The other night I was hanging out with some friends and we were going to have some DMT. Just low doses nobody was trying to break though. One of the people there mentioned that they had just tripped 8Gs of shrooms two days before and another mentioned they had 2 tabs of acid the day before. The one who had taken the shrooms had a great trip but the one who had taken the LSD didnt feel anything the whole night. I found this odd because I was under the impression that DMT had no tolerance or cross tolerance effects but even more so that the LSD would have one yet Psilocybin didnt seem to effect it at all considering DMT and psilocybin are much more chemical related. Has anyone had a similar experience?

i have never known any such cross tolerance but there are instances when dmt simply doesnt work as it should. often referred to as being locked out. seems to have nothing to do with tolerance and everything to do with it just not being your time and place for one reason or another.

it seems to me that putting a bit of a break between any psychedelic experiences and dosing dmt is a good idea.. lockouts dont always happen, but when they do, its much nicer than the alternative.

same thing happened to me 1p lsd the day before, then the next day tried pharma dmt and nothing. brain got into the racing thought mood but 0 OEV's CEV's

There is a cross tolerance between LSD and most other (all?) psychedelics. It generally works more in one direction than the other. For example, taking LSD first, and other psychedelics after, will significantly decrease the effect of the other psychedelic. But taking, say, mushroom or DMT first, and then LSD after, will not diminish LSD's effects too much. Mushrooms and DMT do not seem to have a cross tolerance with each other in either direction.