Hello folks,

about 6-7 years ago, I first got into reading about psychedelic compounds. My interest towards chemistry in general lead me to searching for "LSD synthesis" online. At that point, I didn't even know anything about the effects of this drug, except some vague knowledge about "hallucinations" and "pink elephants". I was very astounded reading about the minuscule amount of compound needed to cause such profound effects. That drugs could be non-addictive. Physically largely safe. Everything.

Shortly after, I began reading books by Albert Hofmann, Alexander&Ann Shulgin, various forums - largely chemistry-related, etc. When I turned 18 and heard about someone having access to acid, I got some myself. Due to my reckless behaviour, this first trip lead to quite some (negative) experience. Another try, some 2.5 years later, wasn't much less reckless. Both trips lead to being reincarnated together with the whole universe, after living through my own personal hell. Both trips featured a cosmic sacrifice of my soul, being ridiculed for my arrogance, stupidity, naivety. Nonetheless, I couldn't bring much home from either of the experiences. Certainly, they were interesting and powerful, but the only insight I got was that my respect towards psychedelics has to grow a lot. Perhaps this will be the most important thing to remember on my journey.

DMT is one of the drugs I have on my list, although probably far in the future. If 150 µg of an 1-acyl-LSD derivative can shatter my soul into an infinite amount of pieces, what will a breakthrough dosage of DMT do to me? I almost have an irrationally big fear about getting to know the answer, but it is overpowered by curiosity - the main driving force of human progress.

For now, my interests are more focused on relatively mild and humble entheogens and empathogens though. I seem to be very sensitive, even cannabis can produce CEVs/OEVs/near egodeath experiences for me at this point.

I hope this introduction could give you some insights into my personality and attitude.

Be safe, best regards,
xdragon

High sensitivity is a blessing in my eyes Consider the opposite: is that preferable? Nevertheless it means to be more cautious. It's unlikely that your responsiveness is binary - either nothing or breakthrough. It's likely a range, that can be explored from bottom to top. So take it slow.

Considering cannabis: I think CEVs are normal. OEVs and LSD-like experiences are mostly connected to oral consumption in my experiences.

Is 1-acyl-LSD comparable to classical LSD-25? 150 µg of that is high dose without tolerance from what I've experienced.

Do you have only extreme experiences, even if you take low dosages? (Maybe you only need less of everything, that would make you more cost-efficient.)

According to the Attitude page, I can not discuss novel psychoactive substances as a new member. This is why I will not further address this topic here. However, please be careful that "Acyl" is not the same as "Acetyl". Acyl is a general name given for carboxylic acid moieties - such as Acetyl, Propionyl, Butanoyl, Cyclopropylcarbonyl, etc. So no concrete answer can be given anyway.

I didn't want to give a concrete example of the two different derivatives I've tried (because of the rules), but still wanted to put emphasis on the fact that it wasn't classical LSD. Nevertheless, I'd still like to give you my answer to this question: 10.1016/j.neuropharm.2019.107856

Regarding cannabis: my opinion is that I've gone through basically all the interesting and valuable experiences and insights it had for me to offer. I currently have no intention to consume it again - just like ethanol. The OEVs I had on a single pure joint of cannabis, smoked together with two other persons. I never had OEVs by oral consumption, but definitely very interesting tactile sensations and a clearly psychedelic mindset, together with some kind of dysmetropsia. I've smoked/vaporised cannabis about as often as I've eaten it. As an asthmatic, I really like oral consumption, though vaporisation is fine too.

Yes, high sensitivity only means having to be more careful. It's neither good nor bad, just one thing to keep in mind when sharing experiences, speaking out warnings, choosing dosages. Taking it slow is a good advice, but it takes some discipline. I think I've finally reached that point now though. It turns out you do not need *that much* amount of material to "titrate" upwards, even starting with as little as 1/100 of the wanted dosage. What it takes is patience.

So far, I've had 2/2 extreme experiences with psychedelics (not counting cannabis in). However, 2/2 dosages have been medium dosages - caused by naivety, impatience and a bit of arrogance. Nonetheless, I am currently more looking into milder psychedelics as I do not feel the need to shatter my reality apart as of now. Still plenty of time to go down that path later in my life. I am hoping to gain some insights regarding a mild form of general sadness which emerged and which I have trouble finding the reason for. Maybe this can be achieved through the responsible and safe usage of some empathogen/mild psychedelic-type drug.

Oh, and I forgot to mention that I am currently also growing lophophora williamsii from seeds. But I couldn't forgive myself for killing any of these plants for hedonistic ambitions!

Vaping DMT at a dose of low effect is in my eyes one of the easiest psychedelics because it's effect is short lived and the body-load is minor under the premise that dosage is securely taken care of. Maybe someone knows a better psychedelic alternative but besides cannabis, I can't think of one. From my experience phenethylamines have a way higher body load than tryptamines, whilst not being as philosophical. So keep your little cactus alive, it will protect you one way or another.

Have you read reports of low-dose dmt-trips? Have you ever heard of marihuanilla? It's like a very mildly calming experience when cooked as a tea - not a psychedelic, not trippy.

I am aware of low dose (vaporised) DMT experience reports. It's not something I am seeking out currently. Also, I am quite convinced that trips for light introspection/psychotherapy have to cover at least some time. Otherwise, there is no chance for working through things. I've read both PiHKAL and TiHKAL, alongside a few academic papers on entheogens/entactogens/empathogens, so I actually have a pretty good idea what I am looking forward to personally. Still need some more time and a clear mind to get things going.

Marihuanilla seems quite interesting, but I do not really feel in need of a mildly calming experience. Just drinking a nice regular tea or relaxing after an exhaustive day gets the job done for me, luckily. Thanks for letting me know, it seems very interesting - but still needs some evaluation towards the actual active compound/mixture. That reminds me of Dendrobium nobile, which was also claimed to have a cannabis-like effect. I would recommend anyone to stay away from too experimental stuff though. There is zero actual knowledge about this, just a handful of anecdotal reports.

Welcome to the Nexus!

Have you ever tried mescaline? Low-mid dose mescaline can be quite soothing one one's soul ime Not forceful like LSD or some other psychedelics.

Is there any particular area of chemistry you are more knowledgeable in?

Be well!