Sinomenine from Sinomenium Acutum Options
#1 Posted : 8/1/2020 6:02:10 AM

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I have read studies about it being a novel analgesic and evidence for it being an NMDA antagonist. Compare the molecule with dextromethopran. Could this possibly be a better analog of DXM for reaching those states?

A listing online for this states:
..3g+ sample of Sinomenium Acutum containing 99% pure Sinomenine. This is frequently used in TCM for it's purported pain relieving effects. I will add additional details in the near future. Feel free to reach out to me with any questions!

Here are two forum threads about it with no conclusions made:

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Minor edit in quoted description. Sales lingo, etc.
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#2 Posted : 8/2/2020 6:25:32 AM

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Dextromethorphan (DXM) molecule for comparison
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#3 Posted : 8/3/2020 5:59:14 PM

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The geometry of sinomenine vs. that of DXM is rather different. Dashed bonds are below the plane of the picture. Wedge bonds project out of the plane. I've attached a side-by-side comparison of the two molecules and a 3-d rendering of each. Crucially, the nitrogen atom is positioned very differently in each respective case. I would predict that sinomenine displays neither an antitussive nor a dissociative effect, at least not at sensible doses.
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DXM vs Sinomenine.jpg (7kb) downloaded 20 time(s).
DXM vs Sinomenine flipped.jpg (7kb) downloaded 20 time(s).
DXM3dVDW.jpg (7kb) downloaded 20 time(s).
Sinomenine3dVDW.jpg (8kb) downloaded 20 time(s).
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