It was my understanding that upon the ingestion of mushrooms, psilocybin gets dephosphorylated to psilocin, which then acts on the serotonin receptors, and none of the effects were due to psilocybin binding to them directly.
However, this article:
Binding of Psilocin and Psilocybin to Serotonin Receptors says psilocybin itself binds to serotonin receptors, although will less affinity.
Does this mean the in vivo dephosphorylation is not complete, and could the difference between the potency of plain mushrooms vs mushrooms prepared using the lemon tek be due to the difference between the affinities of psilocybin and psilocin?