seemed to lack structure and imprint an ambiguity to my awareness. But it provides a strong shamanic trance for sure. Mixing it with my Aya analogues made me feel the strongest spirit connection İ have felt in a long time... İt is water soluble...
 
 
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