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Sinomenine from Sinomenium Acutum Options
 
PsilocybeChild
#1 Posted : 8/1/2020 6:02:10 AM

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I have read studies about it being a novel analgesic and evidence for it being an NMDA antagonist. Compare the molecule with dextromethopran. Could this possibly be a better analog of DXM for reaching those states?

A listing online for this states:
Quote:
..3g+ sample of Sinomenium Acutum containing 99% pure Sinomenine. This is frequently used in TCM for it's purported pain relieving effects. I will add additional details in the near future. Feel free to reach out to me with any questions!


Here are two forum threads about it with no conclusions made:
https://drugs-forum.com/...al-dissociative.294145/
https://www.bluelight.or...nmda-antagonist.807342/

Moderator wrote:
Minor edit in quoted description. Sales lingo, etc.
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Wire 2020-07-31 at 1_16 AM.png (667kb) downloaded 49 time(s).
 

Good quality Syrian rue (Peganum harmala) for an incredible price!
 
PsilocybeChild
#2 Posted : 8/2/2020 6:25:32 AM

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Dextromethorphan (DXM) molecule for comparison
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Screenshot from 2020-08-02 01-24-43.png (12kb) downloaded 31 time(s).
 
downwardsfromzero
#3 Posted : 8/3/2020 5:59:14 PM

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The geometry of sinomenine vs. that of DXM is rather different. Dashed bonds are below the plane of the picture. Wedge bonds project out of the plane. I've attached a side-by-side comparison of the two molecules and a 3-d rendering of each. Crucially, the nitrogen atom is positioned very differently in each respective case. I would predict that sinomenine displays neither an antitussive nor a dissociative effect, at least not at sensible doses.
downwardsfromzero attached the following image(s):
DXM vs Sinomenine.jpg (7kb) downloaded 15 time(s).
DXM vs Sinomenine flipped.jpg (7kb) downloaded 15 time(s).
DXM3dVDW.jpg (7kb) downloaded 15 time(s).
Sinomenine3dVDW.jpg (8kb) downloaded 15 time(s).
Ora, lege, lege, lege, relege et labora

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