Become attuned with your materials. Maybe your rootbark is bunk.
Multiple small extractions from the same material yield more than one big extraction.
It shouldn't be that difficult to extract alkaloids using hot water, assuming they're present in the first place.
“There is a way of manipulating matter and energy so as to produce what modern scientists call 'a field of force'. The field acts on the observer and puts him in a privileged position vis-à-vis the universe. From this position he has access to the realities which are ordinarily hidden from us by time and space, matter and energy. This is what we call the Great Work."
― Jacques Bergier, quoting Fulcanelli