Interesting, thanks for sharing bancopuma!
fathomlessness wrote:so the ocd mice are less prone to losing their marbles?
fathomlessness wrote:
has any study conclusively looked at the alkaloids within Psilocybe argentipes?
This paper says they have found, appart from psilocybin, another substance in Psilocybe argentipes which the author thought might be baeocystin but hasnt confirmed the id. They also found 3 other non-psychoactive substances: ergosterol, ergosterol peroxide and a,a,-trehalose.
As for the original study posted in this thread, and in relation to the difference between psilocybin vs full mushroom, it seems dosage is significant... At the lowest dose of mushroom studied, which is 0.05g/kg (equivalent of 3.5g mushrooms for a 70kg human), there is a reduction from around 20 marbles to 15 marbles buried, but the equivalent 0.025mg/kg of pure psilocybin also reduced the same.
The difference is only really significant at higher doses, but from the data presented its hard to know what is the exact the dosage that the difference appears significant in marble-burying, because the mushroom dosage graph shows data for increases from 0.05 to 0.1 (or equivalent from 3.5g to 7g in humans), but the psilocybin dosage graph increases from 0.025mg/kg to 5x that amount, 0.125mg/kg, or in humans equivalent to 3.5g to 17.5g). That's a large gap. Would be nice to have more data on intermediate dosages for pure psilocybin.
Another interesting thing that the original paper claims is that the effect is probably not related to the hallucinogenic effects because it is not exactly dose-dependent (or at least it is only dose-dependant up to a certain dosage, then it stops reducing the marble-burying numbers), so they think it is not 5-HT2a mediated.
I might be nitpicking but one thing I found a bit of a stretch is that they say
Quote:"Hallucinogenic mushrooms pro-duce a wide variety of tryptamine derivatives other than psilocybin. Some of these, such as psilocin, baeocystin, norbaeocystin, bufotenin, and aerginascin, have psychoactive effects, although many hallucinogeni cmushrooms produce smaller amounts of them than psilocybin. These findings suggest that inhibition of marble-burying behavior by P. argentipesis due to the involvement of a variety of psychoactive substances"
. I think it is not correct to assume "a variety of substances" just because
some (other) species of mushrooms show a variety of substances. Those mentioned substances have certainly not all been found in all psilocybin-containing mushrooms. Taken that together with the fact the analysis paper I linked earlier only shown one extra psychoactive substance, potentially baeocystin, I think a more honest assessment imo would say "these findings suggest ...... due to the involvement of
one or more psychoactivesubstances". The next step for this research should be to include baeocystin in tests with psilocybin, as well as further analyse the mushrooms they have with LC-MS or similar, to find what other compounds are there.
What do we know anything about baeocystin pharmacology?