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Eschscholzia californica (Californian poppy) - simple crude alkaloid extract, smokable Options
 
downwardsfromzero
#1 Posted : 5/12/2014 12:06:23 AM

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IMPORTANT SAFETY NOTICE
DO NOT ATTEMPT TO EMULATE ANY OF THIS

The effects of Eschscholzia californica, the Californian poppy, are well enough known. It is a plant that is easy to grow and obtain in sufficient quantities for worthwhile scientific experimentation.

After having tried smoking pretty much all parts of the plant - petals, stamens, leaves, stems, roots, seed pods (but not the seeds as they are too useful) - as well as ingesting proprietary gelcaps of the herb, I decided to attempt a crude alkaloid extraction as follows:

Seed pods were collected from the plants whenever they were approaching a state of ripeness. This is the point where they begin to lose their green colour a little and start to dry out, but before the pods have burst open. When ready, they detach from their stems with a gentle twist.

The pods were then placed in a paper bag and allowed to dry out in a warm, well-ventilated place. The top of the bag was left open a little in order to prevent mould formation. On sunny days, the pods would pop open from time to time, causing surprise and amusement.

At some point, the paper bag was sufficiently filled with now dried and popped pods. The pods were separated from any remaining seeds and ground to a fine powder in a coffee grinder (rotating blade type). This was achieved by repeatedly sifting out larger pieces and regrinding them. The final sift was through a very fine nylon mesh of the sort sometimes used for infusing tea or coffee.

This process furnished a very fine khaki- to tan-coloured powder, with a curious bleachy-alkaloidal smell, with malty and vanilla tones. The powder made a fairly acceptable snuff which clearly had an appreciable content of active compounds, thus it was used as a material for a (triumphant orchestral chord!) simple extraction process.

A heaped teaspoonful of the Cali-poppy-pod-powder was mixed with a similar amount of sodium bicarbonate powder (pharmaceutical grade) and intimately mixed in a small plastic ziplock baggie. (The actual intention here was to investigate the effect on the powder as a snuff. Perhaps unsurprisingly, it made it eye-wateringly painful, hence the progression to the next ingenious step.)

About a quarter-teaspoonful of the bicarbonate-blended powder (i.e. using not more than 500mg of plant material) was placed in a normal metal teaspoon. Sufficient boiled and cooled (fairly soft) tap water was carefully added to nearly fill the teaspoon.

The teaspoon was then heated over a candle flame and the liquid simmered. Some effervescence was observed which is to be expected when heating sodium bicarbonate solutions alone. The liquid was allowed to evaporate not quite to dryness, then removed from the flame. The remaining heat in the spoon finished off the drying process.

On examining the spoon, a tan waxy substance was seen to have collected around the edge. A small amount of this substance was subjected to a vaporization test using a pipe and lighter. It apparently vaporized leaving very little trace.

The vapour was very mild to inhale and produced a pleasant mood elevation, although a noticeable amount of alcohol had also been consumed by this point. Nonetheless, the described effect was greater than that of the alcohol alone. Further amounts of the product were smoked in a pipe to appreciable effect. The total amount smoked will have been (much) less than 75mg.


...and that is where the experiment currently stands, more or less.

Probably it would be fun to add a solvent extraction on after the boil, and of course to use a larger, measured quantity.

The other thing I would mention is that the product smelt very much like sponge cake Smile :yummy: and had lost the bleachy tang of the starting material.


SOME NOTES ON SAFETY
Oh, yes, also - this describes playing with toxic alkaloids so handling of larger quantities should only be approached with due caution by persons of sufficient skills and experience, if at all.

Some of the activities described above may be dangerous, particularly the smoking of uncharacterised herbal extracts of unknown potency without weighing.

The safety parameter here was in the preparation using only an amount of substance which was known to be tolerated by the subject, plus E. californica's established properties as a recognized herbal medication.


(I weigh 60kg and have a fairly fast metabolism.)

The experiment took place in a safe, domestic, culinary setting.


If we're super lucky, photo's may follow...
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 

STS is a community for people interested in growing, preserving and researching botanical species, particularly those with remarkable therapeutic and/or psychoactive properties.
 
SpartanII
#2 Posted : 5/29/2014 3:04:25 PM

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Sounds like a lot of trouble to get psychoactive effects, but props for experimenting! Smile

Are you looking for an opiate-like experience? If so, kratom seems like a much better candidate (and less toxic), plus you don't have to smoke it so you avoid lung irritation and possible carcinogens from burning plant material.Thumbs up
 
Cognitive Heart
#3 Posted : 5/30/2014 4:41:17 AM

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The experiment was a success! Smile

This is one plant I am interested in for utilization. Being from the Ranunculales family, this family is quite toxic if not used properly and respectfully, but also has incredible health benefits regarding overall health and tone and powerful effects.

California poppy leaves were used medicinally by Native Americans, and the pollen was used cosmetically. The seeds are used in cooking.

An aqueous extract of the plant has sedative and anxiolytic action. The extract acts as a mild sedative when smoked. The effect is far milder than that of opium. California poppy contains a different class of alkaloids:

"An aqueous alcohol extract of Eschscholzia californica has been evaluated for benzodiazepine, neuroleptic, antidepressant, antihistaminic and analgesic properties. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, and did not cause muscle relaxant effects, but appeared to possess an affinity for the benzodiazepine receptor. The extract induced peripheral analgesic effects in mice but did not possess antidepressant, neuroleptic or antihistaminic effects." California poppy leaves were used medicinally by Native Americans, and the pollen was used cosmetically. The seeds are used in cooking.

An aqueous extract of the plant has sedative and anxiolytic action. The extract acts as a mild sedative when smoked. The effect is far milder than that of opium. California poppy contains a different class of alkaloids:

"An aqueous alcohol extract of Eschscholzia californica has been evaluated for benzodiazepine, neuroleptic, antidepressant, antihistaminic and analgesic properties. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, and did not cause muscle relaxant effects, but appeared to possess an affinity for the benzodiazepine receptor. The extract induced peripheral analgesic effects in mice but did not possess antidepressant, neuroleptic or antihistaminic effects." - Wikipedia

Interesting info regarding Eschscholzia Californica..
"What's going to happen?" "Something wonderful."
 
downwardsfromzero
#4 Posted : 1/15/2015 4:41:45 AM

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SpartanII wrote:
Are you looking for an opiate-like experience?
No. I just wanted to see what would happen. I've found the plant to be a very useful and beneficial ally, particularly during stressful times in my life. It appears to have anti-addicting properties and it is always clear when I no longer need its assistance. Hence my attempt to make a freebase alkaloid Cali-poppy-crack to really test this out (tongue fairly firmly in cheek here Pleased )

Plant is incredibly easy to grow and does best in a sunny location in dryish ground with rocks underneath. Likes to establish a taproot so is annual in pots or biennial if pot is large. Either way, sets abundant seed. All parts of the plant appear to be useful. The stamens are particularly nice to smoke.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
The Traveler
#5 Posted : 1/15/2015 9:01:04 PM

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I am missing the very important safety aspects here in the first post.

See this thread about the why and how of this:
[NEW] Policy regarding discussion of different drugs

If the first post will not be changed then this thread will be removed.


Kind regards,

The Traveler
 
downwardsfromzero
#6 Posted : 1/19/2015 3:40:35 AM

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The Traveler wrote:
I am missing the very important safety aspects here in the first post.

See this thread about the why and how of this:
[NEW] Policy regarding discussion of different drugs

If the first post will not be changed then this thread will be removed.


Kind regards,

The Traveler

Could you please be more explicit? I have so far added a temporary warning.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
downwardsfromzero
#7 Posted : 11/18/2019 5:19:25 PM

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So, here's a safety update Big grin - albeit not in connection with a smokeable extract.

Sometimes I still use finely powdered seed pod cases from Californian poppies as a sleep aid. Recently I added a teaspoonful to a cup of chamomlie and hemp tea, to make sure I really got to sleep. When I laid down to sleep afterwards, I noticed my heart rate was elevated to about 80 bpm when it should be around 60. This made me think a bit. It seemed to me there was an effect on my beta-adrenergic systems somehow. It's also worth noting that I ate about an ounce of hard cheese beforehand which may have contributed to the cardiac effect.

One of the main alkaloids in Cali. poppy is calfornine, pictured below - with a comparison to MMDA-2, which has a certain level of structural similariity. It occurred to me to check what the pharmacological properties of MMDA-2 are, and - lo and behold! - it turns out that it has been found to inhibit reuptake of norepinephrine (noradrenaline) [Biochem. Pharm. 27(10): 1497-1501]. So, I would not be at all surprised to find that californine would have some kind of measurable effect on the same systems.

This experiment is worth repeating but without the hemp, which has also caused mild tachycardia for me in higher doses.
downwardsfromzero attached the following image(s):
californine vs MMDA2.jpg (8kb) downloaded 80 time(s).
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
Tony6Strings
#8 Posted : 11/18/2019 7:20:33 PM

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Very interesting. Wonder if these poppies would be helpful to someone going through benzodiazepine withdrawal.
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"We have arrived at truth, and now we find truth is a mystery- a play of joy, creation, and energy. This is source. This is the mystic touchstone that heals and renews. This is the beginning again. This is entheogenic." -Nicholas Sand
 
Cactus Man
#9 Posted : 12/2/2019 9:29:48 PM
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I applaud this thread highly. Never experimented with this type of poppy but I have had the prestigious privilege of getting to know the somniferum's quite well. Would be interested to hear more on the subject of Eschscholzia californica. Although I would say that from all the knowledge I have gained thus far regarding somniferum (which at this point I am not sure is even really relevant to Eschscholzia californica so take this with a grain of salt) it really is for all intents and purposes more practical to use orally than any other method.

They say that prior to opium being introduced in a "smoked" preparation (which from research I have 100% confirmed is in fact pharmacologicaly different than raw opium, raw opium being the only type of real opium I have ever had the pleasure to try and at first was baffled by why it was giving me literally zero effects when smoked) that there never was even remotely as much of an "epidemic" (as it were) of opium addiction as was seen after the introduction of refined opium (chandu) and pipes with which to "smoke" (vaporize) it.

The introduction of smoke-able opium brought with it an increase in the rush and rapid action of the high, while decreasing its longevity. It also supposedly (and most likely it is true) decreased the constipation which would normally be experienced from oral ingestion, as well as decreasing the nausea associated with it.

While these things seemed like a great advancement or benefit at the time they actually boomeranged back in the long run because people realized in its smoked form it was even more addictive and in fact even less practical as a medicine.

Its almost as if the more people have refined a product like opium the more they have exacerbated its narcotic and addictive properties and reduced its truly medicinal value.

Sorry if this post is viewed as "irrelevant" but I find it hard to find any opportunity for conversation which is scholastic and novel on the subject of poppies (regardless of what kind of poppy) and I just thought I would take the bull by da hornz.

Big grin
 
downwardsfromzero
#10 Posted : 2/20/2020 8:52:51 PM

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Cactus Man wrote:
[...]
Eschscholzia californica pharmacology is entirely different from that of Papaver somniferum. This does not mean that concentrated extracts of E. californica are any safer, of course. (Even if I suspect them to be, at least as regards addictive potential - I have found Californian poppy to be functionally self-limiting in that respect. Acute toxicity of the alkaloids is probably higher, however.)

Cognitive Hearts's post above outlines this plant quite nicely. Cali poppy was particularly helpful for me as an anxiolytic when this was really needed. Cessation was entirely painless once the situation was resolved.
Ora, lege, lege, lege, relege et labora

“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli
 
 
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