While not being directly related to your question, my best HBWR was after(*) a night drinking slightly too much brandy (many years ago, when this sort of behaviour still seemed reasonable). At the time I wasn't even particularly aware of the vasoconstriction issue with lysergamides; nausea was a far greater concern - which was about 95% due to alcohol consumption - but an induced purge brought things along very nicely. This turned out to be one of the more significant plant teacher experiences of my lifetime.
(*)The seeds were ingested later that same night, probably washed down with a swig of brandy. The initial effect was highly soporific. Entheogenic effects developed overnight such that I woke up in an altered state.
“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli