I don't regularly suffer from migraines although I have had them infrequently in the past.
I've never used tryptamines to cure a migraine, but whenever I take 4-aco-dmt (mushroom analog) it feels like it's massaging my brain!
I could see this being VERY useful for migraines, possibly more-so than regular mushrooms (which I have read are quite helpful against migraines.)
4-aco-dmt is wayyy gentler than DMT, a light threshold dose will last longer than DMT(4-8h instead of .5h) and be nowhere near as stressful.
In my opinion 4-aco-dmt will likely be more useful than DMT for migraines.
Something that gives 4-aco-dmt an edge over real mushrooms is the ability for quicker sublingual absorption. LSD obviously has this advantage too.
What is really appealing here is the shorter duration to something like LSD. In my case even a barely-threshold dose of LSD is enough to keep me up all night. I imagine a small oral dose of 5-10mg of 4-aco-dmt would be more than enough to abort a migraine and still allow one to get to sleep relatively easily.
Sorry I don't have any real experience in this area to confirm my beliefs.
Disclaimer: All Entheogens and other research materials are not for Human consumption! I have researched by text the effects of consuming such things in case of accidental consumption. I have never actually consumed any of the materials I speak about and it should be assumed I'm speaking hypothetically. I have a wild imagination.