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Sublingual psilocybin trials Options
 
Loveall
#1 Posted : 5/22/2021 2:30:23 PM

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Sublingual psilocybin trials have been approved.

Does anyone know how psilocybin was made sublingually active? All I can find are vague mentions of polymer nanoparticles, but no specifics so far...
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Voidmatrix
#2 Posted : 5/22/2021 8:24:30 PM

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I'm looking too to no avail. It seems they're primarily disolvable strips, so the psilocybin presumably is absorbed through those sublingual membranes, bypassing the gastrointestinal tract. But no mention of actual production method of the product.

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downwardsfromzero
#3 Posted : 5/22/2021 8:39:16 PM

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Voidmatrix wrote:
I'm looking too to no avail. It seems they're primarily disolvable strips, so the psilocybin presumably is absorbed through those sublingual membranes, bypassing the gastrointestinal tract. But no mention of actual production method of the product.

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That'll be part of where they want to be making their money, on the patented delivery method.

I wonder if it involves HPBCD?
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― Jacques Bergier, quoting Fulcanelli
 
Loveall
#4 Posted : 5/24/2021 3:06:50 PM

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Thanks guys. I haven't been able to find what they use to make psilocybin sublingually active. I guess it is a mystery for now...
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Loveall
#5 Posted : 5/27/2021 12:13:00 PM

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The attached review is the most relevant info I have been able to find.

Chitosan is mentioned and is interesting. It can be made into ~250nm size polymer spheres.

Maybe it is worth adding OTC chitosan to a mushroom tincture and test for sublingual activity πŸ€·β€β™‚οΈ.
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jamie
#6 Posted : 5/27/2021 1:14:51 PM

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Sublingual psilocybin was explored here years ago. Ice house was talking about successfully quidding mushrooms over a decade ago, and a number of us were using psilocybe tinctures both sublingual as well as snuffed with positive results.

Psilocybin is already active as a sublingual drug, so you will be looking for an increase in effect rather than simple activity.
 
downwardsfromzero
#7 Posted : 5/27/2021 4:16:01 PM

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Here's an idea for an experimental method. Would alkaline quidding of mushroom powder perhaps do the trick? A pinch of lime, a pinch of cornstarch and a pinch of powdered shrooms might be worth a try. I would suggest mixing with the lime immediately before quidding because psiloc~in becomes unstable in alkaline environments.

Chitosan is derived from chitin, and chitin is the principal structural material of mushrooms:
Quote:
Chitosan is a linear polysaccharide composed of randomly distributed Ξ²-(1β†’4)-linked D-glucosamine (deacetylated unit) and N-acetyl-D-glucosamine (acetylated unit). It is made by treating the chitin shells of shrimp and other crustaceans with an alkaline substance, such as sodium hydroxide.

Quote:
Chitin is a long-chain polymer of N-acetylglucosamine, a derivative of glucose. This polysaccharide is a primary component of cell walls in fungi, the exoskeletons of arthropods, such as crustaceans and insects, the radulae of molluscs, cephalopod beaks, and the scales of fish and skin of lissamphibians. The structure of chitin is comparable to another polysaccharide, cellulose, forming crystalline nanofibrils or whiskers. It is functionally comparable to the protein keratin.

Obviously, pure chitosan is readily available for purchase, but the intrepid (cheapskate) researcher will see that any one of a number of naturally-occurring materials (insect wings?) would be a pretty good source of fairly pure chitin. A simple pre-treatment with sodium - maybe even calcium - hydroxide followed by neutralisation should furnish some level of deacetylation. Besides that, some fungi produce a certain amount of chitosan as it is.

This looks like a good read for would-be chitosan nerds: https://www.sciencedirec...pii/B9780128179703000146
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β€œThere is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
Loveall
#8 Posted : 5/27/2021 4:29:48 PM

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For the record, I'm starting with 90% deacetylated chitosan. Above 85% it is considered water soluble.

Thanks for the feedback Jamie. This would be to increase bioavailability then.

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Voidmatrix
#9 Posted : 5/28/2021 1:44:33 AM

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Watch, in a week Loveall is going to be telling us how to make our own psilocybin sublingual strips ha!Big grin

I'll be waitingRolling eyes Rolling eyes

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Question everything... including questioning everything...
There's so much I could be wrong about and have no idea...
The only safe place is the choice you make
All posts, responses, ideas and supposed experiences are that of an imaginary interdimensional being . This being comes to you with the proclivity and compulsion for delving in depths it shouldn't. That being said, everything posted must, perhaps, be taken lightly and with a grain of salt. πŸ‘½
 
Fruit is life
#10 Posted : 5/29/2021 9:57:46 AM

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jamie wrote:
Sublingual psilocybin was explored here years ago. Ice house was talking about successfully quidding mushrooms over a decade ago, and a number of us were using psilocybe tinctures both sublingual as well as snuffed with positive results.

Psilocybin is already active as a sublingual drug, so you will be looking for an increase in effect rather than simple activity.


I can attest, my experience with fresh mushrooms is that If I chew them throughouly and hole them in my mouth, the psychoactive effects are felt immediately albut subtle, lingering until the remainder of the alkaloids become active via oral route.
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