I have found that since starting Zoloft 100mg, DMT has almost no effect on me. A substantial smoked dose gives me a weak body rush lasting about 30 seconds. That's it. Before Zoloft, DMT affected me normally. A friend who takes Paxil has experienced the same thing. Anyone else experience this, first-, second-, or third-hand?

Pharmaceuticals kill it.... Almost all and any will rapidly decrease the effects. Example is a friend of mine takes adderall and always takes a 2-3 day break before indulging in the molecule. Sometimes 5 days if there is going to be any MAOi involved. That may be reckless but has noticed no effects and has been doing it for about a year meow.

That's not true. SSRIs are known to reduce/change the effects of vaporized DMT, and I'm sure many other drugs change the experience also... but certainly not all. I don't think I need to offer personal anecdotes or paste in others' experiences to support this.

Yeah pretty sure serotonin will compete with dmt for receptor sites, my friend who is on a pharmacuetical ssri is quite insensitive to dmt, although it obviously still effects him, there is not much substance to his experiences he reports, and he needs 5x the dose I would need to get somewhere

I've read that SSRIs are experience-dampeners for sure. From recent personal experience I can attest that, for me, the SARI trazodone (Desyrel) certainly seems to inhibit DMT. This is all new personal territory but I believe some (?) of the mechanism of action is the same. Hey, three of the the initials are identical! (it's a serotonin antagonist and reuptake inhibitor)