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Data on 5-AcO-DMT Options
 
Brennendes Wasser
#1 Posted : 9/16/2020 11:22:05 AM

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Posts: 499
Joined: 23-Sep-2017
Last visit: 16-Sep-2020
There is practically no information about 5-AcO-DMT on the Internet (not to be confused with 4-AcO-DMT).



Here is some maybe helpful stuff:



Solubility:

boiling n-Hexane (69 °C)
5,0 g in 1 L
500 mg in 100 ml

n-Hexane in the freezer (-20 °C)
1,3 g in 1 L
130 mg in 100 ml

besides for sure super soluble in all kind of solvents like DCM, Ethanol, Acetone, EtOAc, Xylene, ...



Phase Transitions:
Measured with IR Thermometer on a hot plate (give it +- 5 %)

Melting Point
83 - 88 °C

First fumes starting
190 °C

No fumes arising anymore
240 °C



IR-Spectrum (measured in attenuated total reflection method (ATR)




UV-Vis spectrum (concentration < 0,01 wt-% in Acetonitril)




Bioassay:

no effect lol


long story:

20 mg 5-AcO-DMT were vaporized over the course of 10 min.
The vapor taste is very smooth and not yukky like 5-OH-DMT. Also it does not turn black upon heating and vaporizes without any residue - just like pure DMT. In contrast this is not the case for 5-OH-DMT. It quickly turns black above 170 °C and only 50 % will vaporize, while the other 50 % will form a black burned layer on the surface, no matter how soft and gently you are heating it.
Seems like the 5-OH is the source of evil regarding the properties of 5-OH-DMT aka. Bufotenine which makes it hard to crystalize and also generates an unconvenient vaporization profile. Therefore the 5-AcO seems to make the molecule much easier to handle in any way.

Nevertheless no effect was felt. Rolling eyes

Vaporization overcomes first-pass-effect by the liver, maybe this is a reason. 5-AcO-DMT should be a prodrug of 5-OH-DMT. De-Acetylation should be fast in the body, but no idea where it takes place - maybe that step is skipped when inhaling vapors. Nevertheless that would mean the prodrug is totally inactive. Compared to Psilocin, its prodrug 4-AcO-DMT is reported to be instantly active when inhaled, suggesting it has an effect itself. Therefore it would be strange if thats not the case for 5-AcO-DMT. Only solution would be: What you see in the first picture is not 5-AcO-DMT, which is nearly impossible, but cant be proven by MS or NMR right now.
Still, it has a distinct Tryptamine / Alkaloid taste. Maybe I should spend some time comparing the IR to this one.

3257 is hard to see, but might be there
(2186 not in literature spectra)
1752 is there
(1698 not in literature spectra - Acetic Acid?)
1373 is there
1216 is there
1168 is there
948 is there

... seems like true 5-AcO-DMT. 2186 + 1698 might be any residual stuff, but their signals are quite strong and in contrast the purity should be super high.
Check the

BIG Analysis on DMT !

Lots of interesting and possibly new stuff unraveled ;o
 

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downwardsfromzero
#2 Posted : 9/21/2020 12:46:14 PM

No way ticket

Chemical expertSenior Member

Posts: 5031
Joined: 30-Aug-2008
Last visit: 26-Sep-2020
Location: square root of minus one
Great work, BW. I'm always impressed by your practical efforts.
Brennendes Wasser wrote:
Compared to Psilocin, its prodrug 4-AcO-DMT is reported to be instantly active when inhaled, suggesting it has an effect itself. Therefore it would be strange if thats not the case for 5-AcO-DMT. Only solution would be: What you see in the first picture is not 5-AcO-DMT, which is nearly impossible, but cant be proven by MS or NMR right now.

Maybe 5-AcO-DMT is inactive as a prodrug because of steric bulk and/or bad electron distribution? Then metabolism stops the 5-OH from getting to an active concentration in any of the important places, if that makes sense.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
 
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