Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain Options
#21 Posted : 11/11/2019 1:36:02 AM

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This is the kind of analytical science homework they need to have university students doing. Especially on the sophomore(+) levels.

I absolutely Hated Biochemistry Lab back in college, but this is some seriously interesting stuff. I'd like to see more published studies like this.

I'll admit, I was skeptical when I first heard Strassman's hypothesis, and his book was a really unique experience to say the least.

I'm just really surprised that there aren't more of these assays being done. I mean it's not that difficult.

Light and Love and Travel Well.

Good quality Syrian rue (Peganum harmala) for an incredible price!
#22 Posted : 11/18/2019 11:46:27 PM


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A commentary to this research has come out (posted by Bancopuma here).

I believe the scientific commentary mostly agrees with the points we brought up here. Mainly that the DMT surge alone is unlikely to be a bioactive driver of NDE. Also, they point to important surges in many other neurotransmitters, including serotonin which could compete with the increase in DMT for 5HT2 receptor sites.

They also point to the natural activation of kappa opiod receptors (by for example a possible dynorphin increase). In this regard, it is interesting that Aum_Shanti postulated here a natural opioid agonist acting together with some kind of serotenergic compound (but more 5-MEO-DMT like than DMT) as possibly similar to their personal NDE.
“... (a) psychedelic substance occasionally causes psychotic behaviour in people who have not taken it.”
Excerpt from a McKenna talk transcript / audio.
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